-
1
-
-
0035450601
-
Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7
-
Aarons, E. J., S. Beddows, T. Willingham, L. Wu, and R. A. Koup. 2001. Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7. Virology 287:382-390.
-
(2001)
Virology
, vol.287
, pp. 382-390
-
-
Aarons, E.J.1
Beddows, S.2
Willingham, T.3
Wu, L.4
Koup, R.A.5
-
2
-
-
0842264042
-
Specific inhibition of HIV-1 coreceptor activity by synthetic peptides corresponding to the predicted extracellular loops of CCR5
-
Agrawal, L., Z. VanHorn-Ali, E. A. Berger, and G. Alkhatib. 2004. Specific inhibition of HIV-1 coreceptor activity by synthetic peptides corresponding to the predicted extracellular loops of CCR5. Blood 103:1211-1217.
-
(2004)
Blood
, vol.103
, pp. 1211-1217
-
-
Agrawal, L.1
VanHorn-Ali, Z.2
Berger, E.A.3
Alkhatib, G.4
-
3
-
-
0033012398
-
Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
-
Berger, E. A., P. M. Murphy, and J. M. Farber. 1999. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17:657-700.
-
(1999)
Annu. Rev. Immunol
, vol.17
, pp. 657-700
-
-
Berger, E.A.1
Murphy, P.M.2
Farber, J.M.3
-
4
-
-
0035524114
-
Improving the efficacy of antibody-based cancer therapies
-
Carter, P. 2001. Improving the efficacy of antibody-based cancer therapies. Nat. Rev. Cancer 1:118-129.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 118-129
-
-
Carter, P.1
-
5
-
-
0035000023
-
Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes
-
Cormier, E. G., D. N. Tran, L. Yukhayeva, W. C. Olson, and T. Dragic. 2001. Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes. J. Virol. 75:5541-5549.
-
(2001)
J. Virol
, vol.75
, pp. 5541-5549
-
-
Cormier, E.G.1
Tran, D.N.2
Yukhayeva, L.3
Olson, W.C.4
Dragic, T.5
-
6
-
-
0028209166
-
-
De Clercq, E., N. Yamamoto, R. Pauwels, J. Balzarini, M. Witvrouw, K. De Vreese, Z. Debyser, B. Rosenwirth, P. Peichl, R. Datema, et al. 1994. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. Agents Chemother. 38:668-674.
-
De Clercq, E., N. Yamamoto, R. Pauwels, J. Balzarini, M. Witvrouw, K. De Vreese, Z. Debyser, B. Rosenwirth, P. Peichl, R. Datema, et al. 1994. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. Agents Chemother. 38:668-674.
-
-
-
-
7
-
-
0032103997
-
Chemokine receptors and the clinical course of HIV-1 infection
-
de Roda Husman, A. M., and H. Schuitemaker. 1998. Chemokine receptors and the clinical course of HIV-1 infection. Trends Microbiol. 6:244-249.
-
(1998)
Trends Microbiol
, vol.6
, pp. 244-249
-
-
de Roda Husman, A.M.1
Schuitemaker, H.2
-
8
-
-
0030861238
-
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1
-
Doranz, B. J., Z. H. Lu, J. Rucker, T. Y. Zhang, M. Sharron, Y. H. Cen, Z. X. Wang, H. H. Guo, J. G. Du, M. A. Accavitti, R. W. Doms, and S. C. Peiper. 1997. Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J. Virol. 71:6305-6314.
-
(1997)
J. Virol
, vol.71
, pp. 6305-6314
-
-
Doranz, B.J.1
Lu, Z.H.2
Rucker, J.3
Zhang, T.Y.4
Sharron, M.5
Cen, Y.H.6
Wang, Z.X.7
Guo, H.H.8
Du, J.G.9
Accavitti, M.A.10
Doms, R.W.11
Peiper, S.C.12
-
9
-
-
0031984539
-
Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry
-
Dragic, T., A. Trkola, S. W. Lin, K. A. Nagashima, F. Kajumo, L. Zhao, W. C. Olson, L. Wu, C. R. Mackay, G. P. Allaway, T. P. Sakmar, J. P. Moore, and P. J. Maddon. 1998. Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry. J. Virol. 72:279-285.
