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Volumn 25, Issue 3, 2008, Pages 216-229

Recombinant human erythropoietin as a neuroprotective therapy in brain ischemia;La eritropoyetina humana recombinante como terapia para la neuroprotección en la isquemia cerebral

Author keywords

Brain ischemia; Erythropoietin; Intranasal; Neuroprotection

Indexed keywords

RECOMBINANT ERYTHROPOIETIN; SIALIC ACID;

EID: 76749115236     PISSN: 08644551     EISSN: 10272852     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (111)
  • 2
    • 0032564133 scopus 로고    scopus 로고
    • Stroke treatment: Time is brain
    • SIII10-4
    • Hill MD, Hachinski V. Stroke treatment: Time is brain. Lancet 1998;352(3): SIII10-4.
    • (1998) Lancet , vol.352 , Issue.3
    • Hill, M.D.1    Hachinski, V.2
  • 4
    • 36348932490 scopus 로고    scopus 로고
    • Enfermedades cerebrovasculares
    • Santiago de Cuba;
    • Miranda QJA. Enfermedades cerebrovasculares. Editorial Oriente, Santiago de Cuba; 2004.
    • (2004) Editorial Oriente
    • Miranda, Q.J.A.1
  • 5
    • 36349023523 scopus 로고    scopus 로고
    • Mecanismos celulares y moleculares de la enfermedad cerebrovascular isquémica.
    • Disponible en
    • Guevara GM, Rodríguez R, Álvarez LA, Riaño MA, Rodríguez P. Mecanismos celulares y moleculares de la enfermedad cerebrovascular isquémica. Rev Cubana Med 2004;43(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci-arttext&pid=S0034-75232004000400- 008&lng=es&nrm=iso.
    • (2004) Rev Cubana Med , vol.43 , Issue.4
    • Guevara, G.M.1    Rodríguez, R.2    Álvarez, L.A.3    Riaño, M.A.4    Rodríguez, P.5
  • 6
    • 52649181125 scopus 로고    scopus 로고
    • Neuromodulació n farmacológica en la enfermedad cerebrovascular. Temas actualizados.
    • Rodríguez ML, Galvizu SR, Álvarez GE. Neuromodulació n farmacológica en la enfermedad cerebrovascular. Temas actualizados. Rev Cubana Med 2002;41: 34-9.
    • (2002) Rev Cubana Med , vol.41 , pp. 34-39
    • Rodríguez, M.L.1    Galvizu, S.R.2    Álvarez, G.E.3
  • 7
    • 76749159715 scopus 로고    scopus 로고
    • Pharmacology of cerebral ischemia
    • Krieglstein J, Klump S. Pharmacology of cerebral ischemia. Rev Mex 2002; 3(3):179.
    • (2002) Rev Mex , vol.3 , Issue.3 , pp. 179
    • Krieglstein, J.1    Klump, S.2
  • 8
    • 76749169316 scopus 로고    scopus 로고
    • Neuroprotective Strategies for Early Intervention in Acute Ischaemic Stroke
    • Hacke W. Neuroprotective Strategies for Early Intervention in Acute Ischaemic Stroke. Cerebrovascular Diseases 1997, Vol. 7 Suppl 2.
    • (1997) Cerebrovascular Diseases , vol.7 , Issue.SUPPL. 2
    • Hacke, W.1
  • 9
    • 76749131481 scopus 로고    scopus 로고
    • Buergo Zuaznábar MA, Fernández-Concepción O, Pérez Nellar J, Pando Cabrera A. Guías de práctica clínica para las enfermedades cerebrovasculares. Medisur 2007 (Número Especial):1-25. Disponible en: http://medisur.sld.cu/index.php/ medisur/article/view/246/730.
    • Buergo Zuaznábar MA, Fernández-Concepción O, Pérez Nellar J, Pando Cabrera A. Guías de práctica clínica para las enfermedades cerebrovasculares. Medisur 2007 (Número Especial):1-25. Disponible en: http://medisur.sld.cu/index.php/ medisur/article/view/246/730.
  • 10
    • 1342269493 scopus 로고    scopus 로고
    • Protección neuronal endógena: Un enfoque alternativo.
    • García Salman JD. Protección neuronal endógena: un enfoque alternativo. Rev Neurol 2004;38:150-5.
    • (2004) Rev Neurol , vol.38 , pp. 150-155
    • García Salman, J.D.1
  • 11
  • 12
    • 0141784841 scopus 로고    scopus 로고
    • Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    • Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 2003;198:971-5.
