A DNA damage signal is required for p53 to activate gadd45

Cancer Research

Volumn 60, Issue 6, 2000, Pages 1711-1719

  Gu, Xiao ^a   Chicas, Agustin ^a   Olivier, Magali ^a   Taya, Yoichi ^b   Tyagi, Sanjay ^c   Kramer, Fred Rusell ^c   Bargonetti, Jill ^a,d  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DEOXYRIBONUCLEASE I; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; WORTMANNIN;

ACETYLATION; ARTICLE; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSACTIVATION;

ACETYLATION; ANDROSTADIENES; CAMPTOTHECIN; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DEOXYRIBONUCLEASE I; DNA; DNA DAMAGE; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSINE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SERINE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0343729496     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Freedman, D. A., and Levine, A. J. Regulation of the p53 protein by the MDM2 oncoprotein-thirty-eighth G. H. A. Clowes Memorial Award Lecture. Cancer Res., 59: 1-7, 1999.
2. 1 cyclin-dependent kinases. Cell, 75: 805-816, 1993.
3. Papathanasiou, M. A., Kerr, N. C., Robbins, J. H., McBride, O. W., Alamo, I. J., Barrett, S. F., Hickson, I. D., and Fornace, A. J., Jr. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol. Cell. Biol., 11: 1009-1016, 1991.
4. Kastan, M. B., Zhan, Q., El-Deiry, Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell, 71: 587-597, 1992.
5. Cox, L. S., and Lane, D. P. Tumor suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays, 17: 501-508, 1995.
6. Momand, J., Zambetti, G., Olson, D. C., George, D., and Levine, A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69: 1237-1245, 1992.
7. Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., and Vogelstein, B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (Lond.), 362: 857-860, 1993.
8. Haupt, Y., Maya, R., Kazaz, A., and Oren, M. Mdm2 promotes the rapid degradation of p53. Nature (Lond.), 387: 296-299, 1997.
9. Kubbutat, M. H. G., Jones, S. N., and Vousden, K. H. Regulation of p53 stability by Mdm2. Nature (Lond.), 387: 299-302, 1997.
10. waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-mdm2 autoregulatory feedback loop. Oncogene, 18: 1081-1091, 1999.
11. 1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. USA, 92: 8493-8497, 1995.
12. Milczarek, G. J., Martinez, J., and Broden, G. T. p53 phosphorylation: biochemical and functional consequences. Life Sci., 60: 1-11, 1997.
13. Banin, S., Moyal, L., Shieh, S. Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (Washington DC), 281: 1674-1677, 1998.
14. Canman, C. E., Lim, D., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M., and Siliciano, J. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (Washington DC), 281: 1677-1679, 1998.
15. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S., Taya, Y., Prives, C., and Abraham, R. T. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev., 13: 152-157, 1999.
16. Lehman, T. A., Modali, R., Boukamp, P., Stanek, J., Bennett, W. P., Welsh, J. A., Metcalf, R. A., Stampfer, M. R., Fusenig, N., Rogan, E. M., and Harris, C. C. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis (Lond.), 14: 833-839, 1993.
17. Xiao, G., White, D., and Bargonetti, J. p53 binds to a constitutively nucleosome free region of the mdm2 gene. Oncogene, 16: 1171-1181, 1998.
18. Fort, P., Marty, L., Piechaczyk, M., Sabrouty, S. L., Dani, C., Jeanteur, P., and Blanchard, J. M. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res., 13: 1431-1442, 1985.
19. Tyagi, S., and Kramer, F. R. Molecular beacons: probes that fluoresce upon hybridization. Nat. Biotechnol., 14: 303-308, 1996.
20. Sakaguchi, K., Herrera, J. E., Satio, S. S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., and Appella, E. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev., 12: 2831-2841, 1998.
21. Ui, M., Okada, T., Hazeki, K., and Hazeki, O. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci., 20: 303-307, 1995.
22. Shieh, S., Ikeda, M., Taya, Y., and Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91: 325-334, 1997.
23. Tishler, R. B., Calderwood, S. C., Coleman, C. N., and Price, B. D. Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res., 53: 2212-2216, 1993.
24. Price, B., and Youmell, M. B. The phosphatidylinosilol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res., 56: 246-250, 1996.
