메뉴 건너뛰기




Volumn 7, Issue 11, 2006, Pages 485-496

Triazoloquinazolines as human A3 adenosine receptor antagonists: A QSAR study

Author keywords

Human A 3 receptor; QSAR; Triazoloquinazoline adenosine antagonist

Indexed keywords

ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; TRIAZOLOQUINAZOLINE DERIVATIVE;

EID: 33947322016     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/i7110485     Document Type: Article
Times cited : (7)

References (24)
  • 2
    • 0028946706 scopus 로고
    • Adenosine Receptor Subtypes: Characterization and Therapeutic Regulation
    • Olah, M. E.; Stiles, G. L. Adenosine Receptor Subtypes: Characterization and Therapeutic Regulation, Annu. Rev. Pharmacol. Toxicol. 1995, 35, 581-606.
    • (1995) Annu. Rev. Pharmacol. Toxicol , vol.35 , pp. 581-606
    • Olah, M.E.1    Stiles, G.L.2
  • 3
    • 0028242791 scopus 로고
    • Cellular mechanisms in ischemic preconditioning: The role of adenosine and protein kinase C
    • Downey, J. M.; Cohen, M. V.; Ytrehus, K.; Liu, Y. Cellular mechanisms in ischemic preconditioning: The role of adenosine and protein kinase C. Ann. NY Acad. Sci. 1994, 723, 82-98.
    • (1994) Ann. NY Acad. Sci , vol.723 , pp. 82-98
    • Downey, J.M.1    Cohen, M.V.2    Ytrehus, K.3    Liu, Y.4
  • 4
    • 0033594327 scopus 로고    scopus 로고
    • 5′-N-substituted carboxamidoadenosines as agonists for adenosine receptors
    • De Zwart, M.; Kourounakis, A.; Kooijman, H.; Spek, A. L.; Link, R. 5′-N-substituted carboxamidoadenosines as agonists for adenosine receptors. J. Med. Chem. 1999, 42, 1384-1392.
    • (1999) J. Med. Chem , vol.42 , pp. 1384-1392
    • De Zwart, M.1    Kourounakis, A.2    Kooijman, H.3    Spek, A.L.4    Link, R.5
  • 5
    • 0029089476 scopus 로고
    • A role for mast cells in adenosine A3 receptormediated hypotension in the rat
    • Hannon, J. P.; Pfannkuche, H. J.; Fozard, J. R. A role for mast cells in adenosine A3 receptormediated hypotension in the rat. Br. J. Pharmacol. 1995, 115, 945-952.
    • (1995) Br. J. Pharmacol , vol.115 , pp. 945-952
    • Hannon, J.P.1    Pfannkuche, H.J.2    Fozard, J.R.3
  • 6
    • 0027337474 scopus 로고
    • 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells
    • 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem. 1993, 268, 16887-16890.
    • (1993) J. Biol. Chem , vol.268 , pp. 16887-16890
    • Ramkumar, V.1    Stiles, G.L.2    Beaven, M.A.3    Ali, H.4
  • 8
    • 0030051539 scopus 로고    scopus 로고
    • Interactions of flavonoids and other phytochemicals with adenosine receptors
    • Ji, X. D.; Melman, N.; Jacobson, K. A. Interactions of flavonoids and other phytochemicals with adenosine receptors. J. Med. Chem. 1996, 39, 781-788.
    • (1996) J. Med. Chem , vol.39 , pp. 781-788
    • Ji, X.D.1    Melman, N.2    Jacobson, K.A.3
  • 9
    • 15444338833 scopus 로고    scopus 로고
    • Flavonoid derivatives as adenosine receptor antagonists: A comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model
    • Moro, S.; van Rhee, A. M.; Sanders, L. H.; Jacobson, K. A. Flavonoid derivatives as adenosine receptor antagonists: A comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model. J. Med. Chem. 1998, 41, 46-52.
    • (1998) J. Med. Chem , vol.41 , pp. 46-52
    • Moro, S.1    van Rhee, A.M.2    Sanders, L.H.3    Jacobson, K.A.4
  • 10
    • 0033602131 scopus 로고    scopus 로고
    • Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2,4- dialkylpyridine derivatives as selective A3 adenosine receptor antagonists
    • Li, A. H.; Moro, S.; Forsyth, N.; Melman, N.; Ji, X. D.; Jacobson, K. A. Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2,4- dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J. Med. Chem. 1999, 42, 706-721.
    • (1999) J. Med. Chem , vol.42 , pp. 706-721
    • Li, A.H.1    Moro, S.2    Forsyth, N.3    Melman, N.4    Ji, X.D.5    Jacobson, K.A.6
  • 11
    • 0029977331 scopus 로고    scopus 로고
    • Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors
    • Van Rhee, M.; Jiang, J. L.; Melman, N.; Olah, M. E.; Stiles, G. L.; Jacobson, K. A. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors. J. Med. Chem. 1996, 39, 2980-2989.
