Evaluation of patulin toxicity in the thymus of growing male rats

Arhiv za Higijenu Rada i Toksikologiju

Volumn 60, Issue 4, 2009, Pages 411-418

  Arzu Koçkaya, Evrim ^a   Selmanoǧlu, Güdeniz ^b   Özsoy, Nesrin ^c   Gül, Nursel ^c  

^a GAZI UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c ANKARA UNIVERSITY   (Turkey)

Author keywords

Cell ultrastructure; Histopathology; Immunotoxicity; Light microscopy; Morphometry; Mycotoxin

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PATULIN;

ADIPOSE TISSUE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASPERGILLUS; BLEEDING; BYSSACHLAMYS; CELL DESTRUCTION; CELL HYPERPLASIA; CELL NUCLEUS; CELL ORGANELLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EVALUATION; FUNGUS; HISTOPATHOLOGY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; INTERSTITIUM; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY MEDULLA; MALE; MITOCHONDRION; MORPHOMETRICS; NONHUMAN; PENICILLIUM; RAT; THYMUS;

ANIMALS; EPIDERMAL GROWTH FACTOR; IMMUNOHISTOCHEMISTRY; MALE; MYCOTOXINS; PATULIN; RATS; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; THYMUS GLAND;

ASPERGILLUS; PENICILLIUM; RATTUS;

EID: 75449102230     PISSN: 00041254     EISSN: None     Source Type: Journal    
DOI: 10.2478/10004-1254-60-2009-1973     Document Type: Article

References (40)