    • (2003) J Exp Med , vol.198 , pp. 971-975
    • Villa, P.1    Bigini, P.2    Mennini, T.3    Agnello, D.4    Laragione, T.5    Cagnotto, A.6
  • 13
    • 0346756186 scopus 로고    scopus 로고
    • New insights into erythropoietin and epoetin alfa: Mechanisms of action, target tissues, and clinical applications
    • Weiss MJ. New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications. Oncologist 2003;8(3):18-29.
    • (2003) Oncologist , vol.8 , Issue.3 , pp. 18-29
    • Weiss, M.J.1
  • 19
    • 33847203208 scopus 로고    scopus 로고
    • Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives
    • Villa P, van BJ, Larsen AK, Gerwien J, Christensen S, Cerami A, et al. Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab 2007;27:552-63.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 552-563
    • Villa, P.V.B.1    Larsen, A.K.2    Gerwien, J.3    Christensen, S.4    Cerami, A.5
  • 21
    • 7944230999 scopus 로고    scopus 로고
    • Understanding the pattern of functional recovery after stroke: Facts and theories
    • Kwakkel G, Kollen B, Lindeman E. Understanding the pattern of functional recovery after stroke: Facts and theories. Restor Neurol Neurosci 2004;22:281-99.
    • (2004) Restor Neurol Neurosci , vol.22 , pp. 281-299
    • Kwakkel, G.1    Kollen, B.2    Lindeman, E.3
  • 22
    • 19544376511 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: Two decades of success and failure
    • Cheng YD, Al-Khoury L, Zivin JA. Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 2004;1:36-45.
    • (2004) NeuroRx , vol.1 , pp. 36-45
    • Cheng, Y.D.1    Al-Khoury, L.2    Zivin, J.A.3
  • 23
    • 0346787875 scopus 로고    scopus 로고
    • Biochemical changes and inflammatory response as markers for brain ischaemia: Molecular markers of diagnostic utility and prognosis in human clinical practice
    • Castillo J, Rodríguez I. Biochemical changes and inflammatory response as markers for brain ischaemia: Molecular markers of diagnostic utility and prognosis in human clinical practice. Cerebrovasc Dis 2004;17:7-18.
    • (2004) Cerebrovasc Dis , vol.17 , pp. 7-18
    • Castillo, J.1    Rodríguez, I.2
  • 24
    • 33748208266 scopus 로고    scopus 로고
    • Secades JJ, Varez-Sabin J, Rubio F, Lozano R, Davalos A, Castillo J. Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study. Cerebrovasc Dis 2006;21:380-5.
    • Secades JJ, Varez-Sabin J, Rubio F, Lozano R, Davalos A, Castillo J. Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study. Cerebrovasc Dis 2006;21:380-5.
  • 25
    • 33751327483 scopus 로고    scopus 로고
    • Bench to bedside: The quest for quality in experimental stroke research
    • Dirnagl U. Bench to bedside: the quest for quality in experimental stroke research. J Cereb Blood Flow Metab 2006;26: 1465-78.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1465-1478
    • Dirnagl, U.1
  • 26
    • 0035666857 scopus 로고    scopus 로고
    • Magnesium for neuroprotection in ischaemic stroke: Rationale for use and evidence of effectiveness
    • Muir KW. Magnesium for neuroprotection in ischaemic stroke: rationale for use and evidence of effectiveness. CNS Drugs 2001;15:921-30.
    • (2001) CNS Drugs , vol.15 , pp. 921-930
    • Muir, K.W.1
  • 27
    • 5444233626 scopus 로고    scopus 로고
    • Pathophysiology of Stroke: Lessons from animal models
    • Mergenthaler P, Dirnagl U, Meisel A. Pathophysiology of Stroke: Lessons from animal models. Metab Brain Dis 2004; 19:151-67.
    • (2004) Metab Brain Dis , vol.19 , pp. 151-167
    • Mergenthaler, P.1    Dirnagl, U.2    Meisel, A.3
  • 28
    • 0348048849 scopus 로고    scopus 로고
    • The ischemic penumbra-identification, evolution and treatment concepts
    • Fisher M. The ischemic penumbra-identification, evolution and treatment concepts. Cerebrovasc Dis 2004;17(1):1-6.
    • (2004) Cerebrovasc Dis , vol.17 , Issue.1 , pp. 1-6
    • Fisher, M.1
  • 30
    • 4644283464 scopus 로고    scopus 로고
    • Molecular biology of erythropoietin
    • Jelkmann W. Molecular biology of erythropoietin. Intern Med 2004;43: 649-59.
