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Volumn 16, Issue 2, 2007, Pages 133-143

Neuroprotection in cerebral ischemia: Experience with human recombinant erythropoietin;Neuroprotección en la isquemia cerebral. Experiencias con la eritropoyetina humana recombinante

Author keywords

Cerebral ischaemia; Erythropoietin; Intranasal route; Neuroprotection

Indexed keywords

IMMUNOGLOBULIN E;

EID: 36348981585     PISSN: 10198113     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (108)
  • 1
    • 85032904835 scopus 로고    scopus 로고
    • Annual Health Statistcs report, 1999, 21.
    • Annual Health Statistcs report, 1999, 21.
  • 2
    • 0032564133 scopus 로고    scopus 로고
    • Stroke treatment: Time is brain
    • Hill MD, Hachinski V. Stroke treatment: Time is brain. Lancet 1998, 352 (Suppl): 10-14.
    • (1998) Lancet , vol.352 , Issue.SUPPL. , pp. 10-14
    • Hill, M.D.1    Hachinski, V.2
  • 5
    • 52649181125 scopus 로고    scopus 로고
    • Rodríguez M. L., Galvizu S.R., Alvarez G.E. Neuromodulación farmacológica en la enfermedad cerebrovascular. Temas actualizados. Rev. Cubana Med 2002, 41(2).
    • Rodríguez M. L., Galvizu S.R., Alvarez G.E. Neuromodulación farmacológica en la enfermedad cerebrovascular. Temas actualizados. Rev. Cubana Med 2002, 41(2).
  • 7
    • 1342269493 scopus 로고    scopus 로고
    • Protección neuronal endógena: Un enfoque alternativo
    • García Salman J.D. Protección neuronal endógena: un enfoque alternativo. Rev Neurol 2004, 38(2), 150.
    • (2004) Rev Neurol , vol.38 , Issue.2 , pp. 150
    • García Salman, J.D.1
  • 9
    • 1342269493 scopus 로고    scopus 로고
    • Protección neuronal endógena: Un enfoque alternativo
    • García Salman J.D. Protección neuronal endógena: un enfoque alternativo. Rev Neurol 2004; 38(2): 150.
    • (2004) Rev Neurol , vol.38 , Issue.2 , pp. 150
    • García Salman, J.D.1
  • 11
    • 0141784841 scopus 로고    scopus 로고
    • Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    • Villa Pia, Bigini P., Mennini Tiziana, Agnello D., Laragione Teresa, Cagnotto A., et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 2003; 198: 971.
    • (2003) J Exp Med , vol.198 , pp. 971
    • Villa Pia, B.P.1    Mennini Tiziana, A.D.2    Laragione Teresa, C.A.3
  • 12
    • 0346756186 scopus 로고    scopus 로고
    • New Insights into erythropoietin alfa: Mechanisms of Action, Target Tissues, and clinical application
    • Weiss MJ. New Insights into erythropoietin alfa: Mechanisms of Action, Target Tissues, and clinical application. Oncologist 2003; 18 (Suppl 3).
    • (2003) Oncologist , vol.18 , Issue.SUPPL. 3
    • Weiss, M.J.1
  • 14
    • 4644318784 scopus 로고    scopus 로고
    • Erythopoietin and hypoxic brain. Review article
    • Marti H.H. Erythopoietin and hypoxic brain. Review article. Journal of Experimental Biology 2004; 207: 3233.
    • (2004) Journal of Experimental Biology , vol.207 , pp. 3233
    • Marti, H.H.1
  • 18
    • 0033619054 scopus 로고    scopus 로고
    • El objetivo del tratamiento en la enfermedad cerebrovascular aguda y los enfoques terapéuticos neuroprotectores
    • Fisher M. El objetivo del tratamiento en la enfermedad cerebrovascular aguda y los enfoques terapéuticos neuroprotectores. Rev Neurol 1999; 29:536-544.
    • (1999) Rev Neurol , vol.29 , pp. 536-544
    • Fisher, M.1
  • 19
    • 0346787875 scopus 로고    scopus 로고
    • Castillo J, Rodríguez I. (). Biochemical Changes and Inflammatory Response as Markers for Brain Ischaemia: Molecular Markers of Diagnostic Utility and Prognosis in Human Clinical Practice. Cerebrovascular Diseases 2004; 17:7-18.
