Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis

Amino Acids

Volumn 38, Issue 1, 2010, Pages 189-197

  Qashu, Felicia ^b   Figueiredo, Taiza H ^a   Aroniadou Anderjaska, Vassiliki ^a,b   Apland, James P ^c   Braga, Maria F M ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Amygdala; Benzodiazepines; Epileptogenesis; Hippocampus; Neurodegeneration; Status epilepticus

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; KAINIC ACID;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CONTROLLED STUDY; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPUS; MALE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT;

AMYGDALA; ANIMALS; DIAZEPAM; EPILEPSY; HIPPOCAMPUS; MALE; NERVE DEGENERATION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

RATTUS;

EID: 76449099925     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-008-0227-2     Document Type: Article

References (59)

1. V Aroniadou-Anderjaska B Fritsch F Qashu MF Braga 2008 Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy Epilepsy Res 78 102 116 10.1016/j.eplepsyres.2007.11.011 10.1016/j.eplepsyres.2007.11.011
2. Babb TL (1991) Research on the anatomy and pathology of epileptic tissue. In: Luders H (ed) Epilepsy surgery. Raven Press, New York, pp 719-727
3. Babb TL, Brown WJ (1989) Pathological findings in epilepsy. In: Engel J (ed) Surgical treatment of the epilepsies. Raven Press, New York, pp 511-540
4. Y Ben-Ari 1985 Limbic seizures and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy Neuroscience 14 375 403 10.1016/0306-4522(85)90299-4 (Pubitemid 15169910)
5. TP Bleck 1999 Management approaches to prolonged seizures and status epilepticus Epilepsia 40 S1 59 63 10.1111/j.1528-1157.1999.tb00880.x 10.1111/j.1528-1157.1999.tb00880.x (Pubitemid 29367115)
6. GD Cascino D Hesdorffer G Logroscino WA Hauser 1998 Morbidity of nonfebrile status epilepticus in Rochester, Minnesota, 1965-1984 Epilepsia 39 829 832 10.1111/j.1528-1157.1998.tb01176.x (Pubitemid 128721650)
7. F Cendes F Andermann P Gloor A Evans M Jones-Gotman C Watson D Melanson A Olivier T Peters I Lopes-Cendes RT Leroux 1993 MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy Neurology 43 719 725
8. F Cendes F Andermann P Gloor, et al. 1994 Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy Brain 117 739 746 10.1093/brain/117.4.739 10.1093/brain/117.4.739 7922461
9. S Chen PS Buckmaster 2005 Stereological analysis of forebrain regions in kainate-treated epileptic rats Brain Res 1057 141 152 10.1016/j.brainres.2005. 07.058 10.1016/j.brainres.2005.07.058 (Pubitemid 41338097)
10. JW Chen CG Wasterlain 2006 Status epilepticus: pathophysiology and management in adults Lancet Neurol 5 246 256 10.1016/S1474-4422(06)70374-X 10.1016/S1474-4422(06)70374-X 16488380 (Pubitemid 43238348)
11. L Covolan LE Mello 2000 Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus Epilepsy Res 39 133 152 10.1016/S0920-1211(99)00119-9 10.1016/S0920-1211(99)00119-9 1:STN:280: DC%2BD3c3itFSmsA%3D%3D 10759302 (Pubitemid 30089586)
12. R Druga H Kubová L Suchomelová R Haugvicová 2003 Lithium/pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent Physiol Res 52 251 264
13. HJ Feng GC Mathews C Kao RL Macdonald 2008 Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus J Neurophysiol 99 1285 1293 10.1152/jn.01180.2007 10.1152/jn.01180.2007 18216225
14. JM Fritschy H Mohler 1995 GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits J Comp Neurol 359 154 194 10.1002/cne.903590111 10.1002/cne.903590111
