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Volumn 93, Issue 2, 2005, Pages 392-402

Astroglial cytoprotection by erythropoietin pre-conditioning: Implications for ischemic and degenerative CNS disorders

Author keywords

Apoptosis; Astrocytes; Cytoprotection; Erythropoietin; Heme oxygenase 1; Oxidative stress

Indexed keywords

ARSENIC TRIOXIDE; HEME OXYGENASE 1; MESOPORPHYRIN TIN; NITRIC OXIDE; PROTEIN KINASE B; RECOMBINANT ERYTHROPOIETIN; STAUROSPORINE;

EID: 17444386695     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03038.x     Document Type: Article
Times cited : (49)

References (75)
  • 1
    • 0037064261 scopus 로고    scopus 로고
    • Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis
    • Agnello D., Bigini P., Villa P., Mennini T., Cerami A., Brines M. L. and Ghezzi P. (2002) Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res. 952, 128-134.
    • (2002) Brain Res. , vol.952 , pp. 128-134
    • Agnello, D.1    Bigini, P.2    Villa, P.3    Mennini, T.4    Cerami, A.5    Brines, M.L.6    Ghezzi, P.7
  • 2
    • 0032876719 scopus 로고    scopus 로고
    • Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations
    • Appleton S. D., Chretien M. L., McLaughlin B. E., Vreman H. J., Stevenson D. K., Brien J. F., Nakatsu K., Maurice D. H. and Marks G. S. (1999) Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab. Dispos. 27, 1214-1219.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 1214-1219
    • Appleton, S.D.1    Chretien, M.L.2    McLaughlin, B.E.3    Vreman, H.J.4    Stevenson, D.K.5    Brien, J.F.6    Nakatsu, K.7    Maurice, D.H.8    Marks, G.S.9
  • 3
    • 0034471963 scopus 로고    scopus 로고
    • Neuron-astrocyte interactions: Implications for cellular energetics and antioxidant levels
    • Aschner M. (2000) Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels. Neurotoxicology 21, 1101-1107.
    • (2000) Neurotoxicology , vol.21 , pp. 1101-1107
    • Aschner, M.1
  • 4
    • 0036208077 scopus 로고    scopus 로고
    • Erythropoietin stimulates vasculogenesis in neonatal rat mesenteric microvascular endothelial cells
    • Ashley R. A., Dubuque S. H., Dvorak B., Woodward S. S., Williams S. K. and Kling P. J. (2002) Erythropoietin stimulates vasculogenesis in neonatal rat mesenteric microvascular endothelial cells. Pediatr. Res. 51, 472-478.
    • (2002) Pediatr. Res. , vol.51 , pp. 472-478
    • Ashley, R.A.1    Dubuque, S.H.2    Dvorak, B.3    Woodward, S.S.4    Williams, S.K.5    Kling, P.J.6
  • 7
    • 0035949667 scopus 로고    scopus 로고
    • Neural roles for heme oxygenase: Contrasts to nitric oxide synthase
    • Baranano D. E. and Snyder S. H. (2001) Neural roles for heme oxygenase: contrasts to nitric oxide synthase. Proc. Natl Acad. Sci. USA 98, 10 996-11 002.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10996-11002
    • Baranano, D.E.1    Snyder, S.H.2
  • 8
    • 0034687662 scopus 로고    scopus 로고
    • The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death
    • Beltran B., Mathur A., Duchen M. R., Erusalimsky J. D. and Moncada S. (2000) The effect of nitric oxide on cell respiration: a key to understanding its role in cell survival or death. Proc. Natl Acad. Sci. USA 97, 14 602-14 607.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 14602-14607
    • Beltran, B.1    Mathur, A.2    Duchen, M.R.3    Erusalimsky, J.D.4    Moncada, S.5
  • 10
    • 0034013854 scopus 로고    scopus 로고
    • Neurons and astrocytes express EPO mRNA: Oxygen-sensing mechanisms that involve the redox-state of the brain
    • Bernaudin M., Bellail A., Marti H. H., Yvon A., Vivien D., Duchatelle I., Mackenzie E. T. and Petit E. (2000) Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 30, 271-278.
