Functional roles of dopamine D2 and D3 autoreceptors on nigrostriatal neurons analyzed by antisense knockdown in vivo

Journal of Neuroscience

Volumn 17, Issue 7, 1997, Pages 2519-2530

  Tepper, James M ^a   Sun, Bao Cun ^a   Martin, Lynn P ^a   Creese, Lan ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

antisense oligodeoxynucleotide; autoreceptor; D2 receptor; D3 receptor; dopamine receptor subtype; electrophysiology; substantia nigra

Indexed keywords

AUTORECEPTOR; COMPLEMENTARY DNA; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; DOPAMINE RELEASE; MALE; NERVE FIBER; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DENSITY; SUBSTANTIA NIGRA;

EID: 0031004899     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-07-02519.1997     Document Type: Article

References (15)

1. Aghajanian GK, Bunney BS (1977) Dopamine "autoreceptors:" pharmacological characterization by microiontophoretic single cell recording studies. Naunyn Schmiedebergs Arch Pharmacol 297:1-7.
2. Agrawal S, Temsamani J, Tang JY (1991) Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc Natl Acad Sci USA 88:7595-7599.
3. Akaoka H, Charléty P, Saunier C-F, Buda M, Chouvet G (1992) Inhibition of nigral dopaminergic neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors. Neuroscience 49:879-892.
4. Bouthenet M-L, Souil E, Martres M-P, Sokoloff P, Giros B, Schwartz J-C (1991) Localization of dopamine D3 receptor mRNA in the rat using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA. Brain Res 564:203-219.
5. Boyar WC, Altar CA (1987) Modulation of in vivo dopamine release by D2 but not Dl receptor agonists and antagonists. J Neurochem 48:824-831.
6. Bunney BS, Aghajanian GK (1978) d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a strio-nigral feedback pathway. Naunyn Schmiedebergs Arch Pharmacol 304:255-261.
7. Bunney BS, Walters JR, Roth RH, Aghajanian GK (1973) Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. J Pharmacol Exp Ther 185:560-571.
8. Burris KD, Pachcco MA, Filtz TM, Kung M-P, Kung HF, Molinoff PB (1995) Lack of discrimination of agonists for D2 and D3 dopamine receptors. Neuropsychopharmacology 12:335-345.
9. Chesi AJR, Feasey-Truger KJ, Alzheimer C, ten Bruggencate G (1995) Dopamine autoreceptor sensitivity is unchanged in rat nucleus accum-bens after chronic haloperidol treatment: an in vivo and in vitro volta-metric study. Eur J Neurosci 7:2450-2457.
10. Deniau JM, Hammond C, Riszk A, Feger J (1978) Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): evidence for the existence of branched neurons. Exp Brain Res 32: 409-422.
11. Trent F, Tepper JM (1991) Dorsal raphé stimulation modifies striatal-evoked antidromic invasion of nigral dopamincrgic neurons in vivo. Exp Brain Res 84:620-630.
12. Valerio A, Belloni M, Gorno ML, Tinti C, Memo M, Spano P (1994) Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging. Neurobiol Aging 15:713-719.
13. White FJ, Wang RY (1984) A10 dopamine neurons: role of autorecep-tors in determining firing rate and sensitivity to dopamine agonists. Life Sci 34:1161-1170.
14. Wolf ME, Roth RH (1990) Autoreceptor regulation of dopamine synthesis. Ann NY Acad Sci 604:323-343.
15. 2 receptors: behavioral correlates. Neurosci Lett 161:223-226.