Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive α4 nicotinic receptors via a cholinergic-dependent mechanism

FASEB Journal

Volumn 24, Issue 1, 2010, Pages 49-57

  Zhao Shea, Rubing ^a   Cohen, Bruce N ^b   Just, Herwig ^b   McClure Begley, Tristan ^c   Whiteaker, Paul ^d   Grady, Sharon R ^c   Salminen, Outi ^e   Gardner, Paul D ^a   Lester, Henry A ^b   Tapper, Andrew R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d BARROW NEUROLOGICAL INSTITUTE   (United States)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Acetylcholine; Interneuron; Nicotine; Parkinsonian; Striatum

Indexed keywords

ACETYLCHOLINE; ALANINE; CHOLINE ACETYLTRANSFERASE; DOPAMINE; DOPAMINE 2 RECEPTOR; LEUCINE; NICOTINIC RECEPTOR ALPHA4; DOPAMINE RECEPTOR STIMULATING AGENT; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4 SUBUNIT; NICOTINIC RECEPTOR; QUINPIROLE; RECOMBINANT PROTEIN;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; CATALEPSY; CHOLINERGIC ACTIVITY; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; INTERNEURON; MALE; MOTOR DYSFUNCTION; MOUSE; MUSCLE RIGIDITY; NONHUMAN; PARKINSON DISEASE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYMPTOM; TREMOR; AMINO ACID SUBSTITUTION; ANIMAL; C57BL MOUSE; CHEMISTRY; CHOLINERGIC NERVE; DRUG EFFECT; GENERALIZED EPILEPSY; GENETICS; METABOLISM; MOUSE MUTANT; PARKINSONISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MUS; PARKINSONIA;

ACETYLCHOLINE; AMINO ACID SUBSTITUTION; ANIMALS; CATALEPSY; CHOLINERGIC FIBERS; DOPAMINE AGONISTS; EPILEPSY, GENERALIZED; FEMALE; INTERNEURONS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE RIGIDITY; MUTAGENESIS, SITE-DIRECTED; PARKINSONIAN DISORDERS; QUINPIROLE; RECEPTORS, DOPAMINE D2; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; TREMOR;

EID: 75349110193     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-137034     Document Type: Article

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