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Volumn 95, Issue 1, 2010, Pages 93-99

Unraveling the directional link between adiposity and inflammation: A bidirectional mendelian randomization approach

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; LEPTIN; MELANOCORTIN 4 RECEPTOR;

EID: 75149163834     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1064     Document Type: Article
Times cited : (114)

References (41)
  • 1
    • 41649092481 scopus 로고    scopus 로고
    • Progress in the genetics of common obesity: Size matters
    • Li S, Loos RJ 2008 Progress in the genetics of common obesity: size matters. Curr Opin Lipidol 19:113-121
    • (2008) Curr Opin Lipidol , vol.19 , pp. 113-121
    • Li, S.1    Loos, R.J.2
  • 2
    • 52949135179 scopus 로고    scopus 로고
    • Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization
    • Smith GD, Timpson N, Ebrahim S 2008 Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Ann Med 40:524-541
    • (2008) Ann Med , vol.40 , pp. 524-541
    • Smith, G.D.1    Timpson, N.2    Ebrahim, S.3
  • 3
    • 0037322022 scopus 로고    scopus 로고
    • Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?
    • Davey Smith G, Ebrahim S 2003 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32:1-22
    • (2003) Int J Epidemiol , vol.32 , pp. 1-22
    • Davey Smith, G.1    Ebrahim, S.2
  • 4
    • 40849083720 scopus 로고    scopus 로고
    • Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
    • Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G 2008 Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 27:1133-1163
    • (2008) Stat Med , vol.27 , pp. 1133-1163
    • Lawlor, D.A.1    Harbord, R.M.2    Sterne, J.A.3    Timpson, N.4    Davey Smith, G.5
  • 5
    • 38049023073 scopus 로고    scopus 로고
    • Clustered environments and randomized genes: A fundamental distinction between conventional and genetic epidemiology
    • Smith GD, Lawlor DA, Harbord R, Timpson N, Day I, Ebrahim S 2007 Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med 4:e352
    • (2007) PLoS Med , vol.4
    • Smith, G.D.1    Lawlor, D.A.2    Harbord, R.3    Timpson, N.4    Day, I.5    Ebrahim, S.6
  • 7
    • 34248594090 scopus 로고    scopus 로고
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894
  • 8
    • 44349142294 scopus 로고    scopus 로고
    • Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, et al. 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40:768-775
    • Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, et al. 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40:768-775
  • 9
    • 57749121512 scopus 로고    scopus 로고
    • An obesity-associated FTO gene variant and increased energy intake in children
    • Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN 2008 An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359:2558-2566
    • (2008) N Engl J Med , vol.359 , pp. 2558-2566
    • Cecil, J.E.1    Tavendale, R.2    Watt, P.3    Hetherington, M.M.4    Palmer, C.N.5
  • 10
    • 54949113309 scopus 로고    scopus 로고
    • The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
    • Qi L, Kraft P, Hunter DJ, Hu FB 2008 The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet 17:3502-3508
    • (2008) Hum Mol Genet , vol.17 , pp. 3502-3508
    • Qi, L.1    Kraft, P.2    Hunter, D.J.3    Hu, F.B.4
  • 13
    • 28244453652 scopus 로고    scopus 로고
    • Nature's randomised trials
    • Hingorani A, Humphries S 2005 Nature's randomised trials. Lancet 366:1906-1908
    • (2005) Lancet , vol.366 , pp. 1906-1908
    • Hingorani, A.1    Humphries, S.2
  • 14
    • 33745683664 scopus 로고    scopus 로고
    • Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease risk
    • Hingorani AD, Shah T, Casas JP 2006 Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease risk. Eur Heart J 27:1261-1263
    • (2006) Eur Heart J , vol.27 , pp. 1261-1263
    • Hingorani, A.D.1    Shah, T.2    Casas, J.P.3
  • 15
    • 44249105434 scopus 로고    scopus 로고
    • Associations of plasma pro-inflammatory cytokines, fibrinogen, viscosity and C-reactive protein with cardiovascular risk factors and social deprivation: The fourth Glasgow MONICA study
    • Welsh P, Woodward M, Rumley A, Lowe G 2008 Associations of plasma pro-inflammatory cytokines, fibrinogen, viscosity and C-reactive protein with cardiovascular risk factors and social deprivation: the fourth Glasgow MONICA study. Br J Haematol 141:852-861
    • (2008) Br J Haematol , vol.141 , pp. 852-861
    • Welsh, P.1    Woodward, M.2    Rumley, A.3    Lowe, G.4
  • 16
    • 58149394252 scopus 로고    scopus 로고
    • Prospective study of physical fitness, adiposity, and inflammatory markers in healthy middle-aged men and women
    • Hamer M, Steptoe A 2009 Prospective study of physical fitness, adiposity, and inflammatory markers in healthy middle-aged men and women. Am J Clin Nutr 89:85-89
    • (2009) Am J Clin Nutr , vol.89 , pp. 85-89
    • Hamer, M.1    Steptoe, A.2
  • 18
    • 0036655175 scopus 로고    scopus 로고
    • The case for an immunologic cause of obesity
    • Rogge MM 2002 The case for an immunologic cause of obesity. Biol Res Nurs 4:43-53
