Design and study of peptide-based inhibitors of amylin cytotoxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1360-1362

  Muthusamy, Karen ^a   Arvidsson, Per I ^b,c   Govender, Patrick ^a   Kruger, Hendrik G ^a   Maguire, Glenn E M ^a   Govender, Thavendran ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UPPSALA UNIVERSITY   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Amylin; Cytotoxicity; N Methylated; Peptides

Indexed keywords

AMYLIN; AMYLIN INHIBITOR; ANTIDIABETIC AGENT; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; NONHUMAN; RAT;

EID: 75749130652     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.004     Document Type: Article

References (31)

1. World Health Organisation, 2008.
2. Opie E. J. Exp. Med. 5 (1901) 528
3. Cooper G.J.S., Willis A.C., Clark A., Turner R.C., Sim R.B., and Reid K.B.M. Proc. Natl. Acad. Sci. 84 (1987) 8628
4. Cooper G.J.S., Leighton B., Dimitriadis G.D., Parry-Billings M., Kowalchuk J.M., Howland K., Rothbard J.B., Willis A.C., and Reid K.B.M. Proc. Natl. Acad. Sci. 85 (1988) 7763
5. Martin C. Diabetes Educ. 32 (2006) 101
6. Grant A.D., and Brain S.D. Physiol. Rev. 84 (2004) 903
7. Kayed R., Bernhagen J., Greenfield N., Sweimeh K., Brunner H., Voelter W., and Kapurniotu A. J. Mol. Biol. 287 (1999) 781
8. Luca S., Yau W., Leapman R., and Tycko R. Biochemistry 46 (2007) 13505
9. Mirzabekov T.A., Lin M., and Kagan B.L. J. Biol. Chem. 271 (1996) 1988
10. Mattson M.P., and Goodman Y. Brain Res. 676 (1995) 219
11. Tomiyama T., Kaneko H., Kataoka K., Asano S., and Endo N. Biochem. J. 322 (1997) 859
12. Kapurniotu A., Bernhagen J., Greenfield N., Al-Abed Y., Teichberg S., Frank R.W., Voelter W., and Bucala R. Eur. J. Biochem. 251 (1998) 208
13. Bai J., Saafi E.L., Zhang S., and Cooper G.J.S. Biochem. J. 343 (1999) 53
14. Hiddinga H.J., and Eberhardt N.L. Am. J. Pathol. 154 (1999) 1077
15. Kapurniotu A., Schmauder A., and Tenidis K. J. Mol. Biol. 315 (2002) 339
16. Tatarek-Nossol M., Yan L., Schmauder A., Tenidis K., Westermark G., and Kapurniotu A. Chem. Biol. 12 (2005) 797
17. Yan L., Velkova A., Tatarek-Nossol M., Andreetto E., and Kapurniotu A. Angew. Chem., Int. Ed. 46 (2007) 1246
18. Janson J., Ashley R.H., Harrison D., McIntyre S., and Butler P.C. Diabetes 48 (1999) 491
19. Anguiano M., Nowak R.J., and Lansbury P.T. Biochemistry 41 (2002) 11338
20. Kayed R., Sokolov Y., Edmonds B., McIntire T.M., Milton S.C., Hall J.E., and Glabe G.C. J. Biol. Chem. 279 (2004) 46363
21. Ritzel R.A., Meier J.J., Lin C., Veldhuis J.D., and Butler P.C. Diabetes 56 (2007) 65
22. Meier J.J., Kayed R., Lin C., Gurlo T., Haataja L., Jayasinghe S., Langen R., Glabe C.G., and Butler P.C. Am. J. Physiol. Endocrinol. Metab. 291 (2006) E1317
23. Rijkers D.T.S., Hoppener J.W.M., Posthuma G., Lips C.J.M., and Liskamp R.M.J. Chem. Eur. J. 8 (2002) 4285
24. Westermark P., Engstrom U., Johnson K.H., Westermark G.T., and Betsholtz C. Proc. Natl. Acad. Sci. 87 (1990) 5036
25. Jaikaran E.T.A.S., Higham C.E., Serpell L.C., Zurdo J., Gross M., Clark A., and Fraser P.E. J. Mol. Biol. 308 (2001) 515
26. Abedini A., and Raleigh D.P. J. Mol. Biol. 355 (2006) 274
27. Yan L., Tatarek-Nossol M., Velkova A., Kazantzis A., and Kapurniotu A. Proc. Natl. Acad. Sci. 103 (2006) 2046
28. Scrocchi L.A., Chen Y., Waschuk S., Wang F., Cheung S., Darabie A.A., McLaurin J., and Fraser P.E. J. Mol. Biol. 318 (2002) 697
29. Scrocchi L.A., Ha K., Chen Y., Wu L., Wang F., and Fraser P.E. J. Struct. Biol. 141 (2003) 218
30. Potter K.J., Scrocchi L.A., Warnock G.L., Ao Z., Younker M.A., Rosenberg L., Lipsett M., Verchere C.B., and Fraser P.E. Biochim. Biophys. Acta (2009) 1
31. Bose P.P., Chatterjee U., Nerelius C., Govender T., Norström T., Gogoll G., Sandegren A., Gthelid E., Johansson J., and Arvidsson P.I. J. Med. Chem. 52 (2009) 8002