Increased transforming growth factor-beta1 in alcohol dependence

Journal of Korean Medical Science

Volumn 24, Issue 5, 2009, Pages 941-944

  Kim, Yong Ku ^a   Lee, Boung Chul ^b   Ham, Byung Joo ^b   Yang, Byung Hwan ^c   Roh, Sungwon ^c   Choi, Joonho ^c   Kang, Tae Cheon ^b   Chai, Young Gyu ^d   Choi, Ihn Geun ^b  

^a Korea University College of Medicine   (South Korea)

^b Hallym University   (South Korea)

^c Hanyang University College of Medicine   (South Korea)

^d Hanyang University   (South Korea)

Author keywords

Alcohols; Transforming growth factor beta1

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ALCOHOLISM; ARTICLE; BLOOD; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LIVER DISEASE; MALE; MIDDLE AGED; PATHOLOGY;

ADULT; ALCOHOLISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIVER DISEASES; MALE; MIDDLE AGED; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA1;

EID: 75349108219     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2009.24.5.941     Document Type: Article

References (30)

1. Breitkopf K, Haas S, Wiercinska E, Singer MV, Dooley S. Anti-TGF-beta strategies for the treatment of chronic liver disease. Alcohol Clin Exp Res 2005; 29 (11 Suppl): 121S-31S.
2. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 2003; 124: 778-90.
3. Lieber CS. Metabolism of alcohol. Clin Liver Dis 2005; 9: 1-35.
4. Kwon OS, Song SH, Ju KT, Chung MG, Park DK, Kim SS, Kim YS, Koo YS, Kim YK, Choi DJ, Kim JH, Hwang YJ, Byun KS, Lee CH. Polymorphism in codons 10 and 25 of the transforming growth factor-beta1 gene in Korean population and in patients with liver cirrhosis and hepatocellular carcinoma. Korean J Gastroenterol 2003; 42: 212-9.
5. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342: 1350-8.
6. Pepper MS. Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 1997; 8: 21-43.
7. Ravitz MJ, Wenner CE. Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-beta. Adv Cancer Res 1997; 71: 165-207.
8. Schuster N, Krieglstein K. Mechanisms of TGF-beta-mediated apoptosis. Cell Tissue Res 2002; 307: 1-14.
9. Elliott RL, Blobe GC. Role of transforming growth factor beta in human cancer. J Clin Oncol 2005; 23: 2078-93.
10. Chen A. Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Biochem J 2002; 368: 683-93.
11. Maehara Y, Kakeji Y, Kabashima A, Emi Y, Watanabe A, Akazawa K, Baba H, Kohnoe S, Sugimachi K. Role of transforming growth factor-beta 1 in invasion and metastasis in gastric carcinoma. J Clin Oncol 1999; 17: 607-14.
12. Luo J, Miller MW. Transforming growth factor beta1-regulated cell proliferation and expression of neural cell adhesion molecule in B104 neuroblastoma cells: differential effects of ethanol. J Neurochem 1999; 72: 2286-93.
13. Miller MW, Luo J. Effects of ethanol and transforming growth factor beta (TGF beta) on neuronal proliferation and nCAM expression. Alcohol Clin Exp Res 2002; 26: 1281-5.
14. Kuhn P, Sarkar DK. Ethanol induces apoptotic death of beta-endorphin neurons in the rat hypothalamus by a TGF-beta 1-dependent mechanism. Alcohol Clin Exp Res 2008; 32: 706-14.
15. Nanji AA, Tahan SR, Golding M, Khwaja S, Rahemtulla A, Lalani EN. Role of transforming growth factor-[beta]1 in inhibiting endothelial cell proliferation in experimental alcoholic liver disease. Am J Pathol 1996; 148: 739-47.
16. Chen WX, Li YM, Yu CH, Cai WM, Zheng M, Chen F. Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease. World J Gastroenterol 2002; 8: 379-81.
17. Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology 2002; 35: 62-73.
18. Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002; 283: G256-65.
19. Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 2000; 31: 1094-106.
20. Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P, Gressner AM. Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 2001; 502: 4-10.
21. Stopa M, Anhuf D, Terstegen L, Gatsios P, Gressner AM, Dooley S. Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7. THE TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J Biol Chem 2000; 275: 29308-17.
22. Fang C, Lindros KO, Badger TM, Ronis MJ, Ingelman-Sundberg M. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology 1998; 27: 1304-10.
23. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 1989; 10: 437-46.
24. Siegenthaler JA, Miller MW. Transforming growth factor beta1 modulates cell migration in rat cortex: effects of ethanol. Cereb Cortex 2004; 14: 791-802.
25. Flanders KC, Ludecke G, Engels S, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K. Localization and actions of transforming growth factor-beta s in the embryonic nervous system. Development 1991; 113: 183-91.
26. Krieglstein K, Strelau J, Schober A, Sullivan A, Unsicker K. TGFbeta and the regulation of neuron survival and death. J Physiol Paris 2002; 96: 25-30.
27. Pelton RW, Saxena B, Jones M, Moses HL, Gold LI. Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol 1991; 115: 1091-105.
28. Gressens P. Mechanisms and disturbances of neuronal migration. Pediatr Res 2000; 48: 725-30.
29. Kastin AJ, Akerstrom V, Pan W. Circulating TGF-beta1 does not cross the intact blood-brain barrier. J Mol Neurosci 2003; 21: 43-8.
30. Unsicker K, Strelau J. Functions of transforming growth factor-beta isoforms in the nervous system. Cues based on localization and experimental in vitro and in vivo evidence. Eur J Biochem 2000; 24: 6972-5.