-
1
-
-
0036558479
-
Chemistry and Biology of the Tetrahydroisoquionoline Antitumor Antibiotics
-
Scott, J.D.; Williams, R.M. Chemistry and Biology of the Tetrahydroisoquionoline Antitumor Antibiotics. Chem. Rev. 2002, 102, 1669-1730.
-
(2002)
Chem. Rev
, vol.102
, pp. 1669-1730
-
-
Scott, J.D.1
Williams, R.M.2
-
2
-
-
0033981511
-
Antitumor Compounds from Tunicates
-
Rinehart, K.L. Antitumor Compounds from Tunicates. Med. Drug. Rev. 2000, 20, 1-27.
-
(2000)
Med. Drug. Rev
, vol.20
, pp. 1-27
-
-
Rinehart, K.L.1
-
3
-
-
0037096739
-
Ecteinascidin 743 Inhibits Activated but not Constitutive Transcription
-
Friedman, D.; Hu, Z.; Kolb, E.A.; Gorfajn, B.; Scotto, K.W. Ecteinascidin 743 Inhibits Activated but not Constitutive Transcription. Cancer Res. 2002, 62, 3377-3381.
-
(2002)
Cancer Res
, vol.62
, pp. 3377-3381
-
-
Friedman, D.1
Hu, Z.2
Kolb, E.A.3
Gorfajn, B.4
Scotto, K.W.5
-
4
-
-
17944374027
-
Antiproliferativity of Ecteinascidin 743 Is Dependent upon Transcription-Coupled Nucleotide-Excision Repair
-
Takebayashi, Y.; Pourquier, P.; Zimonjic, D.B.; Nakayama, K.; Emmert, S.; Ueda, T.; Urasaki, Y.; Kanzaki, A.; Akiyama, S.; Popescu, N.; Kraemer, K.H. Pommier, Antiproliferativity of Ecteinascidin 743 Is Dependent upon Transcription-Coupled Nucleotide-Excision Repair. Nat. Med. 2001, 7, 961-966.
-
(2001)
Nat. Med
, vol.7
, pp. 961-966
-
-
Takebayashi, Y.1
Pourquier, P.2
Zimonjic, D.B.3
Nakayama, K.4
Emmert, S.5
Ueda, T.6
Urasaki, Y.7
Kanzaki, A.8
Akiyama, S.9
Popescu, N.10
Kraemer11
Pommier, K.H.12
-
5
-
-
0036021010
-
Ecteinascidin 743: A Novel Anticancer Drug with a Unique Mechanism of Action
-
Aune, G.J.; Furuta, T.; Pommier, Y. Ecteinascidin 743: A Novel Anticancer Drug with a Unique Mechanism of Action. Anticancer Drugs 2002, 13, 545-555.
-
(2002)
Anticancer Drugs
, vol.13
, pp. 545-555
-
-
Aune, G.J.1
Furuta, T.2
Pommier, Y.3
-
6
-
-
0036830244
-
Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743
-
Gajate, C.; An, F.; Mollinedo, F. Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743. J. Biol. Chem. 2002, 277, 41580-41589.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 41580-41589
-
-
Gajate, C.1
An, F.2
Mollinedo, F.3
-
7
-
-
11844262569
-
New Marine Derived Anticancer Therapeutics - A Journey from the Sea to Clinical Trials
-
Jimeno, J.; Faircloth, G.; Fernandez Sousa-Faro, J.M.; Scheuer, P.J.; Rinehart, K. New Marine Derived Anticancer Therapeutics - A Journey from the Sea to Clinical Trials. Mar. Drugs 2004, 2, 14-29.
-
(2004)
Mar. Drugs
, vol.2
, pp. 14-29
-
-
Jimeno, J.1
Faircloth, G.2
Fernandez Sousa-Faro, J.M.3
Scheuer, P.J.4
Rinehart, K.5
-
8
-
-
31444456167
-
ET-743: A Novel Agent with Activity in Soft Tissue Sarcomas
-
Fayette, J.; Coquard, I.R.; Alberti, L.; Ranchère, D.; Boyle, H.; Blay, J.Y. ET-743: A Novel Agent with Activity in Soft Tissue Sarcomas. Oncologist 2005, 10, 827-832.