    • (2004) Intern Med , vol.43 , pp. 649-659
    • Jelkmann, W.1
  • 31
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor-1
    • Wenger RH, Gassmann M. Oxygen(es) and the hypoxia-inducible factor-1. Biol Chem 1997;378:609-16.
    • (1997) Biol Chem , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 32
    • 41549102616 scopus 로고    scopus 로고
    • Non-erythroid functions of erythropoietin
    • Roach RC, ed, Kluwer Academic/Plenum Publishers, New York
    • Gassmann M, Heinicke K, Soliz J, Ogunshola O. Non-erythroid functions of erythropoietin. In: Roach RC, ed. Hypoxia: Through the lifecycle. Kluwer Academic/Plenum Publishers, New York, 2003:1-8.
    • (2003) Hypoxia: Through the lifecycle , pp. 1-8
    • Gassmann, M.1    Heinicke, K.2    Soliz, J.3    Ogunshola, O.4
  • 33
    • 0042205823 scopus 로고    scopus 로고
    • Erythropoietina new therapy in cerebral ischemia¿
    • Kalialis LV, Olsen NV. Erythropoietina new therapy in cerebral ischemia¿ Ugeskr Laeger 2003;165:2477-81.
    • (2003) Ugeskr Laeger , vol.165 , pp. 2477-2481
    • Kalialis, L.V.1    Olsen, N.V.2
  • 34
    • 0036982647 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for neuroprotection: What is the evidence¿
    • Eid T, Brines M. Recombinant human erythropoietin for neuroprotection: what is the evidence¿ Clin Breast Cancer 2002; Suppl 3:S109-15.
    • (2002) Clin Breast Cancer , Issue.SUPPL. 3
    • Eid, T.1    Brines, M.2
  • 35
    • 4644318784 scopus 로고    scopus 로고
    • Erythropoietin and the hypoxic brain
    • Marti HH. Erythropoietin and the hypoxic brain. J Exp Biol 2004;207: 3233-42.
    • (2004) J Exp Biol , vol.207 , pp. 3233-3242
    • Marti, H.H.1
  • 39
    • 0031893945 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor in the developing human central nervous system
    • Juul SE, Anderson D, Li Y. Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res 1998;43:40-9.
    • (1998) Pediatr Res , vol.43 , pp. 40-49
    • Juul, S.E.1    Anderson, D.2    Li, Y.3
  • 41
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 2004;305:239-42.
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3    Bianchi, R.4    Villa, P.5    Fratelli, M.6
  • 42
    • 0037154573 scopus 로고    scopus 로고
    • Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils
    • Catania MA, Marciano MC, Parisi A, Sturiale A, Buemi M, Grasso G, et al. Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils. Eur J Pharmacol 2002;437:147-50.
    • (2002) Eur J Pharmacol , vol.437 , pp. 147-150
    • Catania, M.A.1    Marciano, M.C.2    Parisi, A.3    Sturiale, A.4    Buemi, M.5    Grasso, G.6
  • 43
    • 18244372152 scopus 로고    scopus 로고
    • Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats
    • Belayev L, Khoutorova L, Zhao W, Vigdorchik A, Belayev A, Busto R, et al. Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats. Stroke 2005;36: 1071-6.
    • (2005) Stroke , vol.36 , pp. 1071-1076
    • Belayev, L.1    Khoutorova, L.2    Zhao, W.3    Vigdorchik, A.4    Belayev, A.5    Busto, R.6
  • 45
    • 0036969337 scopus 로고    scopus 로고
    • Oral administration of a soy extract improves endothelial dysfunction in ovariectomized rats
    • Catania MA, Crupi A, Firenzuoli F, Parisi A, Sturiale A, Squadrito F, et al. Oral administration of a soy extract improves endothelial dysfunction in ovariectomized rats. Planta Med 2002;68:1142-4.
    • (2002) Planta Med , vol.68 , pp. 1142-1144
    • Catania, M.A.1    Crupi, A.2    Firenzuoli, F.3    Parisi, A.4    Sturiale, A.5    Squadrito, F.6
  • 46
    • 0034637297 scopus 로고    scopus 로고
    • Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation
    • Calapai G, Marciano MC, Corica F, Allegra A, Parisi A, Frisina N, et al. Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation. Eur J Pharmacol 2000;401:349-56.
    • (2000) Eur J Pharmacol , vol.401 , pp. 349-356
    • Calapai, G.1    Marciano, M.C.2    Corica, F.3    Allegra, A.4    Parisi, A.5    Frisina, N.6
  • 47
    • 0033961724 scopus 로고    scopus 로고
    • Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical
    • Chattopadhyay A, Choudhury TD, Bandyopadhyay D, Datta AG. Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical. Biochem Pharmacol 2000;59:419-25.