    • (2000) Glia , vol.30 , pp. 271-278
    • Bernaudin, M.1    Bellail, A.2    Marti, H.H.3    Yvon, A.4    Vivien, D.5    Duchatelle, I.6    Mackenzie, E.T.7    Petit, E.8
  • 13
    • 0141482000 scopus 로고    scopus 로고
    • Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury
    • Campana W. M. and Myers R. R. (2003) Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury. Eur. J. Neurosci. 18, 1497-1506.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 1497-1506
    • Campana, W.M.1    Myers, R.R.2
  • 14
    • 0037133191 scopus 로고    scopus 로고
    • Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
    • Celik M., Gokmen N., Erbayraktar S. et al. (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc. Natl Acad. Sci. USA 99, 2258-2263.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 2258-2263
    • Celik, M.1    Gokmen, N.2    Erbayraktar, S.3
  • 16
    • 0030662296 scopus 로고    scopus 로고
    • Recombinant human erythropoietin enhances superoxide production by FMLP-stimulated polymorphonuclear leukocytes in hemodialysis patients
    • Chen H. C., Tsai J. C., Tsai J. H. and Lai Y. H. (1997) Recombinant human erythropoietin enhances superoxide production by FMLP-stimulated polymorphonuclear leukocytes in hemodialysis patients. Kidney Int. 52, 1390-1394.
    • (1997) Kidney Int. , vol.52 , pp. 1390-1394
    • Chen, H.C.1    Tsai, J.C.2    Tsai, J.H.3    Lai, Y.H.4
  • 17
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong Z. Z., Kang J. Q. and Maiese K. (2002) Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106, 2973-2979.
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 18
    • 0029012011 scopus 로고
    • Differential effects of cysteamine on heat shock protein induction and cytoplasmic granulation in astrocytes and glioma cells
    • Chopra V. S., Chalifour L. E. and Schipper H. M. (1995) Differential effects of cysteamine on heat shock protein induction and cytoplasmic granulation in astrocytes and glioma cells. Brain Res. Mol. Brain Res. 31, 173-184.
    • (1995) Brain Res. Mol. Brain Res. , vol.31 , pp. 173-184
    • Chopra, V.S.1    Chalifour, L.E.2    Schipper, H.M.3
  • 19
    • 0031258695 scopus 로고    scopus 로고
    • A cellular stress model for the differential expression of glial lysosomal cathepsins in the aging nervous system
    • Chopra V. S., Moozar K. L., Mehindate K. and Schipper H. M. (1997) A cellular stress model for the differential expression of glial lysosomal cathepsins in the aging nervous system. Exp. Neurol. 147, 221-228.
    • (1997) Exp. Neurol. , vol.147 , pp. 221-228
    • Chopra, V.S.1    Moozar, K.L.2    Mehindate, K.3    Schipper, H.M.4
  • 20
    • 0036633164 scopus 로고    scopus 로고
    • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    • Clark A. S., West K., Streicher S. and Dennis P. A. (2002) Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol. Cancer Ther. 1, 707-717.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 707-717
    • Clark, A.S.1    West, K.2    Streicher, S.3    Dennis, P.A.4
  • 21
    • 0027216223 scopus 로고
    • Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor
    • Damen J. E., Mui A. L., Puil L., Pawson T. and Krystal G. (1993) Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor. Blood 81, 3204-3210.
    • (1993) Blood , vol.81 , pp. 3204-3210
    • Damen, J.E.1    Mui, A.L.2    Puil, L.3    Pawson, T.4    Krystal, G.5
  • 22
    • 0033644002 scopus 로고    scopus 로고
    • Regulation and role of heme oxygenase in oxidative injury
    • Dennery P. A. (2000) Regulation and role of heme oxygenase in oxidative injury. Curr. Top. Cell Regul. 36, 181-199.
    • (2000) Curr. Top. Cell Regul. , vol.36 , pp. 181-199
    • Dennery, P.A.1
  • 23
    • 0035833541 scopus 로고    scopus 로고
    • Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
    • Digicaylioglu M. and Lipton S. A. (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412, 641-647.