15. GV Goddard 1967 Development of epileptic seizures through brain stimulation at low intensity Nature 214 1020 1021 10.1038/2141020a0 10.1038/2141020a0 1:STN:280:DyaF1c%2Fhs1aitg%3D%3D 6055396
16. HP Goodkin JL Yeh J Kapur 2005 Status epilepticus increases the intracellular accumulation of GABAA receptors J Neurosci 25 5511 5520 10.1523/JNEUROSCI.0900-05.2005 10.1523/JNEUROSCI.0900-05.2005 (Pubitemid 40800643)
17. JA Gorter PM Goncalves Pereira EA van Vliet E Aronica FH Lopes da Silva PJ Lucassen 2003 Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures Epilepsia 44 647 658 10.1046/j.1528-1157.2003.53902.x 10.1046/j.1528-1157.2003.53902.x 12752463 (Pubitemid 36554632)
18. DE Heggli D Malthe-Sørensson 1982 Systemic injection of kainic acid: effect on neurotransmitter markers in piriform cortex, amygdaloid complex, and hippocampus and protection by cortical lesioning and anticonvulsants Neuroscience 5 1257 1264 10.1016/0306-4522(82)91132-0 10.1016/0306-4522(82) 91132-0 (Pubitemid 12074768)
19. JL Hellier PR Patrylo PS Buckmaster FE Dudek 1998 Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy Epilepsy Res 31 73 84 10.1016/S0920-1211(98)00017-5 10.1016/S0920-1211(98)00017-5 1:STN:280: DyaK1czlvFCqsw%3D%3D 9696302 (Pubitemid 28305406)
20. DC Hesdorffer G Logroscino G Cascino JF Annegers WA Hauser 1998 Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus Ann Neurol 44 908 912 10.1002/ana.410440609 10.1002/ana.410440609 1:STN:280:DyaK1M%2Fms1Olsg%3D%3D 9851435
21. PF Hsieh 1999 Neuropathology of limbic status epilepticus by electrical stimulation of naïve rats Neurol Res 21 399 403 1:STN:280: DyaK1MzjsVGitg%3D%3D 10406013
22. LP Hudson DG Munoz L Miller RS McLachlan JP Girvin WT Blume 1993 Amygdaloid sclerosis in temporal lobe epilepsy Ann Neurol 33 622 631 10.1002/ana.410330611 10.1002/ana.410330611 1:STN:280:DyaK3s3ntVCluw%3D%3D 8498843 (Pubitemid 23161884)
23. DM Jones N Esmaeil S Maren RL Macdonald 2002 Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus Epilepsy Res 50 301 312 10.1016/S0920-1211(02)00085-2 10.1016/S0920-1211(02)00085-2 (Pubitemid 35015214)
24. EW Kairiss RJ Racine GK Smith 1984 The development of the interictal spike during kindling in the rat Brain Res 322 101 110 10.1016/0006-8993(84) 91185-5 10.1016/0006-8993(84)91185-5 1:STN:280:DyaL2M%2FpvVKltw%3D%3D 6518361 (Pubitemid 15215724)
25. SJ Kish G Sperk O Hornykiewicz 1983 Alterations in benzodiazepine and GABA receptor binding in rat brain following systemic injection of kainic acid Neuropharmacology 22 1303 1309 10.1016/0028-3908(83)90204-6 10.1016/0028- 3908(83)90204-6 (Pubitemid 14244024)
26. A Krumholz GY Sung RS Fisher E Barry GK Bergey LM Grattan 1995 Complex partial status epilepticus accompanied by serious morbidity and mortality Neurology 45 1499 1504 1:STN:280:DyaK2MzntFyruw%3D%3D 7644048
27. T Lemos EA Cavalheiro 1995 Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats Exp Brain Res 102 423 428 10.1007/BF00230647 10.1007/BF00230647 1:STN:280:DyaK2M3lsFGgsQ%3D%3D 7737389
28. G Logroscino DC Hesdorffer GD Cascino JF Annegers E Bagiella WA Hauser 2002 Long-term mortality after a first episode of status epilepticus Neurology 58 537 541 1:STN:280:DC%2BD387ivFSgtg%3D%3D 11865129
29. RL Macdonald RW Olsen 1994 GABAA receptor channels Annu Rev Neurosci 17 569 602