    • Castillo J, Rodríguez I. (). Biochemical Changes and Inflammatory Response as Markers for Brain Ischaemia: Molecular Markers of Diagnostic Utility and Prognosis in Human Clinical Practice. Cerebrovascular Diseases 2004; 17:7-18.
  • 20
    • 85032958378 scopus 로고    scopus 로고
    • Romano J G.. Tratamiento Agudo del Infarto Cerebral. Revista Ecuatoriana de Neurología 2005; (14): 1-3
    • Romano J G.. Tratamiento Agudo del Infarto Cerebral. Revista Ecuatoriana de Neurología 2005; (14): 1-3
  • 21
    • 33845547792 scopus 로고    scopus 로고
    • Pathophysiology and Therapy of Experimental Stroke
    • October/November
    • Hossmann K. A. Pathophysiology and Therapy of Experimental Stroke. Cellular and Molecular Neurobiology 2006; (26): 7/8, October/November.
    • (2006) Cellular and Molecular Neurobiology , Issue.26 , pp. 7-8
    • Hossmann, K.A.1
  • 22
    • 7944230999 scopus 로고    scopus 로고
    • Understanding the pattern of functional recovery after stroke: Facts and theories
    • Kwakkel G, Kollen B, Lindeman E. Understanding the pattern of functional recovery after stroke: Facts and theories. Restorative Neurology and Neuroscience 2004; 22:281-299.
    • (2004) Restorative Neurology and Neuroscience , vol.22 , pp. 281-299
    • Kwakkel, G.1    Kollen, B.2    Lindeman, E.3
  • 23
    • 0023797234 scopus 로고
    • Clinical observations on recovery from stroke
    • Dombovy ML, Bach-y-Rita. P. Clinical observations on recovery from stroke. Adv Neurol 1988; 47: 265-276.
    • (1988) Adv Neurol , vol.47 , pp. 265-276
    • Dombovy, M.L.1    Bach-y-Rita, P.2
  • 24
    • 0028181918 scopus 로고
    • Therapeutic window for multiple drug treament of experimental cerebral ischemia in gerbils
    • Danica B. Stanimirovic, Dejan V. Micic, Marina Markovic, Maria Spatz, Bogomir B. Mrsulja. Therapeutic window for multiple drug treament of experimental cerebral ischemia in gerbils. Neurochemical 1994; Vol 19(2): 189-194.
    • (1994) Neurochemical , vol.19 , Issue.2 , pp. 189-194
    • Stanimirovic, D.B.1    Micic, D.V.2    Markovic, M.3    Spatz, M.4    Mrsulja, B.B.5
  • 25
    • 0028783948 scopus 로고
    • NINDS rt-PA stroke study group Tissue plasminogen activator for acute ischemic stroke
    • NINDS rt-PA stroke study group Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581-7.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 27
    • 0029891443 scopus 로고    scopus 로고
    • Recently developed neuroprotective therapies for acute stroke. A qualitative systematic review of clinical trials
    • Dorman PJ, Counsell CE, Sandercock AG. Recently developed neuroprotective therapies for acute stroke. A qualitative systematic review of clinical trials. CNS Drugs 1996; 5:457-74.
    • (1996) CNS Drugs , vol.5 , pp. 457-474
    • Dorman, P.J.1    Counsell, C.E.2    Sandercock, A.G.3
  • 28
    • 0030949144 scopus 로고    scopus 로고
    • A glycine site antagonist attenuates infarct size in experimental focal ischemia: Postmortem and diffusion mapping studies
    • Takano K, Tatlisumak T, Formato J. A glycine site antagonist attenuates infarct size in experimental focal ischemia: postmortem and diffusion mapping studies. Stroke 1997; 28: 1255-63.
    • (1997) Stroke , vol.28 , pp. 1255-1263
    • Takano, K.1    Tatlisumak, T.2    Formato, J.3
  • 30
    • 1642365861 scopus 로고    scopus 로고
    • Erythropoietin as a tissue-protective cytokine in brain injury: What do we know and where do we go?
    • Grasso G, Sfacteria A, Cerami A, Brines M. Erythropoietin as a tissue-protective cytokine in brain injury: what do we know and where do we go? Neuroscientist 2004; 10:93-98.
