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Volumn 81, Issue 6, 2010, Pages 552-560

Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery

Author keywords

Acetylcholine; Brain development; Dexamethasone; Glucocorticoids; Nicotine; Preterm delivery

Indexed keywords

ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE; DEXAMETHASONE; HEMICHOLINIUM 3; NICOTINE; NICOTINIC RECEPTOR;

EID: 76749100196     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.11.003     Document Type: Article
Times cited : (13)

References (70)
  • 1
    • 1942516979 scopus 로고    scopus 로고
    • Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal
    • Abreu-Villaça Y., Seidler F.J., Tate C.A., Cousins M.M., and Slotkin T.A. Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. Neuropsychopharmacology 29 (2004) 879-890
    • (2004) Neuropsychopharmacology , vol.29 , pp. 879-890
    • Abreu-Villaça, Y.1    Seidler, F.J.2    Tate, C.A.3    Cousins, M.M.4    Slotkin, T.A.5
  • 2
    • 33748071433 scopus 로고    scopus 로고
    • Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study
    • Al Mamun A., Lawlor D.A., Alati R., O'Callaghan M.J., Williams G.M., and Najman J.M. Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study. Am. J. Epidemiol. 164 (2006) 317-325
    • (2006) Am. J. Epidemiol. , vol.164 , pp. 317-325
    • Al Mamun, A.1    Lawlor, D.A.2    Alati, R.3    O'Callaghan, M.J.4    Williams, G.M.5    Najman, J.M.6
  • 3
    • 0041926611 scopus 로고    scopus 로고
    • The developmental origins of adult disease
    • Barker D.J.P. The developmental origins of adult disease. Eur. J. Epidemiol. 18 (2003) 733-736
    • (2003) Eur. J. Epidemiol. , vol.18 , pp. 733-736
    • Barker, D.J.P.1
  • 4
    • 0033846277 scopus 로고    scopus 로고
    • Central nicotinic receptors, neurotrophic factors and neuroprotection
    • Belluardo N., Mudo G., Blum M., and Fuxe K. Central nicotinic receptors, neurotrophic factors and neuroprotection. Behav. Brain Res. 113 (2000) 21-34
    • (2000) Behav. Brain Res. , vol.113 , pp. 21-34
    • Belluardo, N.1    Mudo, G.2    Blum, M.3    Fuxe, K.4
  • 5
    • 0029873573 scopus 로고    scopus 로고
    • High affinity choline transporter status in Alzheimer's Disease tissue from rapid autopsy
    • Bissette G., Seidler F.J., Nemeroff C.B., and Slotkin T.A. High affinity choline transporter status in Alzheimer's Disease tissue from rapid autopsy. Ann. N. Y. Acad. Sci. 777 (1996) 197-204
    • (1996) Ann. N. Y. Acad. Sci. , vol.777 , pp. 197-204
    • Bissette, G.1    Seidler, F.J.2    Nemeroff, C.B.3    Slotkin, T.A.4
  • 6
    • 0035869342 scopus 로고    scopus 로고
    • Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function
    • Buisson B., and Bertrand D. Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function. J. Neurosci. 21 (2001) 1819-1829
    • (2001) J. Neurosci. , vol.21 , pp. 1819-1829
    • Buisson, B.1    Bertrand, D.2
  • 7
    • 0036499938 scopus 로고    scopus 로고
    • Nicotine addiction: the possible role of functional upregulation
    • Buisson B., and Bertrand D. Nicotine addiction: the possible role of functional upregulation. Trends Pharmacol. Sci. 23 (2002) 130-136
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 130-136
    • Buisson, B.1    Bertrand, D.2
  • 9
    • 0034775352 scopus 로고    scopus 로고
    • Repeated antenatal glucocorticoid exposure and the developing brain
    • Dammann O., and Matthews S.G. Repeated antenatal glucocorticoid exposure and the developing brain. Pediatr. Res. 50 (2001) 563-564
    • (2001) Pediatr. Res. , vol.50 , pp. 563-564
