Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase ε in human colorectal cancer

Cancer Genomics and Proteomics

Volumn 6, Issue 6, 2009, Pages 297-304

  Zhou, Qi ^a   Talvinen, Kati ^a   Sundström, Jari ^a   Elzagheid, Adem ^a,d   Pospiech, Helmut ^b   Syväoja, Juhani E ^b,c   Collan, Yrjö ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d Department of Pathology   (Finland)

Author keywords

Colorectal cancer; DNA polymerase epsilon ( ); Genomic changes

Indexed keywords

DNA DIRECTED DNA POLYMERASE EPSILON; HISTIDINE; PROTEIN SUBUNIT; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 76749088088     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Hilska M, Collan Y, Roberts PJ, Ovaska J, Kössi J, Paajanen H and Laato M: Prognostic value of various staging and grading systems in proximal colon cancer. Eur J Surg 168: 84-90, 2002.
2. Hilska M, Collan Y, Laine VJO, Kössi J, Hirsimäki P, Laato M and Roberts PJ: The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer. Dis Colon Rectum 48: 2197-2208, 2005.
3. Zavrides H, Zizi-Sernpetzoglou A, Elemenoglou I, Papatheofanis I, Peros G, Athanasas G and Panousopoulos D: lmmuno-histochemical expression of bcl-2 in Dukes' stage B and C colorectal carcinoma patients: correlation with p53 and Ki-67 in evaluating prognostic significance. Pol J Pathol 56: 179-185, 2005.
4. Diep CB, Thorstensen L, Meling GI, Skovlund E, Rognum TO and Lothe RA: Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients. J Clin Oncol 21: 820-829, 2003.
5. Garrity MM, Burgart LJ, Mahoney MR, Windschitl HE, Salim M, Wiesenfeld M, Krook JE, Michalak JC, Goldberg RM, O'Connell MJ, Furth AF, Sargent DJ, Murphy LM, Hill E, Riehle DL, Meyers CH and Witzig TE; North Central Cancer Treatment Group: Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C colon cancer: a North Central Cancer Treatment Group Study. J Clin Oncol 22: 1572-1582, 2004.
6. Kumar R and Yarmand-Bagheri R: The role of HER2 in angiogenesis. Semin Oncol 28: 27-32, 2001.
7. Hubscher U, Maga G and Spadari S: Eukaryotic DNA polymerases. Annu Rev Biochem 71: 133-163, 2002.
8. Hubscher U, Nasheuer HP and Syväoja JE: Eukaryotic DNA polymerases, a growing family. Trends Biochem Sci 25: 143-147, 2000.
9. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT and Larsson N: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-422, 2004.
10. Wang L, Patel U, Ghosh L and Banerjee S: DNA polymerase β mutations in human colorectal cancer. Cancer Res 52: 4824-4827, 1992.
11. Dobashi Y, Shuin T, Tsuruga H, Uemura H, Torigoe S and Kubota Y: DNA polymerase β gene mutation in human prostate cancer. Cancer Res 54: 2827-2829, 1994.
12. Matsuzaki J, Dobashi Y, Miyamoto H, lkeda I, Fujinami K, Shuin T and Kubota Y: DNA polymerase β gene mutations in human bladder cancer. Mol Carcinog 15: 38-43, 1996.
13. Stary A and Sarasin A: Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells. Res Microbiol 153: 441-445, 2002.
14. Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NG, Fawcett H, Raams A, Garritsen VH, Stary A, Avril MF, Boudsocq F, Masutani C, Hanaoka F, Fuchs RP, Sarasin A and Lehmann AR: Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci USA 99: 815-820, 2002.
15. Flohr T, Dai J, Buttner J, Popanda O, Hagmuller E and Thielmann H: Detection of mutations in the DNA polymerase δ gene of human sporadic colorectal cancers and colon cancer cell lines. Int J Cancer 80: 919-929, 1999.
16. Uchimura A, Hidaka Y, Hirabayashi T, Hirabayashi M and Yagi T: DNA polymerase delta is required for early mammalian embryogenesis. PLoS One. 4: e4184 (1-9), 2009.
17. Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD and Loeb LA: Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol 27: 7669-7682, 2007.