-
(1998)
J. Virol
, vol.72
, pp. 279-285
-
-
Dragic, T.1
Trkola, A.2
Lin, S.W.3
Nagashima, K.A.4
Kajumo, F.5
Zhao, L.6
Olson, W.C.7
Wu, L.8
Mackay, C.R.9
Allaway, G.P.10
Sakmar, T.P.11
Moore, J.P.12
Maddon, P.J.13
-
10
-
-
34848868199
-
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
-
Huang, C. C., S. N. Lam, P. Acharya, M. Tang, S. H. Xiang, S. S. Hussan, R. L. Stanfield, J. Robinson, J. Sodroski, I. A. Wilson, R. Wyatt, C. A. Bewley, and P. D. Kwong. 2007. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science 317:1930-1934.
-
(2007)
Science
, vol.317
, pp. 1930-1934
-
-
Huang, C.C.1
Lam, S.N.2
Acharya, P.3
Tang, M.4
Xiang, S.H.5
Hussan, S.S.6
Stanfield, R.L.7
Robinson, J.8
Sodroski, J.9
Wilson, I.A.10
Wyatt, R.11
Bewley, C.A.12
Kwong, P.D.13
-
11
-
-
54249125999
-
Antiviral activity of single-dose PRO 140, a CCR5 monoclonal antibody, in HIV-infected adults
-
Jacobson, J. M., M. S. Saag, M. A. Thompson, M. A. Fischl, R. Liporace, R. C. Reichman, R. R. Redfield, C. J. Fichtenbaum, B. S. Zingman, M. C. Patel, J. D. Murga, S. M. Pemrick, P. D'Ambrosio, M. Michael, H. Kroger, H. Ly, Y. Rotshteyn, R. Buice, S. A. Morris, J. J. Stavola, P. J. Maddon, A. B. Kremer, and W. C. Olson. 2008. Antiviral activity of single-dose PRO 140, a CCR5 monoclonal antibody, in HIV-infected adults. J. Infect. Dis. 198:1345-1352.
-
(2008)
J. Infect. Dis
, vol.198
, pp. 1345-1352
-
-
Jacobson, J.M.1
Saag, M.S.2
Thompson, M.A.3
Fischl, M.A.4
Liporace, R.5
Reichman, R.C.6
Redfield, R.R.7
Fichtenbaum, C.J.8
Zingman, B.S.9
Patel, M.C.10
Murga, J.D.11
Pemrick, S.M.12
D'Ambrosio, P.13
Michael, M.14
Kroger, H.15
Ly, H.16
Rotshteyn, Y.17
Buice, R.18
Morris, S.A.19
Stavola, J.J.20
Maddon, P.J.21
Kremer, A.B.22
Olson, W.C.23
more..
-
12
-
-
68249114530
-
CD4-BFFI: A novel, bifunctional HIV-1 entry inhibitor with high and broad antiviral potency
-
Jekle, A., E. Chow, E. Kopetzki, C. Ji, M. J. Yan, R. Nguyen, S. Sankuratri, N. Cammack, and G. Heilek. 2009. CD4-BFFI: a novel, bifunctional HIV-1 entry inhibitor with high and broad antiviral potency. Antiviral Res. 83:257-266.
