Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating akt phosphorylation

Molecular Cancer Therapeutics

Volumn 9, Issue 2, 2010, Pages 480-488

  Sinn, Brigitte ^a   Tallen, Gesche ^a   Schroeder, Gisela ^a   Grassl, Birgit ^a   Schulze, Joern ^a   Budach, Volker ^a   Tinhofer, Inge ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; DNA; PENTOXIFYLLINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ACTIVATION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA DAMAGE; DRUG BLOOD LEVEL; GLIOMA CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; MUTANT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RADIOSENSITIZATION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; BRAIN TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION; GLIOMA; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; BRAIN NEOPLASMS; CAFFEINE; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; G1 PHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GLIOMA; HUMANS; MICE; MUTATION; PENTOXIFYLLINE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RADIATION, IONIZING;

EID: 76649106430     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0498     Document Type: Article

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