18. Goldsby RE, Lawrence NA, Hays LE, Olmsted EA, Chen X, Singh M and Preston BD: Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice. Nat Med 7: 638-639, 2001.
19. Goldsby RE, Hays LE, Chen X, Olmsted EA, Slayton WB, Spangrude GJ and Preston BD: High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Proc Natl Acad Sci USA 99: 15560-15565, 2002.
20. Pavlov YI, Maki S, Maki H and Kunkel TA: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations. BMC Biol 2: 11-24, 2004.
21. Pospiech H and Syväoja JE: DNA polymerase ε- More than a polymerase. Sci World J 3: 87-104, 2003.
22. Zhou Q, Effati R, Talvinen K, Pospiech H, Syväoja J and Collan Y: Genomic change of the 55 kDa subunit of DNA polymerase ε in human breast cancer. Cancer genomics and proteomics 5: 287-292, 2008.
23. Huang D, Jokela M, Tuusa J, Skog S, Poikonen K and Syväoja JE: E2F mediates induction of the Spl-controlled promoter of the human DNA polymerase ε B-subunit gene POLE2. Nucleic Acids Res 29: 2810-2821, 2001.
24. Genoscope, Direct submission. Genoscope-Centre National de Sequencage: BP 191 91006 EVRY cedex - FRANCE. Submitted (25-JUN-2001).
25. Lipponen P and Collan Y: Simple quantitation of immunohisto-chemical staining positivity in microscopy. Acta Stereol 11: 125-132, 1992.
26. Jalava PJ, Kuopio T, Kortelainen S, Kronqvist P and Collan Y: Quantitation of erbB2 positivity for evaluation of high-risk patients. Ann Med 34: 544-553, 2002.
27. Siegel S and Castellan NJ: Nonparametric Statistics for the Behavioral Sciences, International Edition. New York, McGraw-Hill Book Company, 1988.
28. Downie NM and Heath RW: Basic Statistical Methods, 4th Edition, New York, Harper & Row Publishers, 1974.
29. Kruskal WH and Wallis WA: Use of ranks in one-criterion variance analysis. J Am Stat Assoc 47: 484-641, 1952.
30. Jaszczur M, FHs K, Rudzka J, Kraszewska J, Budd ME, Polaczek P, Campbell JL, Jonczyk P and Fijalkowska IJ: Dpb2p, a noncatalytic subunit of DNA polymerase ε, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae. Genetics 178: 633-647, 2008.
31. Jaszczur M, Rudzka J, Kraszewska J, Flis K, Polaczek P, Campbell JL, Fijalkowska IJ and Jonczyk P: Defective interaction between Po12p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res 669: 27-35, 2009.
32. Kesti T, McDonald WH, Yates III, JR and Wittenberg C: Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. J Biol Chem 279: 14245-14255, 2004.
33. Baak JPA, van Dop H, Kurver PHJ and Hermans J: The value of morphometry to classic prognosticators in breast cancer. Cancer 56: 374-382, 1985.
34. Collan Y, Eskelinen MJ, Nordling SA, Lipponen P, Pesonen E, Kumpusalo LM, Pajarinen P and Kettunen KO: Prognostic studies in breast cancer. Multivariate combination of nodal status, proliferation index, tumor size, and DNA ploidy. Acta Oncol 33: 873-878, 1994.
35. Laroye GJ and Minkin S: The impact of mitotic index on predicting outcome in breast carcinoma: A comparison of different counting methods in patients with different lymph node status. Mod Pathol 4: 456-460, 1991.
36. Allegra GJ, Paik S, Colangelo LH, Parr AL, Kirsch I, Kim G, Klein P, Johnston PG, Wolmark N and Wieand HS: Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 21: 242-250, 2003.
37. Dziegiel P, Forgacz J, Suder E, Surowiak P, Kornafel J and Zabel M: Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine. Histol Histopathol 18: 401-407, 2003.
38. Jalava P, Kuopio T, Juntti-Patinen L, Kotkansalo T, Kronqvist P and Collan Y. Ki-67 immunohistochemistry: a valuable marker in prognostication but with a risk of misclassification: proliferation subgroups formed based on Ki-67 immunoreactivity and standardized mitotic index. Histopathology 48: 674-682, 2006.