    • (1996) J. Med. Chem , vol.39 , pp. 2980-2989
    • Van Rhee, M.1    Jiang, J.L.2    Melman, N.3    Olah, M.E.4    Stiles, G.L.5    Jacobson, K.A.6
  • 12
    • 0029824179 scopus 로고    scopus 로고
    • 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists
    • Jiang, J. L.; van Rhee, A. M.; Melman, N.; Ji, X. D.; Jacobson, K. A. 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists. J. Med. Chem. 1996, 39, 4667-4675.
    • (1996) J. Med. Chem , vol.39 , pp. 4667-4675
    • Jiang, J.L.1    van Rhee, A.M.2    Melman, N.3    Ji, X.D.4    Jacobson, K.A.5
  • 13
    • 0029842517 scopus 로고    scopus 로고
    • Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype
    • Kim, Y. C.; Ji, X. D.; Jacobson, K. A. Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J. Med. Chem. 1996, 39, 4142-4148.
    • (1996) J. Med. Chem , vol.39 , pp. 4142-4148
    • Kim, Y.C.1    Ji, X.D.2    Jacobson, K.A.3
  • 14
    • 0031824990 scopus 로고    scopus 로고
    • Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A(2B) and A3 receptor subtypes
    • Kim, Y. C.; de Zwart, M.; Chang, L.; Moro, S.; Kunzel, J. K.; Von, F. D.; Melman, N.; Ijzerman, A. P.; Jacobson, K. A. Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A(2B) and A3 receptor subtypes. J. Med. Chem. 1998, 41, 2835-2845.
    • (1998) J. Med. Chem , vol.41 , pp. 2835-2845
    • Kim, Y.C.1    de Zwart, M.2    Chang, L.3    Moro, S.4    Kunzel, J.K.5    Von, F.D.6    Melman, N.7    Ijzerman, A.P.8    Jacobson, K.A.9
  • 16
    • 0032199176 scopus 로고    scopus 로고
    • 3 adenosine antagonists: Structural homology and receptor docking
    • 3 adenosine antagonists: Structural homology and receptor docking. J. Chem. Inf. Comput. Sci. 1998, 38, 1239-1248.
    • (1998) J. Chem. Inf. Comput. Sci , vol.38 , pp. 1239-1248
    • Moro, S.1    Li, A.H.2    Jacobson, K.A.3
  • 17
    • 0040914011 scopus 로고
    • p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
    • Hansch, C.; Fujita, T. p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure. J. Am. Chem. Soc. 1964, 86, 1616-1630.
    • (1964) J. Am. Chem. Soc , vol.86 , pp. 1616-1630
    • Hansch, C.1    Fujita, T.2
  • 18
    • 0001010885 scopus 로고
    • Representation of van der Waals (vdW) interactions in molecular mechanics force fields: Potential form, combination rules, and vdW parameters
    • Halgren, T. A. Representation of van der Waals (vdW) interactions in molecular mechanics force fields: Potential form, combination rules, and vdW parameters. J. Am. Chem. Soc. 1992, 114, 7827-7843.
    • (1992) J. Am. Chem. Soc , vol.114 , pp. 7827-7843
    • Halgren, T.A.1
  • 19
    • 0001061464 scopus 로고    scopus 로고
    • Merck molecular force field. IV. Conformational energies and geometries for MMFF94
    • Halgren, T. A.; Nachbar, R. B. Merck molecular force field. IV. Conformational energies and geometries for MMFF94. J. Comp. Chem. 1996, 19, 587-615.
    • (1996) J. Comp. Chem , vol.19 , pp. 587-615
    • Halgren, T.A.1    Nachbar, R.B.2
  • 20
    • 33748481964 scopus 로고
    • Charge equilibration for molecular dynamics simulations
    • Rappé, A. K.; Goddard, W. A. Charge equilibration for molecular dynamics simulations. J. Phys. Chem. 1991, 95, 3358-3363.
    • (1991) J. Phys. Chem , vol.95 , pp. 3358-3363
    • Rappé, A.K.1    Goddard, W.A.2
  • 21
    • 33947329262 scopus 로고    scopus 로고
    • Kubinyi, H. QSAR: Hansch Analysis and Related Approaches, VCH: WeinHeim, 1993; Methods and principles in medicinal chemistry, 1.
    • Kubinyi, H. QSAR: Hansch Analysis and Related Approaches, VCH: WeinHeim, 1993; Methods and principles in medicinal chemistry, Vol. 1.
  • 24
    • 10344253046 scopus 로고
    • Development and use of charged partial surface area structural descriptors in computer-assisted quantitative structure-property relationship studies
    • Stanton, T.; Jurs, P. C. Development and use of charged partial surface area structural descriptors in computer-assisted quantitative structure-property relationship studies. Anal. Chem. 1990, 62, 2323-2329.
    • (1990) Anal. Chem , vol.62 , pp. 2323-2329
    • Stanton, T.1    Jurs, P.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.