    • (2000) Biochem Pharmacol , vol.59 , pp. 419-425
    • Chattopadhyay, A.1    Choudhury, T.D.2    Bandyopadhyay, D.3    Datta, A.G.4
  • 48
    • 0242489261 scopus 로고    scopus 로고
    • Central nervous system frontiers for the use of erythropoietin
    • Olsen N.V. Central nervous system frontiers for the use of erythropoietin. Clin Infect Dis 2003;37:323.
    • (2003) Clin Infect Dis , vol.37 , pp. 323
    • Olsen, N.V.1
  • 50
    • 0036431388 scopus 로고    scopus 로고
    • Erythropoietin in the central nervous system, and its use to prevent hypoxicischemic brain damage
    • Juul S. Erythropoietin in the central nervous system, and its use to prevent hypoxicischemic brain damage. Acta Paediatr Suppl 2002;91:36-42.
    • (2002) Acta Paediatr Suppl , vol.91 , pp. 36-42
    • Juul, S.1
  • 51
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong ZZ, Kang J, Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 2002;106:2973-9.
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.2    Maiese, K.3
  • 52
    • 0033901502 scopus 로고    scopus 로고
    • Differential glial and vascular expression of endothelins and their receptors in rat brain after neurotrauma
    • Siren AL, Knerlich F, Schilling L, Kamrowski-Kruck H, Hahn A, Ehrenreich H. Differential glial and vascular expression of endothelins and their receptors in rat brain after neurotrauma. Neurochem Res 2000; 25:957-69.
    • (2000) Neurochem Res , vol.25 , pp. 957-969
    • Siren, A.L.1    Knerlich, F.2    Schilling, L.3    Kamrowski-Kruck, H.4    Hahn, A.5    Ehrenreich, H.6
  • 53
    • 0037064261 scopus 로고    scopus 로고
    • Erythropoietin exerts anti-inflammatory effect on the center nerves system in the model of experimental autoinmune encephalomyelitis
    • Agnello D, Bigini P, Villa P, Mennini T, Ceremi A, Brines M, et al. Erythropoietin exerts anti-inflammatory effect on the center nerves system in the model of experimental autoinmune encephalomyelitis. Brain Res 2002; 952:128-34.
    • (2002) Brain Res , vol.952 , pp. 128-134
    • Agnello, D.1    Bigini, P.2    Villa, P.3    Mennini, T.4    Ceremi, A.5    Brines, M.6
  • 54
    • 17444386695 scopus 로고    scopus 로고
    • Astroglial citoprotection by erythopoietin pre-conditioning: Implications for isquemic and degenerative CNS disorders
    • Diaz Z, Assaraf MI, Miller WH Jr, Schipper HM. Astroglial citoprotection by erythopoietin pre-conditioning: implications for isquemic and degenerative CNS disorders. J Neurochem 2005;93:392-402.
    • (2005) J Neurochem , vol.93 , pp. 392-402
    • Diaz, Z.1    Assaraf, M.I.2    Miller Jr, W.H.3    Schipper, H.M.4
  • 55
    • 23744459392 scopus 로고    scopus 로고
    • Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia
    • Yu YP, Xu QQ, Zhang Q, Zhang WP, Zhang LH, Wei EQ. Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia. Neurosci Lett 2005;387:5-10.
    • (2005) Neurosci Lett , vol.387 , pp. 5-10
    • Yu, Y.P.1    Xu, Q.Q.2    Zhang, Q.3    Zhang, W.P.4    Zhang, L.H.5    Wei, E.Q.6
  • 56
    • 0037069780 scopus 로고    scopus 로고
    • Erythropoietin-an endogenous retinal survival factor
    • Becerra SP, Amaral J. Erythropoietin-an endogenous retinal survival factor. Engl J Med 2002;347:1968-70.
    • (2002) Engl J Med , vol.347 , pp. 1968-1970
    • Becerra, S.P.1    Amaral, J.2
  • 57
  • 59
    • 0034928578 scopus 로고    scopus 로고
    • Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage
    • Grasso G. Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage. J Neurosurg Sci 2001;45:7-14.
    • (2001) J Neurosurg Sci , vol.45 , pp. 7-14
    • Grasso, G.1
  • 60
    • 20044373442 scopus 로고    scopus 로고
    • Emerging biological roles for erythropoietin in the nervous system
    • Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 2005;6:484-94.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 484-494
    • Brines, M.1    Cerami, A.2
  • 62
    • 0032797262 scopus 로고    scopus 로고
    • Nitric oxide synthases: Targets for therapeutic strategies in neurological diseases
    • Chabrier PE, Merle-Pallardy C, Auguet M. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell Mol Life Sci 1999;55:1029-35.