-
(2005)
Oncologist
, vol.10
, pp. 827-832
-
-
Fayette, J.1
Coquard, I.R.2
Alberti, L.3
Ranchère, D.4
Boyle, H.5
Blay, J.Y.6
-
9
-
-
27744452788
-
DNA and Non-DNA Targets in the Mechanism of Action of the Antitumor Drug Trabectedin
-
David-Cordonnier, M.-H.; Gajate, C.; Olmea, O.; Laine, W.; de la Iglesia-Vicente, J.; Perez, C.; Cuevas, C.; Otero, G.; Manzanares, I.; Bailly, C.; Mollinedo, F. DNA and Non-DNA Targets in the Mechanism of Action of the Antitumor Drug Trabectedin. Chem. Biol. 2005, 12, 1201-1210.
-
(2005)
Chem. Biol
, vol.12
, pp. 1201-1210
-
-
David-Cordonnier, M.-H.1
Gajate, C.2
Olmea, O.3
Laine, W.4
de la Iglesia-Vicente, J.5
Perez, C.6
Cuevas, C.7
Otero, G.8
Manzanares, I.9
Bailly, C.10
Mollinedo, F.11
-
10
-
-
67651158998
-
Zalypsis (PM00104) is a Potent Inducer of γ-H2AX foci and Reveals the Importance of the C Ring of Trabectedin for Transcription-coupled Repair Inhibition
-
also see
-
Guirouin-Barbat, J.; Antony, S.; Pommier, Y. Zalypsis (PM00104) is a Potent Inducer of γ-H2AX foci and Reveals the Importance of the C Ring of Trabectedin for Transcription-coupled Repair Inhibition. Mol. Cancer Ther. 2009, 8, 2007-2014, also see http://www.pharmamar.com/ en/pipeline/zalypsis.cfm.
-
(2009)
Mol. Cancer Ther
, vol.8
, pp. 2007-2014
-
-
Guirouin-Barbat, J.1
Antony, S.2
Pommier, Y.3
-
11
-
-
0033616691
-
-
Martinez, E.J.; Owa, T.; Schreiber, S.L.; Corey, E.J. Phthalascidin, a Synthetic Antitumor Agent with Potency and Mode of Action Comparable to Ecteinascidin 743. Proc. Natl. Acad. Sci. USA 1999, 96, 3496-3501.
-
Martinez, E.J.; Owa, T.; Schreiber, S.L.; Corey, E.J. Phthalascidin, a Synthetic Antitumor Agent with Potency and Mode of Action Comparable to Ecteinascidin 743. Proc. Natl. Acad. Sci. USA 1999, 96, 3496-3501.
-
-
-
-
12
-
-
0035542848
-
Antitumor Activity and Gene Expression-Based Profiling of Ecteinascidin 743 and Phthalascidin Pt 650
-
Martinez, E.J.; Corey, E.J.; Owa, T. Antitumor Activity and Gene Expression-Based Profiling of Ecteinascidin 743 and Phthalascidin Pt 650. Chem. Biol. 2001, 8, 1151-1160.
-
(2001)
Chem. Biol
, vol.8
, pp. 1151-1160
-
-
Martinez, E.J.1
Corey, E.J.2
Owa, T.3
-
13
-
-
0036015848
-
Transcriptional Response Pathways in a Yeast Strain Sensitive Saframycin A and a More Potent Analog Evidence for a Common Based of Activity
-
Plowright, A.T.; Schaus, S.E.; Myers, A.G. Transcriptional Response Pathways in a Yeast Strain Sensitive Saframycin A and a More Potent Analog Evidence for a Common Based of Activity. Chem. Biol. 2002, 9, 607-618.
-
(2002)
Chem. Biol
, vol.9
, pp. 607-618
-
-
Plowright, A.T.1
Schaus, S.E.2
Myers, A.G.3
-
14
-
-
0024818627
-
Renieramycins E and F from the Sponge Reniera sp: Reassignment of the Stereochemistry of the Renieramycins
-
He, H.; Faulkner, D.J. Renieramycins E and F from the Sponge Reniera sp: Reassignment of the Stereochemistry of the Renieramycins. J. Org. Chem. 1989, 54, 5822-5824.
