Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1659-1664

  Shi, Lei ^a   Yang, Ying ^a   Li, Zi Lin ^a   Zhu, Zhen Wei ^a   Liu, Chang Hong ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Inhibitors; Molecular docking; Monoamine oxidase; Nicotinamides; Structure activity relationship

Indexed keywords

2 BROMO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 2 BROMO N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 2 CHLORO 6 METHYL N(2 MORPHOLINOETHYL)NICOTINAMIDE; 2 CHLORO 6 METHYL N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 2 CHLORO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 2 CHLORO N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 2 HYDROXY N(2 MORPHOLINOETHYL)NICOTINAMIDE; 2 HYDROXY N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 4 CHLORO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 4 CHLORO N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 5 BROMO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 5 BROMO N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 5 CHLORO 6 HYDROXY N(2 MORPHOLINOETHYL)NICOTINAMIDE; 5,6 DICHLORO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 6 CHLORO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 6 CHLORO N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 6 FLUORO N(2 MORPHOLINOETHYL)NICOTINAMIDE; 6 FLUORO N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 6 HYDROXY N(2 MORPHOLINOETHYL)NICOTINAMIDE; 6 HYDROXY N(3 MORPHOLINOPROPYL)NICOTINAMIDE; 6 METHYL N(2 MORPHOLINOETHYL)NICOTINAMIDE; 6 METHYL N(3 MORPHOLINOPROPYL)NICOTINAMIDE; IPRONIAZID; MOCLOBEMIDE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; N(2 MORPHOLINOETHYL)NICOTINAMIDE; N(3 MORPHOLINOPROPYL)NICOTINAMIDE; NICOTINAMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NIACINAMIDE; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75849119637     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.065     Document Type: Article

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