    • (2004) Neuroscientist , vol.10 , pp. 93-98
    • Grasso, G.1    Sfacteria, A.2    Cerami, A.3    Brines, M.4
  • 32
    • 0019822988 scopus 로고
    • Thresholds in cerebral ischemia: The ischemic penumbra
    • Astrup J, Siesjö BK, Symon L. Thresholds in cerebral ischemia: The ischemic penumbra. Stroke 1981; 12: 723-725.
    • (1981) Stroke , vol.12 , pp. 723-725
    • Astrup, J.1    Siesjö, B.K.2    Symon, L.3
  • 33
    • 0033848141 scopus 로고    scopus 로고
    • Ischemic penumbra: Evidence from functional imaging in man
    • Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 2000;20:1276-1293.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1276-1293
    • Heiss, W.D.1
  • 34
    • 0032908247 scopus 로고    scopus 로고
    • Neuroprotection for acute stroke. Making clinical trials work
    • Muir K.W. and Grosset D.G. Neuroprotection for acute stroke. Making clinical trials work. Stroke 1999; 30,180.
    • (1999) Stroke , pp. 30-180
    • Muir, K.W.1    Grosset, D.G.2
  • 35
    • 0032881979 scopus 로고    scopus 로고
    • Attenuated stroke severity after prodromal TIA: A role for ischemic tolerance in the brain?
    • Weih, M., Kallenberg, K., Bergk, A., Dirnagl, U., Harms, L., Wernecke, K.D., and Einhaupl, K.M. Attenuated stroke severity after prodromal TIA: A role for ischemic tolerance in the brain? Stroke 1999; 30:1851-1854.
    • (1999) Stroke , vol.30 , pp. 1851-1854
    • Weih, M.1    Kallenberg, K.2    Bergk, A.3    Dirnagl, U.4    Harms, L.5    Wernecke, K.D.6    Einhaupl, K.M.7
  • 37
    • 0346494287 scopus 로고    scopus 로고
    • Glutamate excitotoxicity attenuates insulin-like growth factor-I prosurvival signaling
    • García-Galloway E, Arango C, Pons S, Torres-Alemán I. Glutamate excitotoxicity attenuates insulin-like growth factor-I prosurvival signaling. Mol Cell Neurosci 2003; 24:1027-37.
    • (2003) Mol Cell Neurosci , vol.24 , pp. 1027-1037
    • García-Galloway, E.1    Arango, C.2    Pons, S.3    Torres-Alemán, I.4
  • 38
    • 4344637089 scopus 로고    scopus 로고
    • Estrogen inhibits glycogen synthase kinase-3b and modulates the interaction of the microtubule-associated protein Tau with glutamate receptor subunits in post-ischemic hippocampus: Implications for hormonal neuroprotective mechanisms
    • Cardona-Gómez GP, Arango-Dávila C, Gallego-Gómez JC, Pimienta H, García-Segura LM. Estrogen inhibits glycogen synthase kinase-3b and modulates the interaction of the microtubule-associated protein Tau with glutamate receptor subunits in post-ischemic hippocampus: implications for hormonal neuroprotective mechanisms. Mol Brain Res 2004; 25:178-187.
    • (2004) Mol Brain Res , vol.25 , pp. 178-187
    • Cardona-Gómez, G.P.1    Arango-Dávila, C.2    Gallego-Gómez, J.C.3    Pimienta, H.4    García-Segura, L.M.5
  • 40
    • 0031923952 scopus 로고    scopus 로고
    • For the European and Australian Lubeluzole Ischemic Satroke Study Group Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke
    • Diener H-C. For the European and Australian Lubeluzole Ischemic Satroke Study Group Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. Cerebrovascular Diseases 1998; 8:172.
    • (1998) Cerebrovascular Diseases , vol.8 , pp. 172
    • Diener, H.-C.1
  • 41
    • 0031438509 scopus 로고    scopus 로고
    • For the US and Canadian Lubeluzole Ischemic Stroke Study Group Lubeluzale treatment of acute ischemic stroke
    • Grotta J. For the US and Canadian Lubeluzole Ischemic Stroke Study Group Lubeluzale treatment of acute ischemic stroke. Stroke 1997; 28: 2338.
    • (1997) Stroke , vol.28 , pp. 2338
    • Grotta, J.1
  • 42
    • 36349013428 scopus 로고    scopus 로고
    • Termination of acute stroke studies involving selfotel treatment: ASSIST Steering Committee
    • Davis S.M., Alber G.W, Diener H.C., Lees K.R. and Norris J. Termination of acute stroke studies involving selfotel treatment: ASSIST Steering Committee. Lancet 1997; 32:349.
