Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 2, 2010, Pages 586-595

  Hoare, Todd ^a   Bellas, Evangelia ^a   Zurakowski, David ^b   Kohane, Daniel S ^b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Drug delivery; Hyaluronic acid; In vivo; Nerve blockade; Polymer blends

Indexed keywords

BUPIVACAINE; DELIVERY VEHICLE; DRUG RELEASE; GEL POINT; HYALURONIC ACIDS; HYDROXY PROPYL METHYL CELLULOSE; IN-VITRO; IN-VIVO; INFLAMMATORY REACTION; LOCAL ANESTHETICS; NERVE BLOCK; NERVE BLOCKADE; POLYMER CONCENTRATIONS; POSTINJECTION; RAT SCIATIC NERVE; SINGLE VARIABLE; TWO-PARAMETER MODELS; ZERO SHEAR VISCOSITY;

ANESTHETICS; BIOCOMPATIBILITY; BLENDING; DRUG DELIVERY; HYDROXYLATION; ORGANIC ACIDS; RHEOLOGY; SHEAR VISCOSITY; TISSUE; YIELD STRESS;

POLYMER BLENDS;

BUPIVACAINE; HYALURONIC ACID; HYDROXYPROPYLMETHYLCELLULOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; FLOW KINETICS; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE BLOCK; NONHUMAN; RAT; SCIATIC NERVE; VISCOSITY;

ANESTHETICS, LOCAL; ANIMALS; BIOCOMPATIBLE MATERIALS; BUPIVACAINE; CELL LINE; COLORING AGENTS; DRUG DELIVERY SYSTEMS; HYALURONIC ACID; INFLAMMATION; MALE; METHYLCELLULOSE; MOLECULAR WEIGHT; NERVE BLOCK; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SCIATIC NERVE; SOLUTIONS; TETRAZOLIUM SALTS; THIAZOLES; VISCOSITY;

EID: 75149150717     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32420     Document Type: Article

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