Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment

Protein Science

Volumn 19, Issue 2, 2010, Pages 299-308

  Robert, Remy ^a   Streltsov, Victor A ^a   Newman, Janet ^a   Pearce, Lesley A ^a   Wark, Kim L ^a   Dolezal, Olan ^a  

^a CSIRO   (Australia)

Author keywords

Alzheimer's disease; Antibody engineering; Crystal structure; Humanization; SPR

Indexed keywords

AMYLOID BETA PROTEIN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; RECOMBINANT IMMUNOGLOBULIN F(AB) FRAGMENT; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN STRUCTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ABSORPTIOMETRY, PHOTON; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE, TUMOR; GERM CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

MURINAE;

EID: 76749151115     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.312     Document Type: Article

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