Thyrotropin secretion in mild and severe primary hypothyroidism is distinguished by amplified burst mass and basal secretion with increased spikiness and approximate entropy

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 2, 2010, Pages 928-934

  Roelfsema, Ferdinand ^a   Pereira, Alberto M ^a   Adriaanse, Ria ^b   Endert, Erik ^c   Fliers, Eric ^c   Romijn, Johannes A ^a   Veldhuis, Johannes D ^d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Department of Internal Medicine ^*  (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN;

ADULT; AGED; ARTICLE; AUTOMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENTROPY; FEMALE; HUMAN; HYPOTHYROIDISM; MALE; PRIORITY JOURNAL; THYROTROPIN RELEASE;

EID: 76149126979     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1959     Document Type: Article

References (44)

1. Mariotti S 2006 Normal physiology of the hypothalamo- pituitarythyroidal system and relation to the neural system and other endocrine gland. In: De Groot LJ, ed. Thyroid disease manager. Chap 4. www.thyroidmanager.com
2. Morley JE 1981 Neuroendocrine control of thyrotropin secretion. Endocr Rev 2:396-436
3. Weeke J, Laurberg P 1976 Diurnal TSH variations in hypothyroidism. J Clin Endocrinol Metab 43:32-37
4. Samuels MH, Veldhuis JD, Henry P, Ridgway EC 1990 Pathophysiology of pulsatile and copulsatile release of thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and α-subunit. J Clin Endocrinol Metab 71:425-432
5. Adriaanse R, Brabant G, Prank K, Endert E, Wiersinga WM 1992 Circadian changes in pulsatile TSH release in primary hypothyroidism. Clin Endocrinol (Oxf) 37:504-510
6. Veldhuis JD, Keenan DM, Pincus SM 2008 Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 29:823-864
7. Wiersinga WM, Chopra IJ 1982 Radioimmunoassay of thyroxine (T4), 3.5,3′-triiodothyronine (T3), 3,3′,5′-triiodothyronine (reverse T3), and 3,3′-diiodothyronine (T2). Methods Enzymol 84: 272-303
8. Keenan DM, Roelfsema F, Biermasz N, Veldhuis JD 2003 Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis. Am J Physiol Regul Integr Comp Physiol 285:R664-R673
9. Liu PY, Keenan DM, Kok P, Padmanabhan V, O'Byrne KT, Veldhuis JD 2009 Sensitivity and specificity of pulse detection using a new deconvolution method. Am J Physiol Endocrinol Metab 297: E538-E544
10. Pincus SM 2000 Irregularity and asynchrony in biologic network signals. Methods Enzymol 321:149-182
11. Veldhuis JD, Straume M, Iranmanesh A, Mulligan T, Jaffe C, Barkan A, Johnson ML, Pincus S 2001 Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. Am J Physiol Regul Integr Comp Physiol 280:R721-R729
12. Keenan DM, Veldhuis JD 2001 Hypothesis testing of the aging male gonadal axis via a biomathematical construct. Am J Physiol Regul Integr Comp Physiol 280:R1755-R1771
13. Pincus SM, Schmidt PJ, Palladino-Negro P, Rubinow DR 2008 Differentiation of women with premenstrual dysphoric disorder, recurrent brief depression, and healthy controls by daily mood rating dynamics. J Psychiatr Res 42:337-347
14. Bigos ST, Ridgway EC, Kourides IA, Maloof F 1978 Spectrum of pituitary alterations with mild and severe thyroid impairment. J Clin Endocrinol Metab 46:317-325
15. Patel YC, Alford FP, Burger HG 1972 The 24-hour plasma thyrotrophin profile. Clin Sci 43:71-77
16. Azukizawa M, Pekary AE, Hershman JM, Parker DC 1976 Plasma thyrotropin, thyroxine, and triiodothyronine relationships in man. J Clin Endocrinol Metab 43:533-542
17. Greenspan SL, Klibanski A, Schoenfeld D, Ridgway EC 1986 Pulsatile secretion of thyrotropin in man. J Clin Endocrinol Metab 63:661-668
18. Brabant G, Ranft U, Ocran K, Hesch RD, von zur Mühlen A 1986 Pulsatile pattern of thyrotropin-release in normal men. Clin Chim Acta 155:159-162
19. Uchiyama M, Ishibashi K, Enomoto T, Nakajima T, Shibui K, Hirokawa G, Okawa M 1998 Twenty-four hour profiles of four hormones under constant routine. Psychiatry Clin Neurosci 52:241-243
20. Russell W, Harrison RF, Smith N, Darzy K, Shalet S, Weetman AP, Ross RJ 2008 Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels. J Clin Endocrinol Metab 93:2300-2306
21. Roelfsema F, Pereira AM, Veldhuis JD, Adriaanse R, Endert E, Fliers E, Romijn JA 2009 Thyrotropin secretion profiles are not different in men and women. J Clin Endocrinol Metab 94:3964-3967
22. Roelfsema F, Biermasz NR, Frolich M, Keenan DM, Veldhuis JD, Romijn JA 2009 Diminished and irregular thyrotropin secretion with preserved diurnal rhythm in patients with active acromegaly. J Clin Endocrinol Metab 94:1945-1950
