메뉴 건너뛰기




Volumn 81, Issue 2, 2000, Pages 117-143

Epithelial stem cell repertoire in the gut: Clues to the origin of cell lineages, proliferative units and cancer

Author keywords

Cell lineage; Colon carcinoma; Crypt fission; FAP; Intestine; Stem cell

Indexed keywords

CARCINOID; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON CARCINOMA; GENE TRANSFER; HUMAN; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL;

EID: 0034014936     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2000.00146.x     Document Type: Review
Times cited : (138)

References (123)
  • 1
    • 4243219909 scopus 로고
    • Expression of multiple growth factors by the ulcer-associated cell lineage
    • AHNEN D., GULLICK W. & WRIGHT N.A. (1991) Expression of multiple growth factors by the ulcer-associated cell lineage. Gastroenterology 100, A512.
    • (1991) Gastroenterology , vol.100
    • Ahnen, D.1    Gullick, W.2    Wright, N.A.3
  • 2
    • 0027017649 scopus 로고
    • Abnormal DNA content as a biomarker of large bowel cancer risk and prognosis
    • AHNEN D. (1992) Abnormal DNA content as a biomarker of large bowel cancer risk and prognosis. J. Cell Biochem. 16(Suppl.), 143-150.
    • (1992) J. Cell Biochem. , vol.16 , Issue.SUPPL. , pp. 143-150
    • Ahnen, D.1
  • 3
    • 0027934797 scopus 로고
    • The ulceration-associated cell lineage reiterates the differentiation programme of Brunners glands, but acquires the proliferate organisation of the gastric gland
    • AHNEN D., POULSOM R., STAMP G. ET AL. (1994) The ulceration-associated cell lineage reiterates the differentiation programme of Brunners glands, but acquires the proliferate organisation of the gastric gland. J. Pathol 173, 317-326.
    • (1994) J. Pathol , vol.173 , pp. 317-326
    • Ahnen, D.1    Poulsom, R.2    Stamp, G.3
  • 4
    • 0021882479 scopus 로고
    • Do cancers arise from a single transformed cell or is monoclonality of tumours a late event in carcinogenesis
    • ALEXANDER P. (1985) Do cancers arise from a single transformed cell or is monoclonality of tumours a late event in carcinogenesis. Br. J. Cancer 51, 453-457.
    • (1985) Br. J. Cancer , vol.51 , pp. 453-457
    • Alexander, P.1
  • 5
    • 0016186232 scopus 로고
    • Further evidence that enterochromaffin cells are not derived from the neural crest
    • ANDREW A. (1973) Further evidence that enterochromaffin cells are not derived from the neural crest. J. Embryol. Exp. Morph. 31, 581-598.
    • (1973) J. Embryol. Exp. Morph. , vol.31 , pp. 581-598
    • Andrew, A.1
  • 6
    • 0031688624 scopus 로고    scopus 로고
    • The origin of gut and pancreatic neuroendocrine (APUD) cells - The last word?
    • ANDREW A., KRAMER B. & RAWDON B.B. (1998) The origin of gut and pancreatic neuroendocrine (APUD) cells - the last word? J. Pathol. 186, 117-118.
    • (1998) J. Pathol. , vol.186 , pp. 117-118
    • Andrew, A.1    Kramer, B.2    Rawdon, B.B.3
  • 7
    • 0031260579 scopus 로고    scopus 로고
    • Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    • APELQVIST A., AHLGREN U. & EDLUND H. (1997) Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7, 810-804.
    • (1997) Curr. Biol. , vol.7 , pp. 810-1804
    • Apelqvist, A.1    Ahlgren, U.2    Edlund, H.3
  • 9
    • 0014208048 scopus 로고
    • Value of genetic variants of glucose-6-phosphate dehydrogenase in tracing the origin of malignant tumors
    • BEUTLER E., COLLINS Z. & IRWIN L.E. (1967) Value of genetic variants of glucose-6-phosphate dehydrogenase in tracing the origin of malignant tumors. N Engl. J. Med. 276, 389-391.
    • (1967) N Engl. J. Med. , vol.276 , pp. 389-391
    • Beutler, E.1    Collins, Z.2    Irwin, L.E.3
  • 10
    • 0002874798 scopus 로고
    • The stem cell zone of the small intestinal epithelium III. Evidence from columnar, mucous and endocrine cells in the adult mouse
    • BJERKNES M. & CHENG H. (1982) The stem cell zone of the small intestinal epithelium III. Evidence from columnar, mucous and endocrine cells in the adult mouse. Am. J. Anat. 166, 76-92.
    • (1982) Am. J. Anat. , vol.166 , pp. 76-92
    • Bjerknes, M.1    Cheng, H.2
  • 11
    • 0028943111 scopus 로고
    • The crypt cycle and the asymptotic dynamics of the proportion of differently sized mutant crypt clones in the mouse intestine
    • BJERKNES M. (1995) The crypt cycle and the asymptotic dynamics of the proportion of differently sized mutant crypt clones in the mouse intestine. Proc. Roy. Soc. Land. B 260, 1-6.
    • (1995) Proc. Roy. Soc. Land. B , vol.260 , pp. 1-6
    • Bjerknes, M.1
  • 12
    • 0029981385 scopus 로고    scopus 로고
    • Expansion of mutant stem cell populations in the human colon
    • BJERKNES M. (1996) Expansion of mutant stem cell populations in the human colon. J. Theor. Biol. 178, 381-385.
    • (1996) J. Theor. Biol. , vol.178 , pp. 381-385
    • Bjerknes, M.1
  • 13
    • 0031059349 scopus 로고    scopus 로고
    • APC mutation and the crypt cycle in murine and human intestine
    • BJERKNES M., CHENG H., HAY K. & GALLINGER S. (1997) APC mutation and the crypt cycle in murine and human intestine. Am. J. Pathol. 150, 833-839.
    • (1997) Am. J. Pathol. , vol.150 , pp. 833-839
    • Bjerknes, M.1    Cheng, H.2    Hay, K.3    Gallinger, S.4
  • 14
    • 0032897996 scopus 로고    scopus 로고
    • Clonal analysis of mouse intestinal epithelial progenitors
    • BJERKNES M. & CHENG H. (1999) Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 116, 7-14.
