Investigations toward the selection of fully-modified 4′-thioRNA aptamers: Optimization of in vitro transcription steps in the presence of 4′-thioNTPs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9450-9456

  Minakawa, Noriaki ^a   Sanji, Mioko ^a   Kato, Yuka ^a   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

4 thioNTP; 4 thioRNA; Aptamer; SELEX

Indexed keywords

4' THIORIBONUCLEOSIDE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; APTAMER; GUANOSINE TRIPHOSPHATE; NUCLEOSIDE 5' (ALPHA THIO)TRIPHOSPHATE; RNA DERIVATIVE; RNA POLYMERASE; THROMBIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; COMBINATORIAL CHEMISTRY; DNA TEMPLATE; GENETIC TRANSCRIPTION; IN VITRO SELECTION; PROMOTER REGION; PROTEIN MODIFICATION;

ADENOSINE TRIPHOSPHATE; APTAMERS, NUCLEOTIDE; BASE SEQUENCE; CYTIDINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; MOLECULAR SEQUENCE DATA; RNA; SELEX APTAMER TECHNIQUE; SEQUENCE HOMOLOGY, NUCLEIC ACID; THIONUCLEOTIDES; THROMBIN; TRANSCRIPTION, GENETIC; URIDINE TRIPHOSPHATE;

EID: 53749105287     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.048     Document Type: Article

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