Synthesis and in vitro evaluation of bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1355-1359

  Tanaka, Kelly S E ^a   Dietrich, Evelyne ^a   Ciblat, Stéphane ^a   Métayer, Claude ^a   Arhin, Francis F ^a   Sarmiento, Ingrid ^a   Moeck, Gregory ^a   Parr Jr , Thomas R ^a   Far, Adel Rafai ^a  

^a The Medicines Company   (Canada)

Author keywords

Glycopeptides; Osteomyelitis; Prodrugs

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; ORITAVANCIN; ORITAVANCIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; PRODRUG; UNCLASSIFIED DRUG; VANCOMYCIN; VANCOMYCIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OSTEOMYELITIS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; GLYCOPEPTIDES; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OSTEOMYELITIS; PRODRUGS; RATS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 75449116595     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.006     Document Type: Article

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