    • (1997) Lancet , vol.32 , pp. 349
    • Davis, S.M.1    Alber, G.W.2    Diener, H.C.3    Lees, K.R.4    Norris, J.5
  • 43
    • 0348048849 scopus 로고    scopus 로고
    • The ischemic penumbra - identification, evolution and treatment concepts
    • Fisher M. The ischemic penumbra - identification, evolution and treatment concepts. Cerebrovasc Dis 2004; 17(1):1-6.
    • (2004) Cerebrovasc Dis , vol.17 , Issue.1 , pp. 1-6
    • Fisher, M.1
  • 45
    • 4644283464 scopus 로고    scopus 로고
    • Molecular biology of erythropoietin
    • Jelkmann W. Molecular biology of erythropoietin. Intern Med 2004;43:649-659.
    • (2004) Intern Med , vol.43 , pp. 649-659
    • Jelkmann, W.1
  • 46
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor-1
    • Wenger RH, Gassmann M. Oxygen(es) and the hypoxia-inducible factor-1. Biol Chem 1997; 378:609-616.
    • (1997) Biol Chem , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 48
    • 0042205823 scopus 로고    scopus 로고
    • Erythropoietin - a new therapy in cerebral ischemia?
    • Kalialis LV, Olsen NV. Erythropoietin - a new therapy in cerebral ischemia?. Ugeskr Laeger 2003; 165: 2477.
    • (2003) Ugeskr Laeger , vol.165 , pp. 2477
    • Kalialis, L.V.1    Olsen, N.V.2
  • 49
    • 0036982647 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for neuroprotection: What is the evidence?
    • Eid T, Brines M. Recombinant human erythropoietin for neuroprotection: what is the evidence?. Clin Breast Cancer 2002; 3: 109-15.
    • (2002) Clin Breast Cancer , vol.3 , pp. 109-115
    • Eid, T.1    Brines, M.2
  • 50
    • 0034368238 scopus 로고    scopus 로고
    • Neuroprotection and Angiogenesis: Dual role of erythropoietin in brain ischemia
    • Marti H, Bernaudin M, Petit E, Bauer C. Neuroprotection and Angiogenesis: Dual role of erythropoietin in brain ischemia. News of Physiology Science 2000; 15: 225-229.
    • (2000) News of Physiology Science , vol.15 , pp. 225-229
    • Marti, H.1    Bernaudin, M.2    Petit, E.3    Bauer, C.4
  • 51
    • 85032931141 scopus 로고    scopus 로고
    • Lipšic E, Schoemaker R., van der Meer P, Voors A., van Veldhuisen D., van Gilst W. Protective effects of erythropoietin in cardiac ischemia: from bench to bed-side. 2006; Chapter 8.
    • Lipšic E, Schoemaker R., van der Meer P, Voors A., van Veldhuisen D., van Gilst W. Protective effects of erythropoietin in cardiac ischemia: from bench to bed-side. 2006; Chapter 8.
  • 53
    • 0029976021 scopus 로고    scopus 로고
    • Erythropoietin gene expression in human, monkey and murine brain
    • Marti HH, Wenger RH, Rivas LA, et al. Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci 1996; 8:666-676.
    • (1996) Eur J Neurosci , vol.8 , pp. 666-676
    • Marti, H.H.1    Wenger, R.H.2    Rivas, L.A.3
  • 54
    • 0031893945 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor in the developing human central nervous system
    • Juul SE, Anderson DK, Li Y, et al. Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res 1998; 43:40-49.
    • (1998) Pediatr Res , vol.43 , pp. 40-49
    • Juul, S.E.1    Anderson, D.K.2    Li, Y.3
  • 55
    • 0035957426 scopus 로고    scopus 로고
    • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • Siren AL, Fratelli M, Brines M, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 2001; 98:4044-4049.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4044-4049
    • Siren, A.L.1    Fratelli, M.2    Brines, M.3
  • 56
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 2004;305:239-242.
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3
  • 58
    • 18244372152 scopus 로고    scopus 로고
    • Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats
    • Belayev L, Khoutorova L, Zhao W, et al. Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats. Stroke 2005;36:1071-1076.