-
(1989)
J. Org. Chem
, vol.54
, pp. 5822-5824
-
-
He, H.1
Faulkner, D.J.2
-
15
-
-
0019995987
-
Antimicrobial Metabolites of the Sponge Reniera sp
-
Frincke, J.M.; Faulkner, D.J. Antimicrobial Metabolites of the Sponge Reniera sp. J. Am. Chem. Soc. 1982, 104, 265-269.
-
(1982)
J. Am. Chem. Soc
, vol.104
, pp. 265-269
-
-
Frincke, J.M.1
Faulkner, D.J.2
-
16
-
-
0034622873
-
A New Antitumor Isoquinoline Alkaloid from the Marine Nudibranch Jorunna funebris
-
Fontana, A.; Cavaliere, P.; Wahidulla, S.; Naik, C.G.; Cimino, G. A New Antitumor Isoquinoline Alkaloid from the Marine Nudibranch Jorunna funebris. Tetrahedron 2000, 56, 7305-7308.
-
(2000)
Tetrahedron
, vol.56
, pp. 7305-7308
-
-
Fontana, A.1
Cavaliere, P.2
Wahidulla, S.3
Naik, C.G.4
Cimino, G.5
-
17
-
-
0344118694
-
Chemistry of Renieramycins. Part 3. Isolation and Structure of Stabilized Renieramycin Type Derivatives Possessing Antitumor Activity from Thai Sponge, Xestospongia Species Pretreated with Potassium Cyanide
-
Suwanborirux, K.; Amnuoypol, S.; Plubrukarn, A.; Pummangura, S.; Kubo, A.; Tanaka, C.; Saito, N. Chemistry of Renieramycins. Part 3. Isolation and Structure of Stabilized Renieramycin Type Derivatives Possessing Antitumor Activity from Thai Sponge, Xestospongia Species Pretreated with Potassium Cyanide. J. Nat. Prod. 2003, 66, 1441-1446.
-
(2003)
J. Nat. Prod
, vol.66
, pp. 1441-1446
-
-
Suwanborirux, K.1
Amnuoypol, S.2
Plubrukarn, A.3
Pummangura, S.4
Kubo, A.5
Tanaka, C.6
Saito, N.7
-
18
-
-
3042675982
-
Chemistry of Renieramycins. Part 5. Structure Elucidation of Minor Components of Renieramycins O and Q-S, from Thai Marine Sponge, Xestospongia Species, Pretreated with Potassium Cyanide
-
Amnuoypol, S.; Suwanborirux, K.; Pummangura, S.; Kubo, A.; Tanaka, C.; Saito, N. Chemistry of Renieramycins. Part 5. Structure Elucidation of Minor Components of Renieramycins O and Q-S, from Thai Marine Sponge, Xestospongia Species, Pretreated with Potassium Cyanide. J. Nat. Prod. 2004, 67, 1023-1028.
-
(2004)
J. Nat. Prod
, vol.67
, pp. 1023-1028
-
-
Amnuoypol, S.1
Suwanborirux, K.2
Pummangura, S.3
Kubo, A.4
Tanaka, C.5
Saito, N.6
-
19
-
-
66749084494
-
Chemistry of Renieramycins. Part 8. Synthesis and Cytotoxicity Evaluation of Renieramycin M-Jorunnamycin A Analogues
-
Charupant, K.; Daikuhara, N.; Saito, E.; Amnuoypol, S.; Suwanborirux, K.; Owa, T.; Saito, N. Chemistry of Renieramycins. Part 8. Synthesis and Cytotoxicity Evaluation of Renieramycin M-Jorunnamycin A Analogues. Bioorg. Med. Chem. 2009, 17, 4548-4558.