    • (2002) Biol Res Nurs , vol.4 , pp. 43-53
    • Rogge, M.M.1
  • 19
    • 33644674993 scopus 로고    scopus 로고
    • Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself
    • Pepys MB, Hawkins PN, Kahan MC, Tennent GA, Gallimore JR, Graham D, Sabin CA, Zychlinsky A, de Diego J 2005 Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself. Circ Res 97:e97-e103
    • (2005) Circ Res , vol.97
    • Pepys, M.B.1    Hawkins, P.N.2    Kahan, M.C.3    Tennent, G.A.4    Gallimore, J.R.5    Graham, D.6    Sabin, C.A.7    Zychlinsky, A.8    de Diego, J.9
  • 21
    • 59749092544 scopus 로고    scopus 로고
    • C-reactive protein and coronary heart disease: Predictive test or therapeutic target?
    • Hingorani AD, Shah T, Casas JP, Humphries SE, Talmud PJ 2009 C-reactive protein and coronary heart disease: predictive test or therapeutic target? Clin Chem 55:239-255
    • (2009) Clin Chem , vol.55 , pp. 239-255
    • Hingorani, A.D.1    Shah, T.2    Casas, J.P.3    Humphries, S.E.4    Talmud, P.J.5
  • 22
    • 0025924025 scopus 로고
    • How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely
    • Phillips AN, Smith GD 1991 How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely. J Clin Epidemiol 44:1223-1231
    • (1991) J Clin Epidemiol , vol.44 , pp. 1223-1231
    • Phillips, A.N.1    Smith, G.D.2
  • 24
    • 32144458889 scopus 로고    scopus 로고
    • Commentary: BMI and mortality in the elderly - a life course perspective
    • Hardy R, Kuh D 2006 Commentary: BMI and mortality in the elderly - a life course perspective. Int J Epidemiol 35:179-180
    • (2006) Int J Epidemiol , vol.35 , pp. 179-180
    • Hardy, R.1    Kuh, D.2
  • 25
    • 0025240895 scopus 로고
    • Age variations in the relation of body mass indices to estimates of body fat and muscle mass
    • Micozzi MS, Harris TM 1990 Age variations in the relation of body mass indices to estimates of body fat and muscle mass. Am J Phys Anthropol 81:375-379
    • (1990) Am J Phys Anthropol , vol.81 , pp. 375-379
    • Micozzi, M.S.1    Harris, T.M.2
  • 27
    • 58149289996 scopus 로고    scopus 로고
    • Hubacek JA, Bohuslavova R, Kuthanova L, Kubinova R, Peasey A, Pikhart H, Marmot MG, Bobak M 2008 The FTO gene and obesity in a large Eastern European Population sample: the HAPIEE study. Obesity (Silver Spring) 16:2764-2766
    • Hubacek JA, Bohuslavova R, Kuthanova L, Kubinova R, Peasey A, Pikhart H, Marmot MG, Bobak M 2008 The FTO gene and obesity in a large Eastern European Population sample: the HAPIEE study. Obesity (Silver Spring) 16:2764-2766
  • 31
    • 33846656917 scopus 로고    scopus 로고
    • Accounting for linkage disequilibrium among markers in linkage analysis: Impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease
    • Sieh W, Yu CE, Bird TD, Schellenberg GD, Wijsman EM 2007 Accounting for linkage disequilibrium among markers in linkage analysis: impact of haplotype frequency estimation and molecular haplotypes for a gene in a candidate region for Alzheimer's disease. Hum Hered 63:26-34
    • (2007) Hum Hered , vol.63 , pp. 26-34
    • Sieh, W.1    Yu, C.E.2    Bird, T.D.3    Schellenberg, G.D.4    Wijsman, E.M.5
  • 35
    • 67649855154 scopus 로고    scopus 로고
    • Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype
    • Timpson NJ, Harbord R, Davey Smith G, Zacho J, Tybjaerg-Hansen A, Nordestgaard BG 2009 Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype. Hypertension 54:84-90
    • (2009) Hypertension , vol.54 , pp. 84-90
    • Timpson, N.J.1    Harbord, R.2    Davey Smith, G.3    Zacho, J.4    Tybjaerg-Hansen, A.5    Nordestgaard, B.G.6
  • 38
    • 61849142843 scopus 로고    scopus 로고
    • How does body fat influence bone mass in childhood? A Mendelian randomisation approach
    • Timpson NJ, Sayers A, Davey-Smith G, Tobias JH 2009 How does body fat influence bone mass in childhood? A Mendelian randomisation approach. J Bone Miner Res 24:522-533
    • (2009) J Bone Miner Res , vol.24 , pp. 522-533
    • Timpson, N.J.1    Sayers, A.2    Davey-Smith, G.3    Tobias, J.H.4
  • 39
    • 42549107052 scopus 로고    scopus 로고
    • C-reactive protein is neither a marker nor a mediator of atherosclerosis
    • Pepys MB 2008 C-reactive protein is neither a marker nor a mediator of atherosclerosis. Nat Clin Pract Nephrol 4:234-235
    • (2008) Nat Clin Pract Nephrol , vol.4 , pp. 234-235
    • Pepys, M.B.1
  • 41
    • 18244407548 scopus 로고    scopus 로고
    • Association of C-reactive protein with blood pressure and hypertension: Life course confounding and Mendelian randomization tests of causality
    • Davey Smith G, Lawlor DA, Harbord R, Timpson N, Rumley A, Lowe GD, Day IN, Ebrahim S 2005 Association of C-reactive protein with blood pressure and hypertension: life course confounding and Mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol 25:1051-1056
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1051-1056
    • Davey Smith, G.1    Lawlor, D.A.2    Harbord, R.3    Timpson, N.4    Rumley, A.5    Lowe, G.D.6    Day, I.N.7    Ebrahim, S.8


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