Comparison of fine-scale recombination rates in humans and chimpanzees

Science

Volumn 308, Issue 5718, 2005, Pages 107-111

  Winckler, Wendy ^a,b,c   Myers, Simon R ^d   Richter, Daniel J ^c   Onofrio, Robert C ^c   McDonald, Gavin J ^a,c   Bontrop, Ronald E ^e   McVean, Gilean A T ^d   Gabriel, Stacey B ^c   Reich, David ^b,c   Donnelly, Peter ^d   Altshuler, David ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; CORRELATION METHODS; DNA; DNA SEQUENCES;

CHIMPANZEES; FINE-SCALE RECOMBINATION RATES; ORTHOLOGOUS LOCI; POLYMORPHISM;

HUMAN ENGINEERING;

HLA ANTIGEN; GLOBIN;

COMPARATIVE STUDY; DNA;

ANALYTIC METHOD; ARTICLE; CHROMATIN STRUCTURE; DNA SEQUENCE; DNA STRAND BREAKAGE; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETIC VARIABILITY; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; NATURAL SELECTION; NONHUMAN; POPULATION GENETICS; PRIORITY JOURNAL; RATING SCALE; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENTIATION; ALLELE; ANIMAL; CHROMOSOME; CHROMOSOME MAP; COMPARATIVE STUDY; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GENOME; GENOTYPE; HAPLOTYPE; HUMAN CHROMOSOME; MOLECULAR EVOLUTION; MONTE CARLO METHOD; NUCLEOTIDE SEQUENCE; PAN TROGLODYTES; PROBABILITY; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALIA; PAN (APE);

ALLELES; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; CHROMOSOMES, MAMMALIAN; EVOLUTION, MOLECULAR; GENOME; GENOME, HUMAN; GENOTYPE; GLOBINS; HAPLOTYPES; HLA ANTIGENS; HUMANS; LINKAGE DISEQUILIBRIUM; MARKOV CHAINS; MONTE CARLO METHOD; PAN TROGLODYTES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 20144387806     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1105322     Document Type: Article

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27. We thank the members of the Altshuler, Daly, and Donnelly laboratories and the participants in the International Haplotype Map Project for helpful discussions. D.A. is a Charles E. Culpeper Scholar of the Rockefeller Brothers Fund and a Burroughs Wellcome Fund clinical scholar in translational research. P.D. is supported by NIH, Wellcome Trust, Nuffield Trust, the SNP Consortium, and Wolfson Foundation. G.A.T.M is supported by NIH, The Royal Society, and the SNP Consortium. D.R. is the recipient of a Career Development Award in Biomedical Science from the Burroughs Wellcome Fund.