    • Dammann, O.1    Matthews, S.G.2
  • 10
    • 0035708568 scopus 로고    scopus 로고
    • Cellular mechanisms of nicotine addiction
    • Dani J.A., and De Biasi M. Cellular mechanisms of nicotine addiction. Pharmacol. Biochem. Behav. 70 (2001) 439-446
    • (2001) Pharmacol. Biochem. Behav. , vol.70 , pp. 439-446
    • Dani, J.A.1    De Biasi, M.2
  • 11
    • 0028922087 scopus 로고
    • Effect of maternal cigarette smoking on pregnancy complications and sudden infant death syndrome
    • DiFranza J.R., and Lew R.A. Effect of maternal cigarette smoking on pregnancy complications and sudden infant death syndrome. J. Family Pract. 40 (1995) 385-394
    • (1995) J. Family Pract. , vol.40 , pp. 385-394
    • DiFranza, J.R.1    Lew, R.A.2
  • 12
    • 34548508434 scopus 로고    scopus 로고
    • Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease
    • Drake A.J., Tang J.I., and Nyirenda M.J. Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease. Clin. Sci. 113 (2007) 219-232
    • (2007) Clin. Sci. , vol.113 , pp. 219-232
    • Drake, A.J.1    Tang, J.I.2    Nyirenda, M.J.3
  • 16
    • 0035060057 scopus 로고    scopus 로고
    • Threshold levels of maternal nicotine impairing protective responses of newborn rats to intermittent hypoxia
    • Fewell J.E., Smith F.G., and Ng V.K.Y. Threshold levels of maternal nicotine impairing protective responses of newborn rats to intermittent hypoxia. J. Appl. Physiol. 90 (2001) 1968-1976
    • (2001) J. Appl. Physiol. , vol.90 , pp. 1968-1976
    • Fewell, J.E.1    Smith, F.G.2    Ng, V.K.Y.3
  • 17
    • 0026593533 scopus 로고
    • A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment
    • Flores C.M., Rogers S.W., Pabreza L.A., Wolfe B.B., and Kellar K.J. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment. Mol. Pharmacol. 41 (1992) 31-37
    • (1992) Mol. Pharmacol. , vol.41 , pp. 31-37
    • Flores, C.M.1    Rogers, S.W.2    Pabreza, L.A.3    Wolfe, B.B.4    Kellar, K.J.5
  • 19
    • 0026637423 scopus 로고
    • High-affinity choline transport regulation by drug administration during postnatal development
    • Happe H.K., and Murrin L.C. High-affinity choline transport regulation by drug administration during postnatal development. J. Neurochem. 58 (1992) 2053-2059
    • (1992) J. Neurochem. , vol.58 , pp. 2053-2059
    • Happe, H.K.1    Murrin, L.C.2
  • 21
    • 40549100024 scopus 로고    scopus 로고
    • Prenatal tobacco smoke and postnatal secondhand smoke exposure and child neurodevelopment
    • Herrmann M., King K., and Weitzman M. Prenatal tobacco smoke and postnatal secondhand smoke exposure and child neurodevelopment. Curr. Opin. Pediatr. 20 (2008) 184-190
    • (2008) Curr. Opin. Pediatr. , vol.20 , pp. 184-190
    • Herrmann, M.1    King, K.2    Weitzman, M.3
  • 22
    • 0042519596 scopus 로고    scopus 로고
    • A morphogenetic role for acetylcholine in mouse cerebral neocortex
    • Hohmann C.F. A morphogenetic role for acetylcholine in mouse cerebral neocortex. Neurosci. Biobehav. Rev. 27 (2003) 351-363
    • (2003) Neurosci. Biobehav. Rev. , vol.27 , pp. 351-363
    • Hohmann, C.F.1
  • 23
    • 0032435521 scopus 로고    scopus 로고
    • Cholinergic regulation of cortical development and plasticity: new twists to an old story
    • Hohmann C.F., and Berger-Sweeney J. Cholinergic regulation of cortical development and plasticity: new twists to an old story. Perspect. Dev. Neurobiol. 5 (1998) 401-425
    • (1998) Perspect. Dev. Neurobiol. , vol.5 , pp. 401-425
    • Hohmann, C.F.1    Berger-Sweeney, J.2
  • 24
    • 43549118648 scopus 로고    scopus 로고
