Control of NF-κB activation by the COP9 signalosome

Biochemical Society Transactions

Volumn 38, Issue 1, 2010, Pages 156-161

  Schweitzer, Katrin ^a   Naumann, Michael ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Carma1 Bcl10 Malt1 complex (CBM); Cullin RING ubiquitin ligase (CRL); Deubiquitinase (DUB); Inhibitor of nuclear factor B (I B); Neural precursor cell expressed developmentally down regulated 8 (NEDD8); Tumour necrosis factor receptor 1 (TNFR1)

Indexed keywords

COP9 SIGNALOSOME; GLYCOGEN SYNTHASE KINASE 3BETA; I KAPPA B ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN BCL 10; PROTEIN KINASE LCK; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; LYMPHOCYTE ANTIGEN RECEPTOR; MULTIPROTEIN COMPLEX; PEPTIDE HYDROLASE;

CELL MATURATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HUMAN; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE;

ANIMALS; IMMUNITY, INNATE; LYMPHOCYTE ACTIVATION; MULTIPROTEIN COMPLEXES; NF-KAPPA B; PEPTIDE HYDROLASES; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 76449101776     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0380156     Document Type: Review

References (50)

1. Schwechheimer, C. (2004) The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eucaryotic development. Biochem. Biophys. Acta 1695, 45-54
2. Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of NEDD8 from Cul1. Science 298, 608-611
3. Wolf, D.A., Zhou, C. and Wee, S. (2003) The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? Nat. Cell Biol. 5, 1029-1033
4. Cope, G. and Deshaies, R. J. (2003) COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 114, 663-671
5. Petroski, M.D. and Deshaies, R.J. (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6, 9-20
6. Pan, Z.-Q., Kentsis, A., Dias, D.C., Yamoah, K. and Wu, K. (2004) NEDD8 on cullin: building an expressway to protein destruction. Oncogene 23, 1985-1997
7. Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K. and Kato, K. (2007) Direct interactions between NEDD8 and ubiquitin E2 conjugating enzyme upregulate cullin-based E3 ligase activity. Nat. Struct. Biol. 14, 167-168
8. Duda, D.M., Borg, L.A., Scott, D.C., Hunt, H.W., Hammel, M. and Schulman, B.A. (2008) Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134, 995-1006
9. Zhou, C., Wee, S., Rhee, E., Naumann, M., Dubiel, W. and Wolf, D.A. (2003) Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol. Cell 11, 927-938
10. Hetfeld, B.K., Helfrich, A., Kapelari, B., Scheel, H., Hofmann, K., Guterman, A., Glickman, M., Schade, R., Kloetzel, P.M. and Dubiel, W. (2005) The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Curr. Biol. 15, 1217-1221
11. Wu, J.-T., Chan, Y.-R. and Chien, C.-T. (2006) Protection of cullin-RING E3 ligases by CSN-UBP12. Trends Cell Biol. 16, 362-369
12. Schweitzer, K., Bozko, P.M., Dubiel, W. and Naumann, M. (2007) CSN controls NF-κB by deubiquitinylation of IκBα. EMBO J. 26, 1532-1541
13. Wu, Y., Deng, J., Rychahou, P.G., Qiu, S., Evers, B.M. and Zhou, B.P. (2009) Stabilization of SNAIL by NF-κB is required for inflammation-induced cell migration and invasion. Cancer Cell 15, 416-428
14. Welteke, V., Eitelhuber, A., Düwel, M., Schweitzer, K., Naumann, M. and Krappmann, D. (2009) COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T cell stimulation. EMBO Rep. 10, 642-648
15. Huang, X., Langelotz, C., Hetfeld-Pechoc, B.K.J., Schwenk, W. and Dubiel, W. (2009) The COP9 signalosome mediates β-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. J. Mol. Biol. 391, 691-702
16. Harari-Steinberg, O. and Chamovitz, D.A. (2004) The COP9 signalosome: mediating between kinase signaling and protein degradation. Curr. Protein Pept. Sci. 5, 185-189
17. Chamovitz, D.A. (2009) Revisiting the COP9 signalosome as a transcriptional regulator. EMBO Rep. 10, 352-358
18. Karin, M. and Greten, F. (2005) NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749-759
19. Courtois, G. and Gilmore, T.D. (2006) Mutations in the NF-κB signaling pathway: implications for human disease. Oncogene 25, 6831-6843
20. Perkins, N.D. and Gilmore, T.D. (2007) Good cob, bad cop: the different faces of NF-κB. Cell Death Differ. 13, 759-772
21. Neumann, M. and Naumann, M. (2007) Beyond IκBs: alternative regulation of NF-κB activity. FASEB J. 21, 2642-2654
22. Ghosh, S. and Hayden, M.S. (2008) New regulators of NF-κB in inflammation. Nat. Rev. Immunol. 8, 837-848
23. Bhoj, V.G. and Chen, J. (2009) Ubiquitylation in innate and adaptive immunity. Nature 458, 430-437
24. Vallabhapurapu, S. and Karin, M. (2009) Regulation and function of NF-κB transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733
25. Tokunaga, F., Sakata, S.-I., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S. et al. (2009) Involvement of linear polyubiquitylation of NEMO in NF-κB activation. Nat. Cell Biol. 11, 123-132
26. Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, T. et al. (2009) Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation. Cell 136, 1098-1109
27. Rothwarf, D.M. and Karin, M. (1999) The NF-κB activation pathway: a paradigm in information transfer from membrane to nucleus. Sci. STKE 1999, RE1
28. Wang, J., Li, C., Liu, Y., Zhang, L., Cao, X., Kimberly, R.P., Grizzle, W. and Zhang, H.-G. (2006) JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α. Am. J. Pathol. 169, 889-902
29. Blonska, M. and Lin, X. (2009) Carma1-mediated NF-κB and JNK activation in lymphocytes. Immunol. Rev. 228, 199-211
30. Park, S.-G., Schulze-Luehrmann, J., Hayden, M.S., Hashimoto, N., Ogawa, W., Kasuga, M. and Ghosh, S. (2009) The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells. Nat. Immunol. 10, 158-166
31. Siebenlist, U., Brown, K. and Claudio, E. (2005) Control of lymphocyte development by nuclear factor-κB. Nat. Rev. Immunol. 5, 435-445
32. Rawlings, D.J., Sommer, K. and Moreno-Garcia, M.E. (2006) The Carma1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes. Nat. Rev. Immunol. 6, 799-812
33. Oeckinghaus, A., Wegener, E., Welteke, V., Ferch, U., Arslan, S.C., Ruland, J., Scheidereit, C. and Krappmann, D. (2007) Malt1 ubiquitination triggers NF-κB signaling upon T-cell activation. EMBO J. 26, 4634-4645
34. Sun, L., Deng, L., Ea, C.K., Xia, Z.P. and Chen, Z.J. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by Bcl10 and Malt1in T lymphocytes. Mol. Cell 14, 289-301
35. Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W. and Dixit, V.M. (2004) Bcl10 activates the NF-κB pathway through ubiquitination of NEMO. Nature 427, 167-171
36. Wu, C.J. and Ashwell, J.D. (2008) NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation. Proc. Natl. Acad. Sci. U.S.A. 105, 3023-3028
37. Wan, Y.Y., Chi, H., Xie, M., Schneider, M.D. and Flavell, R.A. (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7, 851-858
38. Wegener, E., Oeckinghaus, A., Papadopoulou, N., Lavitas, L., Schmidt-Suprian, M., Ferch, U., Mak, T.W., Ruland, J., Heissmeyer, V. and Krappmann, D. (2006) Essential role for IκB kinase β in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol. Cell. Biol. 23, 13-23
39. Scharschmidt, E., Wegener, E., Heissmeyer, V., Rao, A. and Krappmann, D. (2004) Degradation of Bcl10 induced by T-cell activation negatively regulates NF-κB signaling. Mol. Cell. Biol. 24, 3860-3873
40. Lobry, C., Lopez, T., Israel, A. and Weil, R. (2007) Negative feedback loop in T cell activation through IkB kinase-induced phosphorylation and degradation of Bcl10. Proc. Natl. Acad. Sci. U.S.A. 104, 908-913
41. Hu, S., Du, M.-Q., Park, S.-M., Alcivar, A., Qu, L., Gupta, S., Tang, J., Baens, M., Ye, H., Lee, T.H. et al. (2006) cIAP2 is a ubiquitin protein ligase for Bcl10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J. Clin. Invest. 16, 174-181
42. Reiley, W.W., Jin, W., Lee, A.J., Wreight, A., Wu, X., Tewalt, E.F., Leonard, T.O., Norbury, C.C., Fitzpatrick, L., Zhang, M. and Sun, S.-C. (2007) Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase TAK1 and prevents abnormal T cell responses. J. Exp. Med. 204, 1475-1485
43. Coonaert, B., Baens, M., Heyninck, K., Bekaert, T., Haegman, M., Staal, J., Sun, L., Chen, Z.J., Marynen, P. and Bayaert, R. (2008) T cell antigen receptor stimulation induces Malt1 paracaspase-mediated cleavage of the NF-κB inhibitor A20. Nat. Immunol. 9, 263-271
44. Stilo, R., Varricchio, E., Liguoro, D., Leonardi, A. and Vito, P. (2008) A20 is a negative regulator of Bcl10- and Carma3-mediated activation of NF-κB. J. Cell Sci. 121, 1165-1171
45. Düwel, M., Welteke, V., Oeckinghaus, A., Baens, M., Kloo, B., Ferch, U., Darnay, B.G., Ruland, J., Marynen, P. and Krappmann, D. (2009) A20 negatively regulates T cell receptor signaling to NF-κB by cleaving MALT1 ubiquitin chains. J. Immunol. 182, 7718-7728
46. Lin, S.C., Chung, J.Y., Lamothe, B., Rajashancar, K., Lu, M., Lo, Y.C., Lam, A.Y., Darnay, B.G. and Wu, H. (2008) Molecular basis for the unique deubiqitinating activity of the NF-κB inhibitor A20. J. Mol. Biol. 376, 526-540
47. Reiley, W.W., Zhang, M., Wei, J., Losiewicz, M., Donohue, K.B., Norbury, C.C. and Sun, S.C. (2006) CYLD: deubiquitination-induced TCR signaling. Nat. Immnunol. 7, 411-417
48. Panattoni, M., Sanvito, F., Basso, V., Doglioni, C., Casorati, G., Montini, E., Bender, J.R., Mondino, A. and Pardi, R. (2008) Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J. Exp. Med. 205, 465-477
49. Menon, S., Chi, H., Zhang, H., Deng, X.W., Flavell, R.A. and Wei, N. (2007) COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nat. Immunol. 8, 1236-1245
50. Komander, D. and Barford, D. (2008) Structure of the A20 OTU domain and mechanistic insight into deubiquitination. Biochem. J. 409, 77-85