The level of connective tissue growth factor in sera of patients with hepatitis B virus strongly correlates with stage of hepatic fibrosis

Viral Immunology

Volumn 23, Issue 1, 2010, Pages 71-78

  Guo Qiu, Wu ^a   Nai Feng, Liu ^a   Xiao Bo, Van ^b   Linxian, Li ^b   Chen, Zhang ^a   Lixia, Gou ^a   Zhao, Liu ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; CREATININE; GAMMA GLUTAMYLTRANSFERASE; HYALURONIC ACID; LAMININ; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; THROMBOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BIOLOGICAL MARKERS; CONNECTIVE TISSUE GROWTH FACTOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED; RABBITS; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; YOUNG ADULT;

HEPATITIS B VIRUS;

EID: 76449087372     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2009.0067     Document Type: Article

References (26)

1. Brigstock DR: The connective tissue growth factor=cysteinerich 61=nephroblastoma overexpressed (CCN) family. Endocr Rev 1999;20:189-206.
2. Moussad EE, and Brigstock DR: Connective tissue growth factor: what's in a name? Mol Genet Metab 2000;71:276-292.
3. Lau LF, and Lam SC: The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999;248:44-57.
4. Perbal B: NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 2001;54:57-79.
5. Kaimori A, Potter J, Kaimori JY, et al.: Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 2007;282: 22089-22101.
6. Zeisberg M, Yang C, Martino M, et al.: Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007;282:23337-23347.
7. Borkham-Kamphorst E, Herrmann J, Stoll D, et al.: Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab Invest 2004;84:766-777.
8. Frazier K, Williams S, Kothapalli D, et al.: Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 1996;107:404-411.
9. Nakanishi T, Nishida T, Shimo T, et al.: Effects of CTGF=Hcs24, a product of a hypertrophic chondrocytespecific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology 2000;141:264-273. (Pubitemid 32260367)
10. Hong HH, Uzel MI, Duan C, et al.: Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGFbeta1 and detection in human gingiva. Lab Invest 1999; 79:1655-1667.
11. Murphy M, Godson C, Cannon S, et al.: Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 1999;274:5830-5834.
12. Paradis V, Dargere D, Vidaud M, et al.: Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 1999;30:968-976.
13. Gressner OA, Lahme B, Demirci I, et al.: Differential effects of TGF-beta on connective tissue growth factor (CTGF= CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol 2007;47:699-710.
14. Tamatani T, Kobayashi H, Tezuka K, et al.: Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Biochem Biophys Res Commun 1998;251:748-752.
15. Bedossa P, and Poynard T: An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996;24:289-293.
16. Luo YJ, Yu JP, Shi ZH, and Wang L: Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats. World J Gastroenterol 2004;10:1037-1042.
17. Friedman O, and Leslie AM: Mechanisms of belief-desire reasoning. Inhibition and bias. Psychol Sci 2004;15:547-552.
18. Friedman SL: Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-2250.
19. Friedman SL: Cytokines and fibrogenesis. Semin Liver Dis 1999;19:129-140.
20. Rachfal AW, and Brigstock DR: Connective tissue growth factor (CTGF=CCN2) in hepatic fibrosis. Hepatol Res 2003; 26:1-9.
21. Williams EJ, Gaca MD, Brigstock DR, et al.: Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol 2000; 32:754-761.
22. Gressner AM: Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int Suppl 1996;54:S39-S45.
23. Paradis V, Dargere D, Bonvoust F, et al.: Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 2002;82:767-774.
24. Blom IE, Goldschmeding R, and Leask A: Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002;21:473-482.
25. Duncan MR, Frazier KS, Abramson S, et al.: Connective tissue growth factor mediates transforming growth factor betainduced collagen synthesis: down-regulation by cAMP. FASEB J 1999;13:1774-1786.
26. Gao R, and Brigstock DR: Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha( v)beta(3) and heparan sulfate proteoglycan. J Biol Chem 2004;279:8848-8855.