    • How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90
    • Karaolis-Danckert N., Buyken A.E., Kulig M., Kroke A., Forster J., Kamin W., Schuster A., Hornberg C., Keil T., Bergmann R.L., Wahn U., and Lau S. How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90. Am. J. Clin. Nutr. 87 (2008) 1356-1364
    • (2008) Am. J. Clin. Nutr. , vol.87 , pp. 1356-1364
    • Karaolis-Danckert, N.1    Buyken, A.E.2    Kulig, M.3    Kroke, A.4    Forster, J.5    Kamin, W.6    Schuster, A.7    Hornberg, C.8    Keil, T.9    Bergmann, R.L.10    Wahn, U.11    Lau, S.12
  • 25
    • 0018421443 scopus 로고
    • Post-mortem changes in high affinity choline uptake
    • Klemm N., and Kuhar M.J. Post-mortem changes in high affinity choline uptake. J. Neurochem. 32 (1979) 1487-1494
    • (1979) J. Neurochem. , vol.32 , pp. 1487-1494
    • Klemm, N.1    Kuhar, M.J.2
  • 26
    • 27144534253 scopus 로고    scopus 로고
    • Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses
    • Kreider M.L., Aldridge J.E., Cousins M.M., Oliver C.A., Seidler F.J., and Slotkin T.A. Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses. Neuropsychopharmacology 30 (2005) 1841-1855
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1841-1855
    • Kreider, M.L.1    Aldridge, J.E.2    Cousins, M.M.3    Oliver, C.A.4    Seidler, F.J.5    Slotkin, T.A.6
  • 27
    • 32844454651 scopus 로고    scopus 로고
    • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets and sex selectivity
    • Kreider M.L., Tate C.A., Cousins M.M., Oliver C.A., Seidler F.J., and Slotkin T.A. Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets and sex selectivity. Neuropsychopharmacology 31 (2006) 12-35
    • (2006) Neuropsychopharmacology , vol.31 , pp. 12-35
    • Kreider, M.L.1    Tate, C.A.2    Cousins, M.M.3    Oliver, C.A.4    Seidler, F.J.5    Slotkin, T.A.6
  • 28
    • 39249083938 scopus 로고    scopus 로고
    • Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos
    • Lassiter T.L., and Brimijoin S. Rats gain excess weight after developmental exposure to the organophosphorothionate pesticide, chlorpyrifos. Neurotoxicol. Teratol. 30 (2008) 125-130
    • (2008) Neurotoxicol. Teratol. , vol.30 , pp. 125-130
    • Lassiter, T.L.1    Brimijoin, S.2
  • 29
    • 71349084068 scopus 로고    scopus 로고
    • Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits
    • in press
    • T.L. Lassiter, I.T. Ryde, E.D. Levin, F.J. Seidler, T.A. Slotkin, Neonatal exposure to parathion alters lipid metabolism in adulthood: interactions with dietary fat intake and implications for neurodevelopmental deficits, Brain Res. Bull., in press.
    • Brain Res. Bull
    • Lassiter, T.L.1    Ryde, I.T.2    Levin, E.D.3    Seidler, F.J.4    Slotkin, T.A.5
  • 30
    • 57149128283 scopus 로고    scopus 로고
    • Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood
    • Lassiter T.L., Ryde I.T., MacKillop E.A., Brown K.K., Levin E.D., Seidler F.J., and Slotkin T.A. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environ. Health Perspect. 116 (2008) 1456-1462
    • (2008) Environ. Health Perspect. , vol.116 , pp. 1456-1462
    • Lassiter, T.L.1    Ryde, I.T.2    MacKillop, E.A.3    Brown, K.K.4    Levin, E.D.5    Seidler, F.J.6    Slotkin, T.A.7
  • 31
    • 0032908629 scopus 로고    scopus 로고
    • Morphogenetic roles of acetylcholine
    • Lauder J.M., and Schambra U.B. Morphogenetic roles of acetylcholine. Environ. Health Perspect. 107 Suppl. 1 (1999) 65-69
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 1 , pp. 65-69
    • Lauder, J.M.1    Schambra, U.B.2
  • 34