    • (2005) Stroke , vol.36 , pp. 1071-1076
    • Belayev, L.1    Khoutorova, L.2    Zhao, W.3
  • 59
    • 0035101039 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
    • Siren AL, Knerlich F, Poser W. Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain. Acta Neuropathol 2001; 101: 271-276.
    • (2001) Acta Neuropathol , vol.101 , pp. 271-276
    • Siren, A.L.1    Knerlich, F.2    Poser, W.3
  • 60
    • 0032501397 scopus 로고    scopus 로고
    • Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery
    • Sadamoto Y, Igase K, Sakanaka M, Sato K, Otsuka H, Sakaki S, Masuda S, Sasaki R. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem Biophys Res Commun 1998; 253: 26-32.
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 26-32
    • Sadamoto, Y.1    Igase, K.2    Sakanaka, M.3    Sato, K.4    Otsuka, H.5    Sakaki, S.6    Masuda, S.7    Sasaki, R.8
  • 62
    • 0033961724 scopus 로고    scopus 로고
    • Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical
    • Chattopadhyay A, Choudhury TD, Bandyopadhyay D, Datta AG. Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical. Biochem Pharmacol 2000; 59: 419-425.
    • (2000) Biochem Pharmacol , vol.59 , pp. 419-425
    • Chattopadhyay, A.1    Choudhury, T.D.2    Bandyopadhyay, D.3    Datta, A.G.4
  • 64
    • 0242489261 scopus 로고    scopus 로고
    • Central nervous system frontiers for the use of erythropoietin
    • Olsen NV. Central nervous system frontiers for the use of erythropoietin. Clin Infect Dis, 37 (Suppl 4), S323, 2003.
    • (2003) Clin Infect Dis , vol.37 , Issue.SUPPL. 4
    • Olsen, N.V.1
  • 65
    • 0036431388 scopus 로고    scopus 로고
    • Erythropoietin in the central nervous system, and its use to prevent hypoxic-ischemic brain damage
    • Juul S. Erythropoietin in the central nervous system, and its use to prevent hypoxic-ischemic brain damage. Acta Paediatr Suppl 2002; 91, 36-42.
    • (2002) Acta Paediatr Suppl , vol.91 , pp. 36-42
    • Juul, S.1
  • 66
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong ZZ, Kang JQ, Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 2002;106:2973-2979.
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 67
    • 0037064261 scopus 로고    scopus 로고
    • Erythropoietin exerts anti-inflammatory effect on the center nerves system in the model of experimental autoinmune encephalomyelitis
    • Agnello D, Bigini P, Villa P, Mennini T, Ceremi A, Brines M, Ghezzi P. Erythropoietin exerts anti-inflammatory effect on the center nerves system in the model of experimental autoinmune encephalomyelitis. Brain Res 2002;952: 128-134.
    • (2002) Brain Res , vol.952 , pp. 128-134
    • Agnello, D.1    Bigini, P.2    Villa, P.3    Mennini, T.4    Ceremi, A.5    Brines, M.6    Ghezzi, P.7
  • 69
    • 0037365196 scopus 로고    scopus 로고
    • Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways
    • Chong ZZ, Kang JQ, Maiese K. Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol 2003; 138: 1107-1118.
    • (2003) Br J Pharmacol , vol.138 , pp. 1107-1118
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 70
    • 0035064310 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    • Nagai A, Nakagawa E, Choi HB. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 2001; 60:386-392.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 386-392
    • Nagai, A.1    Nakagawa, E.2    Choi, H.B.3
  • 71
    • 0025297296 scopus 로고
    • Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells
    • Anagnostou A, Lee ES, Kessimian N. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA. 1990; 87:5978-5982.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5978-5982
    • Anagnostou, A.1    Lee, E.S.2    Kessimian, N.3
  • 72
    • 0036896201 scopus 로고    scopus 로고
    • Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: Evidence from an in vitro model
    • Ruscher K, Freyer D, Karsch M, et al. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 2002; 22:10291-10301.
    • (2002) J Neurosci , vol.22 , pp. 10291-10301
    • Ruscher, K.1    Freyer, D.2    Karsch, M.3
  • 74
    • 0034644878 scopus 로고    scopus 로고
    • Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage
    • Alafaci C, Salpietro F, Grasso G. Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage. Eur J Pharmacol 2000;406: 219-225.