    • (1999) Cell Mol Life Sci , vol.55 , pp. 1029-1035
    • Chabrier, P.E.1    Merle-Pallardy, C.2    Auguet, M.3
  • 63
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 1997;76:105-16.
    • (1997) Neuroscience , vol.76 , pp. 105-116
    • Morishita, E.1    Masuda, S.2    Nagao, M.3    Yasuda, Y.4    Sasaki, R.5
  • 64
  • 65
    • 0034854184 scopus 로고    scopus 로고
    • Beyond erythropoiesis: Novel application for recombinant human erythropoietin
    • Cerami A. Beyond erythropoiesis: novel application for recombinant human erythropoietin. Semin Hematol 2001;38:33-9.
    • (2001) Semin Hematol , vol.38 , pp. 33-39
    • Cerami, A.1
  • 66
    • 0032995001 scopus 로고    scopus 로고
    • Immunohistochemical localization of erythropoietin and its receptor in the developing human brain
    • Juul SE, Yachnis AT, Rojiani AM, Christensen RD. Immunohistochemical localization of erythropoietin and its receptor in the developing human brain. Pediatr Dev Pathol 1999;2:148-58.
    • (1999) Pediatr Dev Pathol , vol.2 , pp. 148-158
    • Juul, S.E.1    Yachnis, A.T.2    Rojiani, A.M.3    Christensen, R.D.4
  • 68
    • 0035064310 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    • Nagai A, Nakagawa E, Choi HB. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 2001;60:386-92.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 386-392
    • Nagai, A.1    Nakagawa, E.2    Choi, H.B.3
  • 69
    • 0036896201 scopus 로고    scopus 로고
    • Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: Evidence from an in vitro model
    • Ruscher K, Freyer D, Karsch M, Isaev N, Megow D, Sawitzki B, et al. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 2002;22:10291-301.
    • (2002) J Neurosci , vol.22 , pp. 10291-10301
    • Ruscher, K.1    Freyer, D.2    Karsch, M.3    Isaev, N.4    Megow, D.5    Sawitzki, B.6
  • 71
    • 0035101039 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
    • Siren AL, Knerlich F, Poser W. Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain. Acta Neuropathol 2001;101:271-6.
    • (2001) Acta Neuropathol , vol.101 , pp. 271-276
    • Siren, A.L.1    Knerlich, F.2    Poser, W.3
  • 72
    • 0348050036 scopus 로고    scopus 로고
    • Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis
    • Eid T, Brines ML, Cerami A, Spencer DD, Kim JH, Schweitzer JS, et al. Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis. J Neuropathol Exp Neurol 2004;63:73-83.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 73-83
    • Eid, T.1    Brines, M.L.2    Cerami, A.3    Spencer, D.D.4    Kim, J.H.5    Schweitzer, J.S.6
  • 74
    • 0034644878 scopus 로고    scopus 로고
    • Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage
    • Alafaci C, Salpietro F, Grasso G, Sfacteria A, Passalacqua M, Morabito A, et al. Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage. Eur J Pharmacol 2000;406:219-25.
    • (2000) Eur J Pharmacol , vol.406 , pp. 219-225
    • Alafaci, C.1    Salpietro, F.2    Grasso, G.3    Sfacteria, A.4    Passalacqua, M.5    Morabito, A.6
  • 75
    • 76749117926 scopus 로고    scopus 로고
    • Sinn D, Chu K, Lee S. Erythropoietin has neuroprotective effects with functional recovery in experimental intracerebral hemorrhage. Disponible en: http://www. abstracts2view. com/aan. 57th Annual Meeting of the American Academy of Neurology. 2005. Ref Type: Internet Communication.
    • Sinn D, Chu K, Lee S. Erythropoietin has neuroprotective effects with functional recovery in experimental intracerebral hemorrhage. Disponible en: http://www. abstracts2view. com/aan. 57th Annual Meeting of the American Academy of Neurology. 2005. Ref Type: Internet Communication.
  • 76
    • 25444461637 scopus 로고    scopus 로고
    • Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury
    • Lu D, Mahmood A, Qu C. Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma 2005;22:1011-7.
    • (2005) J Neurotrauma , vol.22 , pp. 1011-1017
    • Lu, D.1    Mahmood, A.2    Qu, C.3
  • 77
    • 26444572335 scopus 로고    scopus 로고
    • Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury
    • atsiv I, Grigoriadis N, Simeonidou C. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. FASEB J 2005;19:1701-3.