    • (2001) Nature , vol.412 , pp. 641-647
    • Digicaylioglu, M.1    Lipton, S.A.2
  • 25
    • 0028929896 scopus 로고
    • Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody. Response to oxidative stress
    • Dwyer B. E., Nishimura R. N. and Lu S. Y. (1995) Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody. Response to oxidative stress. Brain Res. Mol. Brain Res. 30, 37-47.
    • (1995) Brain Res. Mol. Brain Res. , vol.30 , pp. 37-47
    • Dwyer, B.E.1    Nishimura, R.N.2    Lu, S.Y.3
  • 26
    • 0036705708 scopus 로고    scopus 로고
    • Erythropoietin therapy for acute stroke is both safe and beneficial
    • Ehrenreich H., Hasselblatt M., Dembowski C et al. (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol. Med. 8, 495-505.
    • (2002) Mol. Med. , vol.8 , pp. 495-505
    • Ehrenreich, H.1    Hasselblatt, M.2    Dembowski, C.3
  • 27
    • 0842329753 scopus 로고    scopus 로고
    • Erythropoietin: A candidate compound for neuroprotection in schizophrenia
    • Ehrenreich H., Degner D., Meller J. et al. (2004) Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol. Psychiat. 9, 42-54.
    • (2004) Mol. Psychiat. , vol.9 , pp. 42-54
    • Ehrenreich, H.1    Degner, D.2    Meller, J.3
  • 28
    • 0036982647 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for neuroprotection: What is the evidence?
    • Eid T. and Brines M. (2002) Recombinant human erythropoietin for neuroprotection: what is the evidence? Clin. Breast Cancer 3, S109-S115.
    • (2002) Clin. Breast Cancer , vol.3
    • Eid, T.1    Brines, M.2
  • 29
    • 0037974734 scopus 로고    scopus 로고
    • Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
    • Erbayraktar S., Grasso G., Sfacteria A. et al. (2003) Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc. Natl Acad. Sci. USA 100, 6741-6746.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 6741-6746
    • Erbayraktar, S.1    Grasso, G.2    Sfacteria, A.3
  • 30
    • 0141953215 scopus 로고    scopus 로고
    • Systemic chemotherapy in elderly patients with locally advanced and/or inoperable squamous cell carcinoma of the head and neck: Impact of anemia and role of recombinant human erythropoietin
    • Gebbia V., Di Marco P. and Citarrella P. (2003) Systemic chemotherapy in elderly patients with locally advanced and/or inoperable squamous cell carcinoma of the head and neck: impact of anemia and role of recombinant human erythropoietin. Crit. Rev. Oncol. Hematol. 48, S49-S55.
    • (2003) Crit. Rev. Oncol. Hematol. , vol.48
    • Gebbia, V.1    Di Marco, P.2    Citarrella, P.3
  • 31
    • 0037087120 scopus 로고    scopus 로고
    • Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro
    • Gene S., Akhisaroglu M., Kuralay F. and Gene K. (2002) Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro. Neurosci. Lett. 321, 73-76.
    • (2002) Neurosci. Lett. , vol.321 , pp. 73-76
    • Gene, S.1    Akhisaroglu, M.2    Kuralay, F.3    Gene, K.4
  • 32
    • 0028323164 scopus 로고
    • A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry
    • Gong J., Traganos F. and Darzynkiewicz Z. (1994a) A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem. 218, 314-319.
    • (1994) Anal. Biochem. , vol.218 , pp. 314-319
    • Gong, J.1    Traganos, F.2    Darzynkiewicz, Z.3
  • 33
    • 0028264302 scopus 로고
    • Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points
    • Gong J., Traganos F. and Darzynkiewicz Z. (1994b) Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points. Cancer Res. 54, 3136-3139.
    • (1994) Cancer Res. , vol.54 , pp. 3136-3139
    • Gong, J.1    Traganos, F.2    Darzynkiewicz, Z.3
  • 34
    • 0026669254 scopus 로고
    • A simple fluorescence method for surface antigen phenotyping of lymphocytes undergoing DNA fragmentation
    • Hardin J. A., Sherr D. H., DeMaria M. and Lopez P. A. (1992) A simple fluorescence method for surface antigen phenotyping of lymphocytes undergoing DNA fragmentation. J. Immunol. Meth. 154, 99-107.
