Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: Investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines

Toxicology Letters

Volumn 193, Issue 2, 2010, Pages 183-188

  Vrzal, Radim ^a   Kubesova, Katerina ^a   Pavek, Petr ^b   Dvorak, Zdenek ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Benzodiazepines; Cytochrome P450; Enzyme induction; Human hepatocytes

Indexed keywords

ALPRAZOLAM; AROMATIC HYDROCARBON RECEPTOR; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; CHLORDIAZEPOXIDE; CLONAZEPAM; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DIAZEPAM; LORAZEPAM; MEDAZEPAM; MESSENGER RNA; MIDAZOLAM; NITRAZEPAM; OXAZEPAM; PREGNANE X RECEPTOR; TETRAZEPAM; TRIAZOLAM;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SAFETY; ENZYME INDUCTION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER CARCINOMA; LIVER CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REPORTER GENE;

ANTI-ANXIETY AGENTS; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MEDAZEPAM; MIDAZOLAM; NUCLEAR RECEPTOR COACTIVATOR 1; RECEPTORS, STEROID; RNA, MESSENGER;

MAMMALIA;

EID: 76749159759     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.01.004     Document Type: Article

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