Effect of 3′-end capping of aptamer with various 2′,4′-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamers

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1626-1629

  Kasahara, Yuuya ^a   Kitadume, Shunsuke ^a   Morihiro, Kunihiko ^b   Kuwahara, Masayasu ^a,c   Ozaki, Hiroaki ^a   Sawai, Hiroaki ^a   Imanishi, Takeshi ^b   Obika, Satoshi ^b,c  

^a GUNMA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

2 ,4 Bridged nucleoside 5 triphosphate; Bridged nucleic acid (BNA); Nuclease resistance; Post modification; Terminal deoxynucleotidyl transferase (TdT)

Indexed keywords

APTAMER; DNA NUCLEOTIDYLEXOTRANSFERASE; NUCLEASE; PHOSPHATE; THROMBIN; NUCLEOTIDE; PHOSPHODIESTERASE I; THROMBIN APTAMER;

ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CAPILLARY ELECTROPHORESIS; CAPPING PHENOMENON; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME MODIFICATION; HUMAN; CHEMISTRY; METABOLISM; PROTEIN BINDING; PROTEIN PROCESSING; PROTEIN STABILITY; TIME;

APTAMERS, NUCLEOTIDE; DNA NUCLEOTIDYLEXOTRANSFERASE; HUMANS; NUCLEOTIDES; PHOSPHODIESTERASE I; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; TIME FACTORS;

EID: 76649140810     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.028     Document Type: Article

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