    • 0028279939 scopus 로고
    • The effect of smoking cessation during pregnancy on preterm delivery and low birthweight
    • Mainous A.G., and Hueston W.J. The effect of smoking cessation during pregnancy on preterm delivery and low birthweight. J. Fam. Pract. 38 (1994) 262-266
    • (1994) J. Fam. Pract. , vol.38 , pp. 262-266
    • Mainous, A.G.1    Hueston, W.J.2
  • 35
    • 13844262784 scopus 로고    scopus 로고
    • Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide, chlorpyrifos
    • Meyer A., Seidler F.J., Aldridge J.E., and Slotkin T.A. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide, chlorpyrifos. Toxicol. Appl. Pharmacol. 203 (2005) 154-166
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , pp. 154-166
    • Meyer, A.1    Seidler, F.J.2    Aldridge, J.E.3    Slotkin, T.A.4
  • 36
    • 0023101017 scopus 로고
    • Nicotine administration to rats: methodological considerations
    • Murrin L.C., Ferrer J.R., Wanyun Z., and Haley N.J. Nicotine administration to rats: methodological considerations. Life Sci. 40 (1987) 1699-1708
    • (1987) Life Sci. , vol.40 , pp. 1699-1708
    • Murrin, L.C.1    Ferrer, J.R.2    Wanyun, Z.3    Haley, N.J.4
  • 37
    • 51349163606 scopus 로고    scopus 로고
    • Maternal tobacco smoking, nicotine replacement and neurobehavioural development
    • Pauly J.R., and Slotkin T.A. Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Pædiatr. 97 (2008) 1331-1337
    • (2008) Acta Pædiatr. , vol.97 , pp. 1331-1337
    • Pauly, J.R.1    Slotkin, T.A.2
  • 38
    • 0029123172 scopus 로고
    • Preterm delivery: effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine
    • Peacock J.L., Bland J.M., and Anderson H.R. Preterm delivery: effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine. BMJ 311 (1995) 531-535
    • (1995) BMJ , vol.311 , pp. 531-535
    • Peacock, J.L.1    Bland, J.M.2    Anderson, H.R.3
  • 39
    • 0036106163 scopus 로고    scopus 로고
    • Fetal environment and subsequent obesity: a study of maternal smoking
    • Power C., and Jefferis B.J. Fetal environment and subsequent obesity: a study of maternal smoking. Int. J. Epidemiol. 31 (2002) 413-419
    • (2002) Int. J. Epidemiol. , vol.31 , pp. 413-419
    • Power, C.1    Jefferis, B.J.2
  • 40
    • 0742306813 scopus 로고    scopus 로고
    • Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood
    • Qiao D., Seidler F.J., Abreu-Villaça Y., Tate C.A., Cousins M.M., and Slotkin T.A. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Dev. Brain Res. 148 (2004) 43-52
    • (2004) Dev. Brain Res. , vol.148 , pp. 43-52
    • Qiao, D.1    Seidler, F.J.2    Abreu-Villaça, Y.3    Tate, C.A.4    Cousins, M.M.5    Slotkin, T.A.6
  • 41
    • 0037732695 scopus 로고    scopus 로고
    • Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood
    • Qiao D., Seidler F.J., Tate C.A., Cousins M.M., and Slotkin T.A. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ. Health Perspect. 111 (2003) 536-544
    • (2003) Environ. Health Perspect. , vol.111 , pp. 536-544
    • Qiao, D.1    Seidler, F.J.2    Tate, C.A.3    Cousins, M.M.4    Slotkin, T.A.5
  • 42
    • 0036891571 scopus 로고    scopus 로고
    • Desensitization of neuronal nicotinic receptors
    • Quick M.W., and Lester R.A. Desensitization of neuronal nicotinic receptors. J. Neurobiol. 53 (2002) 457-478
    • (2002) J. Neurobiol. , vol.53 , pp. 457-478
    • Quick, M.W.1    Lester, R.A.2
  • 43
    • 4544346832 scopus 로고    scopus 로고
    • Neonatal dexamethasone therapy: short- and long-term consequences