    • (2005) FASEB J , vol.19 , pp. 1701-1703
    • atsiv, I.1    Grigoriadis, N.2    Simeonidou, C.3
  • 78
    • 0037133191 scopus 로고    scopus 로고
    • Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
    • Celik M, Gokmen N, Erbayraktar S. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci USA 2002;99:2258-63.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2258-2263
    • Celik, M.1    Gokmen, N.2    Erbayraktar, S.3
  • 79
    • 28044447674 scopus 로고    scopus 로고
    • Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury
    • Gorio A, Madaschi L, Di SB, Carelli S, Di Giulio AM, De BS, et al. Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury. Proc Natl Acad Sci USA 2005;102:16379-84.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16379-16384
    • Gorio, A.1    Madaschi, L.2    Di, S.B.3    Carelli, S.4    Di Giulio, A.M.5    De, B.S.6
  • 80
    • 12744273391 scopus 로고    scopus 로고
    • Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis
    • Sattler MB, Merkler D, Maier K, Stadelmann C, Ehrenreich H, Bahr M, et al. Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Cell Death Differ 2004; 11(2):S181-92.
    • (2004) Cell Death Differ , vol.11 , Issue.2
    • Sattler, M.B.1    Merkler, D.2    Maier, K.3    Stadelmann, C.4    Ehrenreich, H.5    Bahr, M.6
  • 81
    • 13544269276 scopus 로고    scopus 로고
    • Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis
    • Diem R, Sattler MB, Merkler D, Demmer I, Maier K, Stadelmann C, et al. Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Brain 2005;128:375-85.
    • (2005) Brain , vol.128 , pp. 375-385
    • Diem, R.1    Sattler, M.B.2    Merkler, D.3    Demmer, I.4    Maier, K.5    Stadelmann, C.6
  • 84
    • 15244341057 scopus 로고    scopus 로고
    • Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats
    • Sola A, Rogido M, Lee BH, Genetta T, Wen TC. Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats. Pediatr Res 2005;57:481-7.
    • (2005) Pediatr Res , vol.57 , pp. 481-487
    • Sola, A.1    Rogido, M.2    Lee, B.H.3    Genetta, T.4    Wen, T.C.5
  • 85
    • 0037225493 scopus 로고    scopus 로고
    • Neuroprotective effect of erythropoietin on hypoxicischemic brain injury in neonatal rats
    • Kumral A, Ozer E, Yilmaz O, Akhisaroglu M, Gokmen N, Duman N, et al. Neuroprotective effect of erythropoietin on hypoxicischemic brain injury in neonatal rats. Biol Neonate 2003;83:224-8.
    • (2003) Biol Neonate , vol.83 , pp. 224-228
    • Kumral, A.1    Ozer, E.2    Yilmaz, O.3    Akhisaroglu, M.4    Gokmen, N.5    Duman, N.6
  • 86
    • 17844393791 scopus 로고    scopus 로고
    • Erythropoietin improves functional and histological outcome in neonatal stroke
    • Chang Y, Mu D, Wendland M. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr Res 2005;58:106-11.
    • (2005) Pediatr Res , vol.58 , pp. 106-111
    • Chang, Y.1    Mu, D.2    Wendland, M.3
  • 87
    • 15944374753 scopus 로고    scopus 로고
    • Recombinant human erythropoietin and overall survival in cancer patients: Results of a comprehensive meta-analysis
    • Bohlius J, Langensiepen S, Schwarzer G. Recombinant human erythropoietin and overall survival in cancer patients: results of a comprehensive meta-analysis. J Natl Cancer Inst 2005;97:489-98.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 489-498
    • Bohlius, J.1    Langensiepen, S.2    Schwarzer, G.3
  • 88
    • 0035894847 scopus 로고    scopus 로고
    • Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells
    • Shingo T, Sorokan ST, Shimazaki T, Weiss S. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 2001;21:9733-43.
    • (2001) J Neurosci , vol.21 , pp. 9733-9743
    • Shingo, T.1    Sorokan, S.T.2    Shimazaki, T.3    Weiss, S.4
  • 89
    • 0033619054 scopus 로고    scopus 로고
    • El objetivo del tratamiento en la enfermedad cerebrovascular aguda y los enfoques terapéuticos neuroprotectores.
    • Fisher M. El objetivo del tratamiento en la enfermedad cerebrovascular aguda y los enfoques terapéuticos neuroprotectores. Rev Neurol 1999;29:536-44.