    • (1992) J. Immunol. Meth. , vol.154 , pp. 99-107
    • Hardin, J.A.1    Sherr, D.H.2    DeMaria, M.3    Lopez, P.A.4
  • 36
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • Ihle J. N. (1995) Cytokine receptor signalling. Nature 377, 591-594.
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 37
    • 0028340331 scopus 로고
    • Biology of erythropoietin
    • Jelkmann W. (1994) Biology of erythropoietin. Clin. Invest. 72, S3-S10.
    • (1994) Clin. Invest. , vol.72
    • Jelkmann, W.1
  • 38
    • 85047692700 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
    • Juhaszova M., Zorov D. B., Kim S. H. et al. (2004) Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J. Clin. Invest. 113, 1535-1549.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1535-1549
    • Juhaszova, M.1    Zorov, D.B.2    Kim, S.H.3
  • 40
    • 0035914398 scopus 로고    scopus 로고
    • Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia
    • Kawakami M., Sekiguchi M., Sato K., Kozaki S. and Takahashi M. (2001) Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia. J. Biol. Chem. 276, 39 469-39 475.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39469-39475
    • Kawakami, M.1    Sekiguchi, M.2    Sato, K.3    Kozaki, S.4    Takahashi, M.5
  • 41
    • 0026019106 scopus 로고
    • Erythropoietin
    • Krantz S. B. (1991) Erythropoietin. Blood 77, 419-434.
    • (1991) Blood , vol.77 , pp. 419-434
    • Krantz, S.B.1
  • 42
    • 0028245331 scopus 로고
    • Serum deprivation induces apoptotic cell death in a subset of Balb/c 3T3 fibroblasts
    • Kulkami G. V. and McCulloch C. A. (1994) Serum deprivation induces apoptotic cell death in a subset of Balb/c 3T3 fibroblasts. J. Cell Sci. 107, 1169-1179.
    • (1994) J. Cell Sci. , vol.107 , pp. 1169-1179
    • Kulkami, G.V.1    McCulloch, C.A.2
  • 44
    • 0027933447 scopus 로고
    • Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage
    • Llesuy S. F. and Tomaro M. L. (1994) Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim. Biophys. Acta 1223, 9-14.
    • (1994) Biochim. Biophys. Acta , vol.1223 , pp. 9-14
    • Llesuy, S.F.1    Tomaro, M.L.2
  • 45
    • 3042536665 scopus 로고    scopus 로고
    • Erythropoietin and renal failure
    • Macdougall I. C. (2003) Erythropoietin and renal failure. Curr. Hematol. Rep. 2, 459-464.
    • (2003) Curr. Hematol. Rep. , vol.2 , pp. 459-464
    • Macdougall, I.C.1
  • 46
    • 0028856231 scopus 로고
    • Redox perturbations in cysteamine-stressed astroglia: Implications for inclusion formation and gliosis in the aging brain
    • Manganaro F., Chopra V. S., Mydlarski M. B., Bernatchez G. and Schipper H. M. (1995) Redox perturbations in cysteamine-stressed astroglia: implications for inclusion formation and gliosis in the aging brain. Free Radic. Biol. Med. 19, 823-835.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 823-835
    • Manganaro, F.1    Chopra, V.S.2    Mydlarski, M.B.3    Bernatchez, G.4    Schipper, H.M.5
  • 48
    • 0027956115 scopus 로고
    • A novel site of erythropoietin production. Oxygendependent production in cultured rat astrocytes
    • Masuda S., Okano M., Yamagishi K., Nagao M., Ueda M. and Sasaki R. (1994) A novel site of erythropoietin production. Oxygendependent production in cultured rat astrocytes. J. Biol. Chem. 269, 19 488-19 493.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19488-19493
    • Masuda, S.1    Okano, M.2    Yamagishi, K.3    Nagao, M.4    Ueda, M.5    Sasaki, R.6
  • 49
    • 0028866845 scopus 로고
    • Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2
    • Meggio F., Donella Deana A., Ruzzene M. et al. (1995) Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur. J. Biochem. 234, 317-322.