    • (2000) Eur J Pharmacol , vol.406 , pp. 219-225
    • Alafaci, C.1    Salpietro, F.2    Grasso, G.3
  • 75
    • 33749449685 scopus 로고    scopus 로고
    • Erythropoietin has neuroprotective effects with functional recovery in experimental intracerebral hemorrhage
    • Sinn D, Chu K, Lee S, et al. Erythropoietin has neuroprotective effects with functional recovery in experimental intracerebral hemorrhage. 57th Annual Meeting of the American Academy of Neurology. 2005; S48.008:http://www. abstracts2view.com/aan/
    • (2005) 57th Annual Meeting of the American Academy of Neurology
    • Sinn, D.1    Chu, K.2    Lee, S.3
  • 76
    • 25444461637 scopus 로고    scopus 로고
    • Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury
    • Lu D, Mahmood A, Qu C, et al. Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma 2005; 22:1011-1017.
    • (2005) J Neurotrauma , vol.22 , pp. 1011-1017
    • Lu, D.1    Mahmood, A.2    Qu, C.3
  • 77
    • 26444572335 scopus 로고    scopus 로고
    • Yatsiv I, Grigoriadis N, Simeonidou C. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. Faseb J 2005.
    • Yatsiv I, Grigoriadis N, Simeonidou C. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. Faseb J 2005.
  • 78
    • 25444461637 scopus 로고    scopus 로고
    • Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury
    • Lu D, Mahmood A, Qu C. Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma. 2005; 22:1011-1017.
    • (2005) J Neurotrauma , vol.22 , pp. 1011-1017
    • Lu, D.1    Mahmood, A.2    Qu, C.3
  • 79
    • 0037133191 scopus 로고    scopus 로고
    • Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
    • Celik M, Gokmen N, Erbayraktar S. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci USA. 2002; 99:2258-2263.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2258-2263
    • Celik, M.1    Gokmen, N.2    Erbayraktar, S.3
  • 80
    • 0037047154 scopus 로고    scopus 로고
    • Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
    • Gorio A, Gokmen N, Erbayraktar S. Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci USA. 2002; 99:9450-9455.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9450-9455
    • Gorio, A.1    Gokmen, N.2    Erbayraktar, S.3
  • 81
    • 9644278256 scopus 로고    scopus 로고
    • Beneficial effect of erythropoietin on experimental allergic encephalomyelitis
    • Li W, Maeda Y, Yuan RR, et al. Beneficial effect of erythropoietin on experimental allergic encephalomyelitis. Ann Neurol 2004;56:767-777.
    • (2004) Ann Neurol , vol.56 , pp. 767-777
    • Li, W.1    Maeda, Y.2    Yuan, R.R.3
  • 82
    • 13844251822 scopus 로고    scopus 로고
    • Erythropoietin treatment improves neurological functional recovery in EAE mice
    • Zhang J, Li Y, Cui Y. Erythropoietin treatment improves neurological functional recovery in EAE mice. Brain Res 2005;1034:34-39.
    • (2005) Brain Res , vol.1034 , pp. 34-39
    • Zhang, J.1    Li, Y.2    Cui, Y.3
  • 83
    • 12744273391 scopus 로고    scopus 로고
    • Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis
    • Sattler MB, Merkler D, Maier K, et al. Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis. Cell Death Dier 2004; 11 (Suppl 2): S181-S192.
    • (2004) Cell Death Dier , vol.11 , Issue.SUPPL. 2
    • Sattler, M.B.1    Merkler, D.2    Maier, K.3
  • 84
    • 13544269276 scopus 로고    scopus 로고
    • Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis
    • Diem R, Sattler MB, Merkler D. Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Brain 2005;128:375-385.
    • (2005) Brain , vol.128 , pp. 375-385
    • Diem, R.1    Sattler, M.B.2    Merkler, D.3
  • 85
    • 9144237424 scopus 로고    scopus 로고
    • Erythropoietin both protects from and reverses experimental diabetic neuropathy
    • Bianchi R, Buyukakilli B, Brines M. Erythropoietin both protects from and reverses experimental diabetic neuropathy. Proc Natl Acad Sci USA 2004; 101:823-828.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 823-828
    • Bianchi, R.1    Buyukakilli, B.2    Brines, M.3
  • 86
    • 0037069780 scopus 로고    scopus 로고
    • Erythropoietin - an endogenous retinal survival factor
    • Becerra SP, Amaral J. Erythropoietin - an endogenous retinal survival factor. N Engl J Med 2002;347:1968-1970.
