Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: A potential mechanism underlying its anti-parkinsonian tremor effect

Parkinsonism and Related Disorders

Volumn 15, Issue 1, 2009, Pages 30-35

  Miwa, Hideto ^a   Kubo, Tomomi ^a   Suzuki, Ai ^a   Kondo, Tomoyoshi ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

C Fos; Parkinson's disease; Tacrine; Tremor; Zonisamide

Indexed keywords

ANTICONVULSIVE AGENT; ISOXAZOLE DERIVATIVE; PROTEIN C FOS; TACRINE; ZONISAMIDE;

ANIMAL; ARTICLE; BRAIN; CELL COUNT; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; GENE EXPRESSION REGULATION; GENETICS; JAW; MALE; METABOLISM; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; TREMOR;

ANIMALS; ANTICONVULSANTS; BRAIN; CELL COUNT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; ISOXAZOLES; JAW; MALE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; TACRINE; TREMOR;

EID: 63049131382     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2008.02.008     Document Type: Article

References (24)

1. Murata M, Horiuchi E, Kanazawa I. Zonisamide has beneficial effects on Parkinson's disease patients. Neurosci Res 2001;41:397-9.
2. Murata M. Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease. Curr Pharm Des 2004;10:687-93.
3. Miwa H. Zonisamide for the treatment of Parkinson's disease. Expert Rev Neurother 2007;7:1077-83.
4. Murata M, Hasegawa K, Kanazawa IThe Japan Zonisamide on PD Study Group. Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study. Neurology 2007;68:45-50.
5. Nakanishi I, Kohmoto J, Miwa H, Kondo T. Effect of zonisamide on resting tremor resistant to antiparkinsonian medication. No To Shinkei 2003;55:685-9.
6. Morita S, Miwa H, Kondo T. Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol. Parkinsonism Relat Disord 2005;11:101-3.
7. Bermejo PE. Zonisamide in patients with essential tremor and Parkinson's disease. Mov Disord 2007 Oct 31;22(14):2137-8.
8. Miwa H, Hama K, Kajimoto Y, Kondo T. Effects of zonisamide on experimental tremors in rats. Parkinsonism Relat Disord 2008;14:33-6.
9. Mayorga AJ, Carriero DL, Cousins MS, Gianutsos G, Salamone JD. Tremulous jaw movements produced by acute tacrine administration: possible relation to parkinsonian side effects. Pharmacol Biochem Behav 1997;56:273-9.
10. Salamone JD, Mayorga AJ, Trevitt JT, Cousins MS, Conlan A, Nawab A. Tremulous jaw movements in rats: a model of parkinsonian tremor. Prog Neurobiol 1998;56:591-611.
11. Cousins MS, Finn M, Trevitt J, Carriero DL, Conlan A, Salamone JD. The role of ventrolateral striatal acetylcholine in the production of tacrine-induced jaw movements. Pharmacol Biochem Behav 1999;62: 439-47.
12. Salamone JD, Correa M, Carlson BB, Wisniecki A, Mayorga AJ, Nisenbaum E, et al. Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents: implications for cholinergic involvement in parkinsonism. Life Sci 2001;68: 2579-84.
13. Miwa H. Rodent models of tremor. Cerebellum 2007;6:66-72.
14. Miwa H, Nishi K, Fuwa T, Mizuno Y. Differential expression of c-fos following administration of two tremorgenic agents: harmaline and oxotremorine. NeuroReport 2000;11:2385-90.
15. Morgan JI, Cohen DR, Hempstead JL, Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 1987;237:192-7.
16. Chaudhuri A. Neural activity mapping with inducible transcription factors. NeuroReport 1997;8:iii-vii.
17. Sharp FR, Sagar SM, Swanson RA. Metabolic mapping with cellular resolution: c-fos vs. 2-deoxyglucose. Crit Rev Neurobiol 1993;7:205-28.
18. Hughes P, Dragunow M. Muscarinic receptor-mediated induction of Fos protein in rat brain. Neurosci Lett 1993;150:122-6.
19. Barone P, Morelli M, Cicarelli G, Cozzolino A, DeJoanna G, Campanella G, et al. Expression of c-fos protein in the experimental epilepsy induced by pilocarpine. Synapse 1993;14:1-9.
20. Cousins MS, Atherton A, Salamone JD. Behavioral and electromyographic characterization of the local frequency of tacrine-induced tremulous jaw movements. Physiol Behav 1998;64:153-8.
21. Hughes P, Dragunow M. Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol Rev 1995;47:133-78.
22. Goto M, Swanson LW. Axonal projections from the parasubthalamic nucleus. J Comp Neurol 2004;469:581-607.
23. Mascaro MB, Bittencourt JC, Casatti CA, Elias CF. Alternative pathways for catecholamine action in oral motor control. Neurosci Lett 2005;386: 34-9.
24. Prinssen EP, Balestra W, Bemelmans FF, Cools AR. Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats. J Neurosci 1994;14:1555-62.