    • (1999) Rev Neurol , vol.29 , pp. 536-544
    • Fisher, M.1
  • 90
    • 33845547792 scopus 로고    scopus 로고
    • Pathophysiology and Therapy of Experimental Stroke
    • Hossmann KA. Pathophysiology and Therapy of Experimental Stroke. Cell Mol Neurobiol 2006;26:1057-83.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 1057-1083
    • Hossmann, K.A.1
  • 91
    • 0024805137 scopus 로고
    • Rodent models of ce-rebral ischemia
    • Ginsberg C, Busto R. Rodent models of ce-rebral ischemia. Stroke 1989;20:1627-42.
    • (1989) Stroke , vol.20 , pp. 1627-1642
    • Ginsberg, C.1    Busto, R.2
  • 92
    • 0037249712 scopus 로고    scopus 로고
    • Animals models of focal and global cerebral ischaemia
    • Traysman RJ. Animals models of focal and global cerebral ischaemia. ILAR J 2003;44:85-95.
    • (2003) ILAR J , vol.44 , pp. 85-95
    • Traysman, R.J.1
  • 93
    • 76749138874 scopus 로고    scopus 로고
    • Sosa I, García Salman JD. Isquemia cerebral y neuroprotección. Disponible en: www.monografias.com\trabajos45\ isquemiacerebral\isquemia-cerebral.shtml. 2007. Ref Type: Internet Communication.
    • Sosa I, García Salman JD. Isquemia cerebral y neuroprotección. Disponible en: www.monografias.com\trabajos45\ isquemiacerebral\isquemia-cerebral.shtml. 2007. Ref Type: Internet Communication.
  • 94
    • 76749108382 scopus 로고    scopus 로고
    • Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials
    • Springer US, ed
    • Ehrenreich H, Siren AL. Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials. In: Springer US, ed. Erythropoietin and the Nervous System. 2006.
    • (2006) Erythropoietin and the Nervous System
    • Ehrenreich, H.1    Siren, A.L.2
  • 96
    • 78049235364 scopus 로고    scopus 로고
    • Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection
    • Springer US, ed
    • Torup L, Leist M. Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection. In: Springer US, ed. Erythropoietin and the Nervous System. 2006.
    • (2006) Erythropoietin and the Nervous System
    • Torup, L.1    Leist, M.2
  • 98
    • 13844320400 scopus 로고    scopus 로고
    • A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury
    • Fiordaliso F, Chimenti S, Staszewsky L, Bai A, Carlo E, Cuccovillo I, et al. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury. Proc Natl Acad Sci USA 2005;102:2046-51.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2046-2051
    • Fiordaliso, F.1    Chimenti, S.2    Staszewsky, L.3    Bai, A.4    Carlo, E.5    Cuccovillo, I.6
  • 99
    • 0037184707 scopus 로고    scopus 로고
    • Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures
    • Weber A, Maier RF, Hoffmann U, Grips M, Hoppenz M, Aktas AG, et al. Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures. Brain Res 2002;958:305-11.
    • (2002) Brain Res , vol.958 , pp. 305-311
    • Weber, A.1    Maier, R.F.2    Hoffmann, U.3    Grips, M.4    Hoppenz, M.5    Aktas, A.G.6
  • 100
    • 0002239243 scopus 로고
    • Applied anatomy and physiology of the nose
    • Adams GL, Boies LR, Hilger PA, eds, Philadelphia: WB Saunders;
    • Hilger PA. Applied anatomy and physiology of the nose. En: Adams GL, Boies LR, Hilger PA, eds. Boies Fundamentals of Otolaryngology. Philadelphia: WB Saunders; 1989.
    • (1989) Boies Fundamentals of Otolaryngology
    • Hilger, P.A.1
  • 101
    • 0037459005 scopus 로고    scopus 로고
    • Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003;87:187-98
    • Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003;87:187-98.
  • 102
    • 0035875455 scopus 로고    scopus 로고
    • Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage
    • Liu XF, Fawcett JR, Thorne RG, DeFor TA, Frey WH. Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. J Neurol Sci 2001;187:91-7.
    • (2001) J Neurol Sci , vol.187 , pp. 91-97
    • Liu, X.F.1    Fawcett, J.R.2    Thorne, R.G.3    DeFor, T.A.4    Frey, W.H.5
  • 103
    • 0036896831 scopus 로고    scopus 로고
    • Nasal drug delivery: New developments and strategies
    • Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today 2002;7:1184-9.