25. Powis, G., Bonjouklian, R., Berggren, M. M., Gallegos, A., Abraham, R., Ashendel, C., Zalkow, L., Matter, W. F., Dodge, J., Gindley, G., and Vlahos, C. J. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res., 54: 2419-2423, 1994.
26. Manganelli, R., Dubnau, E., Tyagi, S., Kraner, F. R., and Smith, I. Differential expression of 10 σ factor genes in Mycobaterium tuberculosis. Mol. Microbiol., 31: 715-724, 1999.
27. Gu, W., and Roeder, R. G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-termmal domain. Cell, 90: 595-606, 1997.
28. Halazonetis, T. D., Davis, L. J., and Kandil, A. N. Wild-type p53 adopts a "mutant"-like conformation when bound to DNA. EMBO J., 12: 1021-1028, 1993.
29. Hupp, T. R., Meek, D. W., Midgley, C. A., and Lane, D. P. Regulation of the specific DNA binding function of p53. Cell, 71: 875-886, 1992.
30. Takenaka, I., Morin, F., Seizinger, B. P., and Kley, N. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatase. J. Biol. Chem., 270: 5405-5411, 1995.
31. Pommier, Y. G., Pourquier, P., Fan, Y., and Strumberg, D. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim. Biophys. Acta, 1400: 83-106, 1998.
32. Carrier, F., Georgel, P. T., Pourquier, P., Blake, M., Kontny, H. U., Antinore, M. J., Gariboldi, M., Myers, T. G., Weinstein, J. N., Pommier, Y., and Fornace, A. J., Jr. Gadd45, a p53-reponsive stress protein, modifies DNA accessibility on damaged chromatin. Mol. Cell. Biol., 19: 1673-1685, 1999.
33. McKnight, S. Transcription revisited: a commentary on the 1995 Cold Spring Harbor Laboratory Meeting "Mechanisms of Eukaryotic Transcription." Genes Dev., 10: 367-381, 1996.
34. Beato, M., and Eisfeld, K. Transcription factors access to chromatin. Nucleic Acids Res., 25: 3559-3563, 1997.
35. Amundson, S. A., Zhan, Q., Penn, L. Z., and Fomace, A. J., Jr. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents. Oncogene, 17: 2149-2154, 1998.
36. Zhan, Q., Chen, I., Antinore, M. J., and Fornace, A. J., Jr. Tumor suppressor p53 can participate in transcriptional induction of the gadd45 promoter in the absence of direct DNA binding. Mol. Cell. Biol., 18: 2768-2778, 1998.
37. Agarwal, M. L., Taylor, W. R., Chernov, M. V., Chernova, O. B., and Stark, G. R. The p53 network. J. Biol. Chem., 273: 1-4, 1998.
38. Hollander, M , Alamo, I., Jackman, J., Wang, M. G., McBride, O. W., and Fornace, A. J., Jr. Analysis of the mammalian gadd45 gene and its response to DNA damage. J. Biol. Chem., 268: 24385-24393, 1993.
39. Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., and Kastan, M. B. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev., 11: 3471-3481, 1997.
40. Lees-Miller, S. P., Sakaguchi, K., Ullrich, S. J., Appella, E., and Anderson, C. W. Human DNA-activated protein kinase phosphorylates serine 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol., 12: 5041-5049, 1992.
41. Lambert, P. F., Kashanchi, F., Radonovich, M. F., Shiekhattar, R., and Brady, J. N. Phosphorylation of p53 serine 15 increases interaction with CBP. J. Biol. Chem., 273: 33048-33053, 1998.
42. Fuchs, B., O'Connor, D., Fallis, L., Scheidtmann, K. H., and Lu, X. p53 phosphorylation mutants retain transcription activity. Oncogene, 10: 789-793, 1995.
43. Chin, P. L., Momand, J., and Pfeifer, G. P. In vivo evidence for binding of p53 to consensus binding sites in the p21 and Gadd45 genes in response to ionizing radiation. Oncogene, 15: 87-99, 1997.
44. Zhan, Q., Carrier, F., and Fornace, A. J., Jr. Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol. Cell. Biol., 13: 4242-4250, 1993.
45. Harkin, D. P., Bean, J. M., Miklos, D., Song, Y-H., Truong, V. B., Englert, C., Christians, F. C., Ellisen, L. W., Maheswaran, S., Oliner, J. D., and Haber, D. A. Induction of gadd45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell, 97: 575-586, 1999.
46. Bush, A., Mateyak, M., Dugan, K., Obaya, A., Adachi, S., Sedivy, J., and Cole, M. c-myc null cells misregulate cad and gadd45 but not other proposed c-myc targets. Genes Dev., 12: 3797-3802, 1998.
47. Marhin, W. W., Chen, S., Facchini, L. M., Fornace, A. J., Jr., and Penn, L. Z. Myc represses the growth arrest gene gadd45. Oncogene, 14: 2825-2834, 1997.
48. Wu, L., and Levine, A. J. Differential regulation of the p21/waf1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene. Mol. Med., 3: 441-451, 1997.
49. Takekawa, M., and Saito, H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell, 95: 521-530, 1998.