30. K Majak J Moryś 2007 Endopiriform nucleus connectivities: the implication for epileptogenesis and epilepsy Folia Morphol 66 267 271 1:STN:280:DC%2BD2sjislaitw%3D%3D
31. RM McKernan PJ Whiting 1996 Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 19 139 143 10.1016/S0166-2236(96)80023-3 10.1016/S0166-2236(96)80023-3 1:STN:280:DyaK283lvFKlsQ%3D%3D 8658597
32. LE Mello EA Cavalheiro AM Tan WR Kupfer JK Pretorious TL Babb DM Finch 1993 Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting Epilepsia 34 985 995 10.1111/j.1528-1157.1993.tb02123.x 10.1111/j.1528-1157.1993.tb02123.x 1:STN:280:DyaK2c%2Fmt1Ohuw%3D%3D 7694849 (Pubitemid 24004233)
33. P Mohapel C Dufresne ME Kelly DC McIntyre 1996 Differential sensitivity of various temporal lobe structures in the rat to kindling and status epilepticus induction Epilepsy Res 23 179 187 10.1016/0920-1211(95)00084-4 10.1016/0920-1211(95)00084-4 1:STN:280:DyaK28zitlGltg%3D%3D 8739121 (Pubitemid 26173791)
34. DE Naylor H Liu CG Wasterlain 2005 Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus J Neurosci 25 7724 7733 10.1523/JNEUROSCI.4944-04.2005 10.1523/JNEUROSCI.4944-04. 2005 (Pubitemid 41208643)
35. DL Niehoff MJ Kuhar 1983 Benzodiazepine receptors: localization in rat amygdala J Neurosci 3 2091 2097
36. A Pitkänen J Tuunanen R Kälviänen K Partanen T Salmenperä 1998 Amygdala damage in experimental and human temporal lobe epilepsy Epilepsy Res 32 233 253 10.1016/S0920-1211(98)00055-2 10.1016/S0920-1211(98)00055-2 9761324 (Pubitemid 28419493)
37. A Pitkänen I Kharatishvili S Narkilahti K Lukasiuk J Nissinen 2005 Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat Epilepsy Res 63 27 42 10.1016/j.eplepsyres.2004.10. 003 10.1016/j.eplepsyres.2004.10.003 15716080 (Pubitemid 40215778)
38. A Pitkänen I Kharatishvili H Karhunen K Lukasiuk R Immonen J Nairismägi O Gröhn J Nissinen 2007 Epileptogenesis in experimental models Epilepsia 48 S2 13 20 10.1111/j.1528-1167.2007.01063.x 10.1111/j.1528-1167.2007.01063.x 17571349
39. Qashu F, Fritsch B, Figueiredo T, Aroniadou-Anderjaska V, Braga MF (2008) Functional and molecular alterations of the GABAergic system in the basolateral amygdala during epileptogenesis triggered by status epilepticus. Soc Neurosci 146.9 (abstract)
40. LF Quesney 1986 Clinical and EEG features of complex partial seizures of temporal lobe origin Epilepsia 27 S2 27 45 10.1111/j.1528-1157.1986.tb05738.x 10.1111/j.1528-1157.1986.tb05738.x
41. RJ Racine 1972 Modification of seizure activity by electrical stimulation. II. Motor seizure Electroencephalogr Clin Neurophysiol 32 281 294 10.1016/0013-4694(72)90177-0 10.1016/0013-4694(72)90177-0 1:STN:280: DyaE387gvFCltg%3D%3D 4110397
42. RJ Racine G Paxinos JM Mosher EW Kairiss 1988 The effects of various lesions and knife-cuts on septal and amygdala kindling in the rat Brain Res 454 264 274 10.1016/0006-8993(88)90826-8 (Pubitemid 18159796)
43. A Riba-Bosch J Pérez-Claussell 2004 Response to kainic acid injections: changes in staining for zinc, FOS, cell death and glial response in the rat forebrain Neuroscience 125 803 818 10.1016/j.neuroscience.2004.02.017 10.1016/j.neuroscience.2004.02.017 (Pubitemid 38510189)
44. J Riss J Cloyd S Collins 2008 Benzodiazepines in epilepsy: pharmacology and pharmacokinetics Acta Neurol Scand 118 69 86 10.1111/j.1600-0404.2008.01004. x 10.1111/j.1600-0404.2008.01004.x
45. LC Schmued C Albertson W Slikker Jr 1997 Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration Brain Res 751 37 46 10.1016/S0006-8993(96)01387-X 10.1016/S0006-8993(96)01387-X 1:CAS:528:DyaK2sXhtlyjt7g%3D 9098566 (Pubitemid 27122134)
