Generation of designer receptors exclusively activated by designer drugs (DREADDs) using directed molecular evolution

Current Protocols in Neuroscience

Volumn , Issue SUPPL.50, 2010, Pages

  Pei, Ying ^a   Dong, Shuyun ^a   Roth, Bryan L ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Chemical biology; Directed molecular evolution; DREADD; RASSL; Synthetic biology

Indexed keywords

DESIGNER DRUG; G PROTEIN COUPLED RECEPTOR;

ANIMAL CELL; CONTROLLED STUDY; DIRECTED MOLECULAR EVOLUTION; EXPRESSION VECTOR; FUNGAL STRAIN; FUNGUS GROWTH; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE LIBRARY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; MUTAGENESIS; NERVOUS SYSTEM; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; REVIEW; SIGNAL TRANSDUCTION; WILD TYPE; YEAST;

DESIGNER DRUGS; DIRECTED MOLECULAR EVOLUTION; DRUG DESIGN; GENE LIBRARY; HUMANS; MUTATION; RECEPTORS, G-PROTEIN-COUPLED; YEASTS;

EID: 75949093547     PISSN: 19348584     EISSN: 19348576     Source Type: Journal    
DOI: 10.1002/0471142301.ns0433s50     Document Type: Review

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