    • (2002) N Engl J Med , vol.347 , pp. 1968-1970
    • Becerra, S.P.1    Amaral, J.2
  • 87
    • 26444572335 scopus 로고    scopus 로고
    • Yatsiv I, Grigoriadis N, Simeonidou C. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. Faseb J. 2005.
    • Yatsiv I, Grigoriadis N, Simeonidou C. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. Faseb J. 2005.
  • 88
    • 0842329753 scopus 로고    scopus 로고
    • Erythropoietin: A candidate compound for neuroprotection in schizophrenia
    • Ehrenreich H, Degner D, Meller J, et al. Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol Psychiatry 2004; 9:42-54.
    • (2004) Mol Psychiatry , vol.9 , pp. 42-54
    • Ehrenreich, H.1    Degner, D.2    Meller, J.3
  • 89
    • 15244341057 scopus 로고    scopus 로고
    • Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats
    • Sola A, Rogido M, Lee BH, et al. Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats. Pediatr Res 2005; 57: 481-487.
    • (2005) Pediatr Res , vol.57 , pp. 481-487
    • Sola, A.1    Rogido, M.2    Lee, B.H.3
  • 90
    • 11844266604 scopus 로고    scopus 로고
    • Erythropoietin increases glutathione peroxidase enzyme activity and decreases lipid peroxidation levels in hypoxic-ischemic brain injury in neonatal rats
    • Kumral A, Gonenc S, Acikgoz O. Erythropoietin increases glutathione peroxidase enzyme activity and decreases lipid peroxidation levels in hypoxic-ischemic brain injury in neonatal rats. Biol Neonate 2005; 87:15-18.
    • (2005) Biol Neonate , vol.87 , pp. 15-18
    • Kumral, A.1    Gonenc, S.2    Acikgoz, O.3
  • 91
    • 17844393791 scopus 로고    scopus 로고
    • Erythropoietin improves functional and histological outcome in neonatal stroke
    • Chang YS, Mu D, Wendland M, et al. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr Res 2005;58:106-111.
    • (2005) Pediatr Res , vol.58 , pp. 106-111
    • Chang, Y.S.1    Mu, D.2    Wendland, M.3
  • 92
    • 0346756186 scopus 로고    scopus 로고
    • New Insights into erythropoietin alfa: Mechanisms of Action, Target Tissues, and clinical aplication
    • Weiss Mitchell J. New Insights into erythropoietin alfa: Mechanisms of Action, Target Tissues, and clinical aplication. Oncologist 2003; 18, Suppl 3.
    • (2003) Oncologist , vol.18 , Issue.SUPPL. 3
    • Weiss Mitchell, J.1
  • 93
    • 15944374753 scopus 로고    scopus 로고
    • Recombinant human erythropoietin and overall survival in cancer patients: Results of a comprehensive meta-analysis
    • Bohlius J, Langensiepen S, Schwarzer G, et al. Recombinant human erythropoietin and overall survival in cancer patients: results of a comprehensive meta-analysis. J Natl Cancer Inst 2005; 97:489-498.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 489-498
    • Bohlius, J.1    Langensiepen, S.2    Schwarzer, G.3
  • 94
    • 0035894847 scopus 로고    scopus 로고
    • Erythropoietin regulates the in vitro and production of neuronal progenitors be mammalian forebrain neural stem cells
    • Shingo T., Soracan S.T., Shimazaki T., Weis S. Erythropoietin regulates the in vitro and production of neuronal progenitors be mammalian forebrain neural stem cells. J Neurosci 2001; 21:9733-9743.
    • (2001) J Neurosci , vol.21 , pp. 9733-9743
    • Shingo, T.1    Soracan, S.T.2    Shimazaki, T.3    Weis, S.4
  • 95
    • 3042688444 scopus 로고    scopus 로고
    • Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats
    • Wang L. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 2004; 35: 1732.
    • (2004) Stroke , vol.35 , pp. 1732
    • Wang, L.1
  • 99
    • 0029026040 scopus 로고
    • Quantitative analysis of the olfactory pathway for drug delivery to the brain
    • Sep 18;
    • Thorne RG, Emory CR, Ala TA, Frey WH. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res 1995; Sep 18;692(1-2):278-82.
