Exploration of a new series of PAR1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1735-1739

  Planty, Bruno ^a   Pujol, Chantal ^a   Lamothe, Marie ^a   Maraval, Catherine ^a   Horn, Clemens ^a   Grand, Bruno Le ^a   Perez, Michel ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Antagonist; PAR1; SAR; Thrombosis

Indexed keywords

3 (2 CHLORO PHENYL) 1 [4 (4 FLUORO BENZYL) PIPERAZIN 1 YL] PROPENONE; ANTICOAGULANT AGENT; CINNAMOYLPIPERIDINE; F 16357; PIPERIDINE DERIVATIVE; PROTEINASE ACTIVATED RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS SHUNT; ARTICLE; BIOLOGICAL ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE ACTIVATION; WITTIG REACTION;

AMINO ACID SEQUENCE; ANIMALS; DISEASE MODELS, ANIMAL; FIBRINOLYTIC AGENTS; HUMANS; PEPTIDES; PIPERIDINES; PYRIDINES; RATS; RECEPTOR, PAR-1; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 76649141470     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.050     Document Type: Article

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