    • (1999) Gastroenterology , vol.116 , pp. 7-14
    • Bjerknes, M.1    Cheng, H.2
  • 15
    • 0026782949 scopus 로고
    • Neoplastic progression in ulcerative colitis: Histology, DNA content, and loss of a p53 allele
    • BURNER G.C., RABINOVITCH P.S. & HAGGITT RC ET AL. (1992) Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. Gastroenterology 103, 1602-1611.
    • (1992) Gastroenterology , vol.103 , pp. 1602-1611
    • Burner, G.C.1    Rabinovitch, P.S.2    Haggitt, R.C.3
  • 16
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signalling: A common theme in animal development
    • CADIGAN K.M. & NUSSE R. (1997) Wnt signalling: a common theme in animal development. Genes Dev. 11, 3286-3305.
    • (1997) Genes Dev. , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 17
    • 0028019088 scopus 로고
    • Human colonic stem cell mutation frequency with and without irradiation
    • CAMPBELL F., FULLER C.E., WILLIAMS G.T. & WILLIAMS E.D. (1994) Human colonic stem cell mutation frequency with and without irradiation. J. Pathol. 174, 175-182.
    • (1994) J. Pathol. , vol.174 , pp. 175-182
    • Campbell, F.1    Fuller, C.E.2    Williams, G.T.3    Williams, E.D.4
  • 18
    • 84982634996 scopus 로고
    • Fission of crypts in the small intestine of the irradiated mouse
    • CAIRNIE A.B. & MILLEN B.H. (1975) Fission of crypts in the small intestine of the irradiated mouse. Cell Tissue Kinet. 8, 189-196.
    • (1975) Cell Tissue Kinet. , vol.8 , pp. 189-196
    • Cairnie, A.B.1    Millen, B.H.2
  • 19
    • 0016325705 scopus 로고
    • Origin, differentiation and renewal of the four main cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types
    • CHENG H. & LEBLOND C.P. (1974) Origin, differentiation and renewal of the four main cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat 141, 537-562.
    • (1974) Am. J. Anat , vol.141 , pp. 537-562
    • Cheng, H.1    Leblond, C.P.2
  • 20
    • 0028986591 scopus 로고
    • The induction of dominant somatic mutations at the Dlb-1 locus
    • CONSENTINO L. & HEDDLE J.A. (1995) The induction of dominant somatic mutations at the Dlb-1 locus. Mut. Res. 346, 115-119.
    • (1995) Mut. Res. , vol.346 , pp. 115-119
    • Consentino, L.1    Heddle, J.A.2
  • 21
    • 0019990355 scopus 로고
    • The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat
    • COX W.F. & PIERCE G.B. (1982) The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat. Cancer 50, 1530-1538.
    • (1982) Cancer , vol.50 , pp. 1530-1538
    • Cox, W.F.1    Pierce, G.B.2
  • 22
    • 0013662220 scopus 로고
    • Zur histogenese an soganten appendix-Carcinoide
    • DANISCH F. (1924) Zur histogenese an soganten appendix-Carcinoide. Beitr. Pathol. Anat. 72, 687-709.
    • (1924) Beitr. Pathol. Anat. , vol.72 , pp. 687-709
    • Danisch, F.1
  • 23
    • 0026531453 scopus 로고
    • A nude mouse model of fetal intestinal development and differentiation
    • DEL BUONO R., FLEMING K.A., MOREY A.L., HALL P.A. & WRIGHT N.A. (1992) A nude mouse model of fetal intestinal development and differentiation. Development 114, 67-73.
    • (1992) Development , vol.114 , pp. 67-73
    • Del Buono, R.1    Fleming, K.A.2    Morey, A.L.3    Hall, P.A.4    Wright, N.A.5
  • 25
    • 0023261211 scopus 로고
    • Clonal analysis of human colorectal tumors
    • FEARON E.R., HAMILTON S.R. & VOGELSTEIN B. (1986) Clonal analysis of human colorectal tumors. Science 238, 193-197.
    • (1986) Science , vol.238 , pp. 193-197
    • Fearon, E.R.1    Hamilton, S.R.2    Vogelstein, B.3
  • 27
    • 0018583976 scopus 로고
    • Clonal origin of human tumours
    • FIALKOW P.J. (1979) Clonal origin of human tumours. Ann. Rev. Med. 30, 134-143.
    • (1979) Ann. Rev. Med. , vol.30 , pp. 134-143
    • Fialkow, P.J.1
  • 28
    • 0025232701 scopus 로고
    • Crypt-restricted heterogeneity of goblet cell mucus glycoprotein in histologically normal human colonie mucosa; a potential marker of somatic mutation
    • FULLER C.E., DAVIES R.P., WILLIAMS G.T. & WILLIAMS E.D. (1990) Crypt-restricted heterogeneity of goblet cell mucus glycoprotein in histologically normal human colonie mucosa; a potential marker of somatic mutation. Br. J. Cancer 61, 382-384.
    • (1990) Br. J. Cancer , vol.61 , pp. 382-384
    • Fuller, C.E.1    Davies, R.P.2    Williams, G.T.3    Williams, E.D.4
  • 29
    • 0345130005 scopus 로고    scopus 로고
    • Field cancerization, clonality, and epithelial stem cells: The spread of mutated clones in epithelial sheets
    • GARCIA S.B., PARK H.-S., NOVELLI M. & WRIGHT N.A. (1999) Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets. J. Pathol. 187, 61-81.
    • (1999) J. Pathol. , vol.187 , pp. 61-81
    • Garcia, S.B.1    Park, H.-S.2    Novelli, M.3    Wright, N.A.4
  • 30
    • 0022005514 scopus 로고
    • Human lung tumours; a correlation of antigenic profile and histological type
    • GATTER K., DUNNILL M.S., PULFOD K.A., DUYRET A. & MASON D.Y. (1985) Human lung tumours; a correlation of antigenic profile and histological type. J. Pathol. 9, 805-823.
    • (1985) J. Pathol. , vol.9 , pp. 805-823
    • Gatter, K.1    Dunnill, M.S.2    Pulfod, K.A.3    Duyret, A.4    Mason, D.Y.5
  • 31
    • 0014847585 scopus 로고
    • Histogenetic relation between carcinoids and mucin-secreting carcinomas of the colon as revealed by transplantation
    • GOLDENBERG D.M. & FISHER E.R. (1970) Histogenetic relation between carcinoids and mucin-secreting carcinomas of the colon as revealed by transplantation. Br. J. Cancer 24, 610-614.
