Brugia malayi: In vitro effects of ivermectin and moxidectin on adults and microfilariae

Experimental Parasitology

Volumn 124, Issue 4, 2010, Pages 394-402

  Tompkins, J B ^a   Stitt, L E ^a   Ardelli, B F ^a  

^a BRANDON UNIVERSITY   (Canada)

Author keywords

Brugia malayi; Fecundity; Female; Ivermectin; Male; Microfilariae; Motility; Moxidectin; Nematode; Wolbachia

Indexed keywords

GENE PRODUCT; IVERMECTIN; MOXIDECTIN; PROTEIN WSP; UNCLASSIFIED DRUG;

ARTICLE; BRUGIA MALAYI; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG RESISTANCE; ENDOSYMBIONT; FEMALE; FEMALE FERTILITY; GENE EXPRESSION; LOCOMOTION; MALE; MICROFILARIA (NEMATODE LARVA); NONHUMAN; PRIORITY JOURNAL; WOLBACHIA;

ANALYSIS OF VARIANCE; ANIMALS; ANTINEMATODAL AGENTS; ANTIPARASITIC AGENTS; BRUGIA MALAYI; FEMALE; FERTILITY; GERBILLINAE; IVERMECTIN; MACROLIDES; MALE; MICROFILARIA; MOVEMENT; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; RNA, BACTERIAL; TIME FACTORS; WOLBACHIA;

BACTERIA (MICROORGANISMS); BRUGIA MALAYI; WOLBACHIA;

EID: 76849100333     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2009.12.003     Document Type: Article

References (40)