-
(2009)
Antiviral Res
, vol.83
, pp. 257-266
-
-
Jekle, A.1
Chow, E.2
Kopetzki, E.3
Ji, C.4
Yan, M.J.5
Nguyen, R.6
Sankuratri, S.7
Cammack, N.8
Heilek, G.9
-
13
-
-
33947406436
-
Novel CCR5 monoclonal antibodies with potent and broad-spectrum anti-HIV activities
-
Ji, C., M. Brandt, M. Dioszegi, A. Jekle, S. Schwoerer, S. Challand, J. Zhang, Y. Chen, L. Zautke, G. Achhammer, M. Baehner, S. Kroetz, G. Heilek-Snyder, R. Schumacher, N. Cammack, and S. Sankuratri. 2007. Novel CCR5 monoclonal antibodies with potent and broad-spectrum anti-HIV activities. Antiviral Res. 74:125-137.
-
(2007)
Antiviral Res
, vol.74
, pp. 125-137
-
-
Ji, C.1
Brandt, M.2
Dioszegi, M.3
Jekle, A.4
Schwoerer, S.5
Challand, S.6
Zhang, J.7
Chen, Y.8
Zautke, L.9
Achhammer, G.10
Baehner, M.11
Kroetz, S.12
Heilek-Snyder, G.13
Schumacher, R.14
Cammack, N.15
Sankuratri, S.16
-
14
-
-
64149095857
-
CD4-anchoring HIV-1 fusion inhibitor with enhanced potency and in vivo stability
-
Ji, C., E. Kopetzki, A. Jekle, K. G. Stubenrauch, X. Liu, J. Zhang, E. Rao, T. Schlothauer, S. Fischer, N. Cammack, G. Heilek, S. Ries, and S. Sankuratri. 2009. CD4-anchoring HIV-1 fusion inhibitor with enhanced potency and in vivo stability. J. Biol. Chem. 284:5175-5185.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 5175-5185
-
-
Ji, C.1
Kopetzki, E.2
Jekle, A.3
Stubenrauch, K.G.4
Liu, X.5
Zhang, J.6
Rao, E.7
Schlothauer, T.8
Fischer, S.9
Cammack, N.10
Heilek, G.11
Ries, S.12
Sankuratri, S.13
-
15
-
-
44349096289
-
-
Kopetzki, E., A. Jekle, C. Ji, E. Rao, J. Zhang, S. Fischer, N. Cammack, S. Sankuratri, and G. Heilek. 2008. Closing two doors of viral entry: intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1. Virol. J. 5:56.
-
Kopetzki, E., A. Jekle, C. Ji, E. Rao, J. Zhang, S. Fischer, N. Cammack, S. Sankuratri, and G. Heilek. 2008. Closing two doors of viral entry: intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1. Virol. J. 5:56.
-
-
-
-
16
-
-
40549092975
-
Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patients
-
Lalezari, J., G. K. Yadavalli, M. Para, G. Richmond, E. Dejesus, S. J. Brown, W. Cai, C. Chen, J. Zhong, L. A. Novello, M. M. Lederman, and G. M. Subramanian. 2008. Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patients. J. Infect. Dis. 197:721-727.
-
(2008)
J. Infect. Dis
, vol.197
, pp. 721-727
-
-
Lalezari, J.1
Yadavalli, G.K.2
Para, M.3
Richmond, G.4
Dejesus, E.5
Brown, S.J.6
Cai, W.7
Chen, C.8
Zhong, J.9
Novello, L.A.10
Lederman, M.M.11
Subramanian, G.M.12
-
17
-
-
54749134143
-
Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection
-
Landovitz, R. J., J. B. Angel, C. Hoffmann, H. Horst, M. Opravil, J. Long, W. Greaves, and G. Fatkenheuer. 2008. Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection. J. Infect. Dis. 198:1113-1122.
