Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manner

Nephrology Dialysis Transplantation

Volumn 25, Issue 2, 2010, Pages 364-372

  Ishizawa, Keisuke ^a   Izawa Ishizawa, Yuki ^a   Dorjsuren, Narantungalag ^a   Miki, Erika ^a   Kihira, Yoshitaka ^a   Ikeda, Yasumasa ^a   Hamano, Shuichi ^a   Kawazoe, Kazuyoshi ^a   Minakuchi, Kazuo ^a   Tomita, Shuhei ^a   Tsuchiya, Koichiro ^a   Tamaki, Toshiaki ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Angiotensin II receptor blocker; Big mitogen activated protein kinase 1; Mesangial cells; Oxidative stress; Platelet derived growth factor

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 7; OLMESARTAN; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; GLOMERULONEPHRITIS; MALE; MESANGIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; CELL MOVEMENT; CELLS, CULTURED; IMIDAZOLES; MALE; MESANGIAL CELLS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 75649123444     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp520     Document Type: Article

References (39)

1. Lewis EJ, Hunsicker LG, Clarke WR et al. Renoprotective effectofthe angiotensin-receptor antagonist irbesartan in patients with nephropa-thy due to type 2 diabetes. N Engl J Med 2001; 345: 851-860
2. Brenner BM, Cooper ME, de Zeeuw D et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861-869 (Pubitemid 34940825)
3. Remuzzi G, Schieppati A, Ruggenenti P. Clinical practice. Nephropa-thy in patients with type 2 diabetes. N Engl J Med 2002; 346: 1145-1151
4. Viberti G, Wheeldon NM. Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. Circulation 2002; 106: 672-678
5. Parving HH, Lehnert H, Brochner-Mortensen J et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345: 870-878 (Pubitemid 34940826)
6. Ogawa S, Mori T, Nako K et al. Angiotensin II type 1 receptor block-ers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy. Hypertension 2006; 47: 699-705
7. Yao L, Kobori H, Rahman M et al. Olmesartan improves endothelin-induced hypertension and oxidative stress in rats. Hypertens Res 2004; 27: 493-500
8. Shao J, Nangaku M, Inagi R et al. Receptor-independent intracellu-lar radical scavenging activity of an angiotensin II receptor blocker. J Hypertens 2007; 25: 1643-1649
9. Ishizawa K, Yoshizumi M, Tsuchiya K et al. Dual effects of endothelin-1 (1-31): induction of mesangial cell migration and facilitation of monocyte recruitment through monocyte chemoattractant protein-1 production by mesangial cells. Hypertens Res 2004; 27: 433-440
10. Kagami S, Kondo S, Loster K et al. Alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells is differentially regulated by transforming growth factor-beta and platelet-derived growth factor-BB. J Am Soc Nephrol 1999; 10: 779-789
11. Kohno M, Yasunari K, Minami M et al. Regulation of rat mesangial cell migration by platelet-derived growth factor, angiotensin II, and adrenomedullin. J Am Soc Nephrol 1999; 10: 2495-2502
12. Floege J, Eng E, Young BA et al. Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. J Clin Invest 1993; 92: 2952-2962
13. Isaka Y, Fujiwara Y, Ueda N et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 1993; 92: 2597-2601
14. Johnson RJ, Raines EW, Floege J et al. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 1992; 175: 1413-1416
15. Silver BJ, Jaffer FE, Abboud HE. Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Proc Natl Acad Sci USA 1989; 86: 1056-1060
16. Kelly DJ, Gilbert RE, Cox AJ et al. Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy. J Am Soc Nephrol 2001; 12: 2098-2107
17. 2 production requires the activation of phosphatidyli-nositol 3-kinase. J Biol Chem 2000; 275: 10527-10531
18. Weber DS, Taniyama Y, Rocic P et al. Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration. Circ Res 2004; 94: 1219-1226
19. ten Freyhaus H, Huntgeburth M, Wingler K et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemo-taxis, but not proliferation. Cardiovasc Res 2006; 71: 331-341
20. Kwan J, Wang H, Munk S et al. In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species. Kidney Int 2005; 68: 2526-2541
21. Kagami S, Urushihara M, Kitamura A et al. PDGF-BB enhances alpha1beta1 integrin-mediated activation of the ERK/AP-1 pathway involved in collagen matrix remodeling by rat mesangial cells. J Cell Physiol 2004; 198: 470-478
22. Harper L, Kashiwagi Y, Pusey CD et al. Platelet-derived growth factor reorganizes the actin cytoskeleton through 3-phosphoinositide-dependent and 3-phosphoinositide-independent mechanisms in human mesangial cells. Nephron Physiol 2007; 107: 45-56
23. Lee JD, Ulevitch RJ, Han J. Primary structure of BMK1: a new mammalian map kinase. Biochem Biophys Res Commun 1995; 213: 715-724
24. Suzaki Y, Yoshizumi M, Kagami S et al.Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J Biol Chem 2002; 277: 9614-9621
25. Suzaki Y, Yoshizumi M, Kagami S et al. BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions. Kidney Int 2004; 65: 1749-1760
26. Choudhury GG, Mahimainathan L, Das F et al. c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells. Cell Signal 2006; 18: 1854-1864
27. Izawa Y, Yoshizumi M, Ishizawa K et al. Big mitogen-activated protein kinase1 (BMK1)/ERK5 is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration. Hypertens Res 2007; 30: 1107-1117
28. Ishizawa K, Izawa Y, Ito H et al. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension 2005; 46: 1046-1052
29. Kyaw M, Yoshizumi M, Tsuchiya K et al. Antioxidants inhibit endothelin-1 (1-31)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1). Biochem Pharmacol 2002; 64: 1521-1531
30. Abe J, Takahashi M, Ishida M et al. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1. J Biol Chem 1997; 272: 20389-20394
31. Zahner G, Wolf G, Schroeder S et al. Inhibition of platelet-derived growth factor-induced mesangial cell proliferation by cyclooxygenase-2 overexpression is abolished through reactive oxygen species. FEBS Lett 2006; 580: 2523-2528
32. Akishita M, Nagai K, Xi H et al. Renin-angiotensin system modulates oxidative stress-induced endothelial cell apoptosis in rats. Hypertension 2005; 45: 1188-1193
33. Cianchetti S, Del Fiorentino A, Colognato R et al. Anti-inflammatory and anti-oxidant properties of telmisartan in cultured human umbilical vein endothelial cells. Atherosclerosis 2008; 198: 22-28
34. Sirvent A, Boureux A, Simon V et al. The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene 2007; 26: 7313-7323
35. Catarzi S, Biagioni C, Giannoni E et al. Redox regulation of platelet-derived-growth-factor-receptor: role of NADPH-oxidase and c-Src tyrosine kinase. Biochim Biophys Acta 2005; 1745: 166-175
36. Gorin Y, Ricono JM, Kim NH et al. Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 2003; 285: F219-F229
37. Jones SA, Hancock JT, Jones OT et al. The expression of NADPH oxidase components in human glomerular mesangial cells: detection of protein and mRNA for p47phox, p67phox, and p22phox. J Am Soc Nephrol 1995; 5: 1483-1491
38. Touyz RM, Yao G, Schiffrin EL. c-Src induces phosphorylation and translocation of p47phox: roleinsuperoxide generationbyangiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23: 981-987
39. Montezano AC, Callera GE, Yogi A et al. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler Thromb Vasc Biol 2008; 28: 1511-1518