    • (1995) Eur. J. Biochem. , vol.234 , pp. 317-322
    • Meggio, F.1    Donella Deana, A.2    Ruzzene, M.3
  • 50
    • 0034999085 scopus 로고    scopus 로고
    • Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: Implications for multiple sclerosis
    • Mehindate K., Sahlas D. J., Frankel D., Mawal Y., Liberman A., Corcos J., Dion S. and Schipper H. M. (2001) Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis. J. Neurochem. 77, 1386-1395.
    • (2001) J. Neurochem. , vol.77 , pp. 1386-1395
    • Mehindate, K.1    Sahlas, D.J.2    Frankel, D.3    Mawal, Y.4    Liberman, A.5    Corcos, J.6    Dion, S.7    Schipper, H.M.8
  • 51
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E., Masuda S., Nagao M., Yasuda Y. and Sasaki R. (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76, 105-116.
    • (1997) Neuroscience , vol.76 , pp. 105-116
    • Morishita, E.1    Masuda, S.2    Nagao, M.3    Yasuda, Y.4    Sasaki, R.5
  • 52
    • 0035064310 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    • Nagai A., Nakagawa E., Choi H. B., Hatori K., Kobayashi S. and Kim S. U. (2001) Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J. Neuropathol. Exp. Neurol. 60, 386-392.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 386-392
    • Nagai, A.1    Nakagawa, E.2    Choi, H.B.3    Hatori, K.4    Kobayashi, S.5    Kim, S.U.6
  • 53
    • 0027452195 scopus 로고
    • A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin
    • Nakagami T., Toyomura K., Kinoshita T. and Morisawa S. (1993) A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim. Biophys. Acta 1158, 189-193.
    • (1993) Biochim. Biophys. Acta , vol.1158 , pp. 189-193
    • Nakagami, T.1    Toyomura, K.2    Kinoshita, T.3    Morisawa, S.4
  • 54
    • 0035878762 scopus 로고    scopus 로고
    • Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases
    • Namgung U. and Xia Z. (2001) Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicol. Appl. Pharmacol. 174, 130-138.
    • (2001) Toxicol. Appl. Pharmacol. , vol.174 , pp. 130-138
    • Namgung, U.1    Xia, Z.2
  • 55
    • 0034923434 scopus 로고    scopus 로고
    • Oxidative damage is the earliest event in Alzheimer disease
    • Nunomura A., Perry G., Aliev G. et al. (2001) Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60, 759-767.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 759-767
    • Nunomura, A.1    Perry, G.2    Aliev, G.3
  • 56
    • 0036284936 scopus 로고    scopus 로고
    • Increase of brain oxidative stress in mild cognitive impairment: A possible predictor of Alzheimer disease
    • Pratico D., Clark C. M., Liun F., Rokach J., Lee V. Y. and Trojanowski J. Q. (2002) Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol. 59, 972-976.
    • (2002) Arch. Neurol. , vol.59 , pp. 972-976
    • Pratico, D.1    Clark, C.M.2    Liun, F.3    Rokach, J.4    Lee, V.Y.5    Trojanowski, J.Q.6
  • 57
    • 0033973712 scopus 로고    scopus 로고
    • The heme synthesis and degradation pathways: Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties
    • Ryter S. W. and Tyrrell R. M. (2000) The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic. Biol. Med. 28, 289-309.
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 289-309
    • Ryter, S.W.1    Tyrrell, R.M.2
  • 58
    • 0032501397 scopus 로고    scopus 로고
    • Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery
    • Sadamoto Y, Igase K., Sakanaka M., Sato K., Otsuka H., Sakaki S., Masuda S. and Sasaki R. (1998) Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem. Biophys. Res. Commun. 253, 26-32.
    • (1998) Biochem. Biophys. Res. Commun. , vol.253 , pp. 26-32
    • Sadamoto, Y.1    Igase, K.2    Sakanaka, M.3    Sato, K.4    Otsuka, H.5    Sakaki, S.6    Masuda, S.7    Sasaki, R.8
  • 61
    • 1842608814 scopus 로고    scopus 로고
    • Heme oxygenase-1: Transducer of pathological brain iron sequestration under oxidative stress
    • Schipper H. M. (2004) Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann. NY Acad. Sci. 1012, 84-93.