1. Ardelli B.F., Stitt L.E., Tompkins J.B., Prichard R.K. A comparison of the effects of ivermectin and moxidectin on the nematode Caenorhabditis elegans. Veterinary Parasitology 2009, 165:96-108.
2. Bain O., Babayan S. Behaviour of fibriae: morphological and anatomical signatures of their life style within arthropod and vertebrate hosts. Filaria Journal 2003, 2:16.
3. Baird J.K., Riberu W., Masbar S., Purnomo Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. Journal of Parasitology 1991, 77:162-163.
4. Bazzocchi C., Mortarino M., Grandi G., Kramer L.H., Genchi C., Bandi C., Genchi M., Sacchi L., McCall J.W. Combined ivermectin and doxycycline treatment has microfilaricidal and adulticidal activity against Dirofilaria immitis in experimentally infected dogs. International Journal for Parasitology 2008, 38:1401-1410.
5. Bottomley C., Isham V., Collins R.C., Basáñez M.G. Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments. Parasitology 2008, 135:1571-1581.
6. Breton B., Diagne M., Wanji S., Bougnoux M.E., Chandre F., Maréchal P., Petit G., Vuong P.N., Bain O. Ivermectin and moxidectin in two filarial systems: resistance of Monanema martini; inhibition of Litomosoides sigmodontis insemination. Parasitologia 1997, 39:19-28.
7. Cartel J.L., Moulia-Pelat J.P., Glaziou P., Nguyen L.N., Chanteau S., Roux J.F., Spiegel A. Microfilariae recurrence in Polynesian Wuchereria bancrofti carriers treated with repeated single doses of 100 micrograms/kg of ivermectin. Transactions of the Royal Society of Tropical Medicine and Hygiene 1993, 87:478-480.
8. Chandre F., Petit G., Diagne M., Maréchal P., Bain O. Effect of ivermectin on two filaria-vector pairs. Brugia malayi-Aedes aegypti; Litomosoides sigmodontis-Bdellonyssus bacoti. Annales de Parasitologie Humaine et Comparee 1993, 68:144-149.
9. Cotreau M.M., Warren S., Ryan J.L., Fleckenstein L., Vanapalli S.R., Brown K.R., Rock D., Chen C.Y., Schwertschlag U.S. The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans. Journal of Clinical Pharmacology 2003, 43:1108-1115.
10. Chen S.N., Howells R.E. Brugia pahangi: uptake and incorporation of nucleic acid precursors by microfilariae and macrofilariae in vitro. Experimental Parasitology 1981, 51:296-306.
11. Cully D.F., Vassilatis D.K., Liu K.K., Paress P.S., Van der Ploeg L.H., Schaeffer J.M., Arena J.P. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 1994, 371:707-711.
12. Dent J.A., Mchardy M.S., Vassilatis D.M., Avery L. The genetics of ivermectin resistance in Caenorhabditis elegans. Proceedings of the National Academy of Science of the United States of America 2000, 97:2674-2979.
13. Dent J.A., Davis M.W., Avery L. Avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans. EMBO Journal 1997, 16:5867-5879.
14. Devaney E., Howells R.E. The microfilaricidal activity of ivermectin in vitro and in vivo. Tropenmedizin und Parasitologie 1984, 35:47-49.
15. Gardon J., Boussinesq M., Kamgno J., Gardon-Wendel N., Demanga-Ngangue, Duke B.O.L. Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomized controlled trial. The Lancet 2002, 360:203-210.
16. Geary T.G., Sims S.M., Thomas E.M., Vanover L., Davis J.P., Winterrowd C.A., Klein R.D., Ho N.F., Thompson D.P. Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Experimental Parasitology 1993, 77:88-96.
17. Gyapong J.O., Kumaraswami V., Biswas G., Ottesen E.A. Treatment strategies underpinning the global program to eliminate lymphatic filariasis. Expert Opinion in Pharmacotherapy 2005, 6:179-200.
18. Hodgkin J. More sex-determination mutants of Caenorhabditis elegans. Genetics 1980, 96:649-664.
19. Hoerauf A., Mand S., Volkmann L., Büttner M., Marfo-Debrekyei Y., Taylor M., Adjei O., Büttner D.W. Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microbes and Infection 2003, 5:261-273.
20. Hoerauf A., Mand S., Adjei O., Fleischer B., Büttner D.W. Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. The Lancet 2001, 357:1415-1416.
21. Hoerauf A., Volkmann L., Hamelmann C., Adjei O., Autenrieth I.B., Fleischer B., Büttner D.W. Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. The Lancet 2000, 355:1242-1243.
22. Howells R.E., Chen S.N. Brugia pahangi: feeding and nutrient uptake in vitro and in vivo. Experimental Parasitology 1981, 51:42-58.
23. Kotze A.C. Effects of macrocyclic lactones on ingestion in susceptible and resistant Haemonchus contortus larvae. Journal of Parasitology 1998, 84:631-635.
24. Li B.W., Rush A.C., Crosby S.D., Warren W.C., Williams S.A., Mitreva M., Weil G.J. Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis. Molecular and Biochemical Parasitology 2005, 143:49-57.
25. Mancebo O.A., Verdi J.H., Bulman G.M. Comparative efficacy of moxidectin 2% equine oral gel and ivermectin 2% equine oral paste against Onchocerca cervicalis (Railliet and Henry, 1910) microfilariae in horses with naturally acquired infections in Formosa (Argentina). Veterinary Parasitology 1997, 73:243-248.
26. Martin R.J. An electrophysiological preparation of Ascaris suum pharyngeal muscle reveals a glutamate-gated chloride channel sensitive to the avermectin analogue, milbemycin D. Parasitology 1996, 112:247-252.
27. McCall J.W., Genchi C., Kramer L., Guerrero J., Dzimianski M.T., Supakorndej P., Mansour A.M., McCall S.D., Supakorndej N., Grandi G., Carson B. Heartworm and Wolbachia: therapeutic implications. Veterinary Parasitology 2008, 158:204-214.
28. McCall J.W. The safety-net story about macrocyclic lactone heartworm preventives: a review, an update, and recommendations. Veterinary Parasitology 2005, 133:197-206.
29. Omura S., Crump A. The life and times of ivermectin - a success story. Nature Reviews Microbiology 2004, 2:984-989.
30. Ottesen E.A. Lymphatic filariasis: treatment, control and elimination. Advances in Parasitology 2006, 61:395-441.
31. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 2001, 29:e45.
32. Rao U.R., Vickery A.C., Kwa B.H., Nayar J.K. Brugia malayi: ivermectin inhibits the exsheathment of microfilariae. American Journal of Tropical Medicine and Hygiene 1992, 46:183-188.
33. Schares G., Hofmann B., Zahner H. Antifilarial activity of macrocyclic lactones: comparative studies with ivermectin, doramectin, milbemycin A4 oxime, and moxidectin in Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi, and B. pahangi infection of Mastomys coucha. Tropical Medicine and Parasitology 1994, 45:97-106.
34. Scott A.L. Nematode sperm. Parasitology Today 1996, 12:425-430.
35. Scott A.L., Ghedin E. The genome of Brugia malayi - all worms are not created equal. Parasitology International 2009, 58:6-11.
36. Stolk W.A., Van Oortmarssen G.J., Pani S.P., De Vlas S.J., Subramanian S., Das P.K., Habbema J.D. Effects of ivermectin and diethylcarbamazine on microfilariae and overall microfilaria production in bancroftian filariasis. American Journal of Tropical Medicine and Hygiene 2005, 73:881-887.
37. Strote G., Wieland S., Darge K., Comley J.C. In vitro assessment of the activity of anthelmintic compounds on adults of Onchocerca volvulus. Acta Leidensia 1990, 59:285-296.
38. Tagboto S.K., Townson S. Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo. Annals of Tropical Medicine and Parasitology 1996, 90:497-505.
39. Tippawangkosol P., Choochote W., Na-Bangchang K., Jitpakdi A., Pitasawat B., Riyong D. The in vitro effect of albendazole, ivermectin, diethylcarbamazine, and their combinations against infective third-stage larvae of nocturnally subperiodic Brugia malayi (Narathiwat strain): scanning electron microscopy. Journal of Vector Ecology 2004, 29:101-108.
40. Tippawangkosol P., Choochote W., Na-Bangchang K., Jitpakdi A., Pitasawat B., Riyong D. Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination. Southeast Asian Journal of Tropical Medicine and Public Health 2004, 35:15-21.