Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT

Biochemical and Biophysical Research Communications

Volumn 341, Issue 1, 2006, Pages 128-131

  Matsubara, Yumiko ^a   Murata, Mitsuru ^a   Yoshida, Tadashi ^b   Watanabe, Kiyoaki ^a   Saito, Ikuo ^a   Miyaki, Koichi ^a   Omae, Kazuyuki ^a   Ikeda, Yasuo ^a  

^a KEIO UNIVERSITY   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

Human telomerase reverse transcriptase; Polymorphism; Telomere length

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; GENETIC POLYMORPHISM; HUMAN; LEUKOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION; TELOMERE;

BASE SEQUENCE; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; HUMANS; LEUKOCYTES; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); TELOMERASE; TELOMERE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EID: 30944435031     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.163     Document Type: Article

References (22)

1. G.B. Morin The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats Cell 59 1989 521 529
2. A.O. Wilkie, J. Lamb, P.C. Harris, R.D. Finney, and D.R. Higgs A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n Nature 346 1990 868 871
3. J.M. Wong, and K. Collins Telomere maintenance and disease Lancet 362 2003 983 988
4. R.M. Cawthon, K.R. Smith, E. O'Brien, A. Sivatchenko, and R.A. Kerber Association between telomere length in blood and mortality in people aged 60 years or older Lancet 361 2003 393 395
5. T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, and T.R. Cech Telomerase catalytic subunit homologs from fission yeast and human Science 276 1997 955 959
6. A. Kilian, D.D. Bowtell, H.E. Abud, G.R. Hime, D.J. Venter, P.K. Keese, E.L. Duncan, R.R. Reddel, and R.A. Jefferson Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types Hum. Mol. Genet. 6 1997 2011 2019
7. A.L. Ducrest, H. Szutorisz, J. Lingner, and M. Nabholz Regulation of the human telomerase reverse transcriptase gene Oncogene 21 2002 541 552
8. M. Takakura, S. Kyo, T. Kanaya, H. Hirano, J. Takeda, M. Yutsudo, and M. Inoue Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells Cancer Res. 59 1999 551 557
9. I. Horikawa, P.L. Cable, C. Afshari, and J.C. Barrett Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene Cancer Res. 59 1999 826 830
10. E. Hiyama, K. Hiyama, T. Yokoyama, T. Ichikawa, and Y. Matsuura Length of telomeric repeats in neuroblastoma: correlation with prognosis and other biological characteristics Jpn. J. Cancer Res. 83 1992 159 164
11. R.M. Cawton Telomere measurement by quantitative PCR Nucleic Acid Res. 30 2002 e47
12. H. Iwama, K. Ohyashiki, J.H. Ohyashiki, S. Hayashi, N. Yahata, K. Ando, K. Toyama, A. Hoshika, M. Takasaki, M. Mori, and J.W. Shay Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals Hum. Genet. 102 1998 397 402
13. A. Benetos, K. Okuda, M. Lajemi, M. Kimura, F. Thomas, J. Skurnick, C. Labat, K. Bean, and A. Aviv Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity Hypertension 37 2001 381 385
14. H. Wege, M.S. Chui, H.T. Le, J.M. Tran, and M.A. Zern SYBR green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity Nucleic Acid Res. 31 2003 e3
15. P.E. Slagboom, S. Droog, and D.I. Boomsma Genetic determination of telomere size in humans: a twin study of three age groups Am. J. Hum. Genet. 55 1994 876 882
16. B.A. Kosciolek, and P.T. Rowley Human lymphocyte telomerase is genetically regulated Genes Chromosomes Cancer 21 1998 124 130
17. Y.H. Hsu, and J.J. Lin Telomere and telomerase as targets for anti-cancer and regeneration therapies Acta Pharmacol. Sin. 26 2005 513 518
18. R. Hastings, M. Qureshi, R. Verma, P.S. Lacy, and B. Williams Telomere attrition and accumulation of senescent cells in cultured human endothelial cells Cell Prolif. 37 2004 317 324
19. S.M. Bode-Boger, J. Martens-Lobenhoffer, M. Tager, H. Schroder, and F. Scalera Aspirin reduces endothelial cell senescence Biochem. Biophys. Res. Commun. 334 2005 1226 1232
20. M. Ogami, Y. Ikura, M. Ohsawa, T. Matsuo, S. Kayo, N. Yoshimi, E. Hai, N. Shirai, S. Ehara, R. Komatsu, T. Naruko, and M. Ueda Telomere shortening in human coronary artery diseases Arterioscler. Thromb. Vasc. Biol. 24 2004 546 550
21. E. Chang, and C.B. Harley Telomere length and replicative aging in human vascular tissues Proc. Natl. Acad. Sci. USA 92 1995 11190 11194
22. H. Vaziri, F. Schachter, I. Uchida, L. Wei, X. Zhu, R. Effros, D. Cohen, and C.B. Harley Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes Am. J. Hum. Genet. 52 1993 661 667