EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration

Biochemical and Biophysical Research Communications

Volumn 313, Issue 1, 2004, Pages 80-88

  Sturz, Andrea ^a   Bader, Benjamin ^a   Thierauch, Karl Heinz ^a   Glienke, Jens ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Angiogenesis; CHO; Endothelial cell; EphB4; EphrinB2; Migration; MVEC; PD 153035; PP2

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; EPHRIN B2; EPHRIN B3; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE;

ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0346850785     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.11.092     Document Type: Article

References (21)

1. Holder N., Klein R. Eph receptors and ephrins: effectors of morphogenesis. Development. 126:1999;2033-2044.
2. Gale N.W., Yancopoulos G.D. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGF's, angiopoietins, and ephrins in vascular development. Genes Dev. 13:1999;11055-11066.
3. Wilkinson D.G. Eph receptors and ephrins: regulators of guidance and assembly. Int. Rev. Cytol. 196:2000;177-244.
4. Mellitzer G., Xu Q., Wilkinson D.G. Control of cell behaviour by signalling through Eph receptors and ephrins. Curr. Opin. Neurobiol. 10:2000;400-408.
5. Klein R. Excitatory Eph receptors and adhesive ephrin ligands. Curr. Opin. Cell Biol. 13:2001;196-203.
6. Cheng N., Brantley D.M., Chen J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 13:2002;75-85.
7. Kullander K., Klein R. Mechanisms and functions of Eph and ephrin signalling. Nature Rev. 3:2002;475-486.
8. Stein E., Lane A.A., Cerretti D.P., Schoecklmann H.O., Schroff A.D., Van Etten R.L., Daniel T.O. Eph receptors discriminate specific ligand oligomers to determine alternative signalling complexes attachment and assembly responses. Genes Dev. 12:1998;667-678.
9. Wang H.U., Chen Z.F., Anderson D.J. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 93:1998;741-753.
10. Adams R.H., Wilkinson G.A., Weiss C., Diella F., Gale N.W., Deutsch U., Risau W., Klein R. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13:1999;295-306.
11. Gerety S.S., Wang H.U., Chen Z.F., Anderson D.J. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol. Cell. 4:1999;403-414.
12. Adams R.H., Diella F., Hennig S., Helmbacher F., Deutsch U., Klein R. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell. 104:2001;57-69.
13. Gerety S.S., Anderson D.J. Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development. 129:2002;1397-1410.
14. Oike Y., Ito Y., Hamada K., Zhang X.Q., Miyata K., Arai F., Inada T., Araki K., Nakagata N., Takeya M., Kisanuki Y.Y., Yanagisawa M., Gale N.W., Suda T. Regulation of vasculogenesis and angiogenesis by EphB/ephrinB2 signaling between endothelial cells and surrounding mesenchymal cells. Blood. 100:2002;1326-1333.
15. Helbling P.M., Saulnier D.M.E., Brändli A.W. The receptor tyrosine kinase EphB4 and ephrinB2-ligands restrict angiogenic growth of embryonic veins in Xenopus laevis. Development. 127:2000;269-278.
16. Zhang X.Q., Takakura N., Oike Y., Inada T., Gale N.W., Yancopoulos G.D., Suda T. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. Blood. 98:2001;1028-1037.
17. Kim I., Ryu Y.S., Kwak H.J., Ahn S.Y., Oh J.L., Yancopoulos G.D., Gale N.W., Koh G.Y. EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J. 16:2002;1126-1128.
18. Piossek C., Schneider-Mergener J., Schirner M., Vakalopoulou E., Germeroth L., Thierauch K.H. Vascular endothelial growth factor (VEGF) receptor-II derived peptides inhibit VEGF. J. Biol. Chem. 274:1999;5612-5619.
19. Hanke J.H., Gardner J.P., Dow R.L., Changelian P.S., Brissette W.H., Weringer E.J., Pollok B.A., Connelly P.A. Discovery of a novel, potent, and Src-family selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:1996;695-701.
20. Fry D.W., Kraker A.J., McMichael A., Ambroso L.A., Nelson J.M., Leopold W.R., Connors R.W., Bridges A.J. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 265:1994;1093-1095.
21. H. Maekawa, Y. Oike, S. Kanda, Y. Ito, Y. Yamada, H. Kurihara, R. Nagai, T. Suda, Ephrin-B2 induced migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature, Arterioscler. Thromb. Vasc. Biol. 23 (2003) Epub ahead of print.