Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina

Phytotherapy Research

Volumn 24, Issue 2, 2010, Pages 259-263

  Carpinella, María C ^a   Andrione, Diego G ^a   Ruiz, Gustavo ^a   Palacios, Sara M ^a  

^a UNIVERSIDAD CATÓLICA DE CÓRDOBA   (Argentina)

Author keywords

Acetylcholinesterase inhibitors; Ellman's method; Plant extracts; TLC assay

Indexed keywords

ACETYLCHOLINESTERASE; ACHYROCLINE TOMENTOSA EXTRACT; ALCOHOL; EUPATORIUM VISCIDUM EXTRACT; PLANT EXTRACT; RUPRECHTIA APETALA EXTRACT; SOLVENT; TRICHOCLINE REPTANS EXTRACT; UNCLASSIFIED DRUG; ZANTHOXYLUM COCO EXTRACT;

ARGENTINA; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MEDICINAL PLANT; MOLECULE; NONHUMAN; PHYTOCHEMISTRY; SCREENING;

ARGENTINA; ASTERACEAE; CHOLINESTERASE INHIBITORS; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; POLYGONACEAE; RUTACEAE;

ACHYROCLINE TOMENTOSA; ASTERACEAE; EUPATORIUM; POLYGONACEAE; RUPRECHTIA APETALA; RUTACEAE; TRICHOCLINE; ZANTHOXYLUM;

EID: 75849155444     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2923     Document Type: Article

References (27)

1. Abdala LR, Seeligmann P. 1995. Natural distribution of flavonoids in Tagetes minuta. Biochem Syst Ecol 23: 567-568.
2. Alarcon SR, De la Fuente JR, Novara L, Sasa VE. 1998. A benzofuran and coumarins in Trichocline reptans Weed. An Asoc Quím Arg. 86: 248-251.
3. Bachurin SO. 2003. Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease. Med Res Rev 23: 48-88.
4. Berkov S, Codina C, Viladomat F, Bastida J. 2008. N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum. Bioorg Med Chem Lett 18: 2263-2266.
5. Carpinella MC, Ferrayoli CG, Palacios SM. 2005. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. J Agric Food Chem 53: 2922-2927.
6. Carpinella MC, Miranda M, Almirón WR, Ferrayoli CG, Ludueña Almeida F, Palacios SM. 2007. In vitro pediculicidal and ovicidal activity of an extract and oil from fruits of Melia azedarach L. J Am Acad Dermatol 56: 250-256.
7. Chung Y-K, Heo HJ, Kim E-K et al. 2001. Inhibitory effect of ursolic acid purified from Origanum majorana L. on the acetylcholinesterase. Mol Cells 11: 137-143.
8. Cowan MM. 1999. Plant products as antimicrobial agents. Clin Microbiol Rev 12: 564-582.
9. Di Giovanni S, Borloz A, Urbain A et al. 2008. In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: Thin layer chromatography versus microplate methods. Eur J Pharm Sci 33: 109-119.
10. El-Hassan A, El-Sayed M, Hamed AI et al. 2003. Bioactive constituents of Leptadenia arborrea. Fitoterapia 74: 184-187.
11. Ellman GL, Courtney KD, Andres V Jr, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88-95.
12. Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M. 2008. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorg Med Chem Lett 18: 2905-2909.
13. Ferraro GE, Martino VS, Villar SI, Coussio JD. 1985. Flavonoids from Achyrocline tomentosa. J Nat Prod 48: 817-818.
14. Hnatyszyn O, Moscatelli V, Rondina R et al. 2004. Flavonoids from Achyrocline satureioides with relaxant effects on the smooth muscle of guinea pig corpus cavernosum. Phytomedicine 11: 366-369.
15. Juarez BE, Mendiondo ME, Seeligmann P. 1995. Flavonoids from leaves and flowers of Liabum polymnioides and L. candidum (Asteraceae). Chemotaxonomical significance. Biochem Syst Ecol 23: 335-336.
16. Jung M, Park M. 2007. Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa. Molecules 12: 2130-2139.
17. Khalid A, Azim MK, Parveen S, Rahman A, Choudhary MI. 2005. Structural basis of acetylcholinesterase inhibition by triterpenoidal alkaloids. Biochem Biophs Res Commun 331: 1528-1532.
18. Mukherjee PK, Kumar V, Houghton PJ. 2007a. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 21: 1142-1145.
19. Mukherjee PK, Kumar V, Mal M, Houghton PJ. 2007b. Acetylcholinesterase inhibitors from plants. Phytomedicine 14: 289-300.
20. Palacios S M, Maggi ME, Bazán CM et al. 2007. Screening of Argentinian plants for pesticide activity. Fitoterapia 78: 580-584.
21. Perry NSL, Bollen C, Perry EK, Ballard C. 2003. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 75: 651-659.
22. Plum F. 1988. Demencias. In Cecil. Tratado de Medicina Interna, 18th edn, vol. 2, Wyngaarden JB, Smith LH (eds). Interamericana McGraw-Hill: México, 2311-2315.
23. Rhee K, van de Meent M, Ingkaninan K, Verpoorte R. 2001. Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. J Chromatogr A 915: 217-223.
24. Rhee IK, van Rijn RM, Verpoorte R. 2003. Qualitative determination of false positive effects in the acetylcholinesterase assay using thin layer chromatography. Phytochem Anal 14: 127-131.
25. Rollinger JM, Hornick A, Langer T, Stuppner H, Prast H. 2004. Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products. J Med Chem 47: 6248-6254.
26. Vuorela PM, Oinonen PP, Jokela JK, Hatakka AI. 2006. Linarin, a selective acetylcholinesterase inhibitor. Fitoterapia 77: 429-434.
27. Wagner H. Bladt S. 1996. Plant Drug Analysis: A Thin Layer Chromatography Atlas, 2nd edn. Springer-Verlag: Berlin, Heidelberg.