Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 10, 2008, Pages 4052-4057

  Roelfsema, Ferdinand ^a   Pereira, Alberto M ^a   Keenan, Daniel M ^b   Veldhuis, Johannes D ^c   Romijn, Johannes A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF VIRGINIA   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; ENTROPY; FEMALE; HUMAN; LABORATORY TEST; MALE; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PULSE RATE; THYROTROPIN RELEASE; THYROTROPIN SECRETING ADENOMA;

EID: 53749088321     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1145     Document Type: Article

References (33)

1. Morley JE 1981 Neuroendocrine control of thyrotropin secretion. Endocr Rev 2:396-436
2. Samuels MH, McDaniel PA 1997 Thyrotropin levels during hydrocortisone infusions that mimic fasting-induced cortisol elevations: a clinical research center study. J Clin Endocrinol Metab 82:3700-3704
3. Romijn JA, Adriaanse R, Brabant G, Prank K, Endert E, Wiersinga WM 1990 Pulsatile secretion of thyrotropin during fasting: a decrease of thyrotropin pulse amplitude. J Clin Endocrinol Metab 70:1631-1636
4. Roelfsema F, Frolich M 1991 Pulsatile thyrotropin release and thyroid function in acromegalics before and during subcutaneous octreotide infusion. J Clin Endocrinol Metab 72:77-82
5. Adriaanse R, Brabant G, Prank K, Endert E, Wiersinga WM 1992 Circadian changes in pulsatile TSH release in primary hypothyroidism. Clin Endocrinol (Oxf) 37:504-510
6. Adriaanse R, Brabant G, Endert E, Wiersinga WM 1994 Pulsatile thyrotropin secretion in patients with Cushing's syndrome. Metabolism 43:782-786
7. Kok P, Roelfsema F, Frolich M, Meinders AE, Pijl H 2005 Spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating leptin in obese premenopausal women. J Clin Endocrinol Metab 90:6185-6191
8. Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD 1996 Thyrotropin-secreting pituitary tumors. Endocr Rev 17:610-638
9. Van Aken MO, Pereira AM, van den Berg G, Romijn JA, Veldhuis JD, Roelfsema F 2004 Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease. Clin Endocrinol (Oxf) 60:765-772
10. Groote Veldman R, van den Berg G, Pincus SM, Frolich M, Veldhuis JD, Roelfsema F 1999 Increased episodic release and disorderliness of prolactin secretion in both micro- and macroprolactinomas. Eur J Endocrinol 140:192-200
11. Van den Berg, Frolich M, Veldhuis JD, Roelfsema F 1994 Growth hormone secretion in recently operated acromegalic patients. J Clin Endocrinol Metab 79:1706-1715
12. Veldhuis JD, Evans WS, Johnson ML 1995 Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: estimating basal secretion and neurohormone half-life by deconvolution analysis. Methods Neurosci 28:130-138
13. Keenan DM, Chattopadhyay S, Veldhuis JD 2005 Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood. J Theor Biol 236:242-255
14. Keenan DM, Alexander SL, Irvine CHG, Clarke IJ, Canny BJ, Scott CJ, Tilbrook AJ, Turner AI, Veldhuis JD 2004 Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements in interglandular signaling. Proc Natl Acad Sci USA 101:6740-6745
15. Keenan DM, Licinio J, Veldhuis JD 2001 A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis. Proc Natl Acad Sci USA 98:4028-4033
16. Keenan DM, Roelfsema F, Biermasz N, Veldhuis JD 2003 Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis. Am J Physiol Regul Integr Comp Physiol 285:R664-R673
17. Chattopadhyay S, Veldhuis JD, Keenan DM Probabilistic recovery of pulsatile, secretory and kinetic structure: an alternating discrete and continuous schema. Q Appl Math, in press
18. Pincus SM 1991 Approximate entropy as a measure of system complexity. Proc Natl Acad Sci USA 88:2297-2301
19. Pincus S, Singer BH 1996 Randomness and degrees of irregularity. Proc Natl Acad Sci USA 93:2083-2088
20. Veldhuis JD, Straume M, Iranmanesh A, Mulligan T, Jaffe C, Barkan A, Johnson ML, Pincus S 2001 Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. Am J Physiol Regul Integr Comp Physiol 280:R721-R729
21. Pincus SM, Schmidt PJ, Palladino-Negro P, Rubinow DR 2008 Differentiation of women with premenstrual dysphoric disorder, recurrent brief depression, and healthy controls by daily mood rating dynamics. J Psychiatr Res 42:337-347
22. Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G 1990 Twenty-four hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. J Clin Endocrinol Metab 71:1616-1623
23. Hartman ML, Veldhuis JD, Vance ML, Faria ACS, Furlanetto RW, Thorner MO 1990 Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. J Clin Endocrinol Metab 70:1375-1384
24. Van Aken MO, Pereira AM, van Thiel SW, van den Berg G, Frolich M, Veldhuis JD, Romijn JA, Roelfsema F 2005 Irregular and frequent cortisol secretory episodes with preserved diurnal rhythmicity in primary adrenal Cushing's syndrome. J Clin Endocrinol Metab 90:1570-1577
25. Evans WS, Anderson SM, Hull LT, Azimi PP, Bowers CY, Veldhuis JD 2001 Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1-44)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplemented states. J Clin Endocrinol Metab 86:700-712
26. Bowers CY, Granda R, Mohan S, Kuipers J, Baylink D, Veldhuis JD 2004 Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women. J Clin Endocrinol Metab 89:2290-2300
27. Veldhuis JD, Bidlingmaier M, Anderson SM, Wu Z, Strasburger CJ 2001 Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-Peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men. J Clin Endocrinol Metab 86:3304-3310
28. Veldhuis JD, Johnson ML, Veldhuis OL, Straume M, Pincus SM 2001 Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion. Am J Physiol Regul Integr Comp Physiol 281:R1975-R1985
29. Bonnefont X, Lacampagne A, Sanchez-Hormigo A, Fino E, Creff A, Mathieu MN, Smallwood S, Carmignac D, Fontanaud P, Travo P, Alonso G, Courtois-Coutry N, Pincus SM, Robinson IC, Mollard P 2005 Revealing the large-scale network organization of growth hormone-secreting cells. Proc Natl Acad Sci USA 102:16880-16885
30. Samuels MH, Wood WM, Gordon DF, Kleinschmidt-DeMasters BK, Lillehei K, Ridgway EC 1989 Clinical and molecular studies of a thyrotropin-secreting pituitary adenoma. J Clin Endocrinol Metab 68:1211-1215
31. Beckers A, Abs R, Mahler C, Vandalem JL, Pirens G, Hennen G, Stevenaert A 1991 Thyrotropin-secreting pituitary adenomas: report of seven cases. J Clin Endocrinol Metab 72:477-483
32. Adriaanse R, Brabant G, Endert E, Bemelman FJ, Wiersinga WM 1994 Pulsatile thyrotropin and prolactin secretion in a patient with a mixed thyrotropin- and prolactin-secreting pituitary adenoma. Eur J Endocrinol 130:113-120
33. Beck-Peccoz P, Persani L 1994 Variable biological activity of thyroid-stimulating hormone. Eur J Endocrinol 131:331-340