Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterials

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2338-2341

  Herczegh, Pál ^a   Buxton, Thomas B ^b   McPherson III, James C ^b   Kovács Kulyassa, Árpád ^a,e   Brewer, Phyllis D ^b   Sztaricskai, Ferenc ^a   Stroebel, Gary G ^c   Plowman, Kent M ^b   Farcasiu, Dan ^d   Hartmann, John F ^d  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b Eisenhower Army Medical Center   (Georgia)

^c AUGUSTA STATE UNIVERSITY   (United States)

^d ElizaNor Biopharmaceuticals Inc   (United States)

^e UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

7 [4 (2,2 BISPHOSPHONOETHYL)PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [2,2 BIS(DIETHOXYPHOSPHORYL)ETHYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [BIS(DIETHOXYPHOSPHORYL)METHYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; ANTIBIOTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CIPROFLOXACIN; ENOXACIN; NORFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIOSTASIS; CONTROLLED STUDY; DRUG ADSORPTION; DRUG BINDING; DRUG CONJUGATION; DRUG POTENCY; ESTERIFICATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-INFECTIVE AGENTS; BONE AND BONES; CIPROFLOXACIN; DIPHOSPHONATES; ENOXACIN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HYDROGEN-ION CONCENTRATION; MICROBIAL SENSITIVITY TESTS; NORFLOXACIN; PIPERAZINES; QUINOLONES; RATS; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0037161604     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0105326     Document Type: Article

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