    • (1995) Brain Res , vol.692 , Issue.1-2 , pp. 278-282
    • Thorne, R.G.1    Emory, C.R.2    Ala, T.A.3    Frey, W.H.4
  • 100
    • 23744459392 scopus 로고    scopus 로고
    • Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia
    • Oct 14
    • Yu YP, Xu QQ, Zhang Q, Zhang WP, Zhang LH, Wei EQ. Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia. Neurosci Lett 2005; Oct 14,387(1):5-10.
    • (2005) Neurosci Lett , vol.387 , Issue.1 , pp. 5-10
    • Yu, Y.P.1    Xu, Q.Q.2    Zhang, Q.3    Zhang, W.P.4    Zhang, L.H.5    Wei, E.Q.6
  • 101
    • 85032956903 scopus 로고    scopus 로고
    • Evaluación histológica del efecto de la Eritropoyetina vía intranasal, sobre la muerte neuronal retardada en gerbos sometidos a isquemia cerebral transitoria. Estudio preliminar
    • Subirós Nelvis, García Rodriguez JC, Gonzalez B, Sosa I, García Salman JD. Evaluación histológica del efecto de la Eritropoyetina vía intranasal, sobre la muerte neuronal retardada en gerbos sometidos a isquemia cerebral transitoria. Estudio preliminar. 7° Congreso Virtual Hispanoamericano de Anatomía Patológica 2005 ; http://www.conganat.org/445.pdf.
    • (2005) 7° Congreso Virtual Hispanoamericano de Anatomía Patológica
    • Nelvis, S.1    García Rodriguez, J.C.2    Gonzalez, B.3    Sosa, I.4    García Salman, J.D.5
  • 104
    • 85032921865 scopus 로고    scopus 로고
    • Hilger PA. Applied anatomy and physiology of the nose. In Boies Fundamentals of Otolaryngology, 6tht ed., ed. G.L Adams, L.R. Boies, and P.A Hilger, Philadelphia: W. B. Saunders 1989;177-195.
    • Hilger PA. Applied anatomy and physiology of the nose. In Boies Fundamentals of Otolaryngology, 6tht ed., ed. G.L Adams, L.R. Boies, and P.A Hilger, Philadelphia: W. B. Saunders 1989;177-195.
  • 105
    • 0037459005 scopus 로고    scopus 로고
    • Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003; 7: 187-198
    • Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003; 7: 187-198.
  • 106
    • 2442643119 scopus 로고    scopus 로고
    • Are the extracelluar pathways a conduit for the delivery of therapeutics to the brain?
    • Banks AW. Are the extracelluar pathways a conduit for the delivery of therapeutics to the brain? Current Pharmaceutical Design 2004; 10:1365-70.
    • (2004) Current Pharmaceutical Design , vol.10 , pp. 1365-1370
    • Banks, A.W.1
  • 107
    • 85032898134 scopus 로고    scopus 로고
    • Sosa I; Cruz J, Santana J.; Mengana Y, García-Salman JD; Muñoz A; García T; García Rodríguez JC. Paso de la molécula de eritropoyetina humana recombinante con bajo contenido de ácido siálico al sistema nervioso central por la vía intranasal en los modelos del Meriones unguiculatus y el primate no humano Macaca fascicularis. Rev Salud Animal In press 2007.
    • Sosa I; Cruz J, Santana J.; Mengana Y, García-Salman JD; Muñoz A; García T; García Rodríguez JC. Paso de la molécula de eritropoyetina humana recombinante con bajo contenido de ácido siálico al sistema nervioso central por la vía intranasal en los modelos del Meriones unguiculatus y el primate no humano Macaca fascicularis. Rev Salud Animal In press 2007.
  • 108
    • 85032926575 scopus 로고    scopus 로고
    • Subirós N. Eritropoyetina humana recombinante con bajo contenido de ácidos siálicos. Efecto neuroprotector de su administración nasal sobre la isquemia cerebral. Tesis de Maestría en Neurociencias, Centro de Neurociencias de Cuba. Febrero; 2007.
    • Subirós N. Eritropoyetina humana recombinante con bajo contenido de ácidos siálicos. Efecto neuroprotector de su administración nasal sobre la isquemia cerebral. Tesis de Maestría en Neurociencias, Centro de Neurociencias de Cuba. Febrero; 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.