    • (2004) Ann. NY Acad. Sci. , vol.1012 , pp. 84-93
    • Schipper, H.M.1
  • 62
    • 0029032632 scopus 로고
    • Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
    • Schipper H. M., Cisse S. and Stopa E. G. (1995) Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann. Neurol. 37, 758-768.
    • (1995) Ann. Neurol. , vol.37 , pp. 758-768
    • Schipper, H.M.1    Cisse, S.2    Stopa, E.G.3
  • 63
    • 0032970494 scopus 로고    scopus 로고
    • Mitochondrial iron sequestration in dopamine-challenged astroglia: Role of heme oxygenase-1 and the permeability transition pore
    • Schipper H. M., Bernier L., Mehindate K. and Frankel D. (1999) Mitochondrial iron sequestration in dopamine-challenged astroglia: role of heme oxygenase-1 and the permeability transition pore. J. Neurochem. 72, 1802-1811.
    • (1999) J. Neurochem. , vol.72 , pp. 1802-1811
    • Schipper, H.M.1    Bernier, L.2    Mehindate, K.3    Frankel, D.4
  • 64
    • 0034284026 scopus 로고    scopus 로고
    • Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity
    • Sinor A. D. and Greenberg D. A. (2000) Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity. Neurosci. Lett. 290, 213-215.
    • (2000) Neurosci. Lett. , vol.290 , pp. 213-215
    • Sinor, A.D.1    Greenberg, D.A.2
  • 67
    • 0035957426 scopus 로고    scopus 로고
    • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • Siren A. L., Fratelli M., Brines M. et al. (2001b) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl Acad. Sci. USA 98, 4044-4049.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 4044-4049
    • Siren, A.L.1    Fratelli, M.2    Brines, M.3
  • 68
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker R., Yamamoto Y., McDonagh A. F., Glazer A. N. and Ames B. N. (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046.
    • (1987) Science , vol.235 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3    Glazer, A.N.4    Ames, B.N.5
  • 69
    • 0036890102 scopus 로고    scopus 로고
    • Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation
    • Sugawa M., Sakurai Y., Ishikawa-Ieda Y., Suzuki H. and Asou H. (2002) Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation. Neurosci. Res. 44, 391-403.
    • (2002) Neurosci. Res. , vol.44 , pp. 391-403
    • Sugawa, M.1    Sakurai, Y.2    Ishikawa-Ieda, Y.3    Suzuki, H.4    Asou, H.5
  • 70
    • 1842587600 scopus 로고    scopus 로고
    • Astrocyte influences on ischemic neuronal death
    • Swanson R. A., Ying W. and Kauppinen T. M. (2004) Astrocyte influences on ischemic neuronal death. Curr. Mol. Med. 4, 193-205.
    • (2004) Curr. Mol. Med. , vol.4 , pp. 193-205
    • Swanson, R.A.1    Ying, W.2    Kauppinen, T.M.3
  • 72
    • 0034858859 scopus 로고    scopus 로고
    • Heat shock response and ageing: Mechanisms and applications
    • Verbeke P., Fonager J., Clark B. F. and Rattan S. I. (2001) Heat shock response and ageing: mechanisms and applications. Cell Biol. Int. 25, 845-857.
    • (2001) Cell Biol. Int. , vol.25 , pp. 845-857
    • Verbeke, P.1    Fonager, J.2    Clark, B.F.3    Rattan, S.I.4
  • 75
    • 0027313693 scopus 로고
    • Oxidative injury to erythrocytes, cell rigidity and splenic hemolysis in hemodialyzed patients before and during erythropoietin treatment
    • Zachee P., Ferrant A., Daelemans R., Coolen L., Goossens W., Lins R. L., Couttenye M., De Broe M. E. and Boogaerts M. A. (1993) Oxidative injury to erythrocytes, cell rigidity and splenic hemolysis in hemodialyzed patients before and during erythropoietin treatment. Nephron 65, 288-293.
    • (1993) Nephron , vol.65 , pp. 288-293
    • Zachee, P.1    Ferrant, A.2    Daelemans, R.3    Coolen, L.4    Goossens, W.5    Lins, R.L.6    Couttenye, M.7    De Broe, M.E.8    Boogaerts, M.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.