    • Raff H. Neonatal dexamethasone therapy: short- and long-term consequences. Trends Endocrinol. Metab. 15 (2004) 351-352
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 351-352
    • Raff, H.1
  • 44
    • 1442299469 scopus 로고    scopus 로고
    • Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats
    • Rhodes M.C., Seidler F.J., Qiao D., Tate C.A., Cousins M.M., and Slotkin T.A. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicol. Appl. Pharmacol. 195 (2004) 203-217
    • (2004) Toxicol. Appl. Pharmacol. , vol.195 , pp. 203-217
    • Rhodes, M.C.1    Seidler, F.J.2    Qiao, D.3    Tate, C.A.4    Cousins, M.M.5    Slotkin, T.A.6
  • 45
    • 0024558208 scopus 로고
    • Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring
    • Ribary U., and Lichtensteiger W. Effects of acute and chronic prenatal nicotine treatment on central catecholamine systems of male and female rat fetuses and offspring. J. Pharmacol. Exp. Ther. 248 (1989) 786-792
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 786-792
    • Ribary, U.1    Lichtensteiger, W.2
  • 46
  • 48
    • 0023143994 scopus 로고
    • Abruptio placentae: clinical management in nonacute cases
    • Sholl J.S. Abruptio placentae: clinical management in nonacute cases. Am. J. Obstet. Gynecol. 156 (1987) 40-51
    • (1987) Am. J. Obstet. Gynecol. , vol.156 , pp. 40-51
    • Sholl, J.S.1
  • 49
    • 0017235493 scopus 로고
    • Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine
    • Simon J.R., Atweh S., and Kuhar M.J. Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine. J. Neurochem. 26 (1976) 909-922
    • (1976) J. Neurochem. , vol.26 , pp. 909-922
    • Simon, J.R.1    Atweh, S.2    Kuhar, M.J.3
  • 50
    • 0842342126 scopus 로고    scopus 로고
    • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates
    • Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol. Appl. Pharmacol. 198 (2004) 132-151
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 132-151
    • Slotkin, T.A.1
  • 51
    • 38349105305 scopus 로고    scopus 로고
    • If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents?
    • Slotkin T.A. If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents?. Neurotoxicol. Teratol. 30 (2008) 1-19
    • (2008) Neurotoxicol. Teratol. , vol.30 , pp. 1-19
    • Slotkin, T.A.1
  • 52
    • 0029996834 scopus 로고    scopus 로고
    • Programming of brainstem serotonin transporter development by prenatal glucocorticoids
    • Slotkin T.A., Barnes G.A., McCook E.C., and Seidler F.J. Programming of brainstem serotonin transporter development by prenatal glucocorticoids. Dev. Brain Res. 93 (1996) 155-161
    • (1996) Dev. Brain Res. , vol.93 , pp. 155-161
    • Slotkin, T.A.1    Barnes, G.A.2    McCook, E.C.3    Seidler, F.J.4
  • 53
    • 40849114680 scopus 로고    scopus 로고
    • Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems
    • Slotkin T.A., Bodwell B.E., Levin E.D., and Seidler F.J. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ. Health Perspect. 116 (2008) 340-348
    • (2008) Environ. Health Perspect. , vol.116 , pp. 340-348
    • Slotkin, T.A.1    Bodwell, B.E.2    Levin, E.D.3    Seidler, F.J.4
  • 54
    • 27244454321 scopus 로고    scopus 로고
    • Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood
    • Slotkin T.A., Brown K.K., and Seidler F.J. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ. Health Perspect. 113 (2005) 1291-1294
    • (2005) Environ. Health Perspect. , vol.113 , pp. 1291-1294
    • Slotkin, T.A.1    Brown, K.K.2    Seidler, F.J.3
  • 55
    • 0027981426 scopus 로고
    • Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization?