-
(2009)
Bioorg. Med. Chem
, vol.17
, pp. 4548-4558
-
-
Charupant, K.1
Daikuhara, N.2
Saito, E.3
Amnuoypol, S.4
Suwanborirux, K.5
Owa, T.6
Saito, N.7
-
20
-
-
33846113891
-
-
Charupant, K.; Suwanborirux, K.; Amnuoypol, S.; Saito, E.; Kubo, A.; Saito, N. Jorunnamycins A-C, New Stabilized Renieramycin-Type Bistetrahydroisoquinolines Isolated from the Thai Nudibranch Jorunna funebris. Chem. Pharm. Bull. 2007, 55, 81-86.
-
Charupant, K.; Suwanborirux, K.; Amnuoypol, S.; Saito, E.; Kubo, A.; Saito, N. Jorunnamycins A-C, New Stabilized Renieramycin-Type Bistetrahydroisoquinolines Isolated from the Thai Nudibranch Jorunna funebris. Chem. Pharm. Bull. 2007, 55, 81-86.
-
-
-
-
21
-
-
0021061819
-
Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays
-
Mosmann, T. Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J. Immunol. Methods 1983, 65, 55-63.
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
22
-
-
75149118865
-
-
In vitro antiproliferative activity: Exponentially growing cells (1,500 cells per well for HCT116 and 3,000 cells per well for MDA-MB-435) were seeded into 96-well microtiter plates and pre-cultured for one day. Both compounds (renieramycin M and jorunnamycin C) were dissolved in dimethyl sulfoxide (DMSO) to make 20 mM and further diluted with the culture medium to prepare threefold serial dilutions with the maximum concentration being 100 nM after the addition into each well. The obtained dilutions were added to the plates and incubation was continued for an additional three days. The antiproliferative activity was measured in triplicate by the MTT colorimetric assay. Absorbance was measured with a TECAN microplate reader at a test wavelength of 540 nm and a reference wavelength of 660 nm to be taken as an index of the number of viable cells. The IC50 value the concentration required to inhibit cell growth by 50, was determined by the least squares method
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50 value (the concentration required to inhibit cell growth by 50%) was determined by the least squares method.
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23
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84856091092
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Oligonucleotide microarray gene expression analysis: HCT116 and MDA-MB-435 cells were each plated at 2.0 × 106 cells per dish in 10-cm-diameter dishes with 10 mL of fresh RPMI 1640 medium. After 24 h pre-incubation, HCT116 cells were treated with 2 × IC50 concentration of each test compound (33 nM renieramycin M or 55 nM jorunnamycin C) for 4 h and 12 h. MDA-MB-453 cells were also treated with 2 × IC 50 concentration of each test compound (13 nM renieramycin M or 33 nM jorunnamycin C) for 4 h and 12 h. DMSO (0.2, treatment was used as control. Total RNA was extracted from the cells using Trizol (Invitrogen, The extracted RNA was purified using an RNeasy kit (Qiagen, Double-stranded cDNA was synthesized from 5 μg of total RNA by means of a SuperScript double-stranded cDNA synthesis kit (Invitrogen) with T7-d(T)24 primer. The cDNA product was purified by phenol/chloroform/isoamyl alcohol extraction. In vitro
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24 primer. The cDNA product was purified by phenol/chloroform/isoamyl alcohol extraction. In vitro transcription was carried out by means of a GeneChip IVT Labeling kit (Affymetrix). The resulting biotin-labeled cRNA was purified using the RNeasy kit. cRNA was fragmented at 94 °C for 35 min, and then hybridized for 16 h onto an Affymetrix GeneChip Human Genome Focus array that is capable of probing approximately 8,500 transcripts. The probe arrays were washed and stained with streptavidin-phycoerythrin and biotinylated goat anti-streptavidin on an Affymetrix Fluidics Station. Fluorescence intensities were captured with a Hewlett-Packard confocal laser scanner. All quantitative data were processed using the robust multi-array average (RMA) method [27], and transcriptional signature was defined as the differences between the data for compound treatment and those for DMSO treatment (control) on a logarithmic scale. Hierarchical clustering of the obtained transcriptional signatures for all test samples was done using the unweighted pair grouping method with arithmetic mean (UPGMA) in GeneSpring software to afford a dendrogram (tree graph) based on the similarity (cosine correlation). Up- and down-regulated genes were selected according to the following criteria: i) at least twofold change compared with control data; and ii) statistical significance with p-value < 0.05 by the t-test in triplicate data. Gene Ontology (GO) analysis was used to illuminate compound-related biological processes, cellular components, and molecular functions. Enriched GO terms with Benjamini-Hochberg adjusted p-values < 0.05 were selected using the Bioconductor GOstats library [28].
