Retinol-induced intestinal tumorigenesis in Min/+ mice and importance of vitamin D status

Anticancer Research

Volumn 29, Issue 11, 2009, Pages 4353-4360

  Hetland, Ragna Bogen ^a   Alexander, Jan ^a   Berg, Jens Petter ^b   Svendsen, Camilla ^a   Paulsen, Jan Erik ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Carcinogenesis; Intestine; Min + mouse; Retinol; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; RETINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREEDING; CANCER GROWTH; CARCINOGENESIS; CONTROLLED STUDY; DIETARY INTAKE; DRUG MEGADOSE; FEMALE; INTESTINAL CARCINOGENESIS; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROGENY; SEX DIFFERENCE; TUMOR VOLUME; VITAMIN INTAKE; WEANING;

ANIMALS; BODY WEIGHT; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTESTINAL NEOPLASMS; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; VITAMIN A; VITAMIN D;

EID: 75149159191     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Garland CF and Garland FC: Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 9: 227-231, 1980.
2. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M and Holick MF: Vitamin D and prevention of colorectal cancer. J Ster Biochem MoI Biol 97: 179-194,2005.
3. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M and Holick MF: Optimal vitamin D status for colorectal cancer prevention: A quantitative meta analysis. Am J Prev Med 32: 210-216,2007.
4. Giovannucci E: The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 16: 83-95, 2005.
5. Oh K, Willett WC, Wu K, Fuchs CS and Giovannucci EL: Calcium and vitamin D intakes in relation to risk of distal colorectal adenoma in women. Am J Epidemiol 165: 1178-1186, 2007.
6. Wu K, Feskanich D, Fuchs CS, Willett WC, Hollis BW and Giovannucci EL: A nested case-control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst 99: 1120-1129, 2007.
7. Mollersen L, Paulsen JE, Olstorn HB, Knutsen HK and Alexander J: Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice. Carcinogenesis 25: 149-153, 2004.
8. Huerta S, Irwin RW, Heber D, Go VL, Koeffler HP, Uskokovic MR and Harris DM: lα,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse. Cancer Res 62: 741-746, 2002.
9. Yang K, Edelmann W, Fan K, Lau K, Leung D, Newmark H, Kucherlapati R and Lipkin M: Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res 58: 5713-5717, 1998.
10. Paulsen JE, Steffensen IL, Namork E, Eide TJ and Alexander J: Age-dependent susceptibility to azoxymethane-induced and spontaneous tumorigenesis in the Min/+ mouse. Anticancer Res 23: 259-265, 2003.
11. Paulsen JE, Elvsaas IK, Steffensen IL and Alexander J: A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. Carcinogenesis 18: 1905-1910, 1997.
12. Steffensen IL, Paulsen JE, Eide TJ and Alexander J: 2-Amino-1-methyl-6- phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice. Carcinogenesis 18: 1049-1054, 1997.
13. Holick MF: Vitamin D Status: Measurement, interpretation, and clinical application. Ann Epidemiol 19: 73-78, 2009.
14. Zheng Y, Kramer PM, Lubet RA, Steele VE, Kelloff GJ and Pereira MA: Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. Carcinogenesis 20: 255-260, 1999.
15. Wargovich MJ, Jimenez A, McKee K, Steele VE, Velasco M, Woods J, Price R, Gray K and Kelloff GJ: Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 21: 1149-1155, 2000.
16. Dillard AC and Lane MA: Retinol decreases β-catenin protein levels in retinoic acid-resistant colon cancer cell lines. MoI Carcinog 46: 315-329,2007.
17. Dillard AC and Lane MA: Retinol increases β-catenin-RXR-α binding leading to the increased proteasomal degradation of β-catenin and RXR-α. Nutr Cancer 60: 97-108, 2008.
18. Delage BF, Bairras CF, Buaud BF, Pallet VF and Cassand P: A high-fat diet generates alterations in nuclear receptor expression: prevention by vitamin A and links with cyclooxygenase-2 and β-catenin. Int J Cancer 116: 839-846, 2005.
19. Mollersen L, Paulsen JE and Alexander J: Loss of heterozygosity and nonsense mutation in Apc in azoxymethane-induced colonic tumours in Min mice. Anticancer Res 24: 2595-2599, 2004.
20. Jette C, Peterson PW, Sandoval IT, Manos EJ, Hadley E, Ireland CM and Jones DA: The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. J Biol Chem 279: 34397-34405,2004.
21. Shelton DN, Sandoval IT, Eisinger A, Chidester S, Ratnayake A, Ireland CM and Jones DA: Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res 66: 7571-7577,2006.
22. Knutsen HK, Olstorn HB Paulsen, Paulsen JE, Husoy T, Goverud IL, Loberg EM, Kristiansen K and Alexander J: Increased levels of PPARβ/δ and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice. Anticancer Res 25: 3781-3789,2005.
23. He TC, Chan TA, Vogelstein B and Kinzler KW: PPAR-δ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99: 335-345, 1999.
24. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK and DuBois RN: Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth. Nat Med 10: 245-247, 2004.
25. Shaw N, Elholm M and Noy N: Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor-β/δ J Biol Chem 278: 41589-41592, 2003.
26. Schug TT, Berry DC, Shaw NS, Travis SN and Noy N: Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 129: 723-733, 2007.
27. Wolf G: Retinoic acid as cause of cell proliferation or cell growth inhibition depending on activation of one of two different nuclear receptors. Nutr Rev 66: 55-59, 2008.
28. Yang K, Yang W, Mariadason J, Velcich A, Lipkin M and Augenlicht L: Dietary components modify gene expression: implications for carcinogenesis. J Nutr 135: 2710-2714, 2005.
29. Garland CF, Grant WB, Mohr SB, Gorham ED and Garland FC: What is the dose-response relationship between vitamin D and cancer risk? Nutr Rev 65: S91-S95, 2007.
30. Johansson S and Melhus H: Vitamin A antagonizes calcium response to vitamin D in man. J Bone Min Res 16: 1899-1905, 2001.
31. Lind PM, Johansson S, Ronn M and Melhus H: Subclinical hypervitaminosis A in rat: Measurements of bone mineral density (BMD) do not reveal adverse skeletal changes. Chem Biol Interact 159: 73-80, 2006.
32. Rohde CM and DeLuca HF: All-trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecalciferol, in rats. J Nutr 135: 1647-1652, 2005.
33. Forsmo S, Fjeldbo SK and Langhammer A: Childhood cod liver oil consumption and bone mineral density in a population-based cohort of peri- and postmenopausal women: The Nord-Trondelag Health Study. Am J Epidemiol 167: 406-411, 2008.
34. Haussler MR, Haussler CA, Jurutka PW, Thompson PD, Hsieh JC, Remus LS, Selznick SH and Whitfield GK: The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol 154 Suppl: S57-S73, 1997.
35. Ding EL, Mehta S, Fawzi WW and Giovannucci EL: Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: Reanalysis of Women's Health Initiative randomized trial. Int J Cancer 122: 1690-1694, 2007.