Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitis

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 20, 2008, Pages 9217-9229

  Tanaka, Kelly S E ^a   Houghton, Tom J ^a   Kang, Ting ^a   Dietrich, Evelyne ^a   Delorme, Daniel ^a   Ferreira, Sandra S ^a   Caron, Laurence ^a   Viens, Frederic ^a   Arhin, Francis F ^a   Sarmiento, Ingrid ^a   Lehoux, Dario ^a   Fadhil, Ibtihal ^a   Laquerre, Karine ^a   Liu, Jing ^a   Ostiguy, Valérie ^a   Poirier, Hugo ^a   Moeck, Gregory ^a   Parr Jr , Thomas R ^a   Rafai Far, Adel ^a  

^a Targanta Therapeutics Inc   (Canada)

Author keywords

Bisphosphonates; Drug delivery; Fluoroquinolone; Osteomyelitis; Prodrug

Indexed keywords

1,1 BISPHOSPHONOMETHYLCARBAMOYL)METHYL 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 7 (OCTAHYDROPYRROLO[3,4 B]PYRIDIN 6 YL) 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLATE; 1,1 BISPHOSPHONOMETHYLCARBAMOYL)METHYL 7 (3 METHYLPIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXOQUINOLINE 3 CARBOXYLATE; BISPHOSPHONIC ACID DERIVATIVE; CIPROFLOXACIN; GATIFLOXACIN; MOXIFLOXACIN; PRODRUG; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; FEMALE; INFECTION PREVENTION; NONHUMAN; OSTEOMYELITIS; RAT; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; TIBIA;

ANIMALS; DISEASE MODELS, ANIMAL; ESTERS; FEMALE; FLUOROQUINOLONES; HUMANS; MOLECULAR STRUCTURE; OSTEOMYELITIS; PHOSPHONIC ACIDS; PRODRUGS; RATS;

BACTERIA (MICROORGANISMS);

EID: 53249107123     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.010     Document Type: Article

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