1. Harrison MA. Presence and stability of patulin in apple products: A review. J Food Safety 1989;9:147-153
2. Paster N, Huppert D, Barkai-Golan R. Production of patulin by different strains of Penicillium expansum in pear and apple cultivars stored at different temperatures and modifi ed atmospheres. Food Addit Contam 1995;12:51-58
3. Askar A. Patulin in apple juice and children's apple food. Fruit Proces 1999;3:74-77
4. WHO - Joint FAO/WHO Expert Committee on Food Additives (JECFA). Position paper on patulin (prepared by France). The Hague, Netherlands. 9-13 March 1998.
5. Alves I, Oliveira NG, Laires A, Rodrigues AS, Rueff J. Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: role of ascorbic acid as a modulator of patulin clastogenicity. Mutagenesis 2000;15:229-234
6. Junquiera LC, Carnerio J, Kelley RO. Basic Histology. New York (NY): Prentice-Hall International Inc.; 1995.
7. Makinodan T, Kay MMB. Age influence on the immune system. Adv Immunol 1980;29:287-330.
8. Raviola E. Thymus. In: Bloom W, Fawcett DW, editors. A textbook of histology. Philadelphia: Saunders International Edition; 1986. p. 436-445
9. Huff K, End D, Guroff G. Nerve growth factor-induced alteration in response of PC12 pheochromocytoma cell to epidermal growth factor. J Cell Biol 1981;88:189-198
10. Le PT, Lazorich S, Whichard P, Haynes BF, Singer KH. Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor-alfa regulate mRNA levels of interleukin 1 a (IL-1a), IL-1, and IL-6 in human thymic epithelial cells at a post-transcriptional level. J Exp Med 1991;174:1147-1157
11. Nieburgs AC, Korn JH, Picciano PT, Cohen S. Thymic epithelium in vitro. IV. Regulation of growth and mediator production by epidermal growth factor. Cell Immunol 1987;108:396-404.
12. Woodborn JR. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 1999;82:241-250
13. Henley JD, Koukoulis GK, Loehrer PJ Sr. Epidermal growth factor receptor expression in invasive thymoma. J Cancer Res Clin Oncol 2002;128:167-170
14. Escoula L, Bourdiol D, Linas MD, Recco P, Seguela JP. Enhancing resistance and modulation of humoral immune response to experimental Candida albicans infection by patulin. Mycopathologica 1988;103:153-156
15. Escoula L, Thomsen M, Bourdiol D, Pipy B, Peuriete S, Roubinet F. Patulin immunotoxicology: Effects on phagocyte activation and the cellular and humoral immune system of mice and rabbits. Int J Immunopharmacol 1988;10:983-989
16. Llewellyn GC, McCay JA, Brown RD, Musgrove DL, Butterworth LF, Munson AE, White KL. Immunological evaluation of the mycotoxin patulin in female B6C3F1 mice. Food Chem Toxicol 1998;36:1107-1115
17. Ostry V, Skarkova J, Ruprich J. Occurrence of Penicillium expansum and patulin in apples as raw materials for processing of foods - case study. Mycotox Res 2004;20:24-28
18. Elcuman EA and Akay MT. Age-dependent immunolocalization of fi bronectin and histological changes in the thymus of rats. Vet Res Commun 1998;22:525-532
19. Hayat MA. Principles and Techniques of Electron Microscopy: Biological Applications. Vol 1, 2nd ed. Baltimore (MD): University Park Press; 1981.
20. Takeuchi Y, Kosaka T, Hayashi K, Takeda M, Yoshida T, Fujisawa H, Teramoto S, Maita K, Harada T. Thymic atrophy induced by methoxychlor in rat pups. Toxicol Lett 2002;135:199-207.
21. Selmanolu G, Kockaya EA. Investigation of the effects of patulin on thyroid and testis, and hormone levels in growing male rats. Food Chem Toxicol 2004;42:721-727
22. Kuper CF, Beems RB, Hollanders VMH. Spontaneous pathology of the thymus in aging Wistar (Cpb:Wu) rats. Vet Pathol 1986;23:270-277
23. Utsuyama M, Hirokawa K. Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy. Mech Ageing Dev 1989;47:175-185
24. Miller JF, Osoba D. Current concepts of the immunological function of the thymus. Physiol Rev 1967;47:437-520.
25. Haynes BF. The human thymic microenvironment. Adv Immunol 1987;36:87-142.
26. Ichikawa J, Kiyohara T. Supression of EGF-induced cell proliferation by the blockade of Ca2+ mobilization and capacitative Ca2+ entry in mouse mammary epithelial cells. Cell Biochem Funct 2001;19:213-219
27. Friedman L. Patulin: mycotoxin or fungal metabolité (Current state of knowledge). Biodeterior Res 1990;3:21-54.
28. Riley RT, Showker JL. The mechanism of patulin's cytotoxicity and the antioxidant activity of indole tetramic acids. Toxicol Appl Pharmacol 1991;109:108-126
29. Saxena N, Ansari KM, Kumar R, Dhawan A, Dwivedi PD, Das M. Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p53 and p21/WAF1 proteins in skin of mice. Toxicol Appl Pharmacol 2009;234:192-201.
30. Cooray R, Kiessling KH, Lindahl-Kiessling K. The effects of patulin and patulin cysteine mixtures on DNA synthesis and the frequency of sister-chromatid exchanges in human lymphocytes. Food Chem Toxicol 1982;20:893-898
31. Sorenson WG, Gerberick GF, Lewis DM, Castranova V. Toxicity of mycotoxins for the rat pulmonary macrophage in vitro. Environ Health Persp 1986;66:45-53.
32. Burghardt RC, Barhoumi R, Lewis EH, Bailey RH, Pyle KA, Clement BA, Phillips TD. Patulin-induced cellular toxicity: a vital fluorescence study. Toxicol Appl Pharmacol 1992;112:235-244
33. Nodera M, Yamagisawa H, Wada O. Increased apoptosis in a variety of tissues of zinc-deficient rats. Life Sci 2001;69:1639-1649
34. Gul N, Ozsoy N, Osmanaaolu O, Selmanólu G, Kockaya EA. Effects of patulin on thymus capillary of rats. Cell Biochem Funct 2006;24:541-546
35. Ozsoy N, Selmanolu G, Kockaya EA, Gul N, Cebesoy S. Effect of patulin on the interdigitating dendritic cells (IDCs) of rat thymus. Cell Biochem Funct 2008;26:192-196
36. Elmore SA. Enhanced histopathology of the thymus. Toxicol Pathol 2006;34:656-665
37. Sharma RP. Immunotoxicity of mycotoxins. J Dairy Sci 1993;76:892-897
38. World Health Organization (WHO). Food Additivies Series 35 [displayed 18 November 2009]. Available at http://www. inchem.org/documents/jecfa/jecmono/ v35je01.htm.
39. Berek L, Petri IB, Mesterhazy A, Teren J, Molnar J. Effects of mycotoxins on human immune functions in vitro. Toxicol In Vitro 2001;15:25-30.
40. Tammer B, Lehmann I, Nieber K, Altenburger R. Combined effects of mycotoxin mixtures on human T cell function. Toxicol Lett 2007;170:124-133