    • (1970) Br. J. Cancer , vol.24 , pp. 610-614
    • Goldenberg, D.M.1    Fisher, E.R.2
  • 32
    • 0023179755 scopus 로고
    • Intravenous but not intragastric urogastrone/EGF is trophic to the intestine of parenterally-fed rats
    • GOODLAD R., WILSON G., LENTON W. ET AL. (1987) Intravenous but not intragastric urogastrone/EGF is trophic to the intestine of parenterally-fed rats. Gut 78, 573-582.
    • (1987) Gut , vol.78 , pp. 573-582
    • Goodlad, R.1    Wilson, G.2    Lenton, W.3
  • 33
    • 0025824483 scopus 로고
    • Effects of urogastrone/epidermal growth factor on intestinal brush border enzymes and mitotic activity
    • GOODLAD R.A., RAJA K.P., PETERS T.J. & WRIGHT N.A. (1991) Effects of urogastrone/epidermal growth factor on intestinal brush border enzymes and mitotic activity. Gut 32, 994-998.
    • (1991) Gut , vol.32 , pp. 994-998
    • Goodlad, R.A.1    Raja, K.P.2    Peters, T.J.3    Wright, N.A.4
  • 34
    • 0030965763 scopus 로고    scopus 로고
    • Localised gene action controlling intestinal neoplasia in mice
    • GOULD K.A. & DOVE W.F. (1997) Localised gene action controlling intestinal neoplasia in mice. Proc. Natl. Acad. Sci. USA 94, 5848-5853.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5848-5853
    • Gould, K.A.1    Dove, W.F.2
  • 35
    • 0023887029 scopus 로고
    • Demonstration of somatic mutation and crypt clonality by X-linked enzyme histochemistry
    • GRIFFITHS D.F., DAVIES S.J., WILLIAMS D., WILLIAMS G.T. & WILLIAMS E.D. (1988) Demonstration of somatic mutation and crypt clonality by X-linked enzyme histochemistry. Nature 333, 461-463.
    • (1988) Nature , vol.333 , pp. 461-463
    • Griffiths, D.F.1    Davies, S.J.2    Williams, D.3    Williams, G.T.4    Williams, E.D.5
  • 36
    • 0028875761 scopus 로고
    • Expression of the APC gene after transfection into a colonic cancer cell line
    • HAHGEST R. & WILLIAMSON R. (1995) Expression of the APC gene after transfection into a colonic cancer cell line. Gut 37, 826-829.
    • (1995) Gut , vol.37 , pp. 826-829
    • Hahgest, R.1    Williamson, R.2
  • 37
    • 0027275826 scopus 로고
    • P.1b, a human p-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus
    • HAUSER F., POULSOM R., CHINERY R. ET AL. (1993) hP.1b, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc. Natl. Acad. Sci. (USA) 90, 6961-6965.
    • (1993) Proc. Natl. Acad. Sci. (USA) , vol.90 , pp. 6961-6965
    • Hauser, F.1    Poulsom, R.2    Chinery, R.3
  • 38
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • HE T.-C., SPARKES A.B., RAGO C. ET AL. (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1511.
    • (1998) Science , vol.281 , pp. 1509-1511
    • He, T.-C.1    Sparkes, A.B.2    Rago, C.3
  • 39
    • 0026478947 scopus 로고
    • The clonogen content of murine intestinal crypts: Dependence on radiation dose used in its determination
    • HENDRY J.H., ROBERTS S.A. & POTTEN C.S. (1992) The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. Rad. Res. 132, 115-119.
    • (1992) Rad. Res. , vol.132 , pp. 115-119
    • Hendry, J.H.1    Roberts, S.A.2    Potten, C.S.3
  • 40
    • 0001920462 scopus 로고
    • Model systems for studying cell fate specification and differentiation in the gut epithelium
    • Ed L.R. JOHNSON. New York: Raven Press
    • HERMISTON M.L., SIMON T.C., CROSSMAN M.W. & GORDON J.I. (1994) Model systems for studying cell fate specification and differentiation in the gut epithelium. In Physiology of the Gastrointestinal Tract, Ed L.R. JOHNSON. New York: Raven Press, pp. 521-569.
    • (1994) Physiology of the Gastrointestinal Tract , pp. 521-569
    • Hermiston, M.L.1    Simon, T.C.2    Crossman, M.W.3    Gordon, J.I.4
  • 41
    • 0001878841 scopus 로고
    • Cell lineages, stem cells and the 'quantal cell cycle concept'
    • Eds. C.S. POTTEN, B.I. LORD & R. SCHOFIELD. Cambridge: Cambridge University Press
    • HOLZER H. (1978) Cell lineages, stem cells and the 'quantal cell cycle concept'. In Stem cells and tissue homeostasis. Eds. C.S. POTTEN, B.I. LORD & R. SCHOFIELD. Cambridge: Cambridge University Press, pp. 1-27.
    • (1978) Stem Cells and Tissue Homeostasis , pp. 1-27
    • Holzer, H.1
  • 43
    • 0019472594 scopus 로고
    • Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumour)
    • ISAACSON P. (1981) Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumour). Am. J. Surg. Pathol. 5, 213-224.
    • (1981) Am. J. Surg. Pathol. , vol.5 , pp. 213-224
    • Isaacson, P.1
  • 44
    • 0028298263 scopus 로고
    • Colorectal mucin histochemistry in health and disease: A critical review
    • JASS J.R. & ROBERTSON A.M. (1994) Colorectal mucin histochemistry in health and disease: a critical review. Pathol. Int. 44, 487-504.
    • (1994) Pathol. Int. , vol.44 , pp. 487-504
    • Jass, J.R.1    Robertson, A.M.2
  • 45
    • 0030907001 scopus 로고    scopus 로고
    • The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation
    • KAESTNER K.H., SILBERG D.G., TRABER P.G. & SCHUTZ G. (1997) The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev. 11, 1583-1595.
    • (1997) Genes Dev. , vol.11 , pp. 1583-1595
    • Kaestner, K.H.1    Silberg, D.G.2    Traber, P.G.3    Schutz, G.4
  • 46
    • 0027253264 scopus 로고
    • Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell
    • KAHAM S.M. & LEBLOND C.P. (1993) Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat. Rec. 236, 269-279.
    • (1993) Anat. Rec. , vol.236 , pp. 269-279
    • Kaham, S.M.1    Leblond, C.P.2
  • 47
    • 0001193138 scopus 로고
    • Brunner type glands in regional enteritis
    • KAWEL C.A. & TESLUK H. (1955) Brunner type glands in regional enteritis. Gastroenterology 28, 210-221.
