Enhanced Histopathology of the Thymus

Toxicologic Pathology

Volumn 34, Issue 5, 2006, Pages 656-665

  Elmore, Susan A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Apoptosis; cortex; medulla; stress response; tingible body macrophage

Indexed keywords

CORTICOSTEROID;

ANTIGENICITY; APOPTOSIS; BRAIN CORTEX; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CONFERENCE PAPER; EPITHELIUM CELL; HISTOPATHOLOGY; HUMAN; IMMUNE SYSTEM; IMMUNOTOXICITY; LYMPHOCYTE; LYMPHOID ORGAN; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; SCREENING; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALS; CELL DEATH; IMMUNOTOXINS; MICE; RATS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 33750445961     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230600865556     Document Type: Article

References (21)

1. Bruijntjes JP, Kuper CF, Robinson JE, Schuurman HJ Epithelium-free area in the thymic cortex of rats Dev Immunol 1993 3 113-22
2. Duijvestijn AM, Sminia T, Kohler YJ, Janse EM, Hoefsmit ECM Nieuwenhuis P, van den Broek A, Hanna MG Rat thymus micro-environment: An ultrastructural and functional characterization In vivo Immunology 1982 New York Plenum 441-6
3. Germolec DR, Kashon M, Nyska A, Kuper CF, Portier C, Kommineni C, Johnson KA, Luster MI The accuracy of extended histopathology to detect immunotoxic chemicals Toxicol Sci 2004 82 504-14
4. Godfrey DI, Izon DJ, Tucek CL, Wilson TJ, Boyd RL The phenotypic heterogeneity of mouse thymic stromal cells Immunology 1990 70 66 74
5. Greenstein BD, Fitzpatrick FTA, Kendall MD, Wheeler MJ Regeneration of the thymus in old male rats treated with a stable analogue of LHRH J Endocr 1987 112 345-50
6. Haley P, Perry R, Ennulat D, Frame S, Johnson C, Lapointe JM, Nyska A, Snyder P, Walker D, Walter G STP position paper: Best Practice Guideline for the Routine Pathology Evaluation of the Immune System Toxicol Pathol 2005 33 404-7
7. Harleman JH Approaches to the identification and recording of findings in the lymphoreticular organs indicative for immunotoxicity in regulatory type toxicity studies Toxicology 2000 142 213-9
8. Kuper CF, Harleman JH, Richter-Reichelm HB, Vos JG Histopathologic approaches to detect changes indicative of immunotoxicity Toxicol Pathol 2000 28 454-66
9. Levin S, Bucci TJ, Cohen SM, Fix AS, Hardisty JF, LeGrand EK, Maronpot RR, Trump BF The nomenclature of cell death: recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists Toxicol Pathol 1999 Jul–Aug 27 4 484-90
10. Pearse G Normal structure, function, and histology of the thymus Toxicol Pathol 2006 34 504 514
11. Pulido O, Caldwell D, Murphy M, Gill S Tryphonas H, Fournier M, Blakely BR, Smits JEG, Brousseau P Practical considerations for toxicologic pathology assessment of the immune system in rodents and nonhuman primates Investigative Immunotoxicology 2005 Boca Raton, Florida CRC Press 229-43
12. Schuurman H-J, Van Loveren H, Rozing J, Vos JG Chemicals trophic for the thymus: Risk for immunodeficiency and autoimmunity Int J Immunopharmacol 1992 14 369-75
13. Stefanski SA, Elwell MR, Stromberg PC Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF Spleen, lymph nodes and thymus Pathology of the Fischer rat 1990 San Diego, California Academic Press, Inc 388-93
14. van Ewijk W Immunohistochemistry of lymphoid and non lymphoid cells in the thymus in relation to T lymphocyte differentiation Amer J Anat 1984 170 311-30
15. van Loveren H, Vos JG, De Waal EJ Testing immunotoxicity of chemicals as a guide for testing approaches for pharmaceuticals Drug Info J 1996 30 275-9
16. Vos JG, Kuper CF, Schuurman HJ Lawrence DA Lymphoid tissue architecture and pathological influences of toxicants Toxicology of the Immune System, Comprehensive Toxicology 1997 5 Oxford, United Kingdom Elsevier 113 130
17. Wachsmuth ED Gibson GG, Hubbard R, Parke DV Evaluating immunopathological effects of new drugs Immunotoxicology 1983 London Academic Press 237-50
18. Ward JM, Mann PC, Morishima H, Frith CH Maronpot RR Thymus, spleen and lymph nodes Pathology of the mouse 1999 Vienna, Illinois Cache River Press 333-7
19. Watanabe M, Hitomi M, van der Wee K, Rothenberg F, Fisher SA, Zucker R, Svoboda KK, Goldsmith EC, Heiskanen KM, Nieminen AL The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs Microsc Microanal Oct 2002 8 5 375-91
20. Yao G, Hou Y Thymic atrophy via estrogen-induced apoptosis is related to Fas/FasL pathway Int Immunopharmacol 2004 Feb 4 2 213-21
21. Zeiss CJ The apoptosis-necrosis continuum: insights from genetically altered mice Vet Pathol Sep 2003 40 5 481-95