-
(2008)
J. Infect. Dis
, vol.198
, pp. 1113-1122
-
-
Landovitz, R.J.1
Angel, J.B.2
Hoffmann, C.3
Horst, H.4
Opravil, M.5
Long, J.6
Greaves, W.7
Fatkenheuer, G.8
-
18
-
-
0033515588
-
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
-
Lee, B., M. Sharron, C. Blanpain, B. J. Doranz, J. Vakili, P. Setoh, E. Berg, G. Liu, H. R. Guy, S. R. Durell, M. Parmentier, C. N. Chang, K. Price, M. Tsang, and R. W. Doms. 1999. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J. Biol. Chem. 274:9617-9626.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 9617-9626
-
-
Lee, B.1
Sharron, M.2
Blanpain, C.3
Doranz, B.J.4
Vakili, J.5
Setoh, P.6
Berg, E.7
Liu, G.8
Guy, H.R.9
Durell, S.R.10
Parmentier, M.11
Chang, C.N.12
Price, K.13
Tsang, M.14
Doms, R.W.15
-
19
-
-
15844388931
-
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiplyexposed individuals to HIV-1 infection
-
Liu, R., W. A. Paxton, S. Choe, D. Ceradini, S. R. Martin, R. Horuk, M. E. MacDonald, H. Stuhlmann, R. A. Koup, and N. R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiplyexposed individuals to HIV-1 infection. Cell 86:367-377.
-
(1996)
Cell
, vol.86
, pp. 367-377
-
-
Liu, R.1
Paxton, W.A.2
Choe, S.3
Ceradini, D.4
Martin, S.R.5
Horuk, R.6
MacDonald, M.E.7
Stuhlmann, H.8
Koup, R.A.9
Landau, N.R.10
-
20
-
-
34547642109
-
Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS
-
Meanwell, N. A., and J. F. Kadow. 2007. Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS. Curr. Opin. Investig. Drugs 8:669-681.
-
(2007)
Curr. Opin. Investig. Drugs
, vol.8
, pp. 669-681
-
-
Meanwell, N.A.1
Kadow, J.F.2
-
21
-
-
64049109934
-
Characterization of a human immunodefi-ciency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor
-
Nolan, K. M., G. Q. Del Prete, A. P. Jordan, B. Haggarty, J. Romano, G. J. Leslie, and J. A. Hoxie. 2009. Characterization of a human immunodefi-ciency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor. J. Virol. 83:3798-3809.
-
(2009)
J. Virol
, vol.83
, pp. 3798-3809
-
-
Nolan, K.M.1
Del Prete, G.Q.2
Jordan, A.P.3
Haggarty, B.4
Romano, J.5
Leslie, G.J.6
Hoxie, J.A.7
-
22
-
-
75749153479
-
-
Olson, W., T. J. Ketas, M. Franti, S. E. Kuhmann, J. P. Moore, and P. J. Maddon. 2006. The CCR5 mAB Pro 140 and small-molecule CCR5 antagonists possess complementary HIV-1 resistance profiles, poster H-241, p. 273. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
-
Olson, W., T. J. Ketas, M. Franti, S. E. Kuhmann, J. P. Moore, and P. J. Maddon. 2006. The CCR5 mAB Pro 140 and small-molecule CCR5 antagonists possess complementary HIV-1 resistance profiles, poster H-241, p. 273. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
-
-
-
-
23
-
-
0032902710
-
Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5
-
Olson, W. C., G. E. Rabut, K. A. Nagashima, D. N. Tran, D. J. Anselma, S. P. Monard, J. P. Segal, D. A. Thompson, F. Kajumo, Y. Guo, J. P. Moore, P. J. Maddon, and T. Dragic. 1999. Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5. J. Virol. 73:4145-4155.
-
(1999)
J. Virol
, vol.73
, pp. 4145-4155
-
-
Olson, W.C.1
Rabut, G.E.2
Nagashima, K.A.3
Tran, D.N.4
Anselma, D.J.5
Monard, S.P.6
Segal, J.P.7
Thompson, D.A.8
Kajumo, F.9
Guo, Y.10
Moore, J.P.11
Maddon, P.J.12
Dragic, T.13
-
24
-
-
15244353557
-
Variants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycan
-
Platt, E. J., D. M. Shea, P. P. Rose, and D. Kabat. 2005. Variants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycan. J. Virol. 79:4357-4368.
