An electrophysiological preparation of Ascaris suum pharyngeal muscle reveals a glutamate-gated chloride channel sensitive to the avermectin analogue, milbemycin D

Parasitology

Volumn 112, Issue 2, 1996, Pages 247-252

  Martin, R J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Anthelmintic; Ascaris suum; Avermectin; Chloride channel; Glutamate; Milbemycin

Indexed keywords

AVERMECTIN DERIVATIVE; CHLORIDE CHANNEL; GLUTAMIC ACID; MILBEMYCIN D;

ANIMAL EXPERIMENT; ARTICLE; ASCARIS SUUM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MUSCLE; NONHUMAN; PHARYNX; PRIORITY JOURNAL;

EID: 0030066574     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0031182000084833     Document Type: Article

References (15)

1. ARENA, J. P. (1994). Expression of Caenorhabditis elegans messenger-RNA in xenopus oocytes: a model system to study the mechanism of action of avermectins. Parasitology Today 10, 35-7.
2. AVERY, L. (1993). Motor-neuron m3 controls pharyngeal muscle-relaxation timing in Caenorhabditis elegans. Journal of Experimental Biology 175, 283-97.
3. AVERY, L., DAVIS, M. W., DENK, W., DENT, J. & HESS, G. (1994). M3 is an inhibitory glutamatergic pharyngeal motoneuron. Worm Breeder's Gazette 13, 72.
4. BYERLY, L. & MASUDA, M. O. (1979). Voltage-clamp analysis of the potassium current that produces a negative-going action potential in Ascaris muscle. Journal of Physiology 288, 263-84.
5. CAMPBELL, W. C. & BENZ, G. W. (1984). Ivermectin: a review of efficacy and safety. Journal of Veterinary Pharmacology and Therapeutics 7, 1-16.
6. CULLY, D. F., VASSILATIS, D. K., LIU, K. K., PARESS, P. S., VANDERPLOEG, L. H. T. & SCHAEFFER, J. M. (1994). Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature, London 371, 707-11.
7. DEL CASTILLO, J. & MORALES, T. (1967). The electrical and mechanical activity of the esophageal cell of Ascaris lumbricoides. Journal of Generative Physiology 50, 603-30.
8. GEARY, T. G., SIMS, S. M., THOMAS, E. M., VANOVER, L., DAVIS, J. P., WINTERROWD, C. A. & KLEIN, R. (1993). Haemonchus contortus - ivermectin-induced paralysis of the pharynx. Experimental Parasitology 77, 88-96.
9. HOLDEN-DYE, L. & WALKER, R. J. (1990). Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptors on the somatic muscle cells of Ascaris: is this the site of anthelmintic action? Parasitology 101, 265-71.
10. HORSEMAN, B. G., SEYMOUR, C., BERMUDEZ, I. & BEADLE, D. J. (1988). The effects of L-glutamate on cultured insect neurons. Neuroscience Letters 85, 65-70.
11. LAUGHTON, D. L., WOLSTENHOLME, A. J. & LUNT, G. (1995). The beta subunit of the avermectin sensitive glutamate receptor is expressed in the pm4 pharyngeal muscle cells. Worm Breeder's Gazette 14, 48.
12. LEA, T. J. & USHERWOOD, P. N. R. (1973). The site of action of ibotenic acid and the identification of two populations of glutamate receptors on insect muscle-fibres. Comparative and General Pharmacology 4, 333-50.
13. LINGLE, C. & MARDER, E. (1981). A glutamate-activated chloride conductance on a crustacean muscle. Brain Research 212, 481-8.
14. MARTIN, R. J. & PENNINGTON, A. J. (1989). A patch-clamp study of effects of dihydroavermectin on Ascaris muscle. British Journal of Pharmacology 98, 747-56.
15. WAFFORD, K. A. & SATTELLE, D. B. (1989). L-glutamate receptors on the cell body membrane of an identified insect motor neuron. Journal of Experimental Biology 144, 449-62.