New frontiers in gut nutrient sensor research: Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying: A possible therapy for patients with functional dyspepsia

Journal of Pharmacological Sciences

Volumn 112, Issue 1, 2010, Pages 33-36

  Kusano, Motoyasu ^a   Zai, Hiroaki ^b   Hosaka, Hiroko ^b   Shimoyama, Yasuyuki ^a   Nagoshi, Atsuto ^b   Maeda, Masaki ^b   Kawamura, Osamu ^b   Mori, Masatomo ^b  

^a GUNMA UNIVERSITY HOSPITAL   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Functional dyspepsia; Gastric emptying; Gastrointestinal tract; Monosodium L glutamate (MSG); Rome III criteria

Indexed keywords

CASEIN; GLUTAMATE SODIUM;

ARTICLE; CALORIC INTAKE; DYSPEPSIA; HUMAN; INTESTINE; NUTRIENT; PROTEIN DIET; RESEARCH; STOMACH EMPTYING;

EID: 75749093009     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09R08FM     Document Type: Article

References (36)

1. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut. 1999;45 Suppl 2:II37-II42.
2. Tack J, Talley NJ, Camilleri M, Holtman G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130:1466-1479.
3. Bisschops R, Karamanolis G, Arts J, Caenepeel P, Verbeke K, Janssens J, et al. Relationship between symptoms and ingestion of a meal in functional dyspepsia. Gut. 2008;57:1495-1503.
4. Malagelada JR, Stanghellini V. Manometric evaluation of functional upper gut symptoms. Gastroenterology. 1985;88: 1223-1231.
5. Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology. 1996;110:1036-1042.
6. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology. 1998;115:1346-1352.
7. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology. 2001;121:526-535.
8. Talley NJ, Locke GR III, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, et al. Functional dyspepsia, delayed gastric emptying and impaired quality of life. Gut. 2006;57:933-936.
9. Sarnelli G, Caenepeel P, Geypens B, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol. 2003;98:783-788
10. Cuomo R, Sarnelli G, Grasso R, Bruzzese D, Pumpo R, Salomon M, et al. Functional dyspepsia symptoms, gastric emptying and satiety provocative test: analysis of relationships. Scand J Gastroenterol. 2001;36:1030-1036.
11. Vasilevskaia LS, Rymshina MV, Shlygin GK. [Effect of glutamate and combined with inosine monophosphate on gastric secretion]. Vopr Pitan. 1993:29-33. (text in Russian with English abstract)
12. Spielman AI. Interaction of saliva and taste. J Dent Res. 1990;69:838-843.
13. Ohara I, Otsuka SI, Yugari Y. The influence of carrier of gustatory stimulation on the cephalic phase of canine pancreatic secretion. J Nutr. 1979;109:2098-2105.
14. Ohara I, Otsuka S, Yugari Y. Cephalic phase response of pancreatic exocrine secretion in conscious dogs. Am J Physiol. 1988;254:G424-G428.
15. Raybould HE. Visceral perception: sensory transduction in visceral afferents and nutrients. Gut. 2002;51 Suppl 1:i11-i14.
16. Graham TE, Sgro V, Friars D, Gibala MJ. Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans. Am J Physiol Endocrinol Metab. 2000;278:E83-E89.
17. Lindemann B. A taste for umami. Nat Neurosci. 2000;3:99-100.
18. Lindemann B. Receptors and transduction in taste. Nature. 2001;413:219-225.
19. Toyono T, Seta Y, Kataoka S, Harada H, Morotomi T, Kawano S, et al. Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. Arch Histol Cytol. 2002;65:91-96.
20. Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res. 2003;313:29-35.
21. Chaudhari N, Landin AM, Roper SD. A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci. 2000;3:113-119.
22. San Gabriel A, Uneyama H, Yoshie S, Torii K. Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli. Chem Senses. 2005;30 Suppl 1:i25-i26.
23. Nelson G, Chandrashekar J, Hoon MA, Feng L, Ahao G, Ryba NJ, et al. An amino-acid taste receptor. Nature. 2002;416:199-202.
24. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, et al. The receptors for mammalian sweet and umami taste. Cell. 2003;115:255-266.
25. Schwartz GJ, Moran TH. Duodenal nutrient exposure elicits nutrient-specific gut motility and vagal afferent signals in rat. Am J Physiol 1998;274:R1236-R1242.
26. Bezencon C, le Coutre J, Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses. 2007;32:41-49.
27. San Gabriel AM, Maekawa T, Uneyama H, Yoshie S, Torii K. mGluR1 in the fundic glands of rat stomach. FEBS Lett. 2007;581:1119-1123.
28. Uneyama H, Niijima A, San Gabriel A, Torii K. Luminal amino acid sensing in the rat gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 2006;291:G1163-G1170.
29. Zai H, Kusano M, Hosaka H. Shimoyama Y, Nagoshi A, Maeda M, et al. Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying. Am J Clin Nutr. 2009;89:431-435.
30. Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993;104:1640-1647.
31. Braden B, Adams S, Duan LP, Orth KH, Maul FD, Lembcke B, et al. The [13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals. Gastroenterology. 1995;108:1048-1055.
32. Kumar D, Wingate D. An illustrated guide to gastrointestinal motility. 2nd ed. In: Burks TF, editor. Actions of pharmacological agents on gastrointestinal function. London: Churchill communications Europe; 1993. p. 144-161.
33. Drossman DA. Pharmacological and pharmacokinetic aspects of functional disorders. In: Camilleri M, Bueno L, Ponti FD, Fioramonti J, Lydiard RB, Tack J, editors. The functional gastrointestinal disorders (Rome III). Mclean, Virginia: Degnon Associates, Inc.; 2006. p. 161-230.
34. Duan LP, Braden B, Caspary WF, Lembcke B. Influence of cisapride on gastric emptying of solids and liquids monitored by 13C breath tests. Dig Dis Sci. 1995;40:2200-2206.
35. Verhagen MA, Samsom M, Maes B, Geypens BJ, Ghoos YF, Smout AJ. Effects of a new motilide, ABT-229, on gastric emptying and postprandial antroduodenal motility in healthy volunteers. Aliment Pharmacol Ther. 1997;11:1077-1086.
36. Yamaguchi S. Basic properties of umami and effects on humans. Physiol Behav 1991;49:833-841.