-
(2005)
J. Virol
, vol.79
, pp. 4357-4368
-
-
Platt, E.J.1
Shea, D.M.2
Rose, P.P.3
Kabat, D.4
-
25
-
-
34047271098
-
HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry
-
Pugach, P., A. J. Marozsan, T. J. Ketas, E. L. Landes, J. P. Moore, and S. E. Kuhmann. 2007. HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry. Virology 361:212-228.
-
(2007)
Virology
, vol.361
, pp. 212-228
-
-
Pugach, P.1
Marozsan, A.J.2
Ketas, T.J.3
Landes, E.L.4
Moore, J.P.5
Kuhmann, S.E.6
-
26
-
-
16044365432
-
Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity
-
Rucker, J., M. Samson, B. J. Doranz, F. Libert, J. F. Berson, Y. Yi, R. J. Smyth, R. G. Collman, C. C. Broder, G. Vassart, R. W. Doms, and M. Parmentier. 1996. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 87:437-446.
-
(1996)
Cell
, vol.87
, pp. 437-446
-
-
Rucker, J.1
Samson, M.2
Doranz, B.J.3
Libert, F.4
Berson, J.F.5
Yi, Y.6
Smyth, R.J.7
Collman, R.G.8
Broder, C.C.9
Vassart, G.10
Doms, R.W.11
Parmentier, M.12
-
27
-
-
16044373004
-
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
-
Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C. M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille, G. Muyldermans, C. Verhofstede, G. Burtonboy, M. Georges, T. Imai, S. Rana, Y. Yi, R. J. Smyth, R. G. Collman, R. W. Doms, G. Vassart, and M. Parmentier. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-725.
-
(1996)
Nature
, vol.382
, pp. 722-725
-
-
Samson, M.1
Libert, F.2
Doranz, B.J.3
Rucker, J.4
Liesnard, C.5
Farber, C.M.6
Saragosti, S.7
Lapoumeroulie, C.8
Cognaux, J.9
Forceille, C.10
Muyldermans, G.11
Verhofstede, C.12
Burtonboy, G.13
Georges, M.14
Imai, T.15
Rana, S.16
Yi, Y.17
Smyth, R.J.18
Collman, R.G.19
Doms, R.W.20
Vassart, G.21
Parmentier, M.22
more..
-
28
-
-
33847237614
-
Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
-
Westby, M., C. Smith-Burchnell, J. Mori, M. Lewis, M. Mosley, M. Stockdale, P. Dorr, G. Ciaramella, and M. Perros. 2007. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J. Virol. 81:2359-2371.
-
(2007)
J. Virol
, vol.81
, pp. 2359-2371
-
-
Westby, M.1
Smith-Burchnell, C.2
Mori, J.3
Lewis, M.4
Mosley, M.5
Stockdale, M.6
Dorr, P.7
Ciaramella, G.8
Perros, M.9
-
29
-
-
34247166544
-
The second extracellular loop of CCR5 contains the dominant epitopes for highly potent anti-human immunodeficiency virus monoclonal antibodies
-
Zhang, J., E. Rao, M. Dioszegi, R. Kondru, A. DeRosier, E. Chan, S. Schwoerer, N. Cammack, M. Brandt, S. Sankuratri, and C. Ji. 2007. The second extracellular loop of CCR5 contains the dominant epitopes for highly potent anti-human immunodeficiency virus monoclonal antibodies. Antimicrob. Agents Chemother. 51:1386-1397.
-
(2007)
Antimicrob. Agents Chemother
, vol.51
, pp. 1386-1397
-
-
Zhang, J.1
Rao, E.2
Dioszegi, M.3
Kondru, R.4
DeRosier, A.5
Chan, E.6
Schwoerer, S.7
Cammack, N.8
Brandt, M.9
Sankuratri, S.10
Ji, C.11
|