Acetylation of cyclin A: A new cell cycle regulatory mechanism

Biochemical Society Transactions

Volumn 38, Issue 1, 2010, Pages 83-86

  Mateo, Francesca ^a   Vidal Laliena, Mariam ^a   Pujol, Maria Jesus ^a   Bachs, Oriol ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acetylation; cAMP response element binding protein (CREB); Cyclin A; Degradation; p300 CREB binding protein associated factor (PCAF); Ubiquitylation

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN A; CYCLIN DEPENDENT KINASE; HISTONE ACETYLTRANSFERASE PCAF; LYSINE; PROTEASOME;

ACETYLATION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; ENZYME ACTIVITY; HUMAN; MITOSIS; PHASE TRANSITION; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN STABILITY; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION;

ACETYLATION; CELL CYCLE; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; LYSINE; MUTATION; P300-CBP TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 76449085145     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0380083     Document Type: Review

References (34)

1. Morgan, D.O. (1997) Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13, 261-291
2. 1-phase progression. Genes Dev. 13, 1501-1512
3. Malumbres, M. and Barbacid, M. (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630-641
4. Rosenberg, A.R., Zindy, F., Le Deist, F., Mouly, H., Metezeau, P., Brechot, C. and Lamas, E. (1995) Overexpression of cyclin A advances entry into S phase. Oncogene 10, 1501-1509
5. Kip1. Mol. Cell. Biol. 15, 4347-4352
6. Furuno, N., den Elzen, N. and Pines, J. (1999) Human cyclin A is required for mitosis until mid prophase. J. Cell Biol. 147, 295-306
7. Pagano, M. and Draetta, G. (1991) Cyclin A, cell cycle control and oncogenesis. Prog. Growth Factor Res. 3, 267-277
8. Gong, D., Pomerening, J.R., Myers, J.W., Gustavsson, C., Jones, J.T., Hahn, A.T., Meyer, T. and Ferrell, Jr, J.E. (2007) Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr. Biol. 17, 85-91
9. den Elzen, N. and Pines, J. (2001) Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. J. Cell Biol. 153, 121-136
10. Hagting, A., den Elzen, N., Vodermaier, H.C., Waizenegger, I.C., Peters, J.M. and Pines, J. (2002) Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157, 1125-1137
11. Parry, D.H. and O'Farrell, P.H. (2001) The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. 11, 671-683
12. Sullivan, M. and Morgan, D.O. (2007) Finishing mitosis, one step at a time. Nat. Rev. Mol. Cell Biol. 8, 894-903
13. Geley, S., Kramer, E., Gieffers, C., Gannon, J., Peters, J.M. and Hunt, T. (2001) Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J. Cell Biol. 153, 137-148
14. 1. Mol. Cell 2, 163-171
15. Sudakin, V., Chan, G.K. and Yen, T.J. (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154, 925-936
16. Nilsson, J., Yekezare, M., Minshull, J. and Pines, J. (2008) The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat. Cell Biol. 10, 1411-1420
17. Wolthuis, R., Clay-Farrace, L., van Zon, W., Yekezare, M., Koop, L., Ogink, J., Medema, R. and Pines, J. (2008) Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol. Cell 30, 290-302
18. Glotzer, M., Murray, A.W. and Kirschner, M.W. (1991) Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138
19. Klotzbucher, A., Stewart, E., Harrison, D. and Hunt, T. (1996) The destruction box of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed. EMBO J. 15, 3053-3064
20. Fung, T.K., Yam, C.H. and Poon, R.Y. (2005) The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites. Cell Cycle 4, 1411-1420
21. Mateo, F., Vidal-Laliena, M., Canela, N., Busino, L., Martinez-Balbas, M.A., Pagano, M., Agell, N. and Bachs, O. (2009) Degradation of cyclin A is regulated by acetylation. Oncogene 28, 2654-2666
22. Imhof, A., Yang, X.J., Ogryzko, V.V., Nakatani, Y., Wolffe, A.P. and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689-692
23. Martinez-Balbas, M.A., Bauer, U.M., Nielsen, S.J., Brehm, A. and Kouzarides, T. (2000) Regulation of E2F1 activity by acetylation. EMBO J. 19, 662-671
24. Patel, J.H., Du, Y., Ard, P.G., Phillips, C., Carella, B., Chen, C.J., Rakowski, C., Chatterjee, C., Lieberman, P.M., Lane, W.S. et al. (2004) The c-Myc oncoprotein is a substrate of the acetyltransferases hGCN5/ PCAF and TIP60. Mol. Cell. Biol. 24, 10826-10834
25. Gu, W. and Roeder, R.G. (1997) Activation of p53 sequence-specific DNA-binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606
26. Sakaguchi, K., Herrera, J.E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C.W. and Appella, E. (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12, 2831-2841
27. Schiltz, R.L. and Nakatani, Y. (2000) The PCAF acetylase complex as a potential tumor suppressor. Biochim. Biophys. Acta 1470, M37-M53
28. Nagy, Z. and Tora, L. (2007) Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Oncogene 26, 5341-5357
29. Linares, L.K., Kiernan, R., Triboulet, R., Chable-Bessia, C., Latreille, D., Cuvier, O., Lacroix, M., Le Cam, L., Coux, O. and Benkirane, M. (2007) Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2. Nat. Cell Biol. 9, 331-338
30. Galbiati, L., Mendoza-Maldonado, R., Gutierrez, M.I. and Giacca, M. (2005) Regulation of E2F1 after DNA damage by p300-mediated acetylation and ubiquitination. Cell Cycle 4, 930-939
31. Jeong, J.W., Bae, M.K., Ahn, M.Y., Kim, S.H., Sohn, T.K., Bae, M.H., Yoo, M.A., Song, E.J., Lee, K.J. and Kim, K.W. (2002) Regulation and destabilization of HIF-1α by ARD-1-mediated acetylation. Cell 111, 709-720
32. Shimazu, T., Komatsu, Y., Nakayama, K.I., Fukazawa, H., Horinouchi, S. and Yoshida, M. (2006) Regulation of the SV40 large T-antigen stability by reversible acetylation. Oncogene 25, 7391-7400
33. Leduc, C., Claverie, P., Eymin, B., Col, E., Khochbin, S., Brambilla, E. and Gazzeri, S. (2006) p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation. Oncogene 25, 4147-4154
34. van Leuken, R., Clijsters, L. and Wolthuis, R. (2008) To cell cycle, swing the APC/C. Biochim. Biophys. Acta 1786, 49-59