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-
-
-
24
-
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30044436233
-
Receptor-type Protein-tyrosine Phosphatse-K regulates Epidermal Growth Factor Receptor Function
-
Xu, Y.; Tan, L.J.; Grachtchouk, V; Voorhees, J.J.; Fisher, G.J. Receptor-type Protein-tyrosine Phosphatse-K regulates Epidermal Growth Factor Receptor Function. J. Biol. Chem. 2005, 280, 42694-42700.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 42694-42700
-
-
Xu, Y.1
Tan, L.J.2
Grachtchouk, V.3
Voorhees, J.J.4
Fisher, G.J.5
-
25
-
-
20044396161
-
Transcriptional Signature of Ecteinascidin 743 (Yondelis, Trabectedin) in Human Sarcoma Cells Explanted from Chemo-Naive Patients
-
Martínez, N.; Sánchez-Beato, M.; Carnero, A.; Moneo, V.; Tercero, J.C.; Fernández, I.; Navarrete, M.; Jimeno, J.; Piris, M.A. Transcriptional Signature of Ecteinascidin 743 (Yondelis, Trabectedin) in Human Sarcoma Cells Explanted from Chemo-Naive Patients. Mol. Cancer Ther. 2005, 4, 814-823.
-
(2005)
Mol. Cancer Ther
, vol.4
, pp. 814-823
-
-
Martínez, N.1
Sánchez-Beato, M.2
Carnero, A.3
Moneo, V.4
Tercero, J.C.5
Fernández, I.6
Navarrete, M.7
Jimeno, J.8
Piris, M.A.9
-
26
-
-
0037168033
-
Array-Based Structure and Gene Expression Relationship Study of Antitumor Sulfonamide Including N-[2-(4-hydroxyphenyl)amino]3-pyridinyl]-4- methoxybenzenesulfonamide and N-(3-Chloro-7-indolyl)-1,4- benzenedisulfonamide
-
Owa, T.; Yokoi, A.; Yamazaki, K.; Yoshimatsu, K.; Yamori, T.; Nagasu, T. Array-Based Structure and Gene Expression Relationship Study of Antitumor Sulfonamide Including N-[2-(4-hydroxyphenyl)amino]3-pyridinyl]-4- methoxybenzenesulfonamide and N-(3-Chloro-7-indolyl)-1,4- benzenedisulfonamide. J. Med. Chem. 2002, 45, 4913-4922.
-
(2002)
J. Med. Chem
, vol.45
, pp. 4913-4922
-
-
Owa, T.1
Yokoi, A.2
Yamazaki, K.3
Yoshimatsu, K.4
Yamori, T.5
Nagasu, T.6
-
27
-
-
0142121516
-
Exploration, Normalization, and Summaries of High Density Oligonucleotide Array Probe
-
Irizarry, R.A.; Hobbs, B.; Collin, F.; Beazer-Barclay, Y.D.; Antonellis, K.J.; Scherf, U. Exploration, Normalization, and Summaries of High Density Oligonucleotide Array Probe. Biostatistic 2003, 4, 249-264.
-
(2003)
Biostatistic
, vol.4
, pp. 249-264
-
-
Irizarry, R.A.1
Hobbs, B.2
Collin, F.3
Beazer-Barclay, Y.D.4
Antonellis, K.J.5
Scherf, U.6
-
28
-
-
27544444402
-
Using GO for Statistical Analyses
-
also see
-
Gentleman, R. Using GO for Statistical Analyses. In Proceedings of COMPSTAT 2004 Symposium, 2004; pp. 171-180, also see http://comostat2004. cuni.cz/.
-
(2004)
Proceedings of COMPSTAT 2004 Symposium
, pp. 171-180
-
-
Gentleman, R.1
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