    • (1955) Gastroenterology , vol.28 , pp. 210-221
    • Kawel, C.A.1    Tesluk, H.2
  • 48
    • 0022457698 scopus 로고
    • Fetal gut mesenchyme induces differentiation of cultured intestinal endodermal and crypt cells
    • KEDINGER M., SIMON-ASSMAN P.M., LACROIX B., MARXER A., HAURI H.P. & HAFFEN K. (1986) Fetal gut mesenchyme induces differentiation of cultured intestinal endodermal and crypt cells. Dev. Biol. 113, 474-483.
    • (1986) Dev. Biol. , vol.113 , pp. 474-483
    • Kedinger, M.1    Simon-Assman, P.M.2    Lacroix, B.3    Marxer, A.4    Hauri, H.P.5    Haffen, K.6
  • 49
    • 0023093505 scopus 로고
    • Importance of a fibroblastic support for an in vitro differentiation of intestinal endodermal cells and for their response to glucocorticoids
    • KEDINGER M., SIMON-ASSMAN P., ALEXANDRE E. & HAFFEN K. (1987) Importance of a fibroblastic support for an in vitro differentiation of intestinal endodermal cells and for their response to glucocorticoids. Cell Differ. 20, 171-182.
    • (1987) Cell Differ. , vol.20 , pp. 171-182
    • Kedinger, M.1    Simon-Assman, P.2    Alexandre, E.3    Haffen, K.4
  • 50
    • 0023835734 scopus 로고
    • Clonal origin of columnar, mucous and endocrine cell lineages in human colorectal epithelium
    • KIRKLAND S.C. (1988) Clonal origin of columnar, mucous and endocrine cell lineages in human colorectal epithelium. Cancer 61, 1359-1363.
    • (1988) Cancer , vol.61 , pp. 1359-1363
    • Kirkland, S.C.1
  • 51
    • 0028334897 scopus 로고
    • Endocrine and mucous cell differentiation by a cloned human rectal adenocarcinoma cell line (HRA-19) in vitro: Inhibition by TGF-β1
    • KIRKLAND S.C. & HENDERSON K. (1994) Endocrine and mucous cell differentiation by a cloned human rectal adenocarcinoma cell line (HRA-19) in vitro: inhibition by TGF-β1. J. Cell Science 107, 1041-1046.
    • (1994) J. Cell Science , vol.107 , pp. 1041-1046
    • Kirkland, S.C.1    Henderson, K.2
  • 52
    • 0016134997 scopus 로고
    • Heredity and human cancer
    • KNUDSON A.G. (1974) Heredity and human cancer. Am. J. Pathol. 77, 77-84.
    • (1974) Am. J. Pathol. , vol.77 , pp. 77-84
    • Knudson, A.G.1
  • 53
    • 0018763266 scopus 로고
    • Neuroendocrine cells in serially-passaged rat stomach cancers induced by N-methyl-N-nitro-guanidine (MNNG)
    • KOBORI O. & OOTA K. (1979) Neuroendocrine cells in serially-passaged rat stomach cancers induced by N-methyl-N-nitro-guanidine (MNNG). Int. J. Cancer 23, 536-541.
    • (1979) Int. J. Cancer , vol.23 , pp. 536-541
    • Kobori, O.1    Oota, K.2
  • 54
    • 0031937635 scopus 로고    scopus 로고
    • Two members of the Tcf family implicated in Wnt/β-catenin signalling during embryogenesis in the mouse
    • KORINEK V., BARKER N., MOERER P. ET AL. (1998a) Two members of the Tcf family implicated in Wnt/β-catenin signalling during embryogenesis in the mouse. Mol Cell Biol 18, 1248-1256.
    • (1998) Mol Cell Biol , vol.18 , pp. 1248-1256
    • Korinek, V.1    Barker, N.2    Moerer, P.3
  • 55
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf-4
    • KORINEK V., BARKER N., MOERER P. ET AL. (1998b) Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf-4. Nature Genet 19, 379-382.
    • (1998) Nature Genet , vol.19 , pp. 379-382
    • Korinek, V.1    Barker, N.2    Moerer, P.3
  • 56
    • 0014936929 scopus 로고
    • Demonstration de l'origine neurale des cellules a calcitonine du corps ultimobranchial chez l'embryon de poulet
    • LE DOUARIN N. & LE LIEVRE C. (1970) Demonstration de l'origine neurale des cellules a calcitonine du corps ultimobranchial chez l'embryon de poulet. C. Hebd. Sean. Acad. Sci. 270, 2857-2860.
    • (1970) C. Hebd. Sean. Acad. Sci. , vol.270 , pp. 2857-2860
    • Le Douarin, N.1    Le Lievre, C.2
  • 57
    • 0015888640 scopus 로고
    • The migration of neural crest cells to the wall of the digestive tract in avian embryos
    • LE DOUARIN N. & TEILLET M.A. (1973) The migration of neural crest cells to the wall of the digestive tract in avian embryos. J. Embryol. Exp. Morph. 30, 31-38.
    • (1973) J. Embryol. Exp. Morph. , vol.30 , pp. 31-38
    • Le Douarin, N.1    Teillet, M.A.2
  • 58
    • 0000329751 scopus 로고
    • Pyloric metaplasia in the small intestine
    • LEE F. (1964) Pyloric metaplasia in the small intestine. J. Path. Bateriol. 87, 257-279.
    • (1964) J. Path. Bateriol. , vol.87 , pp. 257-279
    • Lee, F.1
  • 59
    • 0026012427 scopus 로고
    • Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer
    • LEVIN D.S., RABINOVITCH P.S., HAGGITT R.C. ET AL. (1991) Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer. Gastroenterology 101, 1198-1210.
    • (1991) Gastroenterology , vol.101 , pp. 1198-1210
    • Levin, D.S.1    Rabinovitch, P.S.2    Haggitt, R.C.3
  • 60
    • 0001695792 scopus 로고
    • Aberrant pyloric glands in regional enteritis
    • LIBER A.F. (1951) Aberrant pyloric glands in regional enteritis. Arch. Pathol. (Chicago) 51, 205-219.
