N,N′-alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked dopamine release and hyperactivity

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 2, 2008, Pages 563-576

  Dwoskin, Linda P ^a   Wooters, Thomas E ^b   Sumithran, Sangeetha P ^a   Siripurapu, Kiran B ^a   Joyce, B Matthew ^a   Lockman, Paul R ^c   Manda, Vamshi K ^c   Ayers, Joshua T ^a   Zhang, Zhenfa ^a   Deaciuc, Agripina G ^a   McIntosh, J Michael ^d   Crooks, Peter A ^a   Bardo, Michael T ^b  

^a University of Kentucky   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CONOTOXIN MII; BIS 3 PICOLINIUM DERIVATIVE; DIHYDRO BETA ERYTHROIDINE; DOPAMINE; MECAMYLAMINE; N,N' DECANE 1,10 DIYL BIS 3 PICOLINIUM DIIOIDE; N,N' DODECANE 1,12 DIYL BIS 3 PICOLINIUM DIBROMIDE; N,N' HEPTANE 1,7 DIYL BIS 3 PICOLINIUM DIBROMIDE; N,N' HEXANE 1,6 DIYL BIS 3 PICOLINIUM DIIODIDE; N,N' NONANE 1,9 DIYL BIS 3 PICOLINIUM DIBROMIDE; N,N' OCTANE 1,8 DIYL BIS 3 PICOLINIUM DIIODIDE; N,N' UNDECANE 1,11 DIYL BIS 3 PICOLINIUM DIBROMIDE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PICOLINE DERIVATIVE; N,N'-DODECANE-1,12-DIYL-BIS-3-PICOLINIUM DIBROMIDE; NERVE PROTEIN; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORTER; SLC6A8 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOPAMINE RELEASE; DRUG POTENCY; DRUG RECEPTOR BINDING; HYPERACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ACTIVE TRANSPORT; ANIMAL; ANIMAL BEHAVIOR; CHEMICAL STRUCTURE; CHEMISTRY; CORPUS STRIATUM; DISCRIMINATION LEARNING; DRUG EFFECT; FISCHER 344 RAT; METABOLISM; MOTOR ACTIVITY; PROTEIN BINDING; SECRETION; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; CORPUS STRIATUM; DISCRIMINATION LEARNING; DOPAMINE; MALE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NICOTINE; NICOTINIC ANTAGONISTS; PICOLINES; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; PROTEIN BINDING; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47949098992     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.136630     Document Type: Article

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