    • (2002) Drug Discov Today , vol.7 , pp. 1184-1189
    • Illum, L.1
  • 104
    • 2442643119 scopus 로고    scopus 로고
    • Are the extracellular pathways a conduit for the delivery of therapeutics to the brain¿
    • Banks AW. Are the extracellular pathways a conduit for the delivery of therapeutics to the brain¿ Curr Pharm Des 2004;10:1365-70.
    • (2004) Curr Pharm Des , vol.10 , pp. 1365-1370
    • Banks, A.W.1
  • 105
    • 36348979571 scopus 로고    scopus 로고
    • Intranasal administration of recombinant human Erythropoietin exerts neuroprotective effects on post-ischemic brain injury in Mongolian gerbils
    • Sosa I, García Rodríguez JC, Santana J, Subiros N, González C, Rodríguez Y, et al. Intranasal administration of recombinant human Erythropoietin exerts neuroprotective effects on post-ischemic brain injury in Mongolian gerbils. Pharmacologyonline 2006;1: 100-12.
    • (2006) Pharmacologyonline , vol.1 , pp. 100-112
    • Sosa, I.1    García Rodríguez, J.C.2    Santana, J.3    Subiros, N.4    González, C.5    Rodríguez, Y.6
  • 106
    • 76749166129 scopus 로고    scopus 로고
    • Paso de la molécula de eritropoyetina humana recombinante con bajo contenido de ácido siálico al sistema nervioso central por la vía intranasal en los modelos del meriones unguiculatus y el pri-mate no humano Macaca fascicularis
    • Sosa I, Cruz J, Santana J, Mengana Y, García JD, Ozuna GT, et al. Paso de la molécula de eritropoyetina humana recombinante con bajo contenido de ácido siálico al sistema nervioso central por la vía intranasal en los modelos del meriones unguiculatus y el pri-mate no humano Macaca fascicularis. Rev Salud Anim 2007;29:1-6.
    • (2007) Rev Salud Anim , vol.29 , pp. 1-6
    • Sosa, I.1    Cruz, J.2    Santana, J.3    Mengana, Y.4    García, J.D.5    Ozuna, G.T.6
  • 107
    • 36348981585 scopus 로고    scopus 로고
    • Neuroprotección en la isquemia cerebral. Experiencias con la eritropoyetina humana recombinante.
    • Disponible en
    • Sosa TI, García Salman JD. Neuroprotección en la isquemia cerebral. Experiencias con la eritropoyetina humana recombinante. Rev Ecuat Neurol 2007;16(2). Disponible en http://www.medicosecuador.com/revecuatneurol/ vol16-n2-2007/articulos-revision/neuroprotecciona.htm.
    • (2007) Rev Ecuat Neurol , vol.16 , Issue.2
    • Sosa, T.I.1    García Salman, J.D.2
  • 109
    • 76749163593 scopus 로고    scopus 로고
    • Criterios preclínicos que sustentan el uso de la eritropoyetina recombinante humana.
    • Bacardí DM, Cosme K, Porras DN, Rodríguez. Criterios preclínicos que sustentan el uso de la eritropoyetina recombinante humana. Biotecnol Apl 2005;22:173-7.
    • (2005) Biotecnol Apl , vol.22 , pp. 173-177
    • Bacardí, D.M.1    Cosme, K.2    Porras, D.N.3    Rodríguez4
  • 110
    • 76749099193 scopus 로고    scopus 로고
    • Muñoz Cernuda A, León Rodríguez R, García Rodríguez JC, Nuñez Figueredo Y, Pardo Ruiz Z, García Salman JD, et al. Formulaciones nasales de EPOhr con bajo contenido de ácido siálico para el tratamiento de enfermedades del sistema nervioso central. [20050138]. 22-7-2005. Cuba [Ref Type: Patent].
    • Muñoz Cernuda A, León Rodríguez R, García Rodríguez JC, Nuñez Figueredo Y, Pardo Ruiz Z, García Salman JD, et al. Formulaciones nasales de EPOhr con bajo contenido de ácido siálico para el tratamiento de enfermedades del sistema nervioso central. [20050138]. 22-7-2005. Cuba [Ref Type: Patent].
  • 111
    • 39049193678 scopus 로고    scopus 로고
    • Recent developments in intranasal drug delivery technology are creating new vistas for peptide and protein therapeutics
    • Maggio ET. Recent developments in intranasal drug delivery technology are creating new vistas for peptide and protein therapeutics. Expert Opin Drug Deliv 2005;3(4): 529-39.
    • (2005) Expert Opin Drug Deliv , vol.3 , Issue.4 , pp. 529-539
    • Maggio, E.T.1


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