Molecular determinants of folate levels after leucovorin administration in colorectal cancer

Cancer Chemotherapy and Pharmacology

Volumn 65, Issue 4, 2010, Pages 735-742

  Sadahiro, Sotaro ^a   Suzuki, Toshiyuki ^a   Maeda, Yuji ^a   Tanaka, Akira ^a   Ogoshi, Kyoji ^a   Kamijo, Akemi ^a   Murayama, Chieko ^a   Tsukioka, Sayaka ^b   Sakamoto, Etsuko ^b   Fukui, Yousuke ^b   Oka, Toshinori ^b  

^a TOKAI UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

ABCC1; Colorectal cancer; Folate; FPGS; GGH; Leucovorin

Indexed keywords

ABC TRANSPORTER; ENZYME; FOLIC ACID; FOLINIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; GAMMA GLUTAMYL HYDROLASE; THYMIDYLATE SYNTHASE; UFT; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; PEPTIDE SYNTHASE; VITAMIN B COMPLEX;

ADULT; AGED; ARTICLE; BINDING ASSAY; CANCER TISSUE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLIC ACID BLOOD LEVEL; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; BLOOD; CLINICAL TRIAL; CLUSTER ANALYSIS; COLORECTAL TUMOR; CONTROLLED CLINICAL TRIAL; DRUG ADMINISTRATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL MODEL; TIME;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLUSTER ANALYSIS; COLORECTAL NEOPLASMS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLIC ACID; GAMMA-GLUTAMYL HYDROLASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUCOVORIN; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PEPTIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; VITAMIN B COMPLEX;

EID: 75749127853     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1079-5     Document Type: Article

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