46. JE Schwob T Fuller JL Price W Olney 1980 Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study Neuroscience 5 991 1014 10.1016/0306-4522(80)90181-5 10.1016/0306-4522(80)90181-5 1:CAS:528:DyaL3MXnslKhsQ%3D%3D 7402461 (Pubitemid 10063400)
47. TM Shih SM Duniho JH McDonough 2003 Control of nerve agent-induced seizures is critical for neuroprotection and survival Toxicol Appl Pharmacol 188 69 80 10.1016/S0041-008X(03)00019-X 10.1016/S0041-008X(03)00019-X (Pubitemid 36411751)
48. W Sieghart G Sperk 2002 Subunit composition, distribution, and function of GABA(A) receptor subtypes Curr Top Med Chem 2 795 816 10.2174/ 1568026023393507 10.2174/1568026023393507
49. DM Treiman 1990 The role of benzodiazepines in the management of status epilepticus Neurology 40 S5 32 42 1:CAS:528:DyaK3cXkslSms7w%3D 2159132
50. DM Treiman 2007 Treatment of convulsive status epilepticus Int Rev Neurobiol 81 273 285 10.1016/S0074-7742(06)81018-4 10.1016/S0074-7742(06)81018-4 17433931
51. DM Treiman PD Meyers NY Walton JF Collins C Colling AJ Rowan A Handforth E Faught VP Calabrese BM Uthman RE Ramsay MB Mamdani 1998 A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group N Engl J Med 339 792 798 10.1056/NEJM199809173391202 10.1056/NEJM199809173391202 1:CAS:528: DyaK1cXmt1Gkurc%3D 9738086 (Pubitemid 28447452)
52. J Tuunanen T Halonen A Pitkänen 1996 Status epilepticus causes selective regional damage and loss of GABAergic neurons in the rat amygdaloid complex Eur J Neurosci 8 2711 2725 10.1111/j.1460-9568.1996.tb01566.x 10.1111/j.1460-9568.1996.tb01566.x 1:STN:280:DyaK2s7ltVSnug%3D%3D 8996821 (Pubitemid 27011348)
53. J Tuunanen K Lukasiuk T Halonen A Pitkänen 1999 Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course, and mechanisms Neuroscience 94 473 495 10.1016/S0306-4522(99) 00251-1 10.1016/S0306-4522(99)00251-1 1:CAS:528:DyaK1MXmt1ensbY%3D 10579210 (Pubitemid 29436075)
54. W Van Paesschen MD King JS Duncan A Connelly 2001 The amygdala and temporal lobe simple partial seizures: a prospective and quantitative MRI study Epilepsia 42 857 862 10.1046/j.1528-1157.2001.042007857.x 10.1046/j.1528-1157. 2001.042007857.x 11488884 (Pubitemid 32783093)
55. NY Walton DM Treiman 1988 Response of status epilepticus induced by lithium pilocarpine to treatment with diazepam Exp Neurol 101 267 275 10.1016/0014-4886(88)90010-6 10.1016/0014-4886(88)90010-6 1:CAS:528: DyaL1cXlt1agtbs%3D 3396644 (Pubitemid 18190146)
56. LE White JL Price 1993 The functional anatomy of limbic status epilepticus in the rat. I. Patterns of 14C-2-deoxyglucose uptake and Fos immunocytochemistry J Neurosci 13 4787 4809 1:CAS:528:DyaK2cXnsVKqsA%3D%3D 8229199
57. LE White JL Price 1993 The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation J Neurosci 13 4810 4830 1:STN:280:DyaK2c%2FksF2isw%3D%3D 8229200
58. PD Williamson JA French VM Thadani JH Kim RA Novelly SS Spencer DD Spencer RH Mattson 1993 Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology Ann Neurol 34 781 787 10.1002/ana.410340605 10.1002/ana.410340605 1:STN:280:DyaK2c%2FntFCjuw%3D%3D 8250526 (Pubitemid 23357890)
59. HK Wolf AF Aliashkevich I Blümke OD Wiestler J Zentner 1997 Neuronal loss and gliosis of the amygdaloid nucleus in temporal lobe epilepsy. A quantitative analysis of 70 surgical specimens Acta Neuropathol 93 606 610 10.1007/s004010050658 (Pubitemid 27239250)