Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: The AVENA Study

American Journal of Clinical Nutrition

Volumn 84, Issue 3, 2006, Pages 505-512

  Wärnberg, Julia ^a,b   Nova, Esther ^a   Moreno, Luis A ^c   Romeo, Javier ^a   Mesana, Maria I ^c   Ruiz, Jonatan R ^b,d   Ortega, Francisco B ^b,d   Sjöström, Michael ^b   Bueno, Manuel ^c,f   Marcos, Ascensión ^a,d,e,f   Castillo, M J ^d,f   Zamora, S ^f,g   Garcia Fuentes M ^f,h   Cano, M D ^d   Sola, R ^d   Gutierrez A ^d   Mesa, J L ^d   Delgado, M ^d   Tercedor, P ^d   Chillon P ^d   Martin M ^d   Carreno F ^d   Rodriguez G V ^d   Castillo, R ^d   Arellano, F ^d   Gonzalez Gross M ^a   Gomez S ^a   Alvarez A ^a   Barrios, L ^a   Leyva, A ^a   Paya B ^a   Vallejo, M C ^a   Sanchez Muniz F ^a   Martinez L ^a   Ramos, E ^a   Ortiz De Zarate R ^a   Urzanqui, A ^a   Garaulet, M ^g   Perez Llamas F ^g   Baraza, J C ^g   Marin J F ^g   Perez De Heredia F ^g   Fernandez M A ^g   Gonzalez C ^g   Garcia R ^g   Torralba, C ^g   Donat, E ^g   Morales, E ^g   Garcia M D ^g   Martinez J A ^g   Hernandez J J ^g   Asensio, A ^g   Plaza, F J ^g   Lopez M J ^g   Gonzalez Lamuno D ^h   De Rufino, P ^h   Perez Prieto R ^h   Fernandez D ^h   Amigo, T ^h   Sarria A ^c   Fleta, J ^c   Rodriguez G ^c   Gil, C M ^c   Casajus J A ^c   Blay, V ^c   Blay, M G ^c   more..

^a CSIC   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d UNIVERSITY OF GRANADA   (Spain)

^e INSTITUTO DEL FRÍO CSIC   (Spain)

^f Universidad de Murcia ^*

^g UNIVERSITY OF MURCIA   (Spain)

^h UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Adolescents; C reactive protein; Central obesity; Complement factors; CRP; Inflammation

Indexed keywords

C REACTIVE PROTEIN; CERULOPLASMIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CYTOKINE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

ADOLESCENT; ADULT; ARTICLE; BODY FAT DISTRIBUTION; CHILD NUTRITION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; INFLAMMATION; MALE; NUTRITIONAL STATUS; OBESITY; PREVALENCE; PROTEIN ANALYSIS; RISK ASSESSMENT; WAIST CIRCUMFERENCE; ABDOMINAL FAT; BLOOD; CELL CULTURE; CLINICAL TRIAL; CROSS-SECTIONAL STUDY; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL; MULTICENTER STUDY; SEX DIFFERENCE; SPAIN;

ABDOMINAL FAT; ADOLESCENT; BIOLOGICAL MARKERS; BODY FAT DISTRIBUTION; C-REACTIVE PROTEIN; CELLS, CULTURED; CERULOPLASMIN; COMPLEMENT C3; COMPLEMENT C4; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; OBESITY; SEX FACTORS; SPAIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750110630     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/84.3.505     Document Type: Article

References (49)

1. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-55.
2. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-8.
3. Gonzalez MA, Selwyn AP. Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med 2003;8:115:99S-106S.
4. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Low-grade systemic inflammation in overweight children. Pediatrics 2001;107:1-6.
5. Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH, Dietz WH. C-reactive protein and body mass index in children: findings from the third National Health and Nutrition Examination Survey, 1988-1994. J Pediatr 2001;138:486-92.
6. Lean MEJ, Han TS, Seidell JC. Impairment of health and quality of life in people with large waist circumference. Lancet 1998;351:853-6.
7. Moreno LA, Pineda I, Rodriguez G, Fleta J, Sarria A, Bueno M. Waist circumference for the screening of the metabolic syndrome in children. Acta Paediatr 2002;91:1307-12.
8. Santos AC, Lopes C, Guimaraes JT, Barros H. Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. Int J Obes (Lond) 2005;29:1452-6. Epub ahead of print.
9. Onat A, Uzunlar B, Hergenc G, et al. Cross-sectional study of complement C3 as a coronary risk factor among men and women. Clin Sci (Lond) 2005;108:129-35.
10. Muscari A, Bastagli L, Poggiopollini G, et al. Different associations of C-reactive protein, fibrinogen and C3 with traditional risk factors in middle-aged men. Int J Cardiol 2002;83:63-71.
11. González-Gross M, Castillo MJ, Moreno L, et al. Alimentación y Valoración del Estado Nutricional de los Adolescentes Españoles (Proyeto AVENA). Risk evaluation and intervention proposals. I. Methodological description of the study. Nutr Hosp 2003;18:15-28 (in Spanish).
12. Moreno LA, Mesana MI, Fleta J, et al. Overweight, obesity and body fat composition in Spanish adolescents. The AVENA Study. Ann Nutr Metab 2005;49:71-6.
13. Moreno LA, Joyanes M, Mesana MI, et al. Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 2003;19:481-6.
14. Slaughter MH, Lohman TG, Boileau RA, et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol 1988;60:709-23.
15. Rodriguez G, Moreno LA, Blay MG, et al. Body fat measurement in adolescents: comparison of skinfold-thickness equations with dualenergy X-ray absorptiometry. Eur J Clin Nutr 2005;59:1158-66.
16. Tanner JM. Growth at adolescence. Oxford, United Kingdom: Blackwell, 1962.
17. Ruiz JR, Ortega FB, Moreno LA, et al. Serum lipids and lipoprotein distributions of Spanish adolescents. The AVENA study. Soz Praventivmed 2006;51:99-109.
18. Moreno LA, Mesana MI, González-Gross M, et al. Anthropometric body fat composition reference values in Spanish adolescents. The AVENA Study. Eur J Clin Nutr 2006;60:191-6.
19. Cole TJ, Bellizzi MC, Flegal M, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2002;320:1-6.
20. Ford ES. C-reactive protein concentration and cardiovascular disease risk factors in children. Findings from the National Health and Nutrition Examination Survey 1999-2000. Circulation 2003;108:1053-8.
21. Wu DM, Chu NF, Shen MH, Chang JB. Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children. J Clin Epidemiol 2003;56:94-100.
22. Cook DG, Mendall MA, Whincup PH, et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular disease risk factors. Atherosclerosis 2000;49:139-50.
23. Berenson GS, for the Bogalusa Heart Study Research Group. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease: The Bogalusa Heart Study. Am J Cardiol 2002;90:3L-7L.
24. McGill HC Jr, McMahan CA, Herderick EE, Malcom GT, Tracy RE, Strong JP. Origin of atherosclerosis in childhood and adolescence. Am J Clin Nutr 2000;72(suppl):S1307-15.
25. Millonig G, Malcom GT, Wick G. Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY)-study. Atherosclerosis 2002;160:441-8.
26. Raitakari OT, Juonala M, Kahonen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 2003;5:290:2277-83.
27. Freedman DS, Dietz WH, Tang R, et al. The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2004;28:159-66.
28. Jarvisalo MJ, Harmoinen A, Hakanen M, et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Atheroscler Thromb Vasc Biol 2002;22:1323-8.
29. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-26.
30. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003;27:S53-5.
31. Niculescu F, Rus H. The role of complement activation in atherosclerosis. Immunol Res 2004;30:73-80.
32. Gabrielsson BG, Johansson JM, Lonn M, et al. High expression of complement components in omental adipose tissue in obese men. Obes Res 2003;11:699-708.
33. Pomeroy C, Mitchell J, Eckert E, Raymond N, Crosby R, Dalmasso AP. Effect of body weight and caloric restriction on serum complement proteins, including factor D/adipsin: studies in anorexia nervosa and obesity. Clin Exp Immunol 1997;108:507-15.
34. Nova E, Lopez-Vidriero I, Varela P, Toro O, Casas JJ, Marcos A. Indicators of nutritional status in restricting-type anorexia nervosa patients: a 1-year follow-up study. Clin Nutr 2004;23:1353-9.
35. Cianflone K, Lu H, Smith J, Yu W, Wang H. Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children. Clin Endocrinol (Oxf) 2005;62:567-72.
36. Moreno L, Sarría A, Lázaro A, Bueno M, Larrad L. Serum C4 concentration and risk of atherosclerosis. Br Med J 1994;309:1087 (letter).
37. Freedman DS, Serdula MK, Srinivasan SR, Berenson GS. Relation of circumferences and skinfold thicknesses to lipid and insulin concentrations in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr 1999;69:308-17.
38. Daniels SR, Morrison JA, Sprecher DL, Khoury P, Kimball TR. Association of body fat distribution and cardiovascular risk factors in children and adolescents. Circulation 1999;99:541-5.
39. Gillum RF. Association of serum C-reactive protein and indices of body fat distribution and overweight in Mexican American children. J Natl Med Assoc 2003;95:545-52.
40. Vikram NK, Misra A, Dwivedi M. et al. Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North India. Atherosclerosis 2003;168:305-13.
41. Moreno LA, Sarria A, Fleta J, Marcos A, Bueno M. Secular trends in waist circumference in Spanish adolescents, 1995 to 2000-02. Arch Dis Child 2005;90:818-9.
42. Peake PW, Kriketos AD, Campbell LV, Charlesworth JA. Response of the alternative complement pathway to an oral fat load in first-degree relatives of subjects with type II diabetes. Int J Obes Relat Metab Disord 2005;29:429-35.
43. Weyer C, Tataranni PA, Pratley RE. Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration. Diabetes Care 2000;23:779-85.
44. Koistinen HA, Vidal H, Karonen SL, et al. Plasma acylation stimulating protein concentration and subcutaneous adipose tissue C3 mRNA expression in nondiabetic and type 2 diabetic men. Arterioscler Thromb Vasc Biol 2001;21:1034-9.
45. Bhakdi S, Torzewski M, Klouche M, et al. Complement and atherogenesis: binding of CRP to degraded, nonoxidized LDL enhances complement activation. Arterioscler Thromb Vasc Biol 1999;19:2348-54.
46. Ramadori G, Christ B. Cytokines and the hepatic acute-phase response. Semin Liver Dis 1999;19:141-55.
47. Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998;83:847-50.
48. Mohamed-Ali V, Goodrick S, Rajes A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 1997;82:4196-200.
49. Das UN. Is obesity an inflammatory condition? Nutrition 2001;17:953-66.