    • (1951) Arch. Pathol. (Chicago) , vol.51 , pp. 205-219
    • Liber, A.F.1
  • 61
    • 0027318112 scopus 로고
    • Somatic mutation, monoclonality and stochastic models of stem cell organisation in the intestinal crypt
    • LOEFFLER M., BIRKE A., WINTON D. J. & POTTEN C.S. (1993) Somatic mutation, monoclonality and stochastic models of stem cell organisation in the intestinal crypt. J. Theor. Biol. 162, 471-491.
    • (1993) J. Theor. Biol. , vol.162 , pp. 471-491
    • Loeffler, M.1    Birke, A.2    Winton, D.J.3    Potten, C.S.4
  • 62
    • 0031557884 scopus 로고    scopus 로고
    • Clonality and life cycles of intestinal crypts explained by a state-dependent stochastic model of epithelial stem cell organisation
    • LOEFFLER M., BRATKE T., PAULUS U., LI Y.-Q. & POTTEN C.S. (1997) Clonality and life cycles of intestinal crypts explained by a state-dependent stochastic model of epithelial stem cell organisation. J. Theor. Biol. 186, 41-54.
    • (1997) J. Theor. Biol. , vol.186 , pp. 41-54
    • Loeffler, M.1    Bratke, T.2    Paulus, U.3    Li, Y.-Q.4    Potten, C.S.5
  • 63
    • 0013963496 scopus 로고
    • Lack of evidence that inactivation of the mouse X-chromosome is incomplete
    • LYON M.F. (1966) Lack of evidence that inactivation of the mouse X-chromosome is incomplete. Genet. Res. 8, 197-203.
    • (1966) Genet. Res. , vol.8 , pp. 197-203
    • Lyon, M.F.1
  • 64
    • 0017667496 scopus 로고
    • Mucinous carcinoid tumour of the appendix containing Paneth cells
    • MCDONALD G.S.A. & HOURIHANE D.O'B. (1977) Mucinous carcinoid tumour of the appendix containing Paneth cells. Irish J. Med. Sci. 146, 386-394.
    • (1977) Irish J. Med. Sci. , vol.146 , pp. 386-394
    • McDonald, G.S.A.1    Hourihane, D.O'B.2
  • 65
    • 0019410805 scopus 로고
    • Kinetics of tissue proliferation in colorectal mucosa during postnatal growth
    • MASKENS A.P. & DUJARDIN-LOITS R.M. (1981) Kinetics of tissue proliferation in colorectal mucosa during postnatal growth. Cell Tissue Kinet. 14, 467-477.
    • (1981) Cell Tissue Kinet. , vol.14 , pp. 467-477
    • Maskens, A.P.1    Dujardin-Loits, R.M.2
  • 66
    • 0000603883 scopus 로고
    • Carcinoid tumours (argentaffin tumours) and neural hyperplasia in the appendicular mucosa
    • MASSON P. (1928) Carcinoid tumours (argentaffin tumours) and neural hyperplasia in the appendicular mucosa. Am. J. Pathol 4, 181-212.
    • (1928) Am. J. Pathol , vol.4 , pp. 181-212
    • Masson, P.1
  • 67
    • 0012423699 scopus 로고
    • Neural proliferation in the vermiform appendix
    • Ed. W. PENFELD, New York: Harper & Row
    • MASSON P. (1932) Neural proliferation in the vermiform appendix. In: Cytology and Pathology of the Nervous System, Vol. 3. Ed. W. PENFELD, New York: Harper & Row. pp. 1095-1130.
    • (1932) Cytology and Pathology of the Nervous System , vol.3 , pp. 1095-1130
    • Masson, P.1
  • 68
    • 0014960604 scopus 로고
    • Differentiation of immature mucous cells into parietal, argyrophil and chief cells in stomach grafts
    • MATSUTYAMA M. & SUZUKI H. (1970) Differentiation of immature mucous cells into parietal, argyrophil and chief cells in stomach grafts. Science 169, 385-387.
    • (1970) Science , vol.169 , pp. 385-387
    • Matsutyama, M.1    Suzuki, H.2
  • 71
    • 0026576029 scopus 로고
    • Multistage carcinogenesis: Population-based model for colon cancer
    • MOOLGAVKAR S.H. & LUEBECK E.G. (1992) Multistage carcinogenesis: population-based model for colon cancer. J. Natl. Cancer Inst. 84, 610-618.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 610-618
    • Moolgavkar, S.H.1    Luebeck, E.G.2
  • 72
    • 0026568524 scopus 로고
    • The MIN (Multiple Intestinal Neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system
    • MOSEH A.R., DOVE W.F., ROTH K.A. & GORDON J.I. (1992) The MIN (Multiple Intestinal Neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol. 116, 1517-1526.
    • (1992) J. Cell Biol. , vol.116 , pp. 1517-1526
    • Moseh, A.R.1    Dove, W.F.2    Roth, K.A.3    Gordon, J.I.4
  • 73
    • 0030582344 scopus 로고    scopus 로고
    • Clonal analysis of single fundic and pyloric glands of stomach using X-linked polymorphism
    • NOMURA S., KAMINISHI M., SUGIYAMA K., OOHARA T. & ESUMI H. (1996) Clonal analysis of single fundic and pyloric glands of stomach using X-linked polymorphism. Biochem. Biophys. Res. Commun. 226, 385-390.
    • (1996) Biochem. Biophys. Res. Commun. , vol.226 , pp. 385-390
    • Nomura, S.1    Kaminishi, M.2    Sugiyama, K.3    Oohara, T.4    Esumi, H.5
  • 74
    • 0032373360 scopus 로고    scopus 로고
    • Lineage and clonal development of gastric glands
    • NOMURA S., ESUMI H., JOB C. & TAN S.-S. (1998) Lineage and clonal development of gastric glands. Dev. Biol. 204, 124-135.
    • (1998) Dev. Biol. , vol.204 , pp. 124-135
    • Nomura, S.1    Esumi, H.2    Job, C.3    Tan, S.-S.4
  • 75
    • 0029938751 scopus 로고    scopus 로고
    • Polyclonal origin of colonie adenomas in an XO/XY patient with FAP
    • NOVELLI M.R., WILLIAMSON J.A., TOMLINSON I.P.M. ET AL. (1996) Polyclonal origin of colonie adenomas in an XO/XY patient with FAP. Science 272, 1187-1190.
    • (1996) Science , vol.272 , pp. 1187-1190
    • Novelli, M.R.1    Williamson, J.A.2    Tomlinson, I.P.M.3
  • 76
    • 0013660414 scopus 로고    scopus 로고
    • The effects of epidermal growth factor and crypt fission in the colon: Cell proliferation and crypt fission are controlled independently
    • PARK H.-S., GOODLAD R.A., AHNEN D.J. ET AL. (1996) The effects of epidermal growth factor and crypt fission in the colon: cell proliferation and crypt fission are controlled independently. Am. J. Pathol. 151, 125-136.
    • (1996) Am. J. Pathol. , vol.151 , pp. 125-136
    • Park, H.-S.1    Goodlad, R.A.2    Ahnen, D.J.3
  • 77
    • 0028823365 scopus 로고
    • Crypt fission in the small intestine and colon: A mechanism of the emergence of transformed crypts after treatment with mutagens
    • PARK H.S., GOODLAD R.G. & WRIGHT N.A. (1995) Crypt fission in the small intestine and colon: a mechanism of the emergence of transformed crypts after treatment with mutagens. Am. J. Pathol. 147, 1416-1427.
    • (1995) Am. J. Pathol. , vol.147 , pp. 1416-1427
    • Park, H.S.1    Goodlad, R.G.2    Wright, N.A.3
  • 78
    • 0028674042 scopus 로고
    • The kinetic organisation of the ulcer associated cell lineage (UACL): Delineation of a novel putative stem cell region
    • PATEL K., HANBY A.M., AHNEN D.J., PLAYFORD R.J. & WRIGHT N.A. (1994) The kinetic organisation of the ulcer associated cell lineage (UACL): delineation of a novel putative stem cell region. J. Epithelial Cell Biol. 3, 156-160.
    • (1994) J. Epithelial Cell Biol. , vol.3 , pp. 156-160
    • Patel, K.1    Hanby, A.M.2    Ahnen, D.J.3    Playford, R.J.4    Wright, N.A.5
  • 79
    • 0014007530 scopus 로고
    • 5HT uptake by dog thyroid cells, and it's possible significance in polypeptide hormone production
    • PEARSE A.G.E. (1966a) 5HT uptake by dog thyroid cells, and it's possible significance in polypeptide hormone production. Nature 211, 598-600.
    • (1966) Nature , vol.211 , pp. 598-600
    • Pearse, A.G.E.1
  • 80
    • 0014022216 scopus 로고
    • Common cytochemical properties of cells producing polypeptide hormones, with particular reference to calcitonin and thyroid C cells
    • PEARSE A.G.E. (1966b) Common cytochemical properties of cells producing polypeptide hormones, with particular reference to calcitonin and thyroid C cells. Vet. Rec. 79, 587-590.
    • (1966) Vet. Rec. , vol.79 , pp. 587-590
    • Pearse, A.G.E.1
  • 81
    • 0014510423 scopus 로고
    • The cytochemistry and ultrastructure of polypeptide-producing cells of the APUD cells series and the embryologic, physiologic and pathologic implications of the concept
    • PEARSE A.G.E. (1969) The cytochemistry and ultrastructure of polypeptide-producing cells of the APUD cells series and the embryologic, physiologic and pathologic implications of the concept. J. Histochem. Cytochem. 17, 303-313.
    • (1969) J. Histochem. Cytochem. , vol.17 , pp. 303-313
    • Pearse, A.G.E.1
  • 82
    • 0000784660 scopus 로고
    • Neuroendocrine embryology and the APUD cell concept
    • PEARSE A.G.E. & TAKOR T. (1976) Neuroendocrine embryology and the APUD cell concept. Clin. Endocrinol. 5 (Suppl.), 299-344.
    • (1976) Clin. Endocrinol. , vol.5 , Issue.SUPPL. , pp. 299-344
    • Pearse, A.G.E.1    Takor, T.2
  • 83
    • 0002812936 scopus 로고
    • Clonality and endocrine (APUD) cell tumours
    • Eds. J.M. POLAK & S.L. BLOOM, Edinburgh: Churchill Livingstone
    • PEARSE A.G.E. (1984) Clonality and endocrine (APUD) cell tumours. In: Endocrine Tumours. Eds. J.M. POLAK & S.L. BLOOM, Edinburgh: Churchill Livingstone. pp. 82-94.
    • (1984) Endocrine Tumours , pp. 82-94
    • Pearse, A.G.E.1
  • 85
    • 0022534144 scopus 로고
    • Direct examination of the clonality of carcinogen-induced colonic epithelial dysplasia in chimeric mice
    • PONDER B.A.J. & WILKINSON M.M. (1986) Direct examination of the clonality of carcinogen-induced colonic epithelial dysplasia in chimeric mice. J. Natl. Cancer Inst. 77, 967-976.
    • (1986) J. Natl. Cancer Inst. , vol.77 , pp. 967-976
    • Ponder, B.A.J.1    Wilkinson, M.M.2
  • 86
    • 0025641727 scopus 로고
    • Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt
    • POTTEN C.S. & LOEFFLER M. (1990) Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110, 1001-1020.
    • (1990) Development , vol.110 , pp. 1001-1020
    • Potten, C.S.1    Loeffler, M.2
  • 87
    • 0018575901 scopus 로고
    • A comparison of cell replacement in bone marrow, and three regions of surface epithelium
    • PÖTTEN C.S., SCHOFIELD R. & LAJTHA L.G. (1979) A comparison of cell replacement in bone marrow, and three regions of surface epithelium. Biochem. Biophs Acta 566, 281-299.
    • (1979) Biochem. Biophs Acta , vol.566 , pp. 281-299
    • Pötten, C.S.1    Schofield, R.2    Lajtha, L.G.3
  • 88
    • 0013679644 scopus 로고    scopus 로고
    • The trefoil peptides
    • Eds. R. GOODLAD & N.A. WRIGHT, London: Balliere
    • POULSOM R. (1997) The Trefoil Peptides. In Growth factors and Cytokines in Gastroenterology. Eds. R. GOODLAD & N.A. WRIGHT, London: Balliere, pp. 156-188.
    • (1997) Growth Factors and Cytokines in Gastroenterology , pp. 156-188
    • Poulsom, R.1
  • 89
    • 0030888895 scopus 로고    scopus 로고
    • Making space for intestinal gene therapy
    • RAPER S.E. & WILSON J.M. (1997) Making space for intestinal gene therapy. Gastroenterology 112, 1753-1756.