23. Roelfsema F, Pereira AM, Biermasz NR, Frolich M, Keenan DM, Veldhuis JD, Romijn JA 2009 Diminished and irregular TSH secretion with delayed acrophase in patients with Cushing's syndrome. Eur J Endocrinol 161:695-703
24. Kok P, Roelfsema F, Frölich M, van Pelt J, Meinders AE, Pijl H 2009 Bromocriptine reduces augmented thyrotropin secretion in obese premenopausal women. J Clin Endocrinol Metab 94: 1176-1181
25. Roelfsema F, Pereira AM, Keenan DM, Veldhuis JD, Romijn JA 2008 Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness. J Clin Endocrinol Metab 93:4052-4057
26. Keenan DM, Veldhuis JD 2003 Cortisol feedback state governs adrenocorticotropin secretory-burst shape, frequency and mass in a dual-waveform construct: time-of-day dependent regulation. Am J Physiol Regul Integr Comp Physiol 285:R950-R961
27. Veldhuis JD, Zwart A, Mulligan T, Iranmanesh A 2001 Muting of androgen negative feedback unveils impoverished gonadotropinreleasing hormone/luteinizing hormone secretory reactivity in healthy older men. J Clin Endocrinol Metab 86:529-535
28. Veldhuis JD, Bidlingmaier M, Anderson SM, Wu Z, Strasburger CJ 2001 Lowering total plasma insulin-like growth factor-I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men. J Clin Endocrinol Metab 86: 3304-3310
29. Miura Y, Perkel VS, Papenberg KA, Johnson MJ, Magner JA 1989 Concanavalin-A, lentil, and ricin lectin affinity binding characteristics of human thyrotropin: differences in the sialylation of thyrotropin in sera of euthyroid, primary, and central hypothyroid patients. J Clin Endocrinol Metab 69:985-995
30. Persani L, Terzolo M, Asteria C, Orlandi F, Angeli A, Beck-Peccoz P 1995 Circadian variations of thyrotropin bioactivity in normal subjects and patients with primary hypothyroidism. J Clin Endocrinol Metab 80:2722-2728
31. Weintraub BD, Szkudlinski MW 1999 Development and in vitro characterization of human recombinant thyrotropin. Thyroid 9:447-450
32. Persani L, Borgato S, Romoli R, Asteria C, Pizzocaro A, Beck-Peccoz P 1998 Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states. J Clin Endocrinol Metab 83:2486-2492
33. Szkudlinski MW, Thotakura NR, Tropea JE, Grossmann M, Weintraub BD 1995 Asparagine-linked oligosaccharide structures determine clearance and organ distribution of pituitary and recombinant thyrotropin. Endocrinology 136:3325-3330
34. Thotakura NR, Desai RK, Bates LG, Cole ES, Pratt BM, Weintraub BD1991 Biological activity and metabolic clearance of recombinant human thyrotropin produced in Chinese hamster ovary cells. Endocrinology 128:341-348
35. Odell WD, Utiger RD, Wilber JF, Condliffe PG 1967 Estimation of the secretion rate of thyrotropin in man. J Clin Invest 46:953-959
36. Oliveira JH, Barbosa ER, Kasamatsu T, Abucham J 2007 Evidence for thyroid hormone as a positive regulator of thyrotropin bioactivity. J Clin Endocrinol Metab 92:3108-3113
37. Horvath E, Kovacs K 1988 Fine structural cytology of the adenohypophysis in rat and man. J Electron Microsc Tech 8:401-432
38. Hirshberg B, Veldhuis JD, Sarlis NJ 2000 Diurnal thyrotropin secretion in short-term profound primary hypothyroidism: does it ever persist? Thyroid 10:1101-1106
39. degli Uberti EC, Farah AH, Lo Vecchio G, Bagni B, Trasforini G, Margutti A, Alvisi V 1981 Circadian variations of plasma TSH in patients with severe hypothyroidism. Ric Clin Lab 11:75-80
40. Chiamolera MI, Wondisford FE 2009 Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology 150:1091-1096
41. Radian S, Coculescu M, Morris JF 2003 Somatotroph to thyrotroph cell transdifferentiation during experimental hypothyroidism - a light and electron-microscopy study. J Cell Mol Med 7:297-306
42. Vidal S, Horvath E, Kovacs K, Cohen SM, Lloyd RV, Scheithauer BW 2000 Transdifferentiation of somatotrophs to thyrotrophs in the pituitary of patients with protracted primary hypothyroidism. Virchows Arch 436:43-51
43. Schmitt CP, Löcken S, Mehls O, Veldhuis JD, Lehnert T, Ritz E, Schaefer F 2003 PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation. J Am Soc Nephrol 14:407-414
44. Charmandari E, Pincus SM, Matthews DR, Johnston A, Brook CG, Hindmarsh PC 2003 Sexual dimorphism in the synchrony of joint growth hormone and cortisol dynamics in children with classic 21-hydroxylase deficiency. J Pediatr Endocrinol Metab 16:1119-1130