    • Slotkin T.A., Lau C., McCook E.C., Lappi S.E., and Seidler F.J. Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization?. Toxicol. Appl. Pharmacol. 127 (1994) 64-75
    • (1994) Toxicol. Appl. Pharmacol. , vol.127 , pp. 64-75
    • Slotkin, T.A.1    Lau, C.2    McCook, E.C.3    Lappi, S.E.4    Seidler, F.J.5
  • 56
    • 34247401372 scopus 로고    scopus 로고
    • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at six months of age
    • Slotkin T.A., MacKillop E.A., Rudder C.L., Ryde I.T., Tate C.A., and Seidler F.J. Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at six months of age. Neuropsychopharmacology 32 (2007) 1082-1097
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1082-1097
    • Slotkin, T.A.1    MacKillop, E.A.2    Rudder, C.L.3    Ryde, I.T.4    Tate, C.A.5    Seidler, F.J.6
  • 57
    • 0027964183 scopus 로고
    • Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's Disease: evidence from rapid autopsy studies
    • Slotkin T.A., Nemeroff C.B., Bissette G., and Seidler F.J. Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's Disease: evidence from rapid autopsy studies. J. Clin. Invest. 94 (1994) 696-702
    • (1994) J. Clin. Invest. , vol.94 , pp. 696-702
    • Slotkin, T.A.1    Nemeroff, C.B.2    Bissette, G.3    Seidler, F.J.4
  • 58
    • 34547510182 scopus 로고    scopus 로고
    • Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions
    • Slotkin T.A., Ryde I.T., and Seidler F.J. Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions. Brain Res. Bull. 74 (2007) 91-103
    • (2007) Brain Res. Bull. , vol.74 , pp. 91-103
    • Slotkin, T.A.1    Ryde, I.T.2    Seidler, F.J.3
  • 59
    • 34249935494 scopus 로고    scopus 로고
    • Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats
    • Slotkin T.A., and Seidler F.J. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Res. Bull. 73 (2007) 301-309
    • (2007) Brain Res. Bull. , vol.73 , pp. 301-309
    • Slotkin, T.A.1    Seidler, F.J.2
  • 60
    • 0032212101 scopus 로고    scopus 로고
    • Glucocorticoid administration discoordinates nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids
    • Slotkin T.A., Zhang J., McCook E.C., and Seidler F.J. Glucocorticoid administration discoordinates nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. Dev. Brain Res. 111 (1998) 11-24
    • (1998) Dev. Brain Res. , vol.111 , pp. 11-24
    • Slotkin, T.A.1    Zhang, J.2    McCook, E.C.3    Seidler, F.J.4
  • 63
    • 38349113169 scopus 로고    scopus 로고
    • Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon
    • Timofeeva O.A., Roegge C.S., Seidler F.J., Slotkin T.A., and Levin E.D. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol. Teratol. 30 (2008) 38-45
    • (2008) Neurotoxicol. Teratol. , vol.30 , pp. 38-45
    • Timofeeva, O.A.1    Roegge, C.S.2    Seidler, F.J.3    Slotkin, T.A.4    Levin, E.D.5
  • 64
    • 0034625740 scopus 로고    scopus 로고
    • An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions
    • Trauth J.A., Seidler F.J., and Slotkin T.A. An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions. Brain Res. 867 (2000) 29-39
    • (2000) Brain Res. , vol.867 , pp. 29-39
    • Trauth, J.A.1    Seidler, F.J.2    Slotkin, T.A.3
  • 65
    • 0022572002 scopus 로고
    • Maternal smoking and infant respiratory distress syndrome
    • White E., Shy K.K., Daling J.R., and Guthrie R.D. Maternal smoking and infant respiratory distress syndrome. Obstet. Gynecol. 67 (1986) 365-370
    • (1986) Obstet. Gynecol. , vol.67 , pp. 365-370
    • White, E.1    Shy, K.K.2    Daling, J.R.3    Guthrie, R.D.4
  • 66
    • 0033838258 scopus 로고    scopus 로고
    • Antenatal steroids and the developing brain
    • Whitelaw A., and Thoresen M. Antenatal steroids and the developing brain. Arch. Dis. Child. 83 (2000) F154-F157
    • (2000) Arch. Dis. Child. , vol.83
    • Whitelaw, A.1    Thoresen, M.2
  • 67
    • 1642617187 scopus 로고
    • Purification and characterization of a nicotinic acetylcholine receptor from rat brain
    • Whiting P., and Lindstrom J. Purification and characterization of a nicotinic acetylcholine receptor from rat brain. Proc. Natl. Acad. Sci. 84 (1987) 595-599
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 595-599
    • Whiting, P.1    Lindstrom, J.2
  • 68
    • 0023751963 scopus 로고
    • Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies
    • Whiting P.R., and Lindstrom J. Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies. J. Neurosci. 8 (1988) 3395-3404
    • (1988) J. Neurosci. , vol.8 , pp. 3395-3404
    • Whiting, P.R.1    Lindstrom, J.2
  • 70
    • 0027512511 scopus 로고
    • Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression
    • Zahalka E.A., Seidler F.J., Lappi S.E., Yanai J., and Slotkin T.A. Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression. Brain Res. 601 (1993) 221-229
    • (1993) Brain Res. , vol.601 , pp. 221-229
    • Zahalka, E.A.1    Seidler, F.J.2    Lappi, S.E.3    Yanai, J.4    Slotkin, T.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.