    • (1997) Gastroenterology , vol.112 , pp. 1753-1756
    • Raper, S.E.1    Wilson, J.M.2
  • 90
    • 0027074792 scopus 로고
    • Spatial analysis of transcriptional activation in fetal rat jejunal and ileal gut epithelium
    • RUBIN D.C. (1992) Spatial analysis of transcriptional activation in fetal rat jejunal and ileal gut epithelium. Am. J. Physiol. 263, G853-G863.
    • (1992) Am. J. Physiol. , vol.263
    • Rubin, D.C.1
  • 91
    • 0021867338 scopus 로고
    • Cancer as a dynamic developmental disorder
    • RUBIN H. (1985) Cancer as a dynamic developmental disorder. Cancer Res. 45, 2935-2942.
    • (1985) Cancer Res. , vol.45 , pp. 2935-2942
    • Rubin, H.1
  • 92
    • 0028108164 scopus 로고
    • Use of isografts to study proliferation and differentiation programs of mouse stomach epithelia
    • RUBIN D.C., SWIETLICKI E. & GORDON J.I. (1994) Use of isografts to study proliferation and differentiation programs of mouse stomach epithelia. Am. J. Physiol. 26, G27-G39.
    • (1994) Am. J. Physiol. , vol.26
    • Rubin, D.C.1    Swietlicki, E.2    Gordon, J.I.3
  • 93
    • 0026764105 scopus 로고
    • Use of fetal intestinal isografts from normal and transgenic mice to study the programming of positional information along the duodenal-to-colonic axis
    • RUBIN D.C., SWIETLICKI E., ROTH K.A. & GORDON J.I. (1992) Use of fetal intestinal isografts from normal and transgenic mice to study the programming of positional information along the duodenal-to-colonic axis. J. Biol. Chem. 267, 15122-15133.
    • (1992) J. Biol. Chem. , vol.267 , pp. 15122-15133
    • Rubin, D.C.1    Swietlicki, E.2    Roth, K.A.3    Gordon, J.I.4
  • 94
    • 0013639472 scopus 로고
    • Crypt fission and crypt number in the small and large bowel of adult rats
    • ST CLAIR W.H. & OSBORNE J.W. (1985) Crypt fission and crypt number in the small and large bowel of adult rats. Cell Tissue Kinet. 14, 467-477.
    • (1985) Cell Tissue Kinet. , vol.14 , pp. 467-477
    • St Clair, W.H.1    Osborne, J.W.2
  • 95
    • 0023780022 scopus 로고
    • Development of the pattern of cell renewal in the crypt-villus unit of the chimaeric mouse small intestine
    • SCHMIDT G., WINTON D.J. & PONDER B.A.J. (1988) Development of the pattern of cell renewal in the crypt-villus unit of the chimaeric mouse small intestine. Development 103, 785-790.
    • (1988) Development , vol.103 , pp. 785-790
    • Schmidt, G.1    Winton, D.J.2    Ponder, B.A.J.3
  • 96
    • 0025070580 scopus 로고
    • On the clonal origin of tumours -lessons from studies of intestinal epithelium
    • SCHMIDT G.H. & MEAD R. (1990) On the clonal origin of tumours -lessons from studies of intestinal epithelium. Bioessays 12, 37-40.
    • (1990) Bioessays , vol.12 , pp. 37-40
    • Schmidt, G.H.1    Mead, R.2
  • 97
    • 0023682367 scopus 로고
    • The borderland between embryology and pathology in the gut epithelium
    • SCOTHORNE R.J. (1988) The borderland between embryology and pathology in the gut epithelium. Histopathology 13, 355-359.
    • (1988) Histopathology , vol.13 , pp. 355-359
    • Scothorne, R.J.1
  • 98
    • 0030843461 scopus 로고    scopus 로고
    • Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
    • SHIBATA H., TOYAMA K., SHIOYA H. ET AL. (1997) Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120-123.
    • (1997) Science , vol.278 , pp. 120-123
    • Shibata, H.1    Toyama, K.2    Shioya, H.3
  • 101
  • 102
    • 0028021751 scopus 로고
    • Clonal analysis of glandular stomach carcinogenesis in C3h/HeN Balb/c chimeric mice treated with N-methyl-N-nitrosourea
    • TATEMATSU M., FUKAMI H., YAMAMOTO M. ET AL. (1994) Clonal analysis of glandular stomach carcinogenesis in C3h/HeN Balb/c chimeric mice treated with N-methyl-N-nitrosourea. Cancer Lett. 83, 37-42.
    • (1994) Cancer Lett. , vol.83 , pp. 37-42
    • Tatematsu, M.1    Fukami, H.2    Yamamoto, M.3
  • 103
    • 0025011232 scopus 로고
    • Gastric endocrine cells share a clonal origin with other gastric cell lineages
    • THOMPSON M., FLEMING K., EVANS D.J. & WRIGHT N.A. (1990) Gastric endocrine cells share a clonal origin with other gastric cell lineages. Development 110, 477-481.
    • (1990) Development , vol.110 , pp. 477-481
    • Thompson, M.1    Fleming, K.2    Evans, D.J.3    Wright, N.A.4
  • 104
    • 0023390121 scopus 로고
    • The crypt cycle: Evidence for crypt and villus production in the adult mouse small intestine
    • TOTAFURNO J., BJERKNES M. & CHENG H. (1987) The crypt cycle: evidence for crypt and villus production in the adult mouse small intestine. Biophys. J. 52, 279-294.
    • (1987) Biophys. J. , vol.52 , pp. 279-294
    • Totafurno, J.1    Bjerknes, M.2    Cheng, H.3
  • 105
    • 0031667785 scopus 로고    scopus 로고
    • Tracing cell fates in human colorectal tumors from somatic microsatellite mutations. Evidence of adenomas with stem cell architecture
    • TSAO J.-L., ZHANG J., SALOVAARA R. ET AL. (1998) Tracing cell fates in human colorectal tumors from somatic microsatellite mutations. Evidence of adenomas with stem cell architecture. Am. J. Pathol 153, 1189-1200.
    • (1998) Am. J. Pathol , vol.153 , pp. 1189-1200
    • Tsao, J.-L.1    Zhang, J.2    Salovaara, R.3
  • 108
    • 0031877446 scopus 로고    scopus 로고
    • APC in the regulation of crypt fission
    • WASAN H.S., PARK H.S., LIU K.C. ET AL. (1998) APC in the regulation of crypt fission. J. Pathol. 185, 246-255.
    • (1998) J. Pathol. , vol.185 , pp. 246-255
    • Wasan, H.S.1    Park, H.S.2    Liu, K.C.3
  • 109
    • 0026629811 scopus 로고
    • A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonie mucosa
    • WILLIAMS E.D., LOWES A.P., WILLIAMS D. & WILLIAMS G.T. (1992) A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonie mucosa. Am. J. Pathol. 141, 773-776.
    • (1992) Am. J. Pathol. , vol.141 , pp. 773-776
    • Williams, E.D.1    Lowes, A.P.2    Williams, D.3    Williams, G.T.4
  • 110
    • 0025163541 scopus 로고
    • Stem cell organisation in mouse intestinal epithelium
    • WINTON D.J. & PONDER B.A.J. (1990) Stem cell organisation in mouse intestinal epithelium. Proc. Roy. Soc. B 241, 13-18.
    • (1990) Proc. Roy. Soc. B , vol.241 , pp. 13-18
    • Winton, D.J.1    Ponder, B.A.J.2
  • 111
    • 0014723302 scopus 로고
    • Microcolony survival assay for cells of mouse intestinal mucosa exposed to irradiation
    • WITHERS H.R. & ELKIND M.M. (1970) Microcolony survival assay for cells of mouse intestinal mucosa exposed to irradiation. Int. J. Rad. Biol. 17, 261-267.
    • (1970) Int. J. Rad. Biol. , vol.17 , pp. 261-267
    • Withers, H.R.1    Elkind, M.M.2
  • 112
    • 0032482198 scopus 로고    scopus 로고
    • Effects of forced expression of an N-terminal truncated β-catenin on mouse epithelial homeostasis
    • WONG M.H., RUBINFIELD B. & GORDON J.I. (1998) Effects of forced expression of an N-terminal truncated β-catenin on mouse epithelial homeostasis. J. Cell Biol. 141, 765-777.
    • (1998) J. Cell Biol. , vol.141 , pp. 765-777
    • Wong, M.H.1    Rubinfield, B.2    Gordon, J.I.3
  • 113
    • 0019975121 scopus 로고
    • The kinetics of villus cell populations in the mouse small intestine II. Studies on growth control after death of proliferative cells induced by cytosine arabinoside, with special reference to negative feedback mechanisms
    • WRIGHT N.A. & AL-NAFUSSI A.I. (1982) The kinetics of villus cell populations in the mouse small intestine II. Studies on growth control after death of proliferative cells induced by cytosine arabinoside, with special reference to negative feedback mechanisms. Cell Tissue Kinet. 15, 611-621.
    • (1982) Cell Tissue Kinet. , vol.15 , pp. 611-621
    • Wright, N.A.1    Al-Nafussi, A.I.2
  • 115
    • 0025293657 scopus 로고
    • Endocrine cells in non-endocrine tumours
    • WRIGHT N.A. (1990) Endocrine cells in non-endocrine tumours. J. Pathol. 161, 85-87.
    • (1990) J. Pathol. , vol.161 , pp. 85-87
    • Wright, N.A.1
  • 116
    • 0025139164 scopus 로고
    • Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in gastrointestinal stem cells
    • WRIGHT N.A., PIKE C. & ELIA G. (1990a) Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in gastrointestinal stem cells. Nature 343, 82-85.
    • (1990) Nature , vol.343 , pp. 82-85
    • Wright, N.A.1    Pike, C.2    Elia, G.3
  • 117
    • 0024998951 scopus 로고
    • Ulceration induces a novel epidermal-growth factor-secreting cell lineage in the human gastrointestinal mucosa
    • WRIGHT N.A., PIKE C. & ELIA G. (1990b) Ulceration induces a novel epidermal-growth factor-secreting cell lineage in the human gastrointestinal mucosa. Digestion 45, (Suppl. 2), 125-133.
    • (1990) Digestion , vol.45 , Issue.SUPPL. 2 , pp. 125-133
    • Wright, N.A.1    Pike, C.2    Elia, G.3
  • 118
    • 0025607961 scopus 로고
    • Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged gastrointestinal tissues
    • WRIGHT N.A., POULSOM R., STAMP G. ET AL. (1990c) Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged gastrointestinal tissues. J. Pathol. 162, 279-284.
    • (1990) J. Pathol. , vol.162 , pp. 279-284
    • Wright, N.A.1    Poulsom, R.2    Stamp, G.3
  • 119
    • 0000485076 scopus 로고
    • Stem cell repertoire in the intestine
    • Ed C.S. Potten, London: Academic Press
    • WRIGHT N.A. (1995) Stem cell repertoire in the intestine. In Stem Cells Ed C.S. Potten, London: Academic Press, pp. 315-330.
    • (1995) Stem Cells , pp. 315-330
    • Wright, N.A.1
  • 120
    • 0032884265 scopus 로고    scopus 로고
    • The origin of gut and pancreatic neuroendocrine (APUD) cells
    • WRIGHT N.A. (1999a) The origin of gut and pancreatic neuroendocrine (APUD) cells. J Pathol. 189, 439-440.
    • (1999) J Pathol. , vol.189 , pp. 439-440
    • Wright, N.A.1
  • 121
    • 0032856836 scopus 로고    scopus 로고
    • The origin of gut and pancreatic neuroendocrine (APUD) cells
    • WRIGHT N.A. (1999b) The origin of gut and pancreatic neuroendocrine (APUD) cells. J. Pathol. 189, 442-443.
    • (1999) J. Pathol. , vol.189 , pp. 442-443
    • Wright, N.A.1
  • 122
    • 0027533089 scopus 로고
    • Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease
    • WRIGHT N.A., POULSOM R., STAMP G. ET AL. (1993) Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterol. 104, 12-20.
    • (1993) Gastroenterol. , vol.104 , pp. 12-20
    • Wright, N.A.1    Poulsom, R.2    Stamp, G.3
  • 123
    • 0026689162 scopus 로고
    • Proliferating cell nuclear antigen in normal, preneoplastic and neoplastic colonic epithelium of the rat
    • YAMADA K., YOSHITAKA K., SATO M. & AHNEN D. (1992) Proliferating cell nuclear antigen in normal, preneoplastic and neoplastic colonic epithelium of the rat. Gastroenterol. 103, 160-167.
    • (1992) Gastroenterol. , vol.103 , pp. 160-167
    • Yamada, K.1    Yoshitaka, K.2    Sato, M.3    Ahnen, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.