Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1420-1423

  Zhang, Zhenfa ^a   Pivavarchyk, Marharyta ^a   Subramanian, Karunai Leela ^a   Deaciuc, A Gabriela ^a   Dwoskin, Linda P ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

Dopamine release; Nicotine addiction; Nicotinic acetylcholine receptor; Quaternary ammonium

Indexed keywords

BIS 2,2,6,6 TETRAMETHYLPIPERIDINE; NICOTINE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DOPAMINE RELEASE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; DOPAMINE; INHIBITORY CONCENTRATION 50; MECAMYLAMINE; MOLECULAR STRUCTURE; NICOTINE; NICOTINIC ANTAGONISTS; PIPERIDINES; RATS; RECEPTORS, NICOTINIC;

RATTUS;

EID: 75449111472     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.089     Document Type: Article

References (22)

1. http://www.who.int/tobacco/en/.
2. George T.P., and O'Malley S.S. Trends Pharmacol. Sci. 25 (2004) 42
3. Rose J.E., Westman E.C., Behm F.M., Johnson M.P., and Goldberg J.S. Pharmacol. Biochem. Behav. 62 (1999) 165
4. Dwoskin L.P., Pivavarchyk M., Joyce B.M., Neugebauer N.M., Zheng G., Zhang Z., Bardo M.T., and Crooks P.A. Nebr. Symp. Motiv. 55 (2009) 31
5. Rang H.P. Postgrad. Med. J. 57 (1981) 89
6. Zheng G., Zhang Z., Pivavarchyk M., Deaciuc A.G., Dwoskin L.P., and Crooks P.A. Bioorg. Med. Chem. Lett. 17 (2007) 6734
7. Zhang Z., Lockman P.R., Mittapalli R.K., Allen D.D., Dwoskin L.P., and Crooks P.A. Bioorg. Med. Chem. Lett. 18 (2008) 5622
8. Zheng G., Sumithran S.P., Deaciuc A.G., Dwoskin L.P., and Crooks P.A. Bioorg. Med. Chem. Lett. 17 (2007) 6701
9. Zheng G., Zhang Z., Pivavarchyk M., Deaciuc A.G., Dwoskin L.P., and Crooks P.A. Bioorg. Med. Chem. Lett. 18 (2008) 5753
10. Dwoskin L.P., Sumithran S.P., Zhu J., Deaciuc A.G., Ayers J.T., and Crooks P.A. Bioorg. Med. Chem. Lett. 14 (2004) 1863
11. Albayati Z.A., Dwoskin L.P., and Crooks P.A. Drug Metab. Dispos. 36 (2008) 2024
12. Dwoskin L.P., Wooters T.E., Sumithran S.P., Siripurapu K.B., Joyce B.M., Lockman P.R., Manda V.K., Ayers J.T., Zhang Z., Deaciuc A.G., McIntosh J.M., Crooks P.A., and Bardo M.T. J. Pharmacol. Exp. Ther. 326 (2008) 563
13. Lockman P.R., Manda V.K., Geldenhuys W.J., Mittapalli R.K., Thomas F., Albayati Z.F., Crooks P.A., Dwoskin L.P., and Allen D.D. J. Pharmacol. Exp. Ther. 324 (2008) 244
14. Damaj M.I., Wiley J.L., Martin B.R., and Papke R.L. Eur. J. Pharmcol. 521 (2005) 43
15. Papke R.L., Buhr J.D., Francis M.M., Choi K.I., Thinschmidt J.S., and Horenstein N.A. Mol. Pharmacol. 67 (2005) 1977
16. Graham J.H., Papke R.L., and Buccafusco J.J. Curr. Alzheimer Res. 2 (2005) 141
17. Papke R.L., Craig A.G., and Heinemann S.F. J. Pharmacol. Exp. Ther. 268 (1994) 718
18. Papke R.L., Sanberg P.R., and Shytle R.D. J. Pharmacol. Exp. Ther. 297 (2001) 646
19. Wilkins L.H., Grinevich V.P., Ayers J.T., Crooks P.A., and Dwoskin L.P. J. Pharmacol. Exp. Ther. 304 (2003) 400
20. Laviolette S.R., and van der Kooy D. Nat. Rev. Neurosci. 5 (2004) 55
21. Schultz W. Neuron 36 (2002) 241
22. Samejima K., Ueda Y., Doya K., and Kimura M. Science 310 (2005) 1337