Dose-dependent attenuation of heroin self-administration with lobeline

Journal of Psychopharmacology

Volumn 24, Issue 1, 2010, Pages 51-55

  Hart, N ^a   Rocha, A ^a   Miller, D K ^a   Nation, J R ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Heroin; Lobeline; Nicotinic receptors; Rat; Self administration

Indexed keywords

DIAMORPHINE; LOBELINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CATHETER; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG ACTIVITY; DRUG SELF ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEROIN; LOBELINE; MALE; NARCOTICS; NICOTINIC AGONISTS; RATS; RATS, SPRAGUE-DAWLEY; SELF ADMINISTRATION;

EID: 76249088864     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108092119     Document Type: Article

References (24)

1. Berridge, KC (2007) The debate over dopaminës role in reward: the case for incentive salience. Psychopharmacology 191: 391-431.
2. Bozarth, MA, Wise, RA (1981) Heroin reward is dependent on a dopamine substrate. Life Sci 29: 1881-1886.
3. Eyerman, DJ, Yamamoto, BK (2005) Lobeline attenuates methamphetamine- induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum. J Pharmacol Exp Ther 312: 160-169.
4. Felpin, F., Lebreton, J. (2004) History, chemistry and biology of alkaloids from Lobelia inflata. Tetrahedron 60: 10127-10153.
5. Fugelstad, A., Stenbacka, M., Leifman, A., Nylander, M., Thiblin, I. (2007) Methadone maintenance treatment: the balance between life-saving treatment and fatal poisonings. Addiction 102: 406-412.
6. Harrod, SB, Dwoskin, LP, Crooks, PA, Klebaur, JE, Bardo, MT (2001) Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther 298: 172-179.
7. Harrod, SB, Dwoskin, LP, Green, TA, Gehrke, BJ, Bardo, MT (2003) Lobeline does not serve as a reinforcer in rats. Psychopharmacology 165: 397-404.
8. Hyman, SE, Malenka, RC, Nestler, EF (2006) Neural mechanisms of addiction: the role of reward related learning and memory. Ann Rev Neurosci 29: 565-598.
9. Koob, GF, Le Moal, M. (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97-129.
10. Le Foll, B., Goldberg, SR, Sokoloff, P. (2005) The dopamine D3 receptor and drug dependence: effects on reward or beyond. Neuropharmacology 49: 525-541.
11. Miller, DK, Crooks, PA, Teng, L., Witkin, JM, Munzar, P., Goldberg, SR, et al. (2001) Lobeline inhibits the neurochemical and behavioral effects of amphetamine. J Pharmacol Exp Ther 296: 1023-1034.
12. Miller, DK, Lever, JR, Rodvelt, KR, Baskett, JA, Will, MJ, Kracke, GR (2007) Lobeline, a potential pharmacotherapy for drug addiction, binds to μ opioid receptors and diminishes the effects of opioid receptor agonists. Drug Alcohol Depend 89: 282-291.
13. Polston, JE, Cunningham, CS, Rodvelt, KR, Miller, DK (2006) Lobeline augments and inhibits cocaine-induced hyperactivity in rats. Life Sci 79: 981-990.
14. Rocha, A., Valles, R., Bratton, GR, Nation, JR (2008) Developmental lead exposure alters methamphetamine self-administration in the male rat: Acquisition and reinstatement. Drug and Alcohol Dependence 95 (1-2). 23-29.
15. Salamone, JD, Correa, M., Farrar, A., Mingote, SM (2007) Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology 191: 461-482.
16. Srivastava, A., Kahan, M. (2006) Methadone induction doses: are current practices safe. J Addict Dis 25: 5-13.
17. Stolerman, IP, Garcha, HS, Mirza, NR (1995) Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats. Psychopharmacology 117: 430-437.
18. Takahashi, N., Miner, LL, Sora, I., Ujike, H., Revay, RS, Kostic, V., et al. (1997) VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTPtoxicity. Proc Natl Acad Sci USA 94: 9938-9943.
19. Tatsuta, T., Kitanaka, N., Kitanaka, J., Morita, Y., Takemura, M. (2006) Lobeline attenuates methamphetamine-induced stereotypy in adolescent mice. Neurochem Res 31: 1359-1369.
20. Teng, L., Crooks, PA, Dwoskin, LP (1998) Lobeline displaces [3H] Dihydrotetrabenazine binding and releases [3H]Dopamine from rat striatal synaptic vesicles: comparison with d-Amphetamine. J Neurochem 71: 258-265.
21. Valles, R., Rocha, A., Cardon, A., Bratton, GR, Nation, JR (2005) The effects of the GABAA antagonist bicuculline on cocaine self-administration in rats exposed to lead during gestation/lactation. Pharmacology Biochemistry and Behavior 80 (4). 611-619.
22. White, FJ, Kalivas, PW (1998) Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend 51: 141-153.
23. Wise, RA, Bozarth, MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94: 469-492.
24. Zador, D. (2